Article
Medicine, General & Internal
Trinidad Montero-Vilchez, Juan-Angel Rodriguez-Pozo, Pablo Diaz-Calvillo, Maria Salazar-Nievas, Jesus Tercedor-Sanchez, Alejandro Molina-Leyva, Salvador Arias-Santiago
Summary: The study aimed to evaluate the impact of dupilumab on skin barrier function in patients with atopic dermatitis (AD) and compare it with other treatments. The study found that dupilumab was more effective in improving barrier function in both eczematous lesions and non-lesioned skin compared to topical corticosteroids and cyclosporine.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Anjali Devi Sivakumar, Ruchi Sharma, Chandrakalavathi Thota, Ding Ding, Xudong Fan
Summary: Early diagnosis of skin barrier dysfunction is crucial for preventing skin diseases. A wearable TEWL device (WASP) was developed to accurately and continuously monitor skin water vapor flux, and it can distinguish between different types of sweating. Comparison with a commercial device showed the reliability of WASP's results.
Article
Dermatology
Trinidad Montero-Vilchez, Antonio Martinez-Lopez, Carlos Cuenca-Barrales, Andrea Rodriguez-Tejero, Alejandro Molina-Leyva, Salvador Arias-Santiago
Summary: Wearing masks and gloves may impair skin homeostasis and epidermal barrier function, leading to increased transepidermal water loss and higher skin temperature. High-quality personal protective equipment should be provided, and appropriate skin prevention measures should be implemented.
Article
Medicine, General & Internal
Trinidad Montero-Vilchez, Maria-Victoria Segura-Fernandez-Nogueras, Isabel Perez-Rodriguez, Miguel Soler-Gongora, Antonio Martinez-Lopez, Ana Fernandez-Gonzalez, Alejandro Molina-Leyva, Salvador Arias-Santiago
Summary: This study compared skin barrier function between healthy skin, psoriatic skin, and atopic dermatitis skin, finding that TEWL was higher at psoriatic and AD lesions, while SCH was lower. Specific TEWL and temperature values may help clinicians determine disease severity and treatment needs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Plant Sciences
Shaunak Ray, Brett M. Savoie, Natalia Dudareva, John A. Morgan
Summary: Plant cuticles, consisting of crystalline and amorphous waxes, play a crucial role in regulating the exchange of molecules between plants and the atmosphere. This study investigated the effect of wax composition on the diffusion of water and volatile organic compounds (VOCs) through the cuticle using a model system based on the epicuticular waxes of Petunia hybrida flower petals. Molecular dynamics simulations revealed that the diffusivity of VOCs was significantly influenced by the crystallinity of the wax, with up to a 30-fold increase in diffusivity observed in completely amorphous waxes. The arrangement and spacing of crystalline unit cells also had a significant impact on the diffusion of water and higher molecular weight VOCs. Additionally, the study found that the plant cuticle plays a differential role in controlling the emission of individual VOCs by regulating their composition, quantity, and dynamics.
Article
Biochemistry & Molecular Biology
Kyung-Ha Lee, Hwan-Kwon Do, Do-Yeon Kim, Wanil Kim
Summary: Chlorogenic acid is a polyphenol found in human diet that impacts human cells, promoting procollagen type I production and skin barrier gene expression. It can be used to restore impaired dermal matrix network and epidermal skin barrier.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell & Tissue Engineering
Sixia Huang, Paola Kuri, Yann Aubert, Megan Brewster, Ning Li, Olivia Farrelly, Gabriella Rice, Hyunjin Bae, Stephen Prouty, Tzvete Dentchev, Wenqin Luo, Brian C. Capell, Panteleimon Rompolas
Summary: Lgr6 epidermal stem cells play a crucial role in wound re-epithelialization and interact with nerves to regulate their fate. Loss of nerves affects the wound closure process, leading to recruitment of other stem cell populations for compensation.
Article
Cell Biology
Hanqian Zhang, Simone Westrom, Per Kappelin, Marie Virtanen, Anders Vahlquist, Hans Torma
Summary: This study re-analyzed two sets of microarray data, identifying 24 upregulated genes and confirming 10 of them to be potentially involved in human epidermal keratinocyte differentiation and important for epidermal repair in a genetic skin disease characterized by barrier failure.
Article
Dermatology
Nobutomo Ikarashi, Haruka Kawai, Yui Shinozaki, Keito Tabata, Ryotaro Yoshida, Yui Nishinaka, Risako Kon, Hiroyasu Sakai, Tomoo Hosoe
Summary: Several studies have shown that magnesium can be useful in preventing various skin disorders, but the mechanism is unclear. This study analyzed the mechanism by which magnesium improves skin function, focusing on the water channel aquaporin-3 (AQP3). Magnesium compounds increased the expression level of AQP3 in epidermal keratinocytes, and magnesium acetate had the strongest effect. The phosphorylation of CREB induced by magnesium acetate may be associated with the activation of the cAMP/PKA pathway.
DERMATOLOGIC THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Xiangmei Hua, Conrad Dean Blosch, Hannah Dorsey, Maria K. Ficaro, Nicole L. Wallace, Richard P. Hsung, Jun Dai
Summary: The study found that the expression of epidermal RORα is highly expressed in normal skin and positively regulates the expression of differentiation markers and skin barrier-related genes in keratinocytes. However, in inflammatory skin diseases including atopic dermatitis (AD), the expression of RORα is downregulated. By using a mouse model with epidermis-specific Rora deficiency, it was found that the deficiency intensified AD-like symptoms and impaired the skin barrier function. These results demonstrate the importance of epidermal RORα in suppressing AD development by maintaining normal keratinocyte differentiation and skin barrier function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Leszek Blicharz, Lidia Rudnicka, Joanna Czuwara, Anna Waskiel-Burnat, Mohamad Goldust, Malgorzata Olszewska, Zbigniew Samochocki
Summary: Atopic dermatitis is a common inflammatory skin disease caused by epidermal barrier defects leading to immune dysregulation. Recent research has shown that skin microbiota and bacterial biofilms have a negative impact on skin barrier function, contributing to the onset and exacerbation of atopic dermatitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Veterinary Sciences
Adrien Idee, Marion Mosca, Didier Pin
Summary: This study evaluated the effect of a spot-on containing fatty acids, ceramides, and essential oils on the skin barrier function of dogs. The results showed that the spot-on had a protective effect on the skin barrier function. This suggests that the investigated product may be useful as an adjunctive treatment for canine atopic dermatitis.
VETERINARY SCIENCES
(2022)
Article
Allergy
Jihyun Kim, Byung Eui Kim, Evgeny Berdyshev, Irina Bronova, Lianghua Bin, Jaewoong Bae, Seokjin Kim, Hye-Young Kim, Un Ha Lee, Myoung Shin Kim, Hyunmi Kim, Jinyoung Lee, Clifton F. Hall, Jessica Hui-Beckman, Yunhee Chang, Anna Sofia Bronoff, Dasom Hwang, Hae-Young Lee, Elena Goleva, Kangmo Ahn, Donald Y. M. Leung
Summary: This study found that Staphylococcus aureus infection can cause skin barrier disruption in atopic dermatitis patients. Moreover, the study also found that S. aureus induces aberrant epidermal lipid composition and skin barrier dysfunction by inhibiting fatty acid elongase enzymes in epidermal cells.
Article
Dermatology
Dorothee Daehnhardt, Stephan Daehnhardt-Pfeiffer, Judith Schulte-Walter, Eckhard Hanisch, Thomas Neubourg, Regina Foelster-Holst
Summary: This study demonstrates that lipid foam cream is more effective than basic cream in treating atopic eczema by repairing the skin barrier.
SKIN PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Dermatology
Minjee Lee, Myun Soo Kim, Sung Hee Jang, Hayoung Kim, Gwang Seob Kim, Hyerin Lee, Hyun Min Park, Jungwoo Yang
Summary: Ferment lysates of Lacticaseibacillus rhamnosus IDCC 3201, known as Cera-Glow, were found to significantly improve skin barrier function by enhancing ceramide production and increasing skin hydration.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)