Article
Chemistry, Multidisciplinary
Haoyan Cheng, Chenxiao Wang, Zhiheng Lyu, Zhihong Zhu, Younan Xia
Summary: We present a method for controlling the nucleation and growth of Au nanoparticles on the surface of a-Se nanospheres. The Au0 atoms are only produced on the surface of the a-Se nanospheres during the nucleation stage, allowing us to control the number and morphology of the Au nanoparticles. By adjusting the pH, Se-Au hybrid nanoparticles containing different numbers of Au nanoparticles on each a-Se nanosphere can be obtained. The presence of Au patches on the hybrid nanoparticles can enhance cellular uptake and cytotoxicity of the a-Se nanospheres.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Cell Biology
Elena G. Varlamova, Michail Victorovich Goltyaev, Vladimir Vladimirovich Rogachev, Sergey V. Gudkov, Elena V. Karaduleva, Egor A. Turovsky
Summary: For the first time, this study proposes key markers of endoplasmic reticulum stress and molecular mechanisms for the regulation of fibrosis and accompanying negative processes caused by thioacetamide injections and subsequent injections of selenium-containing nanoparticles and sorafenib. Selenium nanoparticles, both with and without sorafenib, significantly decrease the expression of pro-fibrotic and pro-inflammatory genes. Sorafenib injections also reduce the expression of these genes, but less effectively than selenium nanoparticles. Additionally, this study shows for the first time that thioacetamide can induce endoplasmic reticulum stress and activate apoptotic and pyroptotic pathways. Selenium-containing nanoparticles mitigate the negative effects caused by thioacetamide and activate an adaptive response through the PERK signaling pathway. The advantages of selenium-containing nanoparticles over sorafenib are emphasized as an important factor for the further development of clinical drugs based on selenium.
Article
Chemistry, Medicinal
Sandra Ramos-Inza, Ignacio Encio, Asif Raza, Arun K. Sharma, Carmen Sanmartin, Daniel Plano
Summary: The study reported the cytotoxic effects of novel Se-NSAID analogs, showing that compounds 4a and 4d exhibit potential as chemotherapeutic drugs for breast cancer by inducing apoptosis and releasing the parent NSAID along with the Se fragment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Environmental Sciences
Jiapei Feng, Fan Yang, Huansheng Wu, Chenghong Xing, Haotian Xue, Linwei Zhang, Caiying Zhang, Guoliang Hu, Huabin Cao
Summary: Cadmium has a significant impact on agricultural production, but selenium can alleviate its toxicity. This study aimed to investigate the effects of selenium on cadmium-induced heart injury and found that selenium may protect the heart from cadmium-induced pyroptosis, autophagy, and apoptosis by interfering with the PI3K/AKT/PTEN signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Yinghua Li, Danyang Chen, Jingyao Su, Mingkai Chen, Tianfeng Chen, Wei Jia, Bing Zhu
Summary: This study constructed a selenium-containing metal complex drug delivery system Ru(biim)(PhenSe)2 (RuSe) and investigated its anti-influenza virus efficacy and potential antiviral mechanism. The results showed that RuSe enhanced the expression levels of selenium proteins GPx1 and TrxR1 by regulating selenium metabolism, thereby inhibiting viral replication and assembly and regulating virus-mediated mitochondria-related apoptosis. Animal experiments confirmed that RuSe reduced lung tissue inflammation, inhibited lung tissue cell apoptosis, and improved the survival state of mice. RuSe also effectively improved the low immune response and alleviated lung fibrosis in Se-deficient mice.
Review
Medicine, Research & Experimental
Ayu Shalihat, Aliya Nur Hasanah, Mutakin, Ronny Lesmana, Arif Budiman, Dolih Gozali
Summary: Selenium, as a trace element, plays a crucial role in protecting cells, especially in cardiovascular disease and heart cell survival. Research suggests that selenium may exert cardioprotective effects through multiple signaling pathways, including antioxidant, anti-inflammatory, and anti-apoptotic effects.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Benoit Toubhans, Nour Alkafri, Marcos Quintela, David W. James, Caroline Bissardon, Salvatore Gazze, Franziska Knodel, Olivier Proux, Alexandra T. Gourlan, Philipp Rathert, Sylvain Bohic, Deyarina Gonzalez, Lewis W. Francis, Laurent Charlet, R. Steven Conlan
Summary: At physiological levels, selenium is involved in redox reactions and has potential anti-cancer effects. Selenium nanoparticles, coated with serum albumin or chitosan, enhance biocompatibility and bioavailability. In this study, selenium nanoparticles were found to regulate histone methylation in ovarian cancer cell models, leading to increased histone methylation at specific sites. This novel role of selenium in histone methylation is mediated by a decrease in S-adenosylhomocysteine, an endogenous inhibitor of lysine methyltransferases. These findings broaden our understanding of the action of selenium nanoparticles in cancer therapy and other applications.
Article
Nanoscience & Nanotechnology
Xiaohui Wang, Bo Wu, Guogen Sun, Wenxi He, Jia Gao, Teng Huang, Jing Liu, Qing Zhou, Xiaoyu He, Shu Zhang, Zixiong Zhang, He Zhu
Summary: This study demonstrates that miR167a transported by Se-BDEVs from broccoli enriched with selenium exhibits greater anti-pancreatic cancer potency by inducing apoptosis of PANC-1 cells. The key target gene of miR167a is IRS1, which is involved in the PI3K-AKT pathway.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Environmental Sciences
Khalaf F. Alsharif, Ashraf Albrakati, Naif E. Al Omairi, Abdulraheem S. Almalki, Walaa F. Alsanie, Zakaria Y. Abd Elmageed, Ola A. Habotta, Maha S. Lokman, Hussam A. Althagafi, Abdullah A. A. Alghamdi, Ahmed E. Abdel Moneim, Hussain Alyami, Saied K. M. Belal, Ghaliah Alnefaie, Abdulhakeem S. Alamri, Nisreen Khalid Aref Albezrah, Rami B. Kassab, Alaa Jameel A. Albarakati, Khalid Ebraheem Hassan, Ahmad Agil
Summary: The combined administration of prodigiosin (PDG) and selenium (Na2SeO3) has shown promising therapeutic effects in a rat model of schizophrenia induced by amphetamine. The treatment improved social interaction, decreased acetylcholinesterase (AChE) and dopamine levels, and modulated the expression of NMDAR1 and neurotrophic factors. It also enhanced antioxidant defense, reduced neuroinflammation and apoptosis, resulting in significant improvements in schizophrenia-related symptoms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Deepkamal N. Karelia, Sangyub Kim, Manoj K. Pandey, Daniel Plano, Shantu Amin, Junxuan Lu, Arun K. Sharma
Summary: AS-10, a novel compound, demonstrates potent anti-PDAC effects by inducing apoptosis in PDAC cells and modulating NF-kappa B activity. Combination therapy of AS-10 with gemcitabine shows synergistic cytotoxicity. AS-10 shows promising potential as a lead compound for PDAC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Xue Yang, Chao Yang, Defu Tang, Qunli Yu, Li Zhang
Summary: This study investigated the effects of dietary selenium yeast and jujube powder on mitochondrial oxidative damage and cell apoptosis during postmortem aging of broilers. The findings suggest that different doses of selenium yeast and jujube powder can inhibit mitochondrial oxidation to varying degrees, providing protection against cell apoptosis.
Article
Biochemistry & Molecular Biology
Elena G. Varlamova, Mikhail Goltyaev, Aleksander Simakin, Sergey Gudkov, Egor A. Turovsky
Summary: This study developed a selenium-sorafenib nanocomplex and investigated its molecular mechanisms in anticancer effect on human hepatocyte carcinoma cells. The results indicate that selenium nanoparticles have a significant pro-apoptotic effect, while the selenium-sorafenib nanocomplex is even more effective.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Fisheries
Zhixiong Xu, Junru Hu, Yufan Zhang, Lirong Bai
Summary: The objective of this study was to investigate the effects of selenium yeast on the growth, histomorphology, antioxidant capacity and apoptosis of largemouth bass. The results showed that the addition of 1.5 and 2.0 mg/kg of selenium yeast significantly reduced weight gain rate and specific growth rate, and disorganized the structure of liver cells in largemouth bass. However, the supplementation of 1.0 mg/kg selenium yeast increased the activities of glutathione peroxidase and superoxide dismutase in serum.
AQUACULTURE REPORTS
(2023)
Article
Oncology
Yulin An, Jianfu Zhao
Summary: The use of established drugs in new therapeutic applications shows great potential in cancer treatment. In this study, lentinan-functionalized selenium nanoparticles (LET-SeNPs) combined with zoledronic acid (ZOL) effectively inhibited the growth of prostate cancer cells. The enhanced anti-cancer effect may be attributed to the regulation of BCL2 family proteins, release of cytochrome C, S-phase cell cycle arrest, irreversible DNA damage, and killing of PCa cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaoqi Yang, Yang Fu, Jiabin Zhang, Jiaqi Liu, Xin Liu, Yuxuan Peng, San Loon Kyin, Mengdi Zhang, Donghai Zhou
Summary: Nano-selenium (SeNPs) with small particles can be absorbed by the body and exhibit biological activity. YC-3-SeNPs were biosynthesized by Bacillus cereus YC-3, while CST-SeNPs were chemically synthesized and encapsulated with chitosan. Both types of SeNPs showed excellent stability and the ability to scavenge free radicals, with YC-3-SeNPs being less toxic than CST-SeNPs. YC-3-SeNPs and CST-SeNPs may inhibit oxidative stress and apoptosis in cardiomyocytes, making them potential treatments for cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)
