Article
Dermatology
Jun Liu, Yadan Zhong, Huiting Liu, Huan Yang, Ping Lu, Yanqiang Shi, Xuan Wang, Wen Zheng, Xiaoling Yu, Yingping Xu, Bin Yang
Summary: This study demonstrates that OSM induces pyroptosis in NHEKs and HaCaT cells, with knockout of OSMR abolishing pyroptosis. RNA sequencing revealed upregulation of key genes involved in NLRP3 inflammasome activation after OSM treatment, and knockdown of GSDME alleviated OSM-induced pyroptosis. Pretreatment of OSM enhanced UVB-induced inflammation in keratinocytes, a function lost in keratinocytes lacking OSMR and GSDME.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jia-feng Tang, Guo-li Li, Tao Zhang, Yu-mei Du, Shi-ying Huang, Jian-hua Ran, Jing Li, Di-long Chen
Summary: In this study, it was found that HHT effectively inhibits the proliferation of melanoma cells by inducing DNA damage, apoptosis, and cell cycle arrest. Both in vitro and in vivo experiments confirmed the inhibitory effect of HHT on melanoma, providing evidence for its potential as an anti-melanoma agent.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Sin Ri Kim, Ji Won Park, Byung-Hoon Lee, Kyung Min Lim, Tong-Shin Chang
Summary: Ultraviolet B (UVB) irradiation induces the production of reactive oxygen species (ROS), leading to damage in exposed skin cells. Mitochondria and NADPH oxidase are two major sources of ROS in UVB-irradiated keratinocytes. Peroxiredoxin V (PrxV) is a cysteine-dependent peroxidase enzyme found in mitochondria and cytosol, which effectively removes H2O2. We investigated the role of PrxV in protecting epidermal keratinocytes against UVB-induced ROS damage.
Article
Pharmacology & Pharmacy
Guangya Xu, Xueling Yan, Zhongjia Hu, Lulu Zheng, Ke Ding, Yamei Zhang, Yi Qing, Tao Liu, Lijia Cheng, Zheng Shi
Summary: Glucocappasalin (GCP) from Descurainia sophia seeds shows potential antitumor activity in HeLa cervical carcinoma cells. GCP induces cell cycle G2/M-phase arrest, apoptosis, and autophagy by acting on the PI3K/AKT/mTOR signaling pathways, making it a promising agent for cervical cancer eradication.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Dermatology
Kun Ren, Meng Zhou, Lingjun Li, Cheng Wang, Shengtao Yuan, Hongyang Li
Summary: C118P, a novel tubulin polymerization inhibitor, has shown strong anticancer effects in melanoma cells by inhibiting cell proliferation and inducing apoptosis. Mechanistically, C118P induces G2/M arrest through downregulation of BUB1B expression, providing a potential strategy for the clinical treatment of melanoma.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Mengjiao Hao, Yijun Guo, Zhikang Zhang, Huihao Zhou, Qiong Gu, Jun Xu
Summary: This study discovers the anti-cancer effect of compound 5o on colorectal cancer cells. It inhibits cell proliferation and induces apoptosis through multiple signaling pathways. The target of compound 5o is identified as GRP94.
BIOORGANIC CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Jia Liu, Liangyan Deng, Lingyu Wang, Die Qian, Chengxun He, Qiang Ren, Qing Zhang, Yunhui Chen
Summary: The study suggests that Licochalcone A (LCA) has great therapeutic potential for esophageal cancer (EC) by regulating the p53 signaling pathway to induce cell cycle arrest and apoptosis. In vitro experiments showed that LCA inhibited EC cell proliferation, migration, and invasion, and promoted apoptosis. In vivo experiments demonstrated that LCA administration inhibited tumor growth without causing significant toxicities.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Rong Wu, Zhichao Xi, Mengfan Liu, Hangui Ren, Rongchen Dai, Xue Jiang, Wan Najbah Nik Nabil, Yalin Wang, Jiling Feng, Qiong Chai, Qihan Dong, Hongxi Xu
Summary: This study found that the traditional Chinese medicine formula Pulsatilla Decoction inhibits the growth of pancreatic cancer cells by inducing cell cycle arrest and apoptosis. The bioactive ingredient ss-peltatin in Pulsatilla chinensis demonstrated stronger anti-cancer effects and lower toxicity compared to the clinically obsolete podophyllotoxin.
Article
Oncology
Jiajing Niu, Jiamei Wang, Qi Zhang, Zhihua Zou, Yushuang Ding
Summary: The study revealed that sublethal doses of cinobufagin suppressed the viability of cancer cells by inducing oxidative stress, leading to DNA damage and cell cycle regulation that ultimately resulted in the induction of apoptosis.
CANCER CELL INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Changyin Zhou, Xue Zhang, Yilong Miao, Yu Zhang, Yu Li, Bo Xiong
Summary: Sororin functions as a regulator of meiotic G(2)-M transition and spindle assembly in mammalian oocytes, with its interactions with Cyclin B2 playing a crucial role in driving M phase entry and bipolar spindle formation in meiosis.
Article
Medicine, Research & Experimental
Guanting Li, Xianwei Wu, Peng Sun, Zhiyang Zhang, Enxian Shao, Jianping Mao, Hua Cao, Hongliang Huang
Summary: Indolizine derivatives have shown promising results in inhibiting the proliferation of A549 cells and inducing apoptosis and cell cycle arrest, making them a potential candidate compound against non-small cell lung cancer. The mechanism of action involves triggering apoptosis through endoplasmic reticulum stress and the PI3K/Akt-mediated mitochondrial pathway, with p53 playing a major regulatory role in C8-induced cell cycle arrest.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Maria Gazdova, Radka Michalkova, Martin Kello, Maria Vilkova, Zuzana Kudlickova, Janette Baloghova, Ladislav Mirossay, Jan Mojzis
Summary: This study focused on investigating the antiproliferative effects of chalcone hybrids, particularly the chalcone-acridine hybrid 1C, in melanoma cancer cells. The study revealed that 1C exhibited potent antiproliferative effects by inducing cell cycle arrest and apoptosis. Additionally, the study found that 1C modulated the expression or phosphorylation of specific cell cycle-associated proteins and activated the DNA damage response pathway. Furthermore, 1C also induced apoptosis by causing mitochondrial dysfunction and activating caspase 3/7. The study suggests that the chalcone-acridine hybrid 1C may have potential as an antimelanoma agent in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Huocong He, Keyu Lin, Changyan Zou, Jianru Pan, Wankai Fu, Yan Zhou, Huamei Lin, Chao Chen, Ying Su
Summary: Annexin A2 (ANXA2) is associated with prognosis in nasopharyngeal carcinoma (NPC), with high expression leading to radioresistance. Knockdown of ANXA2 enhances radiosensitivity in NPC cells by inducing G2/M phase arrest, apoptosis, and activating the p38 MAPK-HSP27 pathway. ANXA2 may be a promising therapeutic target for overcoming radioresistance in NPC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Fuyan Xu, Huizhi Xi, Mengya Liao, Yiqian Zhang, Hongbo Ma, Mengling Wu, Qiang Xue, Hongbao Sun, Yiwen Zhang, Yong Xia
Summary: Chlorpromazine effectively suppresses colorectal cancer by inducing cell cycle arrest and apoptosis. It also inhibits autophagic flux and induces cytotoxic autophagy in cancer cells. Furthermore, it suppresses tumor growth in mouse models and has no effect on the proportions of immune cells.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2022)
Article
Environmental Sciences
Hongmin Lu, Lulu Hou, Yue Zhang, Tiantian Guo, Yu Wang, Mingwei Xing
Summary: This study investigated the role of reactive oxygen species (ROS) and cell cycle in nephrotoxicity induced by polystyrene microplastics (PS-MPs). The results demonstrated that PS-MPs can trigger oxidative stress and induce cell cycle arrest, apoptosis, and autophagy in kidney cells.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Dermatology
Alessandra Marconi, Marika Quadri, Francesca Farnetani, Silvana Ciardo, Elisabetta Palazzo, Roberta Lotti, Anna Maria Cesinaro, Luca Fabbiani, Cristina Vaschieri, Mario Puviani, Cristina Magnoni, Shaniko Kaleci, Carlo Pincelli, Giovanni Pellacani
Summary: In this study, four distinct melanoma subtypes were identified using reflectance confocal microscopy, each with a specific biomolecular profile and biological behavior associated with tumor aggressiveness.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Cristina Barbara, Piero Clavario, Vincenzo De Marzo, Roberta Lotti, Giulia Guglielmi, Annalisa Porcile, Carmelo Russo, Raffaele Griffo, Timo Makikallio, Arto Jorma Hautala, Italo Porto
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Review
Medicine, General & Internal
Marika Quadri, Alessandra Marconi, Simran K. Sandhu, Alexi Kiss, Tatiana Efimova, Elisabetta Palazzo
Summary: Cutaneous Squamous Cell Carcinoma (cSCC) is a common type of skin cancer. Various in vitro and in vivo models, including three-dimensional models, have been developed to study its development and invasion. While these models contribute to cancer research, animal models are still needed to address certain issues.
FRONTIERS IN MEDICINE
(2022)
Editorial Material
Medicine, General & Internal
Marika Quadri, Cristina Pellegrini, Tatiana Efimova, Elisabetta Palazzo
FRONTIERS IN MEDICINE
(2022)
Article
Cell & Tissue Engineering
Roberta Lotti, Elisabetta Palazzo, Marika Quadri, Marc Dumas, Sylvianne Schnebert, Diego Biondini, Maria Anastasia Bianchini, Carine Nizard, Carlo Pincelli, Alessandra Marconi
Summary: ETA cells represent the first KSC progenitor with exclusive features, and CD271 identifies and modulates ETA cells, thus participating in the early differentiation and regenerative capacity of the human epidermis.
Article
Biology
Roberta Lotti, Claudio Giacinto Atene, Emma Dorotea Zanfi, Matteo Bertesi, Carlo Pincelli, Tommaso Zanocco-Marani
Summary: Researchers have developed new active models to mimic the main forms of Pemphigus, including PV and mucocutaneous Pemphigus. Immunized animals and animals that received splenocytes from the immunized donors produced high concentrations of circulating antibodies against specific antigens, but the effectiveness of treatment with corticosteroids was limited.
Article
Oncology
Marika Quadri, Natascia Tiso, Francesco Musmeci, Maria I. I. Morasso, Stephen R. R. Brooks, Luca Reggiani Bonetti, Rossana Panini, Roberta Lotti, Alessandra Marconi, Carlo Pincelli, Elisabetta Palazzo
Summary: This study found differential expression of CD271 in low-risk and high-risk cSCC tumors, and demonstrated that CD271 activity can decrease the proliferation and invasiveness of cSCC, while promoting tumor cell differentiation. CD271 also inhibits the metastatic process of cSCC and increases sensitivity to therapy. Therefore, CD271 may be a promising target for future pharmaceutical development.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Immunology
Roberta Lotti, Jennifer E. Hundt, Ralf J. Ludwig, Brydon Bennett, Antonino Amato, Alessandra Marconi, Carlo Pincelli
Summary: Pemphigus is a life-threatening autoimmune bullous disease that affects the skin and mucous membranes. Current therapies aim to suppress the immune system, but PC111, a fully human monoclonal antibody targeting Fas ligand, has shown promising results in reducing blister formation. In vitro and in vivo experiments have confirmed the mechanism of action and efficacy of PC111 in preventing acantholysis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)
