Article
Surgery
Laura Mazer, Patrick Worth, Brendan Visser
Summary: This study reviewed patients undergoing surgery for gastric GIST at a single academic center between 2000 and 2018. The results showed that laparoscopic resection was associated with smaller tumors, lower postoperative complication rates, and shorter length of stay. Different types of resection techniques were identified based on tumor size and location, aiding in the selection of the ideal approach for difficult tumors.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Oncology
Chun Zhuang, Xiaoqi Li, Linxi Yang, Xinli Ma, Yanying Shen, Chen Huang, Tao Pan, Jianzhi Cui, Bo Ni, Ming Wang
Summary: This study analyzed the expression of ferroptosis-related genes in gastrointestinal stromal tumor (GIST) and found that transferrin receptor (TFRC) was significantly upregulated in high-risk patients. Further enrichment analysis revealed that TFRC expression was closely associated with cell growth pathways and metabolism-related pathways. High TFRC expression in GIST patients indicated an unfavorable state of patient relapse and could serve as a powerful independent predictor of recurrence-free survival.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Marta Andrzejewska, Jakub Czarny, Katarzyna Derwich
Summary: This article reviews the latest updates on the management of pediatric gastrointestinal tumors, focusing on the advances in molecular biology of the disease and discussing emerging treatment with kinase inhibitors as targeted therapy.
Editorial Material
Oncology
Alessandro Rizzo, Maria Abbondanza Pantaleo, Annalisa Astolfi, Valentina Indio, Margherita Nannini
Summary: The D842V mutation in PDGFRA is the most common mutation in GIST, conferring primary resistance to conventional treatments. In recent years, new specific inhibitors have been developed for this mutation with promising results in clinical settings.
Article
Pathology
David J. Papke, Erna Forgo, Gregory W. Charville, Jason L. Hornick
Summary: PDGFRA IHC is highly sensitive and moderately specific for PDGFRA-mutant GISTs, and can be used to triage epithelioid GISTs for optimal therapy.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Surgery
Sheng-Chieh Lin, Hung-Hsuan Yen, Po-Chu Lee, I-Rue Lai
Summary: This study demonstrates that laparoscopic surgery is safe and oncologically feasible for gastric GISTs between 5 and 8 cm. The clinical characteristics, peri-operative factors, and oncological outcomes were similar between groups.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Oncology
Maria Cecilia Mathias-Machado, Victor Hugo Fonseca de Jesus, Leandro Jonata de Carvalho Oliveira, Marina Neumann, Renata D'Alpino Peixoto
Summary: Gastrointestinal stromal tumors (GISTs) are malignant mesenchymal tumors arising from the intestinal pacemaker cells of Cajal. They comprise a heterogenous group of tumors due to a variety of molecular alterations. The most common gain-of-function mutations in GISTs are either in the KIT (60-70%) or platelet-derived growth factor receptor alpha (PDGFRA) genes (10-15%), which are mutually exclusive.
Article
Gastroenterology & Hepatology
Michael J. Cavnar, Kenneth Seier, Mithat Gonen, Christina Curtin, Vinod P. Balachandran, William D. Tap, Cristina R. Antonescu, Sam Singer, Ronald P. DeMatteo
Summary: In primary GIST undergoing Neo-IM therapy, progression was uncommon, but substantial down-sizing occurred in the minority. High tumor mitotic rate and incomplete resection following Neo-IM were associated with poor outcome, while adjuvant imatinib was associated with prolonged survival.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Review
Oncology
Hyunjee. V. V. Kwak, Katherine. J. J. Tardy, Andrew Allbee, Kristen Stashek, Ronald. P. P. DeMatteo
Summary: Gastrointestinal stromal tumor (GIST) is usually caused by sporadic mutations in the KIT or PDGFRA genes, but can also be caused by germline mutations. Surgical resection is critical for patients with germline GIST, especially in the stomach, since most tumors do not respond to tyrosine kinase inhibitors. However, there are no formal guidelines for timing or extent of surgical resection. This article discusses the challenges and principles of surgery in patients with germline GIST, with a case study of a patient harboring a germline KIT 579 deletion.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Michael J. Cavnar, Kenneth Seier, Christina Curtin, Vinod P. Balachandran, Daniel G. Coit, Sam S. Yoon, Aimee M. Crago, Vivian E. Strong, William D. Tap, Mithat Gonen, Cristina R. Antonescu, Murray F. Brennan, Sam Singer, Ronald P. DeMatteo
Summary: Surgery for gastrointestinal stromal tumor (GIST) in the imatinib era has resulted in prolonged overall survival compared to the pre-imatinib era. Tumor site, size, and mitotic rate in pre-imatinib era primary tumor patients are associated with survival. Imatinib treatment may benefit patients with high-risk features, particularly tumor size.
Article
Genetics & Heredity
Gloria Ravegnini, Cesar Serrano, Riccardo Ricci, Qianqian Zhang, Irene Terrenato, Agnese Graziosi, Giorgia Valori, Stefania Landolfi, Patrizia Hrelia, Sabrina Angelini
Summary: This study found that miRNA expression in metastatic gastrointestinal stromal tumors has similar characteristics in primary sites and metastases, with the primary origin appearing to be the main determinant of the metastatic miRNA profile.
Review
Oncology
Haidong Zhang, Tianxiang Jiang, Mingchun Mu, Zhou Zhao, Xiaonan Yin, Zhaolun Cai, Bo Zhang, Yuan Yin
Summary: Radiotherapy may help achieve objective response and relieve symptoms in selected patients with advanced or metastatic gastrointestinal stromal tumors. However, survival benefits were not observed. Further clinical studies are needed to confirm these findings.
Article
Surgery
Yuki Hirata, Christopher Scally, Brian D. Badgwell, Naruhiko Ikoma
Summary: Robotic excision of gastric and duodenal GIST has been demonstrated to be feasible and safe, especially in anatomically challenging locations where the stapling technique is not suitable. Robotic surgery platform with augmented surgical skills allows for precise dissection and suturing.
UPDATES IN SURGERY
(2022)
Article
Medicine, General & Internal
Valentina Indio, Angela Schipani, Margherita Nannini, Milena Urbini, Alessandro Rizzo, Antonio De Leo, Annalisa Altimari, Valerio Di Scioscio, Daria Messelodi, Giuseppe Tarantino, Annalisa Astolfi, Maria Abbondanza Pantaleo
Summary: This study uncovered the gene expression profile of SDH-deficient GIST and identified characteristics such as increased expression of neural markers and activation of fibroblast growth factor receptor signaling. The study also revealed shared features with SDH-deficient pheochromocytoma/paraganglioma and depletion of tumor microenvironment and inflammation gene signatures. The findings provide new insights into the histology and dysregulated biological processes in SDH-deficient GISTs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Dengyang Zhang, Chunxiao He, Yao Guo, Jianfeng Li, Bo Li, Yuming Zhao, Liuting Yu, Zhiguang Chang, Hanzhong Pei, Ming Yang, Na Li, Qi Zhang, Yulong He, Yihang Pan, Zhizhuang Joe Zhao, Changhua Zhang, Yun Chen
Summary: The study demonstrates that SCF-DM1 has a favorable inhibitory effect on GIST cells, inducing apoptosis and cell cycle arrest, and shows favorable efficacy and safety profiles in a mouse model.
Article
Chemistry, Multidisciplinary
N. Malithi Fonseka, Fernando Teran Arce, Hamish S. Christie, Craig A. Aspinwall, S. Scott Saavedra
Summary: Polymerization affects the stability and properties of supported lipid bilayers, providing a balance between stability and fluidity. Polymerized PSLBs exhibit increased stiffness, resistance to compression and bending, while DPhPC domains are softer and more compressible in binary PSLBs.
Article
Biochemistry & Molecular Biology
Thilini N. Amarakoon, Neng Ke, Craig A. Aspinwall, Katrina M. Miranda
Summary: Redox signaling is crucial in signal transduction, with thiols serving as primary mediators to initiate cellular effects through a variety of adducts. Capillary zone electrophoresis can be used for identification and quantification of sulfinamides generated from the reaction of thiols with nitroxyl.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Huiyang Yuan, Yujiao Wu, Jing Wang, Xin Qin, Yongsheng Huang, Lei Yan, Yidong Fana, Jan Zedenius, C. Christofer Juhlin, Catharina Larsson, Weng-Onn Lui, Dawei Xu
Summary: Telomerase reverse transcriptase (TERT) and regulator of telomere elongation helicase 1 (RTEL1) play important roles in adrenocortical carcinoma (ACC) and their expression levels are correlated with patient prognosis. High expression of both TERT and RTEL1 may promote ACC aggressiveness through the activation of multiple signaling pathways. Therefore, TERT and RTEL1 may serve as prognostic factors and therapeutic targets for ACC.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Kashif Rasheed, Ugo Moens, Benedetta Policastro, John Inge Johnsen, Virve Koljonen, Harri Sihto, Weng-Onn Lui, Baldur Sveinbjornsson
Summary: This study investigated the expression levels of human cytokines and receptors in virus-positive and virus-negative MCC cell lines. The results showed that MCPyV's LT and sT can induce IL-33 expression, and IL-33 may be involved in tumorigenesis through activation of the MAP kinase and NF-kappa B pathways. Furthermore, the study found higher expression levels of IL-33 in MCC tissues and patient plasma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Marius M. Kostelic, Chih-Chieh Hsieh, Henry M. Sanders, Ciara K. Zak, Jack P. Ryan, Erin S. Baker, Craig A. Aspinwall, Michael T. Marty
Summary: Native mass spectrometry and charge detection-mass spectrometry are versatile tools for characterizing proteins and macromolecular complexes. Researchers have improved sensitivity by modifying the surface of nanoelectrospray ionization needles with inert surface modifiers.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2022)
Article
Cell Biology
Erwin Ilegems, Galyna Bryzgalova, Jorge Correia, Burcak Yesildag, Edurne Berra, Jorge L. Ruas, Teresa S. Pereira, Per-Olof Berggren
Summary: This study found the presence of HIF-1 alpha in pancreatic cells during the progression of type 2 diabetes, and demonstrated that treatment with the HIF-1 alpha inhibitor PX-478 can improve beta cell function, prevent diabetes progression, and increase insulin secretion. The results showed that PX-478 treatment has an improving effect on mouse and human islets.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Alina Rodriguez, Katarzyna Korzeniowska, Kamila Szarejko, Hubert Borowski, Michal Brzezinski, Malgorzata Mysliwiec, Leszek Czupryniak, Per-Olof Berggren, Marcin Radziwill, Piotr Soszynski
Summary: This study provides a comprehensive analysis of adolescent obesity in early adolescence and highlights its significance as a public health problem, particularly in Central and Eastern Europe. The findings suggest that overweight/obesity is more prevalent than thinness in this age group and is characterized by sex/gender differences. The study also emphasizes the need for integrated and personalized intervention strategies, taking into account the differences in behaviors and habits between boys and girls, as well as the impact of poor cardiorespiratory fitness on long-term obesity and disease.
Article
Biochemistry & Molecular Biology
Uma D. Kabra, Noah Moruzzi, Per-Olof Berggren, Martin Jastroch
Summary: Mitochondrial dynamics and bioenergetics play a critical role in glucose-stimulated insulin secretion. Overexpression of mitochondrial fission regulator Drp1 can improve insulin secretion in Drp1-knockdown cells, but does not affect mitochondrial metabolism in wildtype cells. However, constitutive presence of Drp1 unexpectedly impairs insulin content and upregulates ER stress-related genes, possibly impacting insulin production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Patrick Scicluna, Stefano Caramuta, Hanna Kjellin, Cheng Xu, Robin Froebom, Monira Akhtar, Jiwei Gao, Hao Shi, Magnus Kjellman, Malin Almgren, Anders Hoog, Jan Zedenius, Tomas J. Ekstroem, Robert Braenstroem, Weng-Onn Lui, Catharina Larsson
Summary: This study reveals the abnormalities of the IGF2-H19 locus and mitochondrial respiration in adrenocortical carcinoma (ACC). These findings may contribute to a better understanding of the pathogenesis of ACC and have potential values for diagnostics and treatment.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Correction
Biochemistry & Molecular Biology
C. Bersani, L. -d. Xu, A. Vilborg, W. -o. Lui, K. G. Wiman
Article
Surgery
Filip Cvetkovski, Ronia Razavi, Felix Sellberg, Erik Berglund, David Berglund
Summary: Combined therapy of siplizumab with abatacept or belatacept can effectively suppress T cell proliferation, enhance siplizumab-mediated T cell inhibition, and improve the selective depletion of memory T cells. This combination therapy may be used for the prophylaxis of organ transplant rejection and improvement of long-term outcomes following transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Chemistry, Analytical
Deseree J. Reid, Tapasyatanu Dash, Zhihan Wang, Craig A. Aspinwall, Michael T. Marty
Summary: Daptomycin is a cyclic lipopeptide antibiotic that interacts with lipid membranes in a non-specific manner. The interaction strength depends on membrane rigidity, with more rigid membranes showing stronger interactions. More fluid membranes may undergo pore formation to expose daptomycin to oxidation. These findings highlight the complementary use of native mass spectrometry, fast photochemical oxidation of peptides, and membrane conductance experiments in studying antibiotic-membrane interactions.
ANALYTICAL CHEMISTRY
(2023)
Article
Cell Biology
Aravindh Subramani, Weiyingqi Cui, Yuanyuan Zhang, Tomas Friman, Zhihai Zhao, Wenmao Huang, Pedro Fonseca, Weng-Onn Lui, Vani Narayanan, Justyna Bobrowska, Malgorzata Lekka, Jie Yan, Daniel E. E. Conway, Lars Holmgren
Summary: The spread of tumor cells and the formation of distant metastasis are major causes of cancer patient mortality, but the mechanisms behind cell release from micro-environmental constraints are unclear.
Article
Biochemistry & Molecular Biology
Kaixuan Zhao, Yue Shi, Jia Yu, Lina Yu, Martin Kohler, Amber Mael, Anthony Kolton, Thomas Joyce, Jon Odorico, Per-Olof Berggren, Shao-Nian Yang
Summary: Ca(V)3 channels are downregulated during the maturation of electrically excitable cells, including pancreatic beta cells. Excessive Ca(V)3 channels impede the maturation of engineered human-induced pluripotent stem cell-derived islet (hiPSC-islet) cells. Inhibiting Ca(V)3 channels facilitates glucose-activated Ca2+ signaling and the maturation of engineered hiPSC-islet insulin-expressing cells.
