Article
Neurosciences
Yin Luo, Haishuang Tang, Zhaolong Zhang, Rui Zhao, Chuanchuan Wang, Wenguang Hou, Qinghai Huang, Jianmin Liu
Summary: The study found that EGFR activation was present in human IA vessel walls and rat anterior cerebral artery walls. Treatment with erlotinib significantly reduced the incidence of IA in rats by inhibiting vascular remodeling and pro-inflammatory transformation of VSMCs in IA vessel walls. Activation of EGFR in rat VSMCs was associated with phenotypic modulation, which was reduced by erlotinib treatment.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Medicine, Research & Experimental
Claudio Humeres, Arti V. Shinde, Anis Hanna, Linda Alex, Silvia C. Hernandez, Ruoshui Li, Bijun Chen, Simon J. Conway, Nikolaos G. Frangogiannis
Summary: Repair of the infarcted heart requires TGF-beta/Smad3 signaling in cardiac myofibroblasts, but it needs to be tightly regulated to prevent excessive fibrosis and adverse remodeling.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Physiology
Julie M. M. Lade, Manuella R. R. Andrade, Clark Undem, Jasmine Walker, Haiyang Jiang, Xin Yun, Larissa A. A. Shimoda
Summary: Exposure to hypoxia leads to structural changes in pulmonary vascular wall, including hyperplasia and migration of pulmonary arterial smooth muscle cells (PASMCs). In this study, the interaction between ezrin and NHE1 was found to increase under hypoxic conditions, promoting SMA binding and enhancing PASMC migration and proliferation.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Christine Veith, Ipek Varturk-Ozcan, Magdalena Wujak, Stefan Hadzic, Cheng-Yu Wu, Fenja Knoepp, Simone Kraut, Aleksandar Petrovic, Marija Gredic, Oleg Pak, Monika Brosien, Marie Heimbrodt, Jochen Wilhelm, Friederike C. Weisel, Kathrin Malkmus, Katharina Schaefer, Henning Gall, Khodr Tello, Djuro Kosanovic, Akylbek Sydykov, Akpay Sarybaev, Andreas Guenther, Ralf P. Brandes, Werner Seeger, Friedrich Grimminger, Hossein A. Ghofrani, Ralph T. Schermuly, Grazyna Kwapiszewska, Natascha Sommer, Norbert Weissmann
Summary: This study provides evidence for the involvement of SPARC in the pathogenesis of human PH and chronic hypoxia-induced PH in mice, most likely by affecting vascular cell function.
Article
Hematology
Ran Ran, Dunpeng Cai, Skylar D. King, Xingyi Que, Jonathan M. Bath, Shi-You Chen
Summary: The study revealed that SPA plays a crucial role in SMC phenotype modulation and vascular remodeling, with SPA deficiency leading to increased expression of contractile proteins. Blocking the abnormal elevation of SPA could be a potential strategy to inhibit the development of proliferative vascular diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chun-Hsu Pan, Yi-Chung Chien, Min-Shan Sung, Hui-Yu Huang, Ming-Jyh Sheu, Chieh-Hsi Wu
Summary: PGK1 plays a role in promoting neointima formation under hypoxic conditions, and its inhibition may have a beneficial effect in preventing restenosis by suppressing vascular smooth muscle cell proliferation and migration. Blocking the PDGFRB pathway can also reduce PGK1 expression and have a significant impact on neointimal hyperplasia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Odelia Cooper, Vivien S. Bonert, Jeremy Rudnick, Barry D. Pressman, Janet Lo, Roberto Salvatori, Kevin C. J. Yuen, Maria Fleseriu, Shlomo Melmed
Summary: This study evaluated the effect of lapatinib, a tyrosine kinase inhibitor, on aggressive prolactinomas that are resistant to dopamine agonist therapy. While none of the participants achieved the primary endpoint, three showed stable disease and lapatinib was generally well tolerated with reversible side effects.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Barbara Schreier, Christian Stern, Virginie Dubourg, Alexander Nolze, Sindy Rabe, Sigrid Mildenberger, Claudia Wickenhauser, Michael Gekle
Summary: The study revealed that compared to VSMC-EGFR, EC-EGFR has minor and opposite effects on basal renovascular function as well as high fat diet-induced vascular remodeling and renal end organ damage.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Amirala Bakhshian Nik, Hooi Hooi Ng, Sophie K. Ashbrook, Patrick Sun, Francesco Iacoviello, Paul R. Shearing, Sergio Bertazzo, Deniel Mero, Bohdan B. Khomtchouk, Joshua D. Hutcheson
Summary: In this study, the potential of epidermal growth factor receptor (EGFR) inhibition to prevent vascular calcification, a leading indicator of cardiovascular disease, was investigated. It was found that EGFR inhibition reduced vascular calcification by hindering the release of calcifying extracellular vesicles (EVs) and also increased bone mineral density in mice with CKD. Furthermore, individuals with SNPs associated with elevated serum EGFR levels exhibited increased coronary artery calcium. These findings suggest that EGFR may be a novel therapeutic target for preventing pathological vascular calcification in CKD.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Barbara Schreier, Christian Stern, Sindy Rabe, Sigrid Mildenberger, Michael Gekle
Summary: In this study, the role of EGFRs in VSMCs and ECs for blood pressure homeostasis and acute vascular reactivity was investigated. The findings suggest that VSMC-EGFR has a significant impact on blood pressure changes induced by volume load, while EC-EGFR has a minor role in blood pressure regulation. Moreover, there is no significant difference in the response to AII and catecholamine stimulation between lean and obese animals, indicating that obesity and high-fat diet do not significantly affect these mechanisms.
Article
Endocrinology & Metabolism
R. Zhou, X. S. Gu, J. H. Xu, J. Wan
Summary: This study investigated the biological function of EP3 in regulating the phenotypes of VSMCs. The results showed that EP3 promoted the viability, proliferation, and migration of VSMCs, and participated in the dysfunction induced by PDGF through regulating the PI3K/Akt pathway. These findings suggest that EP3 may serve as a therapeutic target for atherosclerosis, AMI, and other cardiovascular diseases.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Review
Pharmacology & Pharmacy
Gabriel Hoi-Huen Chan, Enoch Chan, Carsten Tsun-Ka Kwok, George Pak-Heng Leung, Simon Ming-Yuen Lee, Sai-Wang Seto
Summary: Ageing is a risk factor for degenerative diseases, including cardiovascular diseases. The tumor suppressor gene p53 may play a regulatory role in vascular remodeling, atherosclerosis, and pulmonary hypertension. Further studies are needed to fully understand the effects of p53 in cardiovascular function and its therapeutic potential.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yun-yun Yang, Hua-hui Yu, Xiao-lu Jiao, Lin-yi Li, Yun-hui Du, Juan Li, Qian-wen Lv, Hui-na Zhang, Jing Zhang, Chao-wei Hu, Xiao-ping Zhang, Yong-xiang Wei, Yan-wen Qin
Summary: The lack of ANGPTL8 can prevent CIH-induced aortic vascular remodeling, possibly through the inhibition of the ERS pathway. Therefore, ANGPTL8 may be a potential target in CIH-induced aortic vascular remodeling.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Oncology
Monique B. Nilsson, Jacqulyne Robichaux, Matthew H. Herynk, Tina Cascone, Xiuning Le, Yasir Elamin, Sonia Patel, Fahao Zhang, Li Xu, Limei Hu, Lixia Diao, Li Shen, Junqin He, Xiaoxing Yu, Petros Nikolinakos, Pierre Saintigny, Bingliang Fang, Luc Girard, Jing Wang, John D. Minna, Ignacio I. Wistuba, John V. Heymach
Summary: Research suggests that in EGFR-mutant NSCLC patients, EGFR signaling plays a dominant role in regulating HIF-1 alpha and VEGF in a hypoxia-independent manner, supporting the targeting of VEGF in EGFR-mutant tumors.
JOURNAL OF THORACIC ONCOLOGY
(2021)
Editorial Material
Medicine, Research & Experimental
Michael D. Gershon
Summary: The study identified genetic variants in ERBB3 and ERBB2 in 8 patients with defects in neural crest tissue, affecting the development of the enteric nervous system and highlighting the need for further mechanistic exploration.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Pharmacology & Pharmacy
Satoyasu Ito, Kentaro Ozawa, Jing Zhao, Yoji Kyotani, Kosuke Nagayama, Masanori Yoshizumi
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2015)
Article
Biochemistry & Molecular Biology
Yoji Kyotani, Asako Itaya-Hironaka, Akiyo Yamauchi, Sumiyo Sakuramoto-Tsuchida, Mai Makino, Shin Takasawa, Masanori Yoshizumi
Article
Pharmacology & Pharmacy
Hitoshi Nakayama, Jing Zhao, Amany EI-FAKhrany, Minoru Isosaki, Hiroyasu Satoh, Yoji Kyotani, Masanori Yoshizumi
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2009)
Article
Pharmacology & Pharmacy
Yoji Kyotani, Jing Zhao, Sayuko Tomita, Hitoshi Nakayama, Minoru Isosaki, Masayuki Uno, Masanori Yoshizumi
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2010)
Article
Pharmacology & Pharmacy
Jing Zhao, Yoji Kyotani, Satoyasu Itoh, Hitoshi Nakayama, Minoru Isosaki, Masanori Yoshizumi
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2011)
Article
Pharmacology & Pharmacy
Masanori Yoshizumi, Yoji Kyotani, Jing Zhao, Kosuke Nagayama, Satoyasu Ito, Yuichi Tsuji, Kentaro Ozawa
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2012)
Article
Pharmacology & Pharmacy
Minoru Isosaki, Hitoshi Nakayama, Yoji Kyotani, Jing Zhao, Sayuko Tomita, Hiroyasu Satoh, Masanori Yoshizumi
PHARMACOLOGICAL REPORTS
(2011)
Article
Multidisciplinary Sciences
Jing Zhao, Kentaro Ozawa, Yoji Kyotani, Kosuke Nagayama, Satoyasu Ito, Akira T. Komatsubara, Yuichi Tsuji, Masanori Yoshizumi
Article
Multidisciplinary Sciences
Kosuke Nagayama, Yoji Kyotani, Jing Zhao, Satoyasu Ito, Kentaro Ozawa, Francesco A. Bolstad, Masanori Yoshizumi
Article
Multidisciplinary Sciences
Kentaro Ozawa, Akira T. Komatsubara, Yuhei Nishimura, Tomoyo Sawada, Hiroto Kawafune, Hiroki Tsumoto, Yuichi Tsuji, Jing Zhao, Yoji Kyotani, Toshio Tanaka, Ryosuke Takahashi, Masanori Yoshizumi
SCIENTIFIC REPORTS
(2013)
Review
Biochemistry & Molecular Biology
Yoji Kyotani, Shin Takasawa, Masanori Yoshizumi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Pharmacology & Pharmacy
Yoji Kyotani, Jing Zhao, Kiichi Nakahira, Masanori Yoshizumi
Summary: This study used the Japanese Adverse Drug Event Report (JADER) database to analyze the association between drug use and the onset of appendicitis. Results identified 23 drugs associated with appendicitis, 9 drugs associated with perforated appendicitis, and 1 drug associated with complicated appendicitis. Weibull plot analysis revealed drug-dependent patterns for changes in the risk of appendicitis over time for 8 drugs. Logistic regression analysis detected a significant association between two drugs and appendicitis. These findings suggest that certain drugs may be linked to appendicitis and require attention.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2023)
Article
Multidisciplinary Sciences
Yoji Kyotani, Jing Zhao, Kiichi Nakahira, Masanori Yoshizumi
Summary: This study investigated the drugs associated with neuroleptic malignant syndrome (NMS) using the JADER database and examined their pathways and drug-drug interactions (DDIs). The study found that all drugs associated with NMS, including non-antipsychotics, exhibited signals for NMS. The pathways related to these drugs included dopaminergic or serotonergic synapses. Additionally, several drug combinations were found to have DDIs, increasing the risk of NMS.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Yoji Kyotani, Jing Zhao, Kentaro Ozawa, Takahiko Nakagawa, Francesco A. Bolstad, Masanori Yoshizumi
BRITISH JOURNAL OF PHARMACEUTICAL RESEARCH
(2016)