Article
Immunology
Zhi Huan Chew, Jianzhou Cui, Karishma Sachaphibulkij, Isabelle Tan, Shreya Kar, Kai Kiat Koh, Kritika Singh, Hong Meng Lim, Soo Chin Lee, Alan Prem Kumar, Stephan Gasser, Lina H. K. Lim
Summary: Intracellular recognition of tumor-derived nucleic acids can activate macrophages, leading to inflammasome activation in the tumor microenvironment, which initiates pro-inflammatory and anti-tumorigenic responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Durre Aden, Sufian Zaheer, Himani Ahluwalia, Sunil Ranga
Summary: Tumor microenvironment (TME) plays a crucial role in carcinogenesis and tumor behavior, with cancer-associated fibroblasts (CAF) being the most important player. CAFs modulate the proliferation, invasion, and metastasis of tumor cells. However, due to the lack of specific markers, tracing the origin of different CAF subtypes is difficult. An objective and comprehensive classification of CAFs is needed for better tumor management.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Oncology
Brian G. Hunt, Angelle Jones, Carissa Lester, James C. Davis, Nancy M. Benight, Susan E. Waltz
Summary: The study reveals that co-overexpression of RON and HGFL in cancer cells, augmented by physiological sources of HGFL, promotes tumorigenesis through autocrine-mediated RON activation, MAPK-dependent secretion of chemotactic factors, and paracrine activation of macrophage RON to promote breast cancer stem cell self-renewal.
Review
Biochemistry & Molecular Biology
Martin Vokurka, Lukas Lacina, Jan Brabek, Michal Kolar, Yi Zhen Ng, Karel Smetana
Summary: This review outlines the role of exosomes in cancer cells and cancer-associated fibroblasts, discussing their significance and therapeutic potential in the dialogue between cancer cells and the tumor microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yangbing Jin, Qu Cai, Lingquan Wang, Jun Ji, Ying Sun, Jinling Jiang, Chao Wang, Junwei Wu, Benyan Zhang, Liqin Zhao, Feng Qi, Beiqin Yu, Jun Zhang
Summary: Our study revealed that INHBB is significantly upregulated in gastric cancer (GC) and its increased expression is associated with poor survival. INHBB promotes the proliferation, migration, and invasion of GC cells in vitro. Additionally, activin B reprograms fibroblasts into cancer-associated fibroblasts (CAFs) and promotes GC development. The high expression of INHBB in GC cells activates the NF-kappa B pathway in normal gastric fibroblasts via the secretion of activin B, leading to fibroblast proliferation, migration, and invasion. Activin B induces NF-kappa B pathway activation in fibroblasts through controlling TRAF6 autoubiquitination and TAK1 phosphorylation. Activated fibroblasts release pro-inflammatory factors IL-1 beta, which induce p65 phosphorylation in GC cells. p65 directly binds to the INHBB promoter, increasing INHBB transcription in GC cells and establishing a positive regulatory feedback loop that promotes GC progression.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Pei Tian, Jinxing Wei, Jing Li, Junkai Ren, Chaohong He
Summary: This study reveals that exosomal SNHG1 derived from cancer-associated fibroblasts (CAFs) enhances the progression of renal cell carcinoma (RCC) and provides a potential target for RCC treatment.
BIOCHEMICAL GENETICS
(2023)
Review
Biochemistry & Molecular Biology
Sana Hibino, Tetsuro Kawazoe, Hidenori Kasahara, Shinji Itoh, Takatsugu Ishimoto, Mamiko Sakata-Yanagimoto, Koji Taniguchi
Summary: Inflammation plays a pivotal role in tumorigenesis and metastasis by suppressing anti-tumor immunity. Different types of tumors may have diverse responses to inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Thayaalini Subramaniam, Mh Busra Fauzi, Yogeswaran Lokanathan, Jia Xian Law
Summary: Skin injury healing involves complex processes with various cells, extracellular matrix, and mediators. Cell differentiation, migration, and proliferation are crucial for tissue integrity restoration. Although calcium shows promise in wound healing, challenges need to be addressed before clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Kai Wang, Yuan-Yuan Wang, Liang-Liang Wu, Li-Yan Jiang, Yin Hu, Xin-Hua Xiao, Ya-Di Wang
Summary: Obesity is a chronic low-grade inflammatory disease that leads to insulin resistance and related metabolic disorders. The inflammation in adipose tissue is primarily caused by recruited and activated macrophages, which can undergo polarization from an anti-inflammatory state to a pro-inflammatory state in response to signals from the obese microenvironment. Besides adipocytes, the adipose tissue also contains immune cells, stem cells, and vascular, neural, and lymphatic tissues, which together regulate the microenvironment of adipose tissue. Understanding the biology and polarization of adipose tissue macrophages in the obese environment may provide insights for precise immunotherapy of adipose inflammation and obesity-related metabolic diseases.
Article
Oncology
Yue Zhuo, Shujun Li, Wei Hu, Yu Zhang, Yufan Shi, Faxue Zhang, Jian Zhang, Juan Wang, Meijuan Liao, Jiahao Chen, Huiling Qian, Dejia Li, Chengcao Sun
Summary: SNORA38B is highly expressed in non-small cell lung cancer (NSCLC) and associated with worse prognosis. It promotes tumor progression through various mechanisms, including cell proliferation, migration, invasion, and inhibition of apoptosis. SNORA38B also affects the tumor immune microenvironment, reducing immune efficacy and favoring tumor progression.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Multidisciplinary Sciences
Sophie A. Herbst, Marta Stolarczyk, Tina Becirovic, Felix Czernilofsky, Yi Liu, Carolin Kolb, Mareike Knoll, Marco Herling, Carsten Mueller-Tidow, Sascha Dietrich
Summary: This passage highlights the importance of bone marrow stromal cells in ex vivo drug response studies, emphasizing that these cells' phagocytosis of apoptotic cells may lead to misinterpretation of results. Future research needs to take this into consideration.
Article
Chemistry, Multidisciplinary
Jiaqi Meng, Weier Bao, Ming Liu, Zhecheng Ma, Zhiyuan Tian
Summary: A composite nanoagent based on copper metal-organic frameworks is developed, which actively targets cancer-associated fibroblast and releases substances with anti-tumor and oxidative stress properties to remodel the immunosuppressive tumor microenvironment and activate immune response.
Article
Biochemistry & Molecular Biology
Hui Song Cui, So Young Joo, Seung Yeol Lee, Yoon Soo Cho, Dong Hyun Kim, Cheong Hoon Seo
Summary: It is unclear how scar fibroblasts (SFs) affect keratinocytes in hypertrophic scars (HTS) through cell-cell interaction. This study investigated the effects of HTS-derived exosomes on the proliferation and differentiation of normal human keratinocytes (NHKs) and compared them with normal fibroblasts (NFs).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Nana Zheng, Jiaqi Wei, Depei Wu, Yang Xu, Jianping Guo
Summary: PDK1 is a key protein kinase involved in regulating cell growth and cancer development, and it also modulates the tumor microenvironment and immunotherapies.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Biochemistry & Molecular Biology
Parinya Samart, Gayathri Heenatigala Palliyage, Surapol Issaragrisil, Sudjit Luanpitpong, Yon Rojanasakul
Summary: The upregulation of MSI2 in NSCLC tissues and CAFs is associated with poor prognosis and high metastatic risk. Depletion of MSI2 in CAFs strongly inhibits NSCLC cell migration and invasion in vitro, and attenuates local and distant metastatic spread of NSCLC cells in vivo. The crosstalk between CAFs and NSCLC cells occurs via paracrine signaling mediated by IL-6, which is regulated by MSI2 in CAFs.
CELL AND BIOSCIENCE
(2023)