Article
Cell Biology
Gang Wang, Li Ma, Bowen Wang, Fentang Gao, Jianfeng Li, Hongyi Cai, Juan Wang, Tiancheng Zhang, Hao Guo, Ping Xie, Yi Li
Summary: Tanshinone IIA can counteract radiation-induced myocardial injury by regulating the p38/p53 pathway, restoring cardiomyocyte proliferation and reducing cell apoptosis.
MEDIATORS OF INFLAMMATION
(2022)
Article
Environmental Sciences
Jing Tang, Chenjuan Yao, Yingqi Liu, Jiaming Yuan, Li Wu, Kazuo Hosoi, Shali Yu, Chunyan Huang, Haiyan Wei, Gang Chen
Summary: In this study, it was elucidated that BCL-2, as a pro-apoptotic factor, plays a role in As2O3-induced apoptosis in BEAS-2B cells through NF-kappa B and p38 MAPK signaling pathways. The upregulation, nuclear localization, and phosphorylation of BCL-2 during apoptosis were found to be crucial factors in As2O3-induced cell death.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Yu-Kai Huang, Kun-Che Chang, Chia-Yang Li, Ann-Shung Lieu, Chih-Lung Lin
Summary: This study investigated the role of AKR1B1 in glioma cell proliferation and apoptosis signaling. AKR1B1 expression was measured in different cell lines and tissues. The effects of AKR1B1 overexpression or knockdown, as well as p38 MAPK activation and inhibition, were evaluated. AKR1B1 was found to regulate glioma cell proliferation through the activation of p38 MAPK and apoptosis signaling. Therefore, AKR1B1 may be a potential therapeutic target for glioma therapy.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yin Shi, Shengfeng Xu, Natalie Y. L. Ngoi, Qi Zeng, Zu Ye
Summary: Hypoxia in the tumor microenvironment, causing excessive ROS and genomic instability, is a hallmark of cancer contributing to self-renewal, metastasis, and therapy resistance. PRL-3, an oncoprotein, has been found to regulate apoptosis resistance by negatively affecting p38 MAPK activity in response to hypoxia stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biology
Alejandra Escos, Ester Diaz-Mora, Michael Pattison, Pilar Fajardo, Diego Gonzalez-Romero, Ana Risco, Jose Martin-Gomez, Eric Bonneil, Nahum Sonenberg, Seyed Mehdi Jafarnejad, Juan Jose Sanz-Ezquerro, Steven C. Ley, Ana Cuenda
Summary: Evidence implicating p38? and p38d in inflammation is mainly based on experiments using Mapk12/Mapk13-deficient mice. A new mouse model, p38?/dKIKO, with specific depletion of p38? and p38d was generated to study their functions. The results showed reduced inflammation, susceptibility to septic shock, and Candida albicans infection in p38?/dKIKO mice compared to wild-type mice. Gene expression and phosphorylation analyses revealed the involvement of p38?/p38d in regulating innate immune responses through MEF2D phosphorylation and transcriptional activity.
Article
Biochemistry & Molecular Biology
Lili Sun, Chen Yao, Xiaojiao Li, Yuxing Wang, Ru Wang, Molin Wang, Qiao Liu, Denise J. Montell, Changshun Shao, Yaoqin Gong, Gongping Sun
Summary: This study reveals that cells can survive executioner caspase activation through a process called anastasis, and these surviving cells have enhanced migration and pro-angiogenic capacity. The activation of p38 MAPK plays a crucial role in anastasis and is essential for the elevated migratory and angiogenic capacity in these cells.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Environmental Sciences
Won-Young Lee, Hyun-Jung Park
Summary: T-2 toxin induces reproductive toxicity and germ cell damage. It reduces testicular germ cell number and downregulates their corresponding markers, but increases Sertoli cell markers and steroidogenic enzyme expression. T-2 toxin also decreases cell viability, increases apoptosis, and triggers ROS-mediated JNK/p38-MAPK signaling pathway, leading to mitochondrial dysfunction and apoptotic cell death in germ cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Biochemistry & Molecular Biology
Guy Nadel, Galia Maik-Rachline, Rony Seger
Summary: The response of cells to extracellular signals is mediated by intracellular signaling pathways, one of which is the cJun-N-terminal Kinase (JNK) cascade. Proper regulation of this cascade, involving phosphorylations, dephosphorylation, scaffold proteins, subcellular localization changes, and degradation, is crucial for determining cell fate. This review focuses on these regulatory mechanisms, including the newly discovered PP2A switch, and emphasizes the transmission of apoptotic signals by the JNK cascade. Understanding the regulation of the JNK cascade may lead to new therapeutic approaches for JNK-dependent pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Toxicology
Yanan Li, Huiming Yang, Huiming Nong, Fan Wang, Yajie Wang, Yue Xu, Junhong Zhang, Hao Zhao, Zhixin Cao, Qianqian Yang, Jianfeng Li
Summary: The expression of HMGCR in cochlear hair cells and HEI-OC1 cells and its role in cisplatin-induced ototoxicity were studied. HMGCR was found to be widely expressed in auditory cells and exerted a protective effect against cisplatin-induced ROS injury, regulating p38 MAPK-dependent apoptosis and autophagy.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Endocrinology & Metabolism
Peibei Sun, Yayan Wang, Tian Gao, Kun Li, Dongwang Zheng, Ajuan Liu, Ya Ni
Summary: The study found that Hsp90 is involved in human sperm hyperactivation and acrosome reaction. Hsp90 forms a protein complex with Cdc37 to regulate the kinase activity of Erk1/2 and p38, thus controlling human sperm capacitation through these pathways.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Cell Biology
Qi Yan, Linxin Pan, Shunli Qi, Fang Liu, Zhen Wang, Cheng Qian, Lijian Chen, Jian Du
Summary: The up-regulation of RNF2 in liver fibrosis enhances HSC activation and exerts fibrogenic effects by inhibiting the ERK/p38 signaling pathway induced by TGF-beta 1. The inhibition of RNF2 may be a promising therapeutic target for liver fibrosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Plant Sciences
Zhu Zhang, Wen-qing Chen, Shi-qing Zhang, Jing-xuan Bai, Bin Liu, Ken Kin-Lam Yung, Joshua Ka-Shun Ko
Summary: The study revealed that isoliquiritigenin (ISL) inhibited the progression of pancreatic cancer by blocking autophagy through the p38 MAPK signaling pathway.
Article
Pharmacology & Pharmacy
Yong-Gang Fan, Chuang Guo, Ling-Xiao Zhao, Ri-Le Ge, Zhong-Qiu Pang, Da-Long He, Hang Ren, Ting-Yao Wu, Yan-Hui Zhang, Zhan-You Wang
Summary: In this study, the effects of astrocytic lactoferrin (Lf) on Alzheimer's disease (AD) progression were evaluated. The overexpression of astrocytic Lf reduced Aβ burden and tau hyperphosphorylation in APP/PS1 mice by promoting Lf uptake into neurons and inhibiting p-APP expression. These findings suggest that increasing astrocytic Lf expression may be a potential strategy against AD.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ming Zhang, Jianmei Lai, Qianlong Wu, Jia Lai, Jingyao Su, Bing Zhu, Yinghua Li
Summary: Hepatocarcinoma is a common digestive system tumor worldwide with no effective treatment. Naringenin, isolated from citrus fruits, has shown anticancer effects. This study investigated the molecular mechanisms and oxidative stress implications of naringenin-induced cytotoxicity in HepG2 cells. Naringenin induced apoptosis in HepG2 cells through multiple pathways, enhanced cytotoxic effects, triggered reactive oxygen species, inhibited JAK-2/STAT-3 signaling pathways, and activated caspase-3. These findings suggest that naringenin could be a promising candidate for cancer therapy.
Review
Oncology
J. Tobias, E. Garner-Spitzer, M. Drinic, U. Wiedermann
Summary: Immunotherapy has revolutionized cancer treatment, with a focus on breast cancer. Traditional treatment methods have limitations, but tumor vaccines may offer a potential solution. This review discusses peptide-based Her-2 / neu vaccines and their evaluation in clinical settings.