Article
Medicine, Research & Experimental
Zhaoer Yu, Wei Zhang, Yixiao Wang, Mingming Gao, Min Zhang, Dan Yao, Chengping Qiao, Xianwei Cui, Ruizhe Jia
Summary: HUMSCs-derived extracellular vesicles can ameliorate endothelial dysfunction in preeclampsia by activating the arginine metabolic pathway and may serve as a therapeutic method for treating preeclampsia.
MOLECULAR PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Xiaoli Pan, Junping Pei, Aoxue Wang, Wen Shuai, Lu Feng, Faqian Bu, Yumeng Zhu, Lan Zhang, Guan Wang, Liang Ouyang
Summary: This review provides an overview of the roles of the ERKs signaling pathway in cancer and the structure-activity relationships of small molecule inhibitors targeting ERKs. It offers important insights for drug design and optimization as well as potential therapeutic strategies to overcome drug resistance.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Materials Science, Multidisciplinary
Wei Dai, Yuchen Dong, Ting Han, Jing Wang, Bin Gao, Hui Guo, Feng Xu, Jing Li, Yufei Ma
Summary: This article systematically summarizes recent advances in regulating the features and biological functions of cell-derived exosomes by biochemical and biophysical cues in the cell microenvironment. It also discusses the use of these cue-regulated exosomes as therapeutic strategies to improve chronic wound healing.
NPG ASIA MATERIALS
(2022)
Article
Agriculture, Multidisciplinary
Tianyuan Song, Miao Lv, Minzhi Zhou, Mingtao Huang, Lin Zheng, Mouming Zhao
Summary: The study explored the effect of EVs produced from VSMCs on HUVECs, revealing differential gene expression associated with endothelial dysfunction. LSW can improve endothelial function by repairing miRNA expression in VSMCs, suggesting potential mechanisms for the actions of Ang II and LSW on vascular endothelial cells.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Engineering, Biomedical
Wenkai Jia, Weilue He, Guifang Wang, Jeremy Goldman, Feng Zhao
Summary: This study found that ECM secreted by hMSCs enhances lymphangiogenesis and has the potential for treating lymphedema.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Immunology
Peifeng Jin, Lu Ding, Lei Wang, Sheng Jiang, Jiakan Weng, Yuan Gao, Junming Fan, Li-Zhong Sun
Summary: This study investigated the potential of plasma-derived EVs in protecting against apoptosis of BMSCs, improving angiogenesis, ameliorating myocardial remodeling, and enhancing cardiac function post-MI in rats. Co-culturing with EVs attenuated hypoxia-induced apoptosis of BMSCs in vitro and blunted MI-induced apoptosis in vivo through AKT signaling. The transplantation of BMSCs along with EVs showed significant improvements in cardiac parameters and microRNAs in EVs were identified as potential mediators of these effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Zhe Li, Yuqing Xu, Shiyue Lu, Yuan Gao, Yuxiao Deng
Summary: bMSCs alleviate LPS-induced endothelial glycocalyx degradation and vascular leakage through the delivery of miR let-7-5p via extracellular vesicles, targeting endothelial ABL2 and suppressing p38MAPK and IL-6, IL-1β activation.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell Biology
Jinhui Ma, Mengran Shen, Debo Yue, Weiguo Wang, Fuqiang Gao, Bailiang Wang
Summary: The study found that extracellular vesicles derived from bone marrow stem cells can prevent glucocorticoid-induced injury to bone microvascular endothelial cells by regulating autophagy, thus preventing osteonecrosis of the femoral head.
Review
Chemistry, Multidisciplinary
Prerak Gupta, Biman B. Mandal
Summary: Vascular tissue engineering has made significant progress in recent years, with new technological advancements fostering the development of next-generation tissue-engineered vascular grafts. Traditional therapeutic methods involve bypassing damaged vessels with synthetic counterparts, while contemporary perspectives focus on biodegradable conduits with inherent remodeling capabilities.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Jinfu Qian, Wu Luo, Chengyi Dai, Jun Wang, Xinfu Guan, Chunpeng Zou, Nipon Chattipakorn, Gaojun Wu, Weijian Huang, Guang Liang
Summary: Studies show that MD2 plays a crucial role in Ang II-induced vascular inflammation and EndMT, suggesting that MD2 could be targeted to mitigate inflammatory cardiovascular and EndMT-associated diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Cell Biology
Nhat-Hoang Ngo, Yun-Hsuan Chang, Cat-Khanh Vuong, Toshiharu Yamashita, Mana Obata-Yasuoka, Hiromi Hamada, Motoo Osaka, Yuji Hiramatsu, Osamu Ohneda
Summary: This study compared the functions of EPC-derived EV and WJ-derived EV in rescuing ischemic tissues. It was found that EPC-EV showed poor abilities to induce neovascularization and recovery of ischemic tissues, while WJ-EV had a higher ability to rescue ischemic injury when locally injected. By internalizing EPC with hypoxic pre-treated WJ-EV, a transformed hwEPC was obtained, which produced hwEPC-EV highly expressing miRNAs related to angiogenesis. hwEPC-EV significantly induced neovascularization and exhibited a greater effect in recovering ischemic injury compared to EPC-EV.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Jie Zhou, Junying Yang, Yuan Dong, Yaru Shi, Endong Zhu, Hairui Yuan, Xiaoxia Li, Baoli Wang
Summary: Our study has for the first time established the direct role of OSMR in regulating osteogenic differentiation of marrow stromal progenitor cells through ERK-mediated autophagy signaling. OSMR thus contributes to bone homeostasis through dual regulation of osteoblasts and osteoclasts. It also suggests that OSMR may be a potential target for the treatment of metabolic disorders such as osteoporosis.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Pharmacology & Pharmacy
Steven R. Botts, Jason E. Fish, Kathryn L. Howe
Summary: Atherosclerosis is a chronic disease associated with a spectrum of cardiovascular diseases, prevalent in both high-income countries and low- to middle-income regions worldwide. The vascular endothelium plays a crucial role in atherogenesis by influencing plaque formation and intercellular communication. Future directions in preclinical atherosclerosis research include epigenetic and targeted therapies to halt disease progression in at-risk or affected individuals.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Jieun Jeon, Tamanna Jahan Mony, Eunbi Cho, Huiyoung Kwon, Wan-Seob Cho, Ji Woong Choi, Byeong C. Kim, Jong Hoon Ryu, Se Jin Jeon, Kyoung Ja Kwon, Chan Young Shin, Se Jin Park, Dong Hyun Kim
Summary: In this study, it was found that rubrofusarin enhances learning and memory in mice and promotes neurite outgrowth. These effects may be achieved through activation of the ERK pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Hidenori Kanno, Sei Naito, Yutaro Obara, Hiromi Ito, Osamu Ichiyanagi, Takafumi Narisawa, Tomoyuki Kato, Akira Nagaoka, Norihiko Tsuchiya
Summary: ERK5 has been found to be highly expressed in clear cell renal cell carcinoma (ccRCC) and is associated with high grade, high recurrence rate, and high cancer-specific survival. The expression of ERK5 is regulated by miR-143. Inhibition of ERK5 holds promise as a potential target for ccRCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Jichang Wang, Manvendra Singh, Chuanbo Sun, Daniel Besser, Alessandro Prigione, Zoltan Ivics, Laurence D. Hurst, Zsuzsanna Izsvak
Article
Biochemistry & Molecular Biology
Yongming Wang, Diana Pryputniewicz-Dobrinska, Enikoe Eva Nagy, Christopher D. Kaufman, Manvendra Singh, Steve Yant, Jichang Wang, Anna Dalda, Mark A. Kay, Zoltan Ivics, Zsuzsanna Izsvak
NUCLEIC ACIDS RESEARCH
(2017)
Article
Cell Biology
L. Hu, J. Wang, H. Zhu, X. Wu, L. Zhou, Y. Song, S. Zhu, M. Hao, C. Liu, Y. Fan, Y. Wang, Q. Li
CELL DEATH & DISEASE
(2016)
Article
Multidisciplinary Sciences
Sabine Klawitter, Nina V. Fuchs, Kyle R. Upton, Martin Munoz-Lopez, Ruchi Shukla, Jichang Wang, Marta Garcia-Canadas, Cesar Lopez-Ruiz, Daniel J. Gerhardt, Attila Sebe, Ivana Grabundzija, Sylvia Merkert, Patricia Gerdes, J. Andres Pulgarin, Anja Bock, Ulrike Held, Anett Witthuhn, Alexandra Haase, Balazs Sarkadi, Johannes Loewer, Ernst J. Wolvetang, Ulrich Martin, Zoltan Ivics, Zsuzsanna Izsvak, Jose L. Garcia-Perez, Geoffrey J. Faulkner, Gerald G. Schumann
NATURE COMMUNICATIONS
(2016)
Article
Biochemistry & Molecular Biology
Jia-Li Hu, He Liang, Hong Zhang, Ming-Zhu Yang, Wei Sun, Peng Zhang, Li Luo, Jian-Xiong Feng, Huajun Bai, Fang Liu, Tianpeng Zhang, Jin-Yu Yang, Qingsong Gao, Yongkang Long, Xiao-Yan Ma, Yang Chen, Qian Zhong, Bing Yu, Shuang Liao, Yongbo Wang, Yong Zhao, Mu-Sheng Zeng, Nan Cao, Jichang Wang, Wei Chen, Huang-Tian Yang, Song Gao
NUCLEIC ACIDS RESEARCH
(2020)
Article
Cell & Tissue Engineering
Junjun Xu, Zheng Zheng, Xuguang Du, Bingbo Shi, Jichang Wang, Dengfeng Gao, Qianqian Zhu, Xinze Chen, Jianyong Han
STEM CELL RESEARCH & THERAPY
(2020)
Article
Biochemistry & Molecular Biology
Xiao-Yan Ma, Hong Zhang, Jian-Xiong Feng, Jia-Li Hu, Bing Yu, Li Luo, Yu-Lu Cao, Shuang Liao, Jichang Wang, Song Gao
NUCLEIC ACIDS RESEARCH
(2020)
Article
Cell & Tissue Engineering
Chuanbo Sun, Bing Li, Miaomiao Yang, Ruirui Guo, Simin Yuan, Jichang Wang, Hao Hu
Summary: GPAM, a mitochondrial enzyme, plays a crucial role in glycerolphospholipids and triacylglycerol biosynthesis. Loss-of-function mutation of GPAM has been linked to hypomyelination in cerebral palsy patients. A GPAM knockout human embryonic stem cell line was generated using CRISPR/cas9, maintaining normal karyotype and pluripotent stem cell characteristics.
STEM CELL RESEARCH
(2021)
Article
Cell & Tissue Engineering
Mingzhu Yang, Hanwen Yu, Xiu Yu, Shiqi Liang, Yuanlang Hu, Yuxin Luo, Zsuzsanna Izsvak, Chuanbo Sun, Jichang Wang
Summary: Totipotent cells have greater developmental potency compared to other cell types as they can give rise to both embryonic and extraembryonic tissues. Remodeling the pericentromeric heterochromatin and establishing the totipotency-specific broad H3K4me3 domains can promote the transition from pluripotency to totipotency. These stable totipotent-like stem cells (TLSCs) closely resemble mouse 2-cell (2C) embryos and possess unique molecular features. TLSCs are capable of germline transmission and can generate both embryonic and extraembryonic lineages at a high frequency.
Article
Multidisciplinary Sciences
Vera Zywitza, Ejona Rusha, Dmitry Shaposhnikov, Jorge Ruiz-Orera, Narasimha Telugu, Valentyna Rishko, Masafumi Hayashi, Geert Michel, Lars Wittler, Jan Stejskal, Susanne Holtze, Frank Goeritz, Robert Hermes, Jichang Wang, Zsuzsanna Izsvak, Silvia Colleoni, Giovanna Lazzari, Cesare Galli, Thomas B. Hildebrandt, Katsuhiko Hayashi, Sebastian Diecke, Micha Drukker
Summary: This study aims to rescue the critically endangered northern white rhinoceros species by using induced pluripotent stem cells (iPSCs) to generate gametes and embryos in vitro. The study found that NWR iPSCs have similarities to human iPSCs and can differentiate into multiple germ layers and trophoblast. Furthermore, the naive-like state of NWR iPSCs is pivotal for differentiation into primordial germ cells (PGCs).
SCIENTIFIC REPORTS
(2022)
Article
Cell & Tissue Engineering
Hanwen Yu, Manqi Chen, Yuanlang Hu, Songbang Ou, Xiu Yu, Shiqi Liang, Niannian Li, Mingzhu Yang, Xuhui Kong, Chuanbo Sun, Shiqi Jia, Qingxue Zhang, Lin Liu, Laurence D. Hurst, Ruiqi Li, Wenjun Wang, Jichang Wang
Summary: Reprogramming of H3K9me3-dependent heterochromatin plays an important role in early human development, affecting the interaction between specific promoters and enhancers, regulating zygotic genome activation and transcription of inner cell mass-specific genes.
Article
Cell Biology
Xiu Yu, Shiqi Liang, Manqi Chen, Hanwen Yu, Ruiqi Li, Yuliang Qu, Xuhui Kong, Ruirui Guo, Rongyan Zheng, Zsuzsanna Izsvak, Chuanbo Sun, Mingzhu Yang, Jichang Wang
Summary: In this study, a cell model mimicking human 8-cell stage embryos was developed to study the mechanisms of early human development. This model successfully isolated and maintained a population of cells resembling the 8-cell state, which expressed key genes involved in zygotic genome activation. The findings provide valuable insights into early human development.
Article
Cell & Tissue Engineering
Ruirui Guo, Simin Yuan, Bing Li, Jichang Wang, Chuanbo Sun
Summary: NANOS3 is an RNA-binding protein containing zinc-finger structure, highly expressed in human primordial germ cells (hPGC), thus serving as a marker for hPGC development. The generation of human primordial germ cell-like cells (hPGCLCs) from pluripotent stem cells is an excellent alternative in studying human germ cell-related processes. This mCherry knock-in hESC line before NANOS3's stop codon provides a useful tool for investigating human PGC specification.
STEM CELL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jing Niu, Xu Zhang, Guipeng Li, Pixi Yan, Qing Yan, Qionghai Dai, Dayong Jin, Xiaohua Shen, Jichang Wang, Michael Q. Zhang, Juntao Gao
JOURNAL OF GENETICS AND GENOMICS
(2020)
Article
Multidisciplinary Sciences
Yasamin Dabiri, Rodrigo A. Gama-Brambila, Katerina Taskova, Kristina Herold, Stefanie Reuter, James Adjaye, Jochen Utikal, Ralf Mrowka, Jichang Wang, Miguel A. Andrade-Navarro, Xinlai Cheng