Review
Pharmacology & Pharmacy
Huijie Zhao, Xiaodi Fu, Yanting Zhang, Yihan Yang, Honggang Wang
Summary: Endoplasmic reticulum (ER) plays a critical role in protein synthesis and processing. When ER is overloaded with misfolded proteins, ER stress is triggered. Hydrogen sulfide (H2S) has been recognized as an important gas signal molecule, with regulatory effects on various physiological and pathological processes. This review focuses on the role of H2S in regulating ER stress in myocardial diseases, aiming to provide a better understanding of its mechanisms.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xue Bai, Gerard Batalle, Gianfranco Balboni, Olga Pol
Summary: Recent studies have shown that hydrogen sulfide (H2S) enhances the analgesic effects of the delta-opioid receptor (DOR) in inflammatory pain. It is still unknown whether two slow-releasing H2S donors, DADS and GYY4137, can improve the analgesic effects of mu-opioid receptor (MOR) and DOR agonists on neuropathic pain. This study found that both DADS and GYY4137 improved the antiallodynic effects of MOR and DOR agonists, possibly by up-regulating MOR and DOR expression in the dorsal root ganglia.
Article
Biochemistry & Molecular Biology
Xue Bai, Gerard Batalle, Olga Pol
Summary: The study demonstrates the anxiolytic and antidepressant properties of DADS and GYY4137 during neuropathic pain, revealing their analgesic actions through inhibition of inflammatory, apoptotic, and oxidative responses. These findings support the use of these treatments for managing affective disorders accompanying chronic neuropathic pain.
Article
Cardiac & Cardiovascular Systems
Xianli Wang, Shaokun Yu, Yuting Jian, Hongmin Pan, Jiannan Guo, Jian Wu, Wei Guo
Summary: The study found that hydrogen sulfide (H2S) can prevent oxidative stress injury in extravillous trophoblasts by decreasing ROS concentration, maintaining mitochondrial membrane stability, and promoting apoptosis-inhibiting protein expression in cells.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Weiwei Gong, Shuping Zhang, Yun Chen, Jieru Shen, Yangyang Zheng, Xiao Liu, Mingxian Zhu, Guoliang Meng
Summary: Diabetic cardiomyopathy lacks effective treatments, but our study showed that H2S deficiency can worsen the condition by promoting oxidative stress, necroptosis, and inflammasome activation. However, supplementation of H2S with sodium hydrosulfide can help alleviate these effects and provide a new therapeutic strategy for diabetic cardiomyopathy.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Meng Li, Xiaoming Luo, Shan Lei, Yurong Liu, Huishan Guo, Yu Zhang, Yuantao Pan, Kaiwei Chen, Jing Lin, Peng Huang
Summary: A glycopolymer containing a caged H2S and H2O2 dual-donor is developed to wrap glucose oxidase, which can deplete tumorigenic energy sources and block glycolysis. This strategy induces defects in mitochondrial function and shows good anticancer performance.
ADVANCED MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Yunzhao Yang, Zhongyuan Xia, Cheng Xu, Chunchun Zhai, Xi Yu, Siqi Li
Summary: Ciprofol protects the heart against ISO-induced myocardial infarction by reducing cardiac oxidative stress, the inflammatory response, and cardiomyocyte apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yu-Ting Wu, Ling-Peng Xie, Yue Hua, Hong-Lin Xu, Guang-Hong Chen, Xin Han, Zhang-Bin Tan, Hui-Jie Fan, Hong-Mei Chen, Jun Li, Bin Liu, Ying-Chun Zhou
Summary: Tanshinone I (Tan I) protects cardiomyocytes against oxidative stress-induced injury by activating the Nrf2 signaling pathway, suggesting its potential therapeutic application for oxidative stress-induced cardiovascular diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Shuangyu Lv, Zhu Wang, Jie Wang, Honggang Wang
Summary: Ischemia/reperfusion (I/R) injury is a phenomenon characterized by restricting blood supply to organs followed by restoring blood flow and oxygenation, leading to various diseases. Autophagy, an important cellular pathway, plays a key role in maintaining cellular balance and participating in both physiological and pathological processes. Hydrogen sulfide (H2S) is a significant gas signal molecule that, along with carbon monoxide (CO) and nitric oxide (NO), regulates a range of physiological and pathological processes.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Yuan Feng, Verena Prokosch, Hanhan Liu
Summary: Glaucoma is a group of diseases characterized by the progressive loss of retinal ganglion cells and their axons, with oxidative stress believed to be a main risk factor in neurodegeneration. The gas signaling molecule hydrogen sulfide (H2S) plays a pivotal role in modulating oxidative stress in glaucoma by regulating different pathways in vivo. This review summarizes the distribution and properties of H2S in the eye, emphasizing its role in modulating oxidative stress in glaucoma.
Article
Biochemistry & Molecular Biology
Peipei Zhang, Hao Lu, Yuan Wu, Danbo Lu, Chenguang Li, Xiangdong Yang, Zhangwei Chen, Juying Qian, Junbo Ge
Summary: Doxorubicin (DOX) can lead to mitochondrial dysfunction and heart failure. COX5A, an important regulator of mitochondrial energy metabolism, plays a protective role in DOX-induced cardiomyopathy. The expression of COX5A is decreased in patients with dilated cardiomyopathy and after DOX treatment. Overexpression of COX5A improves cardiac function, glucose uptake, mitochondrial morphology, COX activity, and ATP content in DOX-stimulated mice. COX5A protects against oxidative stress, mitochondrial dysfunction, and cardiomyocyte apoptosis via the PI3K/Akt signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chaemoon Lim, Ao Xuan Zhen, Sungwoo Ok, Pincha Devage Sameera Madushan Fernando, Herath Mudiyanselage Udari Lakmini Herath, Mei Jing Piao, Kyoung Ah Kang, Jin Won Hyun
Summary: This study found that hesperidin can inhibit high glucose-induced apoptosis and mitigate oxidative stress and endoplasmic reticulum stress. It also promotes cell survival through modulation of the mitogen-activated protein kinase signaling pathway.
Article
Biochemistry & Molecular Biology
Sudhir Pandey, Corina T. Madreiter-Sokolowski, Supachoke Mangmool, Warisara Parichatikanond
Summary: This study found that under high glucose conditions, the ET-1 signaling pathway leads to mitochondrial dysfunction, with the involvement of the mTOR pathway. Inhibiting either the ET-1 signaling pathway or the mTOR pathway can alleviate this dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Silvia Abigail Coavoy-Sanchez, Anderson Romerio Azevedo Cerqueira, Simone Aparecida Teixeira, Vincenzo Santagada, Giorgia Andreozzi, Angela Corvino, Antonia Scognamiglio, Rosa Sparaco, Giuseppe Caliendo, Beatrice Severino, Soraia Katia Pereira Costa, Luis Carlos Spolidorio, Marcelo Nicolas Muscara
Summary: Hydrogen sulfide (H2S) is produced in the skin and plays a role in inflammation, pruritus, cytoprotection, scarring, and angiogenesis. H2S-releasing Dex derivatives showed similar anti-inflammatory effects as Dex in a mouse model of atopic dermatitis (AD). The derivatives also prevented IL-4 elevation and oxidative modification of skin proteins, and one of them promoted endogenous H2S production and GPx activity without decreasing GR activity or causing hyperglycemia.
Review
Neurosciences
Dengfeng Lu, Lingling Wang, Guangjie Liu, Shixin Wang, Yi Wang, Yu Wu, Jing Wang, Xiaoou Sun
Summary: Subarachnoid hemorrhage (SAH) is a common acute and severe disease worldwide, with unsatisfactory therapeutic strategies. Recent studies have shown that hydrogen sulfide (H2S) has promising neuroprotective effects in the treatment of central nervous system diseases, reducing secondary damage caused by SAH through antioxidant, anti-inflammatory, and anti-apoptosis mechanisms, as well as alleviating cerebral edema and vasospasm.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)