Metformin's performance in in vitro and in vivo genetic toxicology studies

Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice

(2016) Vladimir N. Anisimov et al.   Aging-US

Metformin Suppresses Ovarian Cancer Growth and Metastasis with Enhancement of Cisplatin Cytotoxicity In Vivo

(2015) Ramandeep Rattan et al.   NEOPLASIA

Sites of genetic instability in mitosis and cancer

(2012) Anne M. Casper et al.   Annals of the New York Academy of Sciences

Metformin Reduces Endogenous Reactive Oxygen Species and Associated DNA Damage

(2012) C. Algire et al.   Cancer Prevention Research

Mitotic recombination of chromosome arm 17q as a cause of loss of heterozygosity of NF1 in neurofibromatosis type 1-associated glomus tumors

(2012) Douglas R. Stewart et al.   GENES CHROMOSOMES & CANCER

Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types

(2011) D. Iliopoulos et al.   CANCER RESEARCH

In vitro and in vivo anti-melanoma action of metformin

(2011) Kristina Janjetovic et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitotic recombination: a genotoxic effect of the antidepressant citalopram in Aspergillus nidulans

(2011) Claudinéia C S Franco et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A continuum model for tumour suppression

(2011) Alice H. Berger et al.   NATURE

Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153

(2011) N. WU et al.   NEOPLASMA

The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells

(2010) Alejandro Vazquez-Martin et al.   BREAST CANCER RESEARCH AND TREATMENT

Metformin Prevents Tobacco Carcinogen-Induced Lung Tumorigenesis

(2010) R. M. Memmott et al.   Cancer Prevention Research

Homologous recombination in cancer development, treatment and development of drug resistance

(2010) T. Helleday   CARCINOGENESIS

Expanding the arsenal: Metformin for the treatment of triple-negative breast cancer?

(2010) Sao Jiralerspong et al.   CELL CYCLE

Genome-wide inhibitory impact of the AMPK activator metformin on [kinesins, tubulins, histones, aurorasandpolo-like kinases] M-phase cell cycle genes in human breast cancer cells

(2010) Cristina Oliveras-Ferraros et al.   CELL CYCLE

Mitotic crossing-over induced by two commercial herbicides in diploid strains of the fungus Aspergillus nidulans

(2010) R.A. Cardoso et al.   GENETICS AND MOLECULAR RESEARCH

Dissecting loss of heterozygosity (LOH) in neurofibromatosis type 1-associated neurofibromas: Importance of copy neutral LOH

(2010) Carles Garcia-Linares et al.   HUMAN MUTATION

Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells

(2010) M. Fenech et al.   MUTAGENESIS

Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

(2010) Mary Ellen Moynahan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rates of loss of heterozygosity and mitotic recombination in NF2 schwannomas, sporadic vestibular schwannomas and schwannomatosis schwannomas

(2010) K D Hadfield et al.   ONCOGENE

Mitotic Recombination in Patients with Ichthyosis Causes Reversion of Dominant Mutations in KRT10

(2010) K. A. Choate et al.   SCIENCE

A mitotic recombination map proximal to the APC locus on chromosome 5q and assessment of influences on colorectal cancer risk

(2009) Kimberley Howarth et al.   BMC Medical Genetics

Metformin use and prostate cancer in Caucasian men: results from a population-based case–control study

(2009) Jonathan L. Wright et al.   CANCER CAUSES & CONTROL

Metformin Disrupts Crosstalk between G Protein-Coupled Receptor and Insulin Receptor Signaling Systems and Inhibits Pancreatic Cancer Growth

(2009) K. Kisfalvi et al.   CANCER RESEARCH

Assessment of genomic instability in normal and diabetic rats treated with metformin

(2009) S.M. Attia et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Evaluation of the genotoxic potential and acute oral toxicity of standardized extract of Andrographis paniculata (KalmCold™)

(2009) C.V. Chandrasekaran et al.   FOOD AND CHEMICAL TOXICOLOGY

Induction of mitotic crossing-over in diploid strains of Aspergillus nidulans using low-dose X-rays

(2009) L.B. Stoll et al.   GENETICS AND MOLECULAR RESEARCH

Metformin is a potent inhibitor of endometrial cancer cell proliferation—implications for a novel treatment strategy

(2009) Leigh A. Cantrell et al.   GYNECOLOGIC ONCOLOGY

Metformin and Pathologic Complete Responses to Neoadjuvant Chemotherapy in Diabetic Patients With Breast Cancer

(2009) Sao Jiralerspong et al.   JOURNAL OF CLINICAL ONCOLOGY

Metformin induces apoptosis of pancreatic cancer cells

(2008) Luo-Wei Wang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Validation of micronuclei frequency in peripheral blood lymphocytes as early cancer risk biomarker in a nested case–control study

(2007) Elena Murgia et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS