Low-dose naltrexone targets the opioid growth factor–opioid growth factor receptor pathway to inhibit cell proliferation: mechanistic evidence from a tissue culture model

The OGF-OGFr axis utilizes the p21 pathway to restrict progression of human pancreatic cancer

(2012) Fan Cheng et al.   Molecular Cancer

Regular Exercise Reverses Sensory Hypersensitivity in a Rat Neuropathic Pain Model

(2011) Nicola J. Stagg et al.   ANESTHESIOLOGY

Prevention and diminished expression of experimental autoimmune encephalomyelitis by low dose naltrexone (LDN) or opioid growth factor (OGF) for an extended period: Therapeutic implications for multiple sclerosis

(2011) Kristen A. Rahn et al.   BRAIN RESEARCH

Therapy with the Opioid Antagonist Naltrexone Promotes Mucosal Healing in Active Crohn’s Disease: A Randomized Placebo-Controlled Trial

(2011) Jill P. Smith et al.   DIGESTIVE DISEASES AND SCIENCES

Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts

(2010) Garrett J. Gross et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesis

(2010) Lin Teng et al.   CELL RESEARCH

T lymphocyte proliferation is suppressed by the opioid growth factor ([Met5]-enkephalin)–opioid growth factor receptor axis: Implication for the treatment of autoimmune diseases

(2010) Ian S. Zagon et al.   IMMUNOBIOLOGY

B lymphocyte proliferation is suppressed by the opioid growth factor–opioid growth factor receptor axis: Implication for the treatment of autoimmune diseases

(2010) Ian S. Zagon et al.   IMMUNOBIOLOGY

Cell proliferation of human ovarian cancer is regulated by the opioid growth factor-opioid growth factor receptor axis

(2009) Renee N. Donahue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Opioid growth factor-opioid growth factor receptor axis is a physiological determinant of cell proliferation in diverse human cancers

(2009) Ian S. Zagon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Growth inhibition of thyroid follicular cell-derived cancers by the opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis

(2009) Patricia J McLaughlin et al.   BMC CANCER

Opioid growth factor suppresses expression of experimental autoimmune encephalomyelitis

(2009) Ian S. Zagon et al.   BRAIN RESEARCH

Endogenous Opioids Regulate Expression of Experimental Autoimmune Encephalomyelitis: A New Paradigm for the Treatment of Multiple Sclerosis

(2009) Ian S. Zagon et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Imiquimod Upregulates the Opioid Growth Factor Receptor to Inhibit Cell Proliferation Independent of Immune Function

(2008) Ian S. Zagon et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The OGF–OGFr Axis Utilizes the p16INK4a and p21WAF1/CIP1 Pathways to Restrict Normal Cell Proliferation

(2008) Fan Cheng et al.   MOLECULAR BIOLOGY OF THE CELL

Naltrexone effects on male sexual behavior, corticosterone, and testosterone in stressed male rats

(2008) S. Retana-Márquez et al.   PHYSIOLOGY & BEHAVIOR