Article
Oncology
Elmira Gheytanchi, Leili Saeednejad Zanjani, Roya Ghods, Maryam Abolhasani, Marzieh Shahin, Somayeh Vafaei, Marzieh Naseri, Fahimeh Fattahi, Zahra Madjd
Summary: This study identified TSG101 gene as a potential biomarker in CRC tissues and exosomes, with significantly increased expression in tumor cells compared to normal tissues, and significant associations with tumor differentiation and distant metastasis. The findings suggest that TSG101, as an exosomal marker, may play a role in the progression and management of CRC, warranting further research on its molecular mechanisms.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Reproductive Biology
Mina Sharbatoghli, Parisa Shamshiripour, Fahimeh Fattahi, Elham Kalantari, Zohre Habibi Shams, Mahshid Panahi, Mehdi Totonchi, Zeynab Asadi-Lari, Zahra Madjd, Leili Saeednejad Zanjani
Summary: The co-expression of SALL4/ALDH1A1 is significantly associated with clinicopathological parameters and prognosis in serous ovarian carcinoma patients, suggesting its potential as a prognostic biomarker for cancer progression.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Oncology
Rong-Quan He, Jian-Di Li, Xiu-Fang Du, Yi-Wu Dang, Lin-Jie Yang, Zhi-Guang Huang, Li-Min Liu, Liu-Feng Liao, Hong Yang, Gang Chen
Summary: This study revealed that increased LPCAT1 expression correlated with poor prognosis in HCC patients and promoted HCC progression by enhancing cellular growth, migration, and metastasis. The cell cycle and chemical carcinogenesis were identified as the most enriched signaling pathways.
CANCER CELL INTERNATIONAL
(2021)
Article
Developmental Biology
Neeraja Purandare, Paige Minchella, Mallika Somayajulu, Katherine J. Kramer, Jordan Zhou, Nellena Adekoya, Robert A. Welch, Lawrence I. Grossman, Siddhesh Aras, Maurice-Andre Recanati
Summary: The study shows that LPCAT1 protein levels peak in late third trimester placental samples, with strong expression on the basal plate. Moreover, LPCAT1 is transcriptionally activated by the bi-organellar regulator MNRR1, and antenatal corticosteroids upregulate LPCAT1 in a MNRR1-dependent manner.
Article
Oncology
Zu-Xuan Chen, Liang Liang, He-Qing Huang, Jian-Di Li, Rong-Quan He, Zhi-Guang Huang, Rui Song, Gang Chen, Jian-Jun Li, Zheng-Wen Cai, Jie-An Huang
Summary: The expression levels of LPCAT1 protein and mRNA were significantly higher in gastric cancer tissues compared to noncancerous controls. LPCAT1 may play a role in promoting invasion and migration of gastric cancer by influencing neutrophil degranulation and the immune microenvironment.
Article
Oncology
Sadegh Safaei, Roya Sajed, Leili Saeednejad Zanjani, Mandana Rahimi, Fahimeh Fattahi, Golnaz Ensieh Kazemi-Sefat, Mahdieh Razmi, Shima Dorafshan, Leila Eini, Zahra Madjd, Roya Ghods
Summary: DNM2 cytoplasmic expression in renal cell carcinoma is associated with tumor aggressiveness and poor outcomes.
Article
Cell Biology
Mingyue Tao, Jing Luo, Tong Gu, Xiaojuan Yu, Zhen Song, Yali Jun, Hao Gu, Kairong Han, Xiujuan Huang, Weiyong Yu, Su'an Sun, Zhengwei Zhang, Lu Liu, Xiaofei Chen, Li Zhang, Chao Luo, Qilong Wang
Summary: This study found that LPCAT1 is highly expressed in ESCC and can reprogram tumor cell cholesterol metabolism, affecting patient prognosis. Knockdown of LPCAT1 significantly inhibits cholesterol synthesis in ESCC cells, leading to reduced cell proliferation, invasion, migration, and tumor growth.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Eugen Bellon, Katharina Grupp, Tarik Ghadban, Michael Tachezy, Kai Bachmann, Jakob Robert Izbicki, Ronald Simon, Guido Sauter, Claudia Hube-Magg, Nathaniel Melling
Summary: LPCAT1 expression is increased in malignant esophageal tissue and correlated with undifferentiated tumor grading, but it is not associated with prognosis in esophageal cancer patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Cell Biology
Ria Uhlig, David Dum, Natalia Gorbokon, Anne Menz, Franziska Buescheck, Andreas M. Luebke, Claudia Hube-Magg, Andrea Hinsch, Doris Hoeflmayer, Christoph Fraune, Katharina Moeller, Christian Bernreuther, Patrick Lebok, Soren Weidemann, Maximilian Lennartz, Frank Jacobsen, Till S. Clauditz, Guido Sauter, Waldemar Wilczak, Stefan Steurer, Eike Burandt, Rainer Krech, Till Krech, Andreas H. Marx, Ronald Simon, Sarah Minner
Summary: The expression of neuroendocrine markers synaptophysin and chromogranin A was examined in various tumor types. These markers were found to be positive in a high percentage of neuroendocrine neoplasms. However, their expression in non-neuroendocrine tumors was less common. Neuroendocrine differentiation was most commonly observed in certain adenocarcinomas, such as those in the female genital tract, pancreatico-/hepato-/biliary tract, and the prostate. The presence of neuroendocrine markers did not seem to correlate with tumor aggressiveness in several types of cancers.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Chemistry, Analytical
Britt S. R. Claes, Kasper K. Krestensen, Gargey Yagnik, Andrej Grgic, Christel Kuik, Mark J. Lim, Kenneth J. Rothschild, Michiel Vandenbosch, Ron M. A. Heeren
Summary: A novel technique called MALDIIHC was published recently, which combines MALDI-MSI and IHC to achieve targeted imaging of biomolecules in tissue. This study explored the utility of targeted MALDIIHC and its complementarity with untargeted spatial proteomics using breast cancer tissue. The combination of multiplexed MALDI-IHC with image-guided proteomics showed great potential for disease investigation. Additionally, the effect of MALDI-2 in improving MALDI-IHC was investigated.
ANALYTICAL CHEMISTRY
(2023)
Article
Cell Biology
Mei Liang, Xiangzhi Meng, Boxuan Zhou, Yushun Gao
Summary: This study found that RASAL3 expression is low in LUAD, and high expression is associated with better prognosis and immune cell infiltration. This suggests that RASAL3 may be a potential prognostic and immunological biomarker for LUAD.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Oncology
Wen Zhang, Zheng-Ji Song, Bao-Yue Zhang, Jin-Li Wang, Qiang Guo, Zhi-Wei Sun, Hui Tang
Summary: The mIHC technology allows for the detection of multiple fluorescent proteins on the same tissue, potentially serving as important diagnostic and prognostic markers in CRC patients.
Article
Oncology
Nathaniel Melling, Julia Grass, Matthias Reeh, Michael Tachezy, Marco Blessmann, Felix Nickel, Thilo Hackert, Katharina Grupp
Summary: This study compared the expression of PHD1 in CRC samples with clinicopathological variables and patient survival. It found that a decrease in PHD1 expression was associated with advanced tumor stage and shorter overall survival in CRC patients. Loss of PHD1 expression may serve as an independent marker for poor overall survival in CRC patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Developmental Biology
Tsukasa Takahashi, Erin L. Fee, Yuki Takahashi, Haruo Usuda, Sean W. D. Carter, Hideyuki Ikeda, Masatoshi Saito, Yusaku Kumagai, James P. Bridges, Alan H. Jobe, Mahesh A. Choolani, Matthew W. Kemp
Summary: In a study using a sheep model, it was found that the expression of LPCAT1 gene in the fetal lung was correlated with the durability of glucocorticoid effects on fetal lung maturation. However, the expression of LPCAT1 gene in the placenta, fetal plasma, and maternal plasma was irrelevant to fetal lung maturation.
Article
Pathology
Fahimeh Fattahi, Leili Saeednejad Zanjani, Somayeh Vafaei, Zohreh Habibi Shams, Jafar Kiani, Marzieh Naseri, Elmira Gheytanchi, Zahra Madjd
Summary: The study revealed a significant association between higher nuclear TWIST1 expression and distant metastases in CRC patients. Furthermore, increased nuclear TWIST1 expression was correlated with poor prognostic outcomes in terms of disease-specific survival (DSS) and progression-free survival (PFS). Additionally, elevated expression of CD105 in tumoral epithelial cells was linked to more advanced TNM stage in CRC cases.
DIAGNOSTIC PATHOLOGY
(2021)