Article
Gastroenterology & Hepatology
Daniela Pugliese, Giuseppe Privitera, Federica Crispino, Nicolo Mezzina, Fabiana Castiglione, Gionata Fiorino, Lucrezia Laterza, Anna Viola, Lorenzo Bertani, Flavio Caprioli, Maria Cappello, Brigida Barberio, Chiara Ricci, Paola Balestrieri, Marco Daperno, Dario Pluchino, Fernando Rizzello, Maria Lia Scribano, Renato Sablich, Luca Pastorelli, Francesco Manguso, Angela Variola, Antonio Di Sario, Laurino Grossi, Alessandro Armuzzi
Summary: The study included 198 elderly (108 UC, 90 CD) and 396 matched nonelderly patients (205 UC, 191 CD). Nonelderly UC patients had a significantly higher persistence on vedolizumab compared to elderly patients. No significant difference in effectiveness was observed between elderly and nonelderly CD patients.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Immunology
Min Li, Lulu Lan, Si Zhang, Yanjiao Xu, Wenxi He, Dong Xiang, Dong Liu, Xiuhua Ren, Chengliang Zhang
Summary: Ulcerative colitis is associated with increased inflammatory factors affecting drug metabolism in the liver. IL-6 inhibits hepatic CESs via the NF-kappa B pathway, leading to potential drug disposition issues.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Beatriz Sicilia, Lara Arias, Gadea Hontoria, Nieves Garcia, Ester Badia, Fernando Gomollon
Summary: This study evaluated the effectiveness of corticosteroids in immunosuppressed patients with inflammatory bowel disease (IBD) and found that 23% of patients needed at least one course of steroids, with CD patients more likely to escalate to biologics or surgery. Patients with CD displaying fibrostenotic (B2) and fistulizing (B3) behaviors were at a higher risk for requiring steroids after immunosuppressive treatment.
FRONTIERS IN MEDICINE
(2021)
Article
Respiratory System
Toshiyuki Sumi, Gen Yamada, Takafumi Yorozuya, Yusuke Tanaka, Yasumasa Tanaka, Yuji Sakuma, Hiroki Takahashi
Summary: The combination of sarcoidosis and ulcerative colitis is rare, with unknown pathogenesis. Genetic and environmental factors may play a role, including the association with HLA genotypes. This case suggests that a susceptible HLA genotype may influence the onset of the combination of sarcoidosis and UC.
SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES
(2021)
Article
Gastroenterology & Hepatology
Remo Panaccione, Silvio Danese, Wen Zhou, Justin Klaff, Dapo Ilo, Xuan Yao, Gweneth Levy, Peter D. R. Higgins, Edward V. Loftus Jr, Su Chen, Yuri Sanchez Gonzalez, Carolyn Leonard, Xavier Hebuterne, James O. Lindsay, Qian Cao, Hiroshi Nakase, Jean-Frederic Colombel, Severine Vermeire
Summary: Upadacitinib demonstrates efficacy and safety for 16-week induction and 52-week maintenance therapy in patients with moderately to severely active ulcerative colitis. Patients without clinical response after 8 weeks' upadacitinib 45 mg induction therapy may benefit from an additional 8 weeks of therapy.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Claudia Veltkamp, Shuai Lan, Eleni Korompoki, Karl-Heinz Weiss, Hartmut Schmidt, Helmut K. Seitz
Summary: IBD patients often develop liver problems such as hepatic steatosis and fibrosis. Factors associated with hepatic steatosis include age, BMI, disease duration, and specific serum activities. Hepatic fibrosis is more common in CD patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Ying Wang, Xuanzhi Huang, Gaoshi Zhou, Jing Han, Zhuo Xie, Mudan Zhang, Xiaoling Li, Qi-rui Wu, Li Li, Ziyin Ye, Minhu Chen, Yun Qiu, Shenghong Zhang
Summary: This study aimed to generate nomograms for the prediction of treatment failures (TFs) in ulcerative colitis (UC) patients. Based on clinical features and mucus integrity, predictive nomograms for TFs were developed and evaluated for performance. These nomograms can serve as practical tools for identifying high-risk subgroups and facilitating timely intervention.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Sunanda Kane, Nancy Reau
Summary: The fields of gastroenterology and hepatology, along with endoscopic practice, have undergone significant changes and innovations in recent years. These changes also extend to maternal fetal medicine and the care of pregnant individuals. Gastroenterologists are frequently involved in providing consultation and performing endoscopy during pregnancy. It is important for gastroenterologists to be familiar with the nuances and considerations related to the care of pregnant patients with gastrointestinal or liver disorders. This article provides a clinical update with references after 2018, as well as discussing the relevance of SARS-CoV-2 infection to pregnancy.
Review
Gastroenterology & Hepatology
Fabio Salvatore Macaluso, Giuseppina Liguori, Massimo Galli
Summary: Vaccination is crucial in managing patients with inflammatory bowel disease (IBD), yet vaccination rates are low due to lack of awareness among healthcare providers and patients. Current evidence-based recommendations for vaccines and prevention of infectious diseases in IBD patients should be widely promoted and implemented.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Haruka Okami, Naoya Ozawa, Makoto Sohda, Takehiko Yokobori, Katsuya Osone, Bilguun Erkhem-Ochir, Gendensuren Dorjkhorloo, Takuya Shiraishi, Takuhisa Okada, Akihiko Sano, Makoto Sakai, Tatsuya Miyazaki, Hiroomi Ogawa, Takashi Yao, Takahiro Oike, Hiro Sato, Ken Shirabe, Atsushi Shibata, Hiroshi Saeki
Summary: This study investigates the significance of DNA damage and HLA-I expression in ulcerative colitis (UC) and colorectal cancer (CC). The results show that HLA-I expression is significantly higher in UC and dysplasia/CC tissues compared to normal mucosa and sporadic colorectal cancer tissues, and is positively correlated with DNA damage and PD-L1 expression. The infiltration of CD8-positive T cells and CD68-positive macrophages is significantly higher in dysplasia/CC tissues with high HLA-I expression compared to UC and sporadic colorectal cancer tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Sarah C. Sasson, Stephanie M. Slevin, Vincent T. F. Cheung, Isar Nassiri, Anna Olsson-Brown, Eve Fryer, Ricardo C. Ferreira, Dominik Trzupek, Tarun Gupta, Lulia Al-Hillawi, Mari-lenna Issaias, Alistair Easton, Leticia Campo, Michael E. B. FitzPatrick, Joss Adams, Meenali Chitnis, Andrew Protheroe, Mark Tuthill, Nicholas Coupe, Alison Simmons, Miranda Payne, Mark R. Middleton, Simon P. L. Travis, Benjamin P. Fairfax, Paul Klenerman, Oliver Brain
Summary: Our study demonstrates that CD8(+) tissue resident memory T (T-RM) cells are the main activated T cell subset in ICI colitis. The pattern of gastrointestinal immunopathology in ICI colitis is distinct from ulcerative colitis at both the immune and epithelial-signaling levels. Activation of CD8+ T-RM cells correlates with clinical and endoscopic severity of ICI colitis.
Article
Pathology
Jiayun M. Fang, Laura Lamps, Amoah Yeboah-Korang, Jerome Cheng, Maria Westerhoff
Summary: The study found that the incidence of de novo chronic idiopathic inflammatory bowel disease (CIIBD) in posttransplant patients is lower than previously reported, with poor response to standard treatment in the two affected patients.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Gastroenterology & Hepatology
Bharati D. Kochar, David Cheng, Tianxi Cai, Ashwin N. Ananthakrishnan
Summary: This retrospective cohort study using a US claims database found that tofacitinib, used to treat IBD, did not increase the risk of adverse thrombotic events compared to anti-TNF therapy.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Review
Immunology
Pablo Juanes-Velasco, Alicia Landeira-Vinuela, Vanessa Acebes-Fernandez, Angela-Patricia Hernandez, Marina L. Garcia-Vaquero, Carlota Arias-Hidalgo, Halin Bareke, Enrique Montalvillo, Rafael Gongora, Manuel Fuentes
Summary: Genetic variability in HLA genes can impact susceptibility to diseases, and understanding immune responses across different populations requires sensitive methods for deciphering peptides loaded on MHC molecules. Developing novel strategies and databases could aid in vaccine development and identifying high-risk HLA types for prioritization in vaccination programs.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Ophthalmology
Edmund Tsui, Jaskirat S. Takhar, Ashlin Joye, Tessnim R. Ahmad, Nisha R. Acharya, John A. Gonzales
Summary: This study describes high-resolution DNA typing of HLA-A29 in two families with familial birdshot chorioretinopathy (BSCR), including clinical outcomes of multigenerational BSCR, with positive results for the HLA-A29*02 allele in all affected individuals.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Article
Surgery
M. T. Mogl, T. Skachko, E. M. Dobrindt, P. Reinke, C. Bures, J. Pratschke, N. Rayes
Summary: This study retrospectively analyzed the outcomes of parathyroidectomy in patients with renal hyperparathyroidism, specifically looking at the influence of cinacalcet. The findings showed that cinacalcet did not impact the surgical outcomes and could be safely offered to patients who did not respond to medical treatment. Additionally, patients receiving cinacalcet had lower preoperative calcium levels, but there were no significant differences in other clinical parameters or complications compared to patients not on cinacalcet.
SCANDINAVIAN JOURNAL OF SURGERY
(2021)
Article
Engineering, Biomedical
Christoph Rueger, Markus A. Feufel, Simon Moosburner, Christopher Oezbek, Johann Pratschke, Igor M. Sauer
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2020)
Article
Medicine, General & Internal
Paul Ritschl, Leke Wiering, Tomasz Dziodzio, Maximilian Jara, Jochen Kruppa, Uwe Schoeneberg, Nathanael Raschzok, Frederike Butz, Brigitta Globke, Philippa Seika, Max Maurer, Matthias Biebl, Wenzel Schoening, Moritz Schmelzle, Igor M. Sauer, Frank Tacke, Robert Ollinger, Johann Pratschke
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Engineering, Biomedical
Hannah Everwien, Eriselda Keshi, Karl H. Hillebrandt, Barbara Ludwig, Marie Weinhart, Peter Tang, Anika S. Beierle, Hendrik Napierala, Joseph M. G. Gassner, Nicolai Seiffert, Simon Moosburner, Dominik Geisel, Anja Reutzel-Selke, Benjamin Strucker, Johann Pratschke, Nils Haep, Igor M. Sauer
ACTA BIOMATERIALIA
(2020)
Article
Engineering, Biomedical
Assal Daneshgar, Oliver Klein, Grit Nebrich, Marie Weinhart, Peter Tang, Alexander Arnold, Imran Ullah, Julian Pohl, Simon Moosburner, Nathanael Raschzok, Benjamin Struecker, Marcus Bahra, Johann Pratschke, Igor M. Sauer, Karl H. Hillebrandt
Article
Surgery
Julian Michelotto, Joseph M. G. V. Gassner, Simon Moosburner, Vanessa Muth, Madhukar S. Patel, Markus Selzner, Johann Pratschke, Igor M. Sauer, Nathanael Raschzok
Summary: Ex vivo liver machine perfusion has been shown in prospective clinical studies to be a safe and feasible strategy for expanding the donor pool in both standard and extended criteria donors. Current research is focused on using ex vivo perfusion in extended criteria donors and declined organs.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Article
Medicine, General & Internal
Francesca Borlak, Anja Reutzel-Selke, Anja Schirmeier, Julia Gogolok, Ellen von Hoerschelmann, Igor M. Sauer, Johann Pratschke, Marcus Bahra, Rosa B. Schmuck
Summary: In pancreatobiliary tumors, there is a significant overexpression of key proteins in the Notch signaling pathway, although this does not have a significant impact on patient survival. Further studies are needed to determine the relevance of the Notch pathway for patient survival.
MEDICINA-LITHUANIA
(2021)
Article
Biochemical Research Methods
Nicolai Seiffert, Peter Tang, Eriselda Keshi, Anja Reutzel-Selke, Simon Moosburner, Hannah Everwien, Dag Wulsten, Hendrik Napierala, Johann Pratschke, Igor M. Sauer, Karl H. Hillebrandt, Benjamin Struecker
Summary: A refined decellularization process was used to create TEVG with retained ECM and mechanical quality, providing a platform for developing small-diameter TEVG. Isolation of ECFC from high cardiovascular risk group was successful and sufficient. Survival of diabetic ECFC depended on support from rMSC/hMSC under static conditions, with a limited survival time of 14 days post seeding.
JOURNAL OF BIOLOGICAL ENGINEERING
(2021)
Correction
Engineering, Biomedical
Christoph Rueger, Markus A. Feufel, Simon Moosburner, Christopher ozbek, Johann Pratschke, Igor M. Sauer
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2021)
Article
Oncology
Uli Fehrenbach, Siyi Xin, Alexander Hartenstein, Timo Alexander Auer, Franziska Drager, Konrad Frobose, Henning Jann, Martina Mogl, Holger Amthauer, Dominik Geisel, Timm Denecke, Bertram Wiedenmann, Tobias Penzkofer
Summary: The study developed a deep-learning model for quantifying liver metastases and hepatic tumor load using Gd-EOB MRI, showing high accuracy and potential for supporting treatment decision-making. The model's measurements correlated well with expert multidisciplinary cancer conference evaluations of therapeutic response, indicating its clinical usefulness.
Review
Oncology
Sandra Pavicevic, Sophie Reichelt, Deniz Uluk, Isabella Lurje, Cornelius Engelmann, Dominik P. Modest, Uwe Pelzer, Felix Krenzien, Nathanael Raschzok, Christian Benzing, Igor M. Sauer, Sebastian Stintzing, Frank Tacke, Wenzel Schoening, Moritz Schmelzle, Johann Pratschke, Georg Lurje
Summary: Cholangiocarcinoma is a rapidly increasing global malignancy of the biliary tract, often presenting with advanced or unresectable disease. Biomarkers obtained from patients' serum or tumor tissue could help guide therapy and identify those at higher risk of recurrence. Genetic aberrations in cholangiocarcinoma have also been linked with improved response to targeted therapies. This review provides an overview of prognostic and predictive biomarkers in cholangiocarcinoma.
Article
Medicine, General & Internal
Matthaus Felsenstein, Flora Lindhammer, Mathilde Feist, Karl Herbert Hillebrandt, Lea Timmermann, Christian Benzing, Brigitta Globke, Dario Zocholl, Mengwen Hu, Uli Fehrenbach, Bruno Valentin Sinn, Uwe Pelzer, Igor Maximillian Sauer, Johann Pratschke, Thomas Malinka
Summary: This study confirms the improvement in long-term survival of PDAC-resected cancer patients with Pn0, and highlights the significant impact of perineural invasion on the long-term survival of formally curative patients. These findings provide new insights into risk stratification and multimodal treatment strategies for pancreatic cancer patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Letter
Gastroenterology & Hepatology
Simon Moosburner, Igor M. Sauer, Bjoern Weiss, Johann Pratschke, Nathanael Raschzok
JOURNAL OF HEPATOLOGY
(2023)
Article
Oncology
Sebastian Knitter, Gregor Duwe, Anika Sophie Beierle, Sina Pesthy, Paul Viktor Ritschl, Karl Herbert Hillebrandt, Alexander Arnold, Thomas Malinka, Dominik Paul Modest, Marcus Bahra, Johann Pratschke, Igor Maximilian Sauer, Moritz Schmelzle, Andreas Andreou
Summary: This study investigated the protective effects of inhibiting vascular endothelial growth factor (VEGF) on the development of sinusoidal obstruction syndrome (SOS) in mice with colorectal liver metastases (CLM) undergoing oxaliplatin-based chemotherapy. The results showed that VEGF inhibition reduced the incidence of SOS, potentially through changes in the VEGF pathway. This suggests that inhibiting VEGF may help reduce complications after liver resection in CLM patients. Further clinical studies are needed to confirm these findings.
Article
Gastroenterology & Hepatology
Simon Moosburner, Igor M. Sauer, Frank Forster, Thomas Winklmann, Joseph Maria George Vernon Gassner, Paul V. Ritschl, Robert Ollinger, Johann Pratschke, Nathanael Raschzok
Summary: Strategies to reduce the incidence of early allograft dysfunction (EAD) are needed to control costs in liver transplantation, as our study found that EAD leads to significantly higher hospital costs primarily attributed to recipient health status.
HEPATOLOGY COMMUNICATIONS
(2021)