Journal
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
Volume 27, Issue 1, Pages 4-21Publisher
SPRINGER
DOI: 10.1007/s13361-015-1253-4
Keywords
Matrix-assisted ionization; Laserspray ionization; Solvent-assisted ionization; Particles; Clusters; Inlet ionization; Vacuum ionization; Mechanism; Fundamentals; Triboluminescence; Sublimation; Evaporation; Temperature; Pressure; Collisions; Applications; Imaging
Funding
- NSF CAREER [0955975, CHE-1411376, STTR-1417124]
- DuPont Young Professor Award
- ASMS Research Award
- Waters Center of Innovation Program
- Thermo Scientific
- PerkinElmer
- Sciex
- Eli Lilly Young Investigator Award in Analytical Chemistry
- WSU Start-up funds
- internal WSU grants (OVPR)
- numerous WSU Schaap (Graduate Fellowship Awards)
- Faculty Scholar Award
- Rumble Graduate
- Summer Undergraduate Fellowships
- ASMS Undergraduate Research Awards
- WSU [10]
- ASMS [10]
- HUPO [1]
- GRC [2]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0955975] Funding Source: National Science Foundation
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1411376] Funding Source: National Science Foundation
Ask authors/readers for more resources
The systematic study of the temperature and pressure dependence of matrix-assisted ionization (MAI) led us to the discovery of the seemingly impossible, initially explained by some reviewers as either sleight of hand or the misinterpretation by an overzealous young scientist of results reported many years before and having little utility. The magic that we were attempting to report was that with matrix assistance, molecules, at least as large as bovine serum albumin (66 kDa), are lifted into the gas phase as multiply charged ions simply by exposure of the matrix:analyte sample to the vacuum of a mass spectrometer. Applied heat, a laser, or voltages are not necessary to achieve charge states and ion abundances only previously observed with electrospray ionization (ESI). The fundamentals of how solid phase volatile or nonvolatile compounds are converted to gas-phase ions without added energy currently involves speculation providing a great opportunity to rethink mechanistic understanding of ionization processes used in mass spectrometry. Improved understanding of the mechanism(s) of these processes and their connection to ESI and matrix-assisted laser desorption/ionization may provide opportunities to further develop new ionization strategies for traditional and yet unforeseen applications of mass spectrometry. This Critical Insights article covers developments leading to the discovery of a seemingly magic ionization process that is simple to use, fast, sensitive, robust, and can be directly applied to surface characterization using portable or high performance mass spectrometers.
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