Article
Oncology
Yongzeng Fan, Yalan Xiong, Xinhong Wang, Jiahao Chen, Danzhou Fang, Jiahui Huang, Gengbiao Yuan
Summary: The study developed I-131-PLGA-rhTSH nanoparticles as a feasible approach to integrate I-131 and rhTSH. These nanoparticles selectively delivered I-131 into thyroid cancer cells, enhancing the effect of radioiodine ablation.
FRONTIERS IN ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Hengqiang Zhao, Jin Hu, Le Cui, Yiping Gong, Tao Huang
Summary: This study investigated the association between iodine intake and nodal metastasis in patients with papillary thyroid microcarcinoma (PTMC). The results showed that iodine intake has a closer association with female patients, and high iodine intake may be associated with lymph node metastasis and extrathyroidal extension in female PTMC patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Salvatore Sorrenti, Enke Baldini, Daniele Pironi, Augusto Lauro, Valerio D'Orazi, Francesco Tartaglia, Domenico Tripodi, Eleonora Lori, Federica Gagliardi, Marianna Pratico, Giulio Illuminati, Vito D'Andrea, Piergaspare Palumbo, Salvatore Ulisse
Summary: In addition to its role in the synthesis of thyroid hormones, iodine acts as an antioxidant, defends against pathogens, and has anti-cancer effects in human cell lines. Its oxidation to hypoiodite has been shown to have bactericidal, antiviral, and antifungal properties. Through tissue-specific peroxidases, iodine serves various evolutionarily conserved physiological functions.
Review
Nutrition & Dietetics
Xueqi Zhang, Fan Zhang, Qiuxian Li, Chuyao Feng, Weiping Teng
Summary: The reasons for the increasing incidence of thyroid cancer are unclear, but lifestyle, environmental factors, and complications may play a role. Iodine intake may affect papillary thyroid carcinoma, but the available evidence is limited due to various factors.
FRONTIERS IN NUTRITION
(2022)
Review
Endocrinology & Metabolism
Peter P. A. Smyth
Summary: Even minor iodine deficiency can have negative effects on thyroid health, while excess iodine intake can lead to thyroid disorders. Seaweed is a source of iodine that is gaining popularity as a food in Western countries. In addition to its role in thyroid health, gaseous iodine released from seaweeds plays a significant role in influencing coastal climate through cloud formation.
EUROPEAN THYROID JOURNAL
(2021)
Review
Endocrinology & Metabolism
Fei Wang, Chunyu Li, Shaoxin Li, Lili Cui, Junyu Zhao, Lin Liao
Summary: Selenium is an essential micronutrient for the biosynthesis of selenoproteins in the thyroid, and its deficiency can increase the prevalence of thyroid diseases. Selenium treatment has shown benefits in delaying disease progression and improving quality of life in patients with Graves' orbitopathy. Supplementation with selenium has also been associated with decreased levels of anti-thyroid antibodies and improved thyroid structure in Hashimoto's thyroiditis. However, the anticancer activity of selenium supplements in thyroid cancer remains conflicting and more clinical evidence is needed.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Bernadette L. Dekker, Mirthe H. Links, Anneke C. Muller Kobold, Linda G. Swart-Busscher, Marleen Kars, Judith A. P. Bons, Adrienne H. Brouwers, Thera P. Links, Anouk N. A. Van der Horst-Schrivers
Summary: This study investigated whether a 4-day low-iodine diet (LID) is sufficient for adequate iodine depletion in differentiated thyroid cancer (DTC) patients preparing for I-131 therapy. The results showed no significant difference in the 24-hour urinary iodine excretion (UIE) between day 4 and day 7 of the LID. On day 4, 72.1% of DTC patients achieved adequate preparation, increasing to 82.0% on day 7. Compared to their regular diet, DTC patients had significantly lower nutrient intake during the LID.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Pharmacology & Pharmacy
Hongxiu Luo, Andrew Tobey, Sungyoung Auh, Craig Cochran, Noha Behairy, Maria Merino, Marina Zemskova, Joanna Klubo-Gwiezdzinska
Summary: This study investigated the association between UIE and PFS in patients with DTC undergoing RAI therapy. It found that patients with UIE >= 200μg/day may have a higher risk of disease progression during treatment, while distant metastases were identified as a strong independent predictor of progression. Adjusting iodine intake could help reduce the risk of progression for patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Xueqi Zhang, Fan Zhang, Qiuxian Li, Renaguli Aihaiti, Chuyao Feng, Deshi Chen, Xu Zhao, Weiping Teng
Summary: The effect of iodine on papillary thyroid cancer has been controversial. This study analyzed the relationship between urinary iodine concentration and PTC using case-control studies. The results showed that excessive iodine intake was positively associated with PTC occurrence, while adequate iodine intake may be a protective factor. However, there was no significant association between urinary iodine and BRAF mutation or lymph node metastasis in PTC patients. The measurement method of urinary iodine may influence the study results.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Wei Lu, Zhuo Sun, Zhengyuan Wang, Mengying Qu, Zehuan Shi, Qi Song, Liping Shen, Shupeng Mai, Yuan Wang, Xinyu Hong, Jiajie Zang
Summary: The aim of this study was to examine the combined effects of bisphenols and iodine exposure on the thyroid gland during pregnancy. The study included 162 pregnant women from Shanghai. Results showed a positive trend in the cumulative effects of bisphenols and iodine on thyroid hormones, as well as a U-shaped dose-response relationship between bisphenols and the likelihood of thyroid autoimmune disease in women with low urinary iodine concentration. The study also found a synergistic effect between certain types of bisphenols on the occurrence of thyroid autoantibodies. Co-exposure to bisphenols and iodine had adverse health effects on the thyroid, and iodine deficiency increased vulnerability to thyroid autoimmune disease even with lower levels of bisphenol exposure.
Review
Endocrinology & Metabolism
Dana Larsen, Sargun Singh, Maria Brito
Summary: With an increasing interest in alternative and dietary approaches to thyroid disease management, patients are seeking information about the benefits of these approaches. However, many popular methods lack proven benefits or adequate research. It is important for physicians to educate patients about the evidence, potential harms, and lack of knowledge behind these strategies.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Environmental Sciences
Yu Zhu, Mingkun Tong, Yingying Wang, Yuchen Liu, Bo Wang, Wanshui Yang, Yi Ning
Summary: This nationwide study in China reveals that thyroid nodules (TNs) are common health problems, and an increased concentration of iodine in drinking water is associated with a higher prevalence of TNs.
ENVIRONMENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Shumi Ji, Xiaoyan Wu, Jiani Wu, Diqun Chen, Zhihui Chen
Summary: This study aimed to assess the relationship between serum iodine concentration (SIC) and urinary iodine concentration (UIC), dietary iodine, thyroid function, and thyroid diseases in pregnant women in the southeast coast of China, and to provide a normal reference range of SIC for pregnant women.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Aomei Zhao, Jing Zhang, Yan Liu, Xi Jia, Xueni Lu, Qi Wang, Ting Ji, Lulu Yang, Jianjun Xue, Rui Gao, Yan Yu, Aimin Yang
Summary: Sinomenine hydrochloride (SH) and iodine-131 show synergistic radiosensitization on papillary thyroid carcinoma cells, indicating a potential therapeutic radiosensitizer in PTC radiotherapy.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Biology
Dongxue Huo, Chaoping Cen, Haibo Chang, Qianying Ou, Shuaiming Jiang, Yonggui Pan, Kaining Chen, Jiachao Zhang
Summary: A 6-month study conducted by Huo et al in patients with Graves' Disease showed that the combination of probiotic Bifidobacterium longum with methimazole potentially improves thyroid function and regulates TRAb concentration through the gut-thyroid axis.
COMMUNICATIONS BIOLOGY
(2021)