Article
Clinical Neurology
Margo W. Menkes, Carolyn M. Andrews, Helen J. Burgess, Isabel Carley, David F. Marshall, Scott A. Langenecker, Melvin G. McInnis, Patricia J. Deldin, Kelly A. Ryan
Summary: Individuals with bipolar I disorder (BD-I) have poorer sleep quality and neuropsychological functioning compared to healthy controls, and poor sleep quality is associated with learning, memory, and executive functioning impairments, with similar effects across groups.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Psychology, Clinical
Ana delCacho-Tena, Bryan R. Christ, Juan Carlos Arango-Lasprilla, Paul B. Perrin, Diego Rivera, Laiene Olabarrieta-Landa
Summary: This study aims to quantify the evolution, impact, and importance of normative data (ND) calculation. The results showed that there were more studies focusing on adults than children, and age, education, and sex were the most studied predictors. Regression-based approaches were widely used, but alternative statistical methods should be considered to address limitations and support growth in the field.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2023)
Article
Psychology, Developmental
Alberto Rodriguez-Lorenzana, Daniela Ramos-Usuga, Lila Adana Diaz, Guido Mascialino, Tarquino Yacelga Ponce, Diego Rivera, Juan Carlos Arango-Lasprilla
Summary: This study aimed to provide normative data for tests of attention and executive functions in a group of Ecuadorian adults, finding significant relationships between age, education, and test performance. The results will enhance clinical practice in neuropsychology and contribute to the development of the field in Ecuador.
AGING NEUROPSYCHOLOGY AND COGNITION
(2021)
Article
Multidisciplinary Sciences
Wei Wu, Paul Hoffman
Summary: Recent studies show that knowledge representations and control processes are crucial for semantic cognition. Notably, older individuals have more detailed semantic knowledge but less effective semantic control processes compared to younger individuals. Additionally, word frequency and inter-item competition have expected effects on performance.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Psychology, Clinical
Sophie Bayard, Clarisse Madiouni, Cecile Niel Carlos, Charlotte Cornu, Aurelie Moulin, Stephane Raffard
Summary: The aim of this study was to establish demographically adjusted normative data of four executive tests commonly used during neuropsychological assessment in France for adults aged 18-65. It was found that younger age and higher education were associated with better executive performance. Gender had no effect on executive performances. Regression equations to calculate Z-scores were presented, and percentiles were provided for the number of recorded errors on the Trail Making Test, Color Word Interference Test, and Verbal Fluency Test. This work provides reliable and updated norms for the assessment of executive functions in French young and middle-aged adults.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2023)
Article
Clinical Neurology
Lone D. HOrlyck, Kia Obenhausen, Ashok Jansari, Henrik Ullum, Kamilla W. Miskowiak
Summary: The study found that the Jansari Assessment of Executive Functions virtual reality test accurately assesses cognitive function and functional capacity in patients with mood disorders. Patients showed significant cognitive deficits in executive functions and neuropsychological tests.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Maria Teresa Ferretti, Huitong Ding, Rhoda Au, Chunyu Liu, Sherral Devine, Sanford Auerbach, Jesse Mez, Ashita Gurnani, Yulin Liu, Antonella Santuccione, Ting Fang Alvin Ang
Summary: This study investigates sex differences in neuropsychological performance among individuals without dementia at baseline and finds that sex differences have an impact on both neuropsychological test scores and AD incidence. Furthermore, machine learning methods were used to identify optimal neuropsychological profiles for men and women.
ALZHEIMERS & DEMENTIA
(2023)
Article
Psychiatry
Judith G. Auerbach, Sydney L. Hans, Yudong Zhang
Summary: This study investigated neurocognitive function in individuals at risk for schizophrenia across adolescence and adulthood, finding deficits in attention and memory in adults with familial risk for schizophrenia. Despite improvement in executive functioning with age in all groups, the schizophrenia and other mental illness groups showed significantly slower rates of improvement compared to the no mental illness group.
SCHIZOPHRENIA RESEARCH
(2022)
Review
Neurosciences
Sara Carucci, Chiara Narducci, Marzia Bazzoni, Carla Balia, Federica Donno, Antonella Gagliano, Alessandro Zuddas
Summary: Recent clinical studies have shown the extreme neuropsychological heterogeneity of attention-deficit hyperactivity disorder (ADHD) in both children/adolescents and adults. Specific neuropsychological deficits are found in only a minority of individuals, and there is no direct correlation between discrete cognitive performances and clinical symptoms. Sex differences contribute to the clinical and neuropsychological heterogeneity of ADHD, with females potentially exhibiting greater working memory problems, poorer vocabulary skills, and worse visual spatial reasoning. However, most clinical studies have primarily or exclusively included male participants, limiting conclusions about sex differences within the disorder.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Oncology
Jenna A. Chiang, Paulina T. Feghali, Anita Saavedra, Ashley M. Whitaker
Summary: This study examined the impact of sleep factors on cognitive and executive functioning in pediatric brain tumor (PBT) patients. The results showed that PBT patients experienced sleep problems, including insufficient nocturnal sleep duration and daytime napping. Inadequate sleep was associated with decreased adaptive functioning and increased symptoms of executive dysfunction.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Clinical Neurology
Francesca Conca, Valentina Esposito, Francesco Rundo, Davide Quaranta, Cristina Muscio, Rosa Manenti, Giulia Caruso, Ugo Lucca, Alessia Antonella Galbussera, Sonia Di Tella, Francesca Baglio, Federica L'Abbate, Elisa Canu, Valentina Catania, Massimo Filippi, Giulia Mattavelli, Barbara Poletti, Vincenzo Silani, Raffaele Lodi, Maddalena De Matteis, Michelangelo Stanzani Maserati, Andrea Arighi, Emanuela Rotondo, Antonio Tanzilli, Andrea Pace, Federica Garramone, Carlo Cavaliere, Matteo Pardini, Cristiano Rizzetto, Sandro Sorbi, Roberta Perri, Pietro Tiraboschi, Nicola Canessa, Maria Cotelli, Raffaele Ferri, Sandra Weintraub, Camillo Marra, Fabrizio Tagliavini, Eleonora Catricala, Stefano Francesco Cappa
Summary: This study aimed to address the issue of heterogeneity in neuropsychological testing by presenting the Italian adaptation of the Uniform Data Set. Data from healthy Italian individuals were collected and regression models were used to derive reference norms. The results showed that higher education and younger age were associated with better performance in most tests, while sex only had an impact on specific tests.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Substance Abuse
Esperanza Vergara-Moragues, Maria Rocio Acosta Barreto, Sandra Santiago-Ramajo, Diego Rivera, Jennifer Alexandra Pardo Pachon, Francisco Gonzalez-Saiz, Juan Carlos Arango-Lasprilla
Summary: Individuals with coca-paste use disorder (CPUD) exhibit significant cognitive deficits in learning and memory, language, and executive functions compared to healthy controls (HC). There is an interaction effect between group (CPUD versus HC) and educational level, with higher education associated with better cognitive performance in HC, particularly in the domains of learning and memory and language.
ADDICTION RESEARCH & THEORY
(2021)
Article
Psychology, Clinical
Scott Roye, Matthew Calamia, Peter J. Castagna, Stephen L. Aita, Benjamin D. Hill
Summary: Research has largely focused on normative personality traits and their relationship with executive functioning (EF). However, limited literature exists on the relationship between maladaptive personality traits and self-reported EF. This study found unique associations between maladaptive personality traits and EF, highlighting the importance of assessing both normative and maladaptive personality traits in understanding the relationship between personality and EF.
Article
Neurosciences
Alfonso Delgado-Alvarez, Cristina Delgado-Alonso, Maria Valles-Salgado, Maria Jose Gil-Moreno, Lucia Fernandez-Romero, Jorge Matias-Guiu, Jordi A. Matias-Guiu
Summary: This study collected and presented normative data on three neuropsychological instruments developed from a cross-cultural perspective in a majority population sample (Spaniards living in Spain) and a minority population sample (Colombians living in Spain). The study found that these instruments have favorable cross-cultural properties and show similar influences of demographic factors in both populations.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Audiology & Speech-Language Pathology
Amy N. Stahl, Jane A. Mondul, Katy A. Alek, Troy A. Hackett, Ramnarayan Ramachandran
Summary: Clinical auditory physiological measures provide specificity for diagnosing hearing impairments, but have limitations in detecting specific sites of lesion and subtle cochlear damage. A normative set of physiological measures using ABRs and DPOAEs in macaque monkeys is presented, serving as a crucial baseline for improving diagnostics.
Article
Clinical Neurology
Maria Stefanidou, Jayandra J. Himali, Orrin Devinsky, Jose R. Romero, Mohammad Arfan Ikram, Alexa S. Beiser, Sudha Seshadri, Daniel Friedman
Summary: The study found that hypertension is a risk factor for predicting late-onset epilepsy, with nearly 2-fold increased risk even after adjustment for previous and interim stroke.
Article
Peripheral Vascular Disease
Ramachandran S. Vasan, Stephanie Pan, Vanessa Xanthakis, Alexa Beiser, Martin G. Larson, Sudha Seshadri, Gary F. Mitchell
Summary: This study examines the association between arterial stiffness and various health outcomes, including hypertension, diabetes, chronic kidney disease, dementia, cardiovascular disease, coronary heart disease, stroke, and death. The results show that arterial stiffness is associated with an increased risk of these health outcomes.
Article
Clinical Neurology
Joel Salinas, Alexa S. Beiser, Jasmeet K. Samra, Adrienne O'Donnell, Charles S. DeCarli, Mitzi M. Gonzales, Hugo J. Aparicio, Sudha Seshadri
Summary: This study found that loneliness is associated with an increased 10-year risk of developing dementia and early cognitive and neuroanatomic markers of Alzheimer's disease and related dementia vulnerability. These findings have important implications for clinical and public health.
Article
Cardiac & Cardiovascular Systems
Jelena Kornej, Honghuang Lin, Ludovic Trinquart, Corban R. Jackson, Darae Ko, Emelia J. Benjamin, Sarah R. Preis
Summary: This study found that high neck circumference was positively associated with the risk of incident atrial fibrillation, even after adjusting for traditional adiposity measures such as BMI and waist circumference.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Ramachandran S. Vasan, Danielle M. Enserro, Vanessa Xanthakis, Alexa S. Beiser, Sudha Seshadri
Summary: This study examined the remaining lifetime risk of cardiovascular disease over the past six decades in a predominantly White community-based cohort. The findings revealed that average life expectancy increased while the risk of cardiovascular disease decreased. This highlights the importance of continued and effective primary prevention efforts, as well as better screening and treatment of risk factors.
Article
Peripheral Vascular Disease
Ramachandran S. Vasan, Rebecca J. Song, Vanessa Xanthakis, Alexa Beiser, Charles DeCarli, Gary F. Mitchell, Sudha Seshadri
Summary: This study examined the prevalence, correlates, and prognosis of hypertension-mediated organ damage (HMOD) in a community-based study. The findings showed that the prevalence of HMOD varied across different blood pressure guidelines and that the presence of HMOD increased the risk of cardiovascular disease.
Article
Health Care Sciences & Services
Jing Yuan, Rhoda Au, Cody Karjadi, Ting Fang Ang, Sherral Devine, Sanford Auerbach, Charles DeCarli, David J. Libon, Jesse Mez, Honghuang Lin
Summary: This study investigated the association between digital Clock Drawing Test (dCDT) features and brain volume in a large population-based cohort. The findings showed that dCDT composite scores were significantly associated with multiple brain MRI measures. The results suggest that dCDT has the potential to be used as a cognitive assessment tool in the clinical diagnosis of mild cognitive impairment (MCI).
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Multidisciplinary Sciences
Jelena Kornej, Darae Ko, Honghuang Lin, Joanne M. Murabito, Emelia J. Benjamin, Ludovic Trinquart, Sarah R. Preis
Summary: Social isolation is associated with mortality without diagnosed AF, while social group participation has a positive impact on the incidence of AF. Further study is needed to better understand the complex relationship between social isolation, incident AF, and mortality.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Jaime Ramos-Cejudo, Andrew D. Johnson, Alexa Beiser, Sudha Seshadri, Joel Salinas, Jeffrey S. Berger, Nathanael R. Fillmore, Nhan Do, Chunlei Zheng, Zanetta Kovbasyuk, Babak A. Ardekani, Pomara Nunzio, Omonigho M. Bubu, Ankit Parekh, Antonio Convit, Rebecca A. Betensky, Thomas M. Wisniewski, Ricardo S. Osorio
Summary: Platelet function in middle age is independently associated with future risk of Alzheimer's disease (AD). Individuals with a higher platelet response have a higher risk of dementia during a 20-year follow-up, highlighting the importance of platelet function in AD risk.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Rebecca Angoff, Jayandra J. Himali, Pauline Maillard, Hugo J. Aparicio, Ramachandran S. Vasan, Sudha Seshadri, Alexa S. Beiser, Connie W. Tsao
Summary: Metabolic unhealthiness and obesity are associated with structural and functional aging of the brain in community dwelling adults. Improving metabolic health and obesity may present opportunities for improving long-term brain health.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Clinical Neurology
Jose Rafael Romero, Adlin Pinheiro, Hugo J. Aparicio, Charles S. DeCarli, Serkalem Demissie, Sudha Seshadri
Summary: The study found that as the burden of PVS visible on MRI scans increased, the risk of developing dementia also increased, and this association remained significant even after adjusting for white matter hyperintensity volume (WMHV), covert infarcts, and total brain volume.
Article
Multidisciplinary Sciences
Jelena Kornej, Maha A. Qadan, Mona Alotaibi, David R. Van Wagoner, Jeramie D. Watrous, Ludovic Trinquart, Sarah R. Preis, Darae Ko, Mohit Jain, Emelia J. Benjamin, Susan Cheng, Honghuang Lin
Summary: This study found an association between chronic inflammation and atrial fibrillation (AF). Using liquid chromatography-mass spectrometry, researchers measured 161 eicosanoids and found that six of them were associated with incident AF. A joint score weighted by the effect sizes of these eicosanoids was also found to be associated with incident AF.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Dana Shulman, Serafima Dubnov, Tamara Zorbaz, Nimrod Madrer, Iddo Paldor, David A. Bennett, Sudha Seshadri, Elliott J. Mufson, David S. Greenberg, Yonatan Loewenstein, Hermona Soreq
Summary: Females with Alzheimer's disease (AD) experience accelerated dementia and loss of cholinergic neurons compared to males, and the underlying mechanisms may involve changes in transfer RNA fragments (tRFs) targeting cholinergic transcripts (CholinotRFs). The study found that NAc CholinotRFs of mitochondrial genome origin had reduced levels, which correlated with elevations in their predicted cholinergic-associated mRNA targets. Single-cell RNA sequencing in AD temporal cortices also indicated altered sex-specific levels of cholinergic transcripts in diverse cell types and sex-specific CholinotRF elevations in neuroblastoma cells under cholinergic differentiation. These findings suggest the involvement of CholinotRFs in cholinergic regulation and their potential role in AD sex-specific cholinergic loss and dementia.
ALZHEIMERS & DEMENTIA
(2023)
Review
Cardiac & Cardiovascular Systems
Tanja Charlotte Frederiksen, Christina Catherine Dahm, Sarah R. Preis, Honghuang Lin, Ludovic Trinquart, Emelia J. Benjamin, Jelena Kornej
Summary: There is a bidirectional relationship between atrial fibrillation (AF) and myocardial infarction (MI) due to shared risk factors and mechanisms. This review discusses the pathogenesis, prevention, and management of AF in patients with MI and of MI in patients with AF.
NATURE REVIEWS CARDIOLOGY
(2023)
