Journal
EXPERIMENTAL AGING RESEARCH
Volume 34, Issue 3, Pages 251-266Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/03610730802070233
Keywords
age; endothelin; ET-A receptor; ET-B receptor; heart
Categories
Ask authors/readers for more resources
Density, affinity, and subtype distribution of endothelin-1 (ET-1) binding sites were determined in rat cardiac tissue as a function of age ill order to evaluate the association of alterations in the endothelin receptor system and aging in the heart. A significant decrease in the receptor subtype ET-A, which represents 70% to 80% of the total receptor population in cardiac tissue of 3- and 12-month-old rats, was observed in 24-month-old rats with respect to the younger groups. These findings indicate an alteration in ET-1 cardiac receptors associated with aging, mainly due to a variation in the receptor subtype distribution.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available