Journal
ANNALS OF NEUROLOGY
Volume 79, Issue 2, Pages 178-189Publisher
WILEY
DOI: 10.1002/ana.24560
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Funding
- National Multiple Sclerosis Society [RG-5003-A-2]
- NIH National Institute of Neurological Disorders and Stroke [K08-NS079493]
- Intramural Research Program of the National Institute of Neurological Disorders and Stroke
- Clinician Scientist Development Award from the National Multiple Sclerosis Society
- American Academy of Neurology [FAN 1755-A-1]
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The Genes and Environment in Multiple Sclerosis project establishes a platform to investigate the events leading to multiple sclerosis (MS) in at-risk individuals. It has recruited 2,632 first-degree relatives from across the USA. Using an integrated genetic and environmental risk score, we identified subjects with twice the MS risk when compared to the average family member, and we report an initial incidence rate in these subjects that is 30 times greater than that of sporadic MS. We discuss the feasibility of large-scale studies of asymptomatic at-risk subjects that leverage modern tools of subject recruitment to execute collaborative projects. Ann Neurol 2016;79:178-189
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