Article
Pharmacology & Pharmacy
Jiayue Zhu, Xinwei Yang, Xiao Li, Shuo Han, Yanbo Zhu, Liping Xu
Summary: Tang Luo Ning (TLN), a traditional Chinese compound prescription, has been used to treat diabetic peripheral neuropathy (DPN) in China. This study aimed to investigate the effects of TLN on mitochondrial dynamics in rat models and Schwann cells. TLN was found to improve mitochondrial function, maintain balance in dynamics, and improve schwannopathy. Study results suggest that TLN may hold promise for clinical application in treating DPN.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemical Research Methods
Yangfan Li, Weijie Yao, Yanbin Gao
Summary: TLN was found to improve peripheral nerve function and reduce demyelination of nerves in DPN. Metabolomics analysis identified potential biomarkers and revealed metabolic pathways associated with DPN and TLN treatment.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Article
Pharmacology & Pharmacy
Rui Zhang, Xiaojun Zhou, Qiqi Sheng, Qian Zhang, Tianyue Xie, Chunmei Xu, Zhiwei Zou, Jianjun Dong, Lin Liao
Summary: The study showed that Gliquidone can lower fasting blood glucose and increase insulin sensitivity in diabetic Sur1-- rats, mainly by increasing hepatic glycogen storage and decreasing gluconeogenesis. However, its effects were still weaker compared to metformin.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kuang-I. Cheng, Hung-Chen Wang, Kuang-Yi Tseng, Yi-Hsuan Wang, Chung-Yu Chang, Yi-Jing Chen, Chung-Sheng Lai, Dar-Ren Chen, Lin-Li Chang
Summary: Oral cilostazol can attenuate the responses of mechanical allodynia and has the potential to treat diabetic neuropathy by attenuating NaV and glial cell dysregulation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Miao-miao Chen, Jin-hao Jia, Yu-jun Tan, Yu-shan Ren, Jun-lin Lv, Ting Chu, Xin-yue Cao, Ru Ma, De-fang Li, Qiu-sheng Zheng, Zhong Liu, Jie Li
Summary: This study aimed to explore the therapeutic effect of Shen-Qi-Jiang-Tang granule (SQJTG) on diabetic nephropathy (DN) through bioinformatics analysis and in vivo experiments. The results showed that SQJTG exerts a kidney protective effect in DN mice by modulating the TNF signaling pathway, suggesting its potential application for the treatment of DN.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xing Wang, Caina Li, Yi Huan, Hui Cao, Sujuan Sun, Lei Lei, Quan Liu, Shuainan Liu, Wenming Ji, Kaixun Huang, Zhufang Shen, Jun Zhou
Summary: DPDS supplementation improved hyperglycemia, glucose intolerance, dyslipidemia, and renal pathological abnormalities in STZ-induced DN rats. It also promoted antioxidant enzyme activities, reduced pro-inflammatory factors levels, and activated the renal Nrf2/Keap1 signaling pathway while attenuating NF kappa B/MAPK signaling pathways, suggesting DPDS as a potential therapeutic approach for DN.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Ning Zhu, Liuyan Zhu, Bingwu Huang, Wenjun Xiang, Xuyong Zhao
Summary: This study found that Gal-3 inhibition can improve myocardial apoptosis, oxidative stress, release of inflammatory cytokines, macrophage infiltration, and fibrosis, thereby reducing cardiac dysfunction in DCM mice. In addition, silencing Gal-3 can also suppress macrophage infiltration and release of inflammatory cytokines induced by high glucose. Finally, a Gal-3/NF-kappa B p65 regulatory network was clarified in the pathogenesis of DCM.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Sadaf Jamal Gilani, May Nasser Bin-Jumah, Fahad A. Al-Abbasi, Muhammad Shahid Nadeem, Syed Sarim Imam, Sultan Alshehri, Mohammed M. Ghoneim, Muhammad Afzal, Sami Alzarea, Nadeem Sayyed, Imran Kazmi
Summary: The study aimed to confirm the anti-diabetic activity and mechanism of rosinidin in a laboratory setting. Treatment with rosinidin showed positive effects on diabetes, including lower blood glucose levels, increased serum insulin levels, and improved pancreatic function in rats induced with streptozotocin.
Article
Immunology
Anand Kumar, Priyanka Prajapati, Vinit Raj, Seong-Cheol Kim, Vikas Mishra, Chaitany Jayprakash Raorane, Ritu Raj, Dinesh Kumar, Sapana Kushwaha
Summary: This study found that salbutamol can alleviate muscle atrophy and has antioxidant and anti-inflammatory effects in streptozotocin-induced diabetic rats.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Juanzhen Yang, Yuxi Wei, Tong Zhao, Xiaoqian Li, Xuejian Zhao, Xingnan Ouyang, Lihua Zhou, Xiuqin Zhan, Minyi Qian, Jiaying Wang, Xu Shen
Summary: The study found that magnolol (MG) can improve neurological dysfunctions in diabetic peripheral neuropathy (DPN) mice, promote neurite outgrowth, protect nerve structure, and regulate inflammation and apoptosis processes through multiple pathways. These results reveal the potential of MG as a treatment for DPN and provide further understanding of its mechanism of action.
Article
Biochemistry & Molecular Biology
Sherif M. Afifi, Naglaa M. Ammar, Rabab Kamel, Tuba Esatbeyoglu, Heba A. Hassan
Summary: The study demonstrated that loading beta-Sitosterol glucoside in self-nanoemulsifying drug delivery systems significantly enhanced its solubility and biological effect, showing potential in ameliorating insulin resistance and protecting against oxidative stress in diabetes progression.
Article
Medicine, Research & Experimental
Tales Lyra de Oliveira, Gisele Silverio Lincevicius, Caroline Gusson Shimoura, Alex Yuri Simoes-Sato, Michelle Louvaes Garcia, Cassia T. Bergamaschi, Ruy R. Campos
Summary: The study found that bilateral renal denervation (BRD) significantly improved glycemia, renal function, and sympathetic nerve activity in streptozotocin-diabetic rats. Renal nerves may play an important role in the treatment of diabetic patients.
Article
Veterinary Sciences
Ehab Kotb Elmahallawy, Khalaf F. Alsharif, Mohamed A. Alblihd, Asmaa A. Hamad, Nani Nasreldin, Walaa Alsanie, Ahmad Majed Aljoudi, Atif Abdulwahab A. Oyouni, Osama M. Al-Amer, Alaa Jameel A. Albarakati, Maha S. Lokman, Ashraf Albrakati, Fatma Abo Zakaib Ali
Summary: This study aimed to investigate the serobiochemical changes and histopathological picture in the diabetic heart and kidney early before chronic complications and highlight the association between hyperglycemia, glomerular alterations, and cardiovascular changes. The role of melatonin in the treatment of cardio-nephro diabetic vascular and cellular adverse changes was also studied.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Prasanta Dey, Amit Kundu, Ha Eun Lee, Babli Kar, Vineet Vishal, Suvakanta Dash, In Su Kim, Tejendra Bhakta, Hyung Sik Kim
Summary: The extract of Molineria recurvata exhibits protective effects on nephropathy in diabetic rats by suppressing inflammation and oxidative stress.
Article
Neurosciences
Meijian Wang, Min Xie, Shuyan Yu, Pan Shang, Cong Zhang, Xiaolin Han, Cuiqin Fan, Li Chen, Xianghua Zhuang, Shihong Chen
Summary: Studies have shown that Lipin1 is involved in the pathogenesis of DPN, playing a role in regulating autophagy and maintaining normal peripheral nerve conduction function. Upregulation of Lipin1 can ameliorate autophagic disorders and pathological changes in nerves, leading to an increase in nerve conduction velocity in DPN rats.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Agronomy
Zhaoqiang Han, Pinshang Xu, Zhutao Li, Haiyan Lin, Chen Zhu, Jinyang Wang, Jianwen Zou
Summary: This study found that organic fertilizer substitution and biochar amendment in tea plantations can enhance soil multifunctionality by altering key species abundance. Soil pH plays a crucial role in soil microbial community composition.
GLOBAL CHANGE BIOLOGY BIOENERGY
(2022)
Article
Environmental Sciences
Weilu Wang, Irakli Loladze, Juan Wang, Yunxia Han, Junfei Gu, Hao Zhang, Lijun Liu, Jinyang Wang, Yunji Xu, Weiyang Zhang, Zhiqin Wang, Jianchang Yang
Summary: The study found that different weighting functions and data interpolation methods have varying effects on assessing the impact of elevated [CO2] on plant growth. The specific research methods influence the impact of missing standard deviations in the dataset on the results.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Agriculture, Multidisciplinary
Zhaoqiang Han, Haiyan Lin, Pinshang Xu, Zhutao Li, Jinyang Wang, Jianwen Zou
Summary: Experimental research conducted in tea plantations showed that organic fertilizer substitution and biochar addition significantly increased soil carbon stock, leading to a substantial decrease in greenhouse gas emissions and achieving low carbon development in tea plantations.
AGRICULTURE ECOSYSTEMS & ENVIRONMENT
(2022)
Review
Environmental Sciences
Jie Wu, Jinyang Wang, Zhutao Li, Shumin Guo, Kejie Li, Pinshang Xu, Yong Sik Ok, Davey L. Jones, Jianwen Zou
Summary: Misuse and overuse of antibiotics have led to the rise of antimicrobial resistance. In agricultural soils, antibiotics and antibiotic resistance genes (ARGs) are mostly found due to the application of livestock and organic wastes. Cattle manure, chicken manure, swine manure, and sewage sludge are the primary sources of antibiotics and ARGs in agricultural soils. Sulfonamides, tetracyclines, fluoroquinolones, and corresponding ARGs are the major types of pollution. Land-use type, soil, and climatic factors affect the concentrations of antibiotics and abundances of ARGs. Mobile genetic elements (MGEs), especially the sul1 gene, play a vital role in promoting the dissemination of ARGs. Better management of antibiotic and ARG contamination in agricultural soils is important for human health.
CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Environmental Sciences
Jie Wu, Yihe Zhang, Mengyuan Huang, Ziheng Zou, Shumin Guo, Jinyang Wang, Jianwen Zou
Summary: Veterinary antibiotics have significant effects on nitrogen loss in soil-plant systems. Addition of antibiotics inhibits nitrous oxide emissions and increases soil ammonia volatilization. These findings provide insights into the ecological risks of antibiotics in agriculture.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Agronomy
Pinshang Xu, Zhaoqiang Han, Jie Wu, Zhutao Li, Jinyang Wang, Jianwen Zou
Summary: Nitrogen inputs and land-use conversion have impacts on soil greenhouse gas and nitric oxide emissions. The recommended nitrogen application rate can reduce greenhouse gas emissions from croplands, and land-use conversion can reduce the global warming potential. Nitrous oxide emissions are mainly influenced by the nitrogen application rate.
Article
Environmental Sciences
Kejie Li, Felicity Hayes, David R. Chadwick, Jinyang Wang, Jianwen Zou, Davey L. Jones
Summary: This study found that elevated ozone has adverse effects on crop growth and soil microbial communities, leading to a decrease in ecosystem multifunctionality. Changes in the abundance of specific bacteria and fungi are associated with ecosystem functioning.
ENVIRONMENTAL RESEARCH
(2022)
Article
Engineering, Environmental
Jinyang Wang, Pete Smith, Kristell Hergoualc'h, Jianwen Zou
Summary: Based on research findings, the sensitivity of N2O emissions in tea plantations is influenced by soil acidity and climate factors. Tea plantations significantly contribute to N2O emissions in the agricultural sector globally, and the intensity of greenhouse gas emissions per unit yield is higher compared to other upland cereals. Implementing climate-smart practices in Chinese tea plantations can reduce emissions equivalent to one-third of the global total, highlighting the importance of targeted measures for achieving global temperature control targets.
RESOURCES CONSERVATION AND RECYCLING
(2022)
Article
Soil Science
Zhutao Li, Pinshang Xu, Zhaoqiang Han, Jie Wu, Xiaomeng Bo, Jinyang Wang, Jianwen Zou
Summary: Applying biochar and 3,4-dimethylpyrazole phosphate (DMPP) can effectively mitigate soil nitrous oxide (N2O) emissions, but their efficiency can be influenced by soil properties and microorganisms. This study investigated the effects of biochar and/or DMPP on N2O emissions from different agricultural soils and found that biochar reduced N2O emissions from vegetable and tea soils by inhibiting ammonia oxidation, while promoting N2O emissions from peach orchard soils. DMPP application mitigated N2O emissions, but its efficiency was weakened when co-applied with biochar in tea and peach soils.
BIOLOGY AND FERTILITY OF SOILS
(2023)
Article
Agronomy
Shumin Guo, Jie Wu, Zhaoqiang Han, Zhutao Li, Pinshang Xu, Shuwei Liu, Jinyang Wang, Jianwen Zou
Summary: Existing studies suggest that biochar application can reduce soil nitrous oxide (N2O) emissions, but the effects and mechanisms of the legacy of biochar on N2O emissions after many years of application are still unclear. This study found that biochar can alleviate soil N2O emissions, possibly through the reduced effectiveness of the soil substrate, decrease in nitrification and denitrification activities, and promotion of N2O reduction. However, the abatement capacity of biochar may weaken over time after application, which needs further investigation.
GLOBAL CHANGE BIOLOGY BIOENERGY
(2023)
Article
Environmental Sciences
Haiyan Lin, Shumin Guo, Zhaoqiang Han, Shuwei Liu, Jinyang Wang, Jianwen Zou
Summary: Biochar applied to tea plantations can enhance ecosystem services and mitigate reactive nitrogen losses. However, the high cost of biochar and its limited economic benefits hinder its widespread adoption. Optimistic scenario analysis suggests that increased yields and higher carbon prices could improve the net ecosystem economic benefits of biochar application.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biodiversity Conservation
Jinyang Wang, Philippe Ciais, Pete Smith, Xiaoyuan Yan, Yakov Kuzyakov, Shuwei Liu, Tingting Li, Jianwen Zou
Summary: The increase in atmospheric methane concentrations since 2007 is a global concern, potentially caused by emissions from rice cultivation. Estimating methane emissions from rice fields and their abatement potential is crucial to assess the contribution of improved rice management. However, the contribution of rice field emissions to the renewed methane increase and global abatement potential remains unclear.
GLOBAL CHANGE BIOLOGY
(2023)
Article
Environmental Sciences
Jie Wu, Shumin Guo, Haiyan Lin, Kejie Li, Zhutao Li, Jinyang Wang, William H. Gaze, Jianwen Zou
Summary: This study comprehensively characterized the profile of antibiotic resistance genes (ARGs) and their drivers in soil samples collected from different land-use patterns across China. The results showed that agricultural soil had the highest abundance and diversity of ARGs, followed by tea plantation and forest land. Significant differences in ARG distribution were observed among different geographical regions, with the greatest enrichment of ARGs found in southern China. Biotic and abiotic factors, including soil properties, climatic factors, and bacterial diversity, were identified as the primary drivers associated with ARG abundance.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Review
Environmental Sciences
Xiaomeng Bo, Zhiwei Zhang, Jinyang Wang, Shumin Guo, Zhutao Li, Haiyan Lin, Yawen Huang, Zhaoqiang Han, Yakov Kuzyakov, Jianwen Zou
Summary: This comprehensive review evaluates the effects of biochar on soil organic carbon (SOC), emission of non-CO2 greenhouse gases, and crop yield, and concludes that targeted applications of biochar can have positive effects on these factors. It also highlights the need for further research to explore potential limitations and challenges of biochar in addressing climate change and ensuring crop production.
Article
Environmental Sciences
Zhaoqiang Han, Pinshang Xu, Zhutao Li, Shumin Guo, Shuqing Li, Shuwei Liu, Shuang Wu, Jinyang Wang, Jianwen Zou
Summary: Applying biochar amendment and manure in tea plantation ecosystems can help reduce soil acidification and degradation. The impact of biochar amendment on soil respiration is not significant, but it can indirectly enhance carbon sequestration. On the other hand, replacing mineral fertilizer with manure significantly stimulates soil respiration and CO2 emissions in a tea plantation.
