Article
Integrative & Complementary Medicine
Huina Wei, Boyu Liu, Chengyu Yin, Danyi Zeng, Huimin Nie, Yuanyuan Li, Yan Tai, Xiaofen He, Boyi Liu
Summary: In this study, we found that electroacupuncture can alleviate pain in gout arthritis by suppressing ROS-mediated NLRP3 inflammasome activation in inflamed ankle joints and upregulation of TRPV1 in sensory neurons. These findings suggest that electroacupuncture may be a promising treatment option for gout pain.
Article
Pharmacology & Pharmacy
Hong Zhang, Wei He, Xue-Fei Hu, Yan-Zhen Li, Yong-Min Liu, Wen-Qiang Ge, Ou-Yang Zhanmu, Chao Chen, Yu-Ye Lan, Yang-Shuai Su, Xiang-Hong Jing, Bing Zhu, Hui-Lin Pan, Ling-Ling Yu, Man Li
Summary: This study demonstrates that electroacupuncture attenuates mechanical allodynia and visceral hypersensitivity associated with inflammatory bowel disease by activating CB2 receptors and inhibiting macrophage activation and expression of IL-1 beta and iNOS.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Masakazu Kotoda, Toru Matsuoka, Keiichi Wada, Selwyn Jayakar, Hirofumi Ino, Koji Kawago, Yasutomo Kumakura
Summary: This study investigated the potential of amiodarone, a multiple channel blocker, as a long-lasting local anesthetic and analgesic. It was found that amiodarone produced robust anesthesia and the co-administration of TRPV1 agonist capsaicin prolonged the duration of sensory blockade without affecting motor blockade. Low-dose amiodarone was also effective in relieving inflammatory pain without the need for capsaicin co-administration. Furthermore, local amiodarone did not cause any cardiovascular or central nervous system side effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Si Yuan, Bo Qiu, Ying Liang, Bing Deng, Jing Xu, Xiaorong Tang, Junshang Wu, Sheng Zhou, Zeli Li, Hongzhu Li, Qiuping Ye, Lin Wang, Shuai Cui, Chunzhi Tang, Wei Yi, Lulu Yao, Nenggui Xu
Summary: This study aimed to investigate whether TRPV1 mediated the signal of EA to the primary sensory cortex (S1) during regulation of swallowing function. The results showed that EA treatment increased blood perfusion and neuronal activity in the S1, and this effect was absent after lidocaine injection near CV23. TRPV1 near CV23 was upregulated by EA-CV23. The findings suggest that TRPV1 may play a key role in mediating local blood perfusion and improving swallowing function in PSD following EA treatment.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Multidisciplinary Sciences
I-Han Hsiao, Hsien-Yin Liao, Yi-Wen Lin
Summary: Peripheral tissue damage and inflammation can cause neuroplastic changes in somatic pain pathways, leading to chronic pain. Electroacupuncture can relieve chronic inflammatory pain by modulating central pain pathways and suppressing CaMKII alpha-dependent plasticity.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Aida Aghazadeh, Mohammad Ali Hosseinpour Feizi, Leila Mehdizadeh Fanid, Mohammad Ghanbari, Leila Roshangar
Summary: Heat stress increases core body temperature, leading to the release of free radicals and neuronal damage in the central nervous system. TRPV1 and TRPV4 channels play essential roles in this process as thermosensors. Results demonstrate a significant upregulation of TRPV1 expression, while TRPV4 expression decreases in a time-dependent manner in heat-stressed mice, along with alterations in oxidative markers.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Immunology
Yonglan Ruan, Jinying Ling, Fan Ye, Nuo Cheng, Fei Wu, Zongxiang Tang, Xiaolan Cheng, Hongquan Liu
Summary: The study showed that PF significantly alleviated CFA-induced paw swelling, mechanical, and thermal hyperalgesia. PF partly relieved inflammatory pain by inhibiting the activation of TRPV1 and succinate/SUCNR1-HIF-1a/NLPR3 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Moritz Moeller, Christine Moser, Ulrike Weiss, Ellen Niederberger
Summary: Alpha Synuclein is a synaptic protein associated with neurodegenerative diseases, particularly Parkinson's disease. Research suggests that inhibiting Alpha Synuclein may be beneficial in alleviating pain symptoms following nerve injury.
Article
Biochemistry & Molecular Biology
Yosuke Nakazawa, Rosica S. Petrova, Yuki Sugiyama, Noriaki Nagai, Hiroomi Tamura, Paul J. Donaldson
Summary: The study reveals that TRPV1 and TRPV4 act as mechanosensitive transducers in regulating lens water transport through a dual-feedback pathway. The membrane localization of TRPV1 and TRPV4 is dynamically affected by external stimuli and activators, leading to changes in water transport in the lens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Bernice Lottering, Yi-Wen Lin
Summary: Depression often coexists with chronic pain, leading to poor prognosis. Electroacupuncture has shown success in pain treatment, with research indicating changes in cerebellum lobules VI, VII, VIII, which are alleviated through its action on TRPV1 and related molecular pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kaori Takahashi, Takashi Yoshida, Minoru Wakamori
Summary: Eugenol is a mode-selective antagonist of TRPV1 and can be evaluated as a lead compound for analgesics targeting TRPV1 without serious side effects. Different concentrations of eugenol have varying effects on TRPV1 activation, enhancing proton-induced currents at low concentrations and initially potentiating but then abolishing TRPV1 currents at high concentrations.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Yidan Zhang, Yuanzeng Wang, Wen Zhao, Luyao Li, Lei Li, Yanyan Sun, Jinping Shao, Xiuhua Ren, Weidong Zang, Jing Cao
Summary: This study reveals that the analgesic effect of EA is associated with the suppression of RIP3 and NLRP3 expression in the SDH, providing potential insights into the underlying spinal mechanisms involved in the analgesic effect of EA.
Article
Neurosciences
Chaofan Wan, Yunlong Xu, Baoyan Cen, Yucen Xia, Lin Yao, Yuanjia Zheng, Jiaying Zhao, Su He, Yongjun Chen
Summary: Electroacupuncture (EA) treatment can alleviate chronic inflammatory pain, with the involvement of NRG1-ErbB4 signaling pathway.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Immunology
Mansour Haddad, Mohammad Alsalem, Sara A. A. Aldossary, Heba Kalbouneh, Sahar M. M. Jaffal, Qusai Alshawabkeh, Sa'ed Al Hayek, Omar Abdelhai, Noor A. A. Barakat, Khalid El-Salem
Summary: This study investigated the role of different adenosine receptor subtypes in inflammatory pain. The results showed that specific adenosine receptor agonists could significantly reverse inflammatory pain. Calcium imaging studies in neurons also revealed that effective adenosine receptor ligands could inhibit specific receptor responses to painful stimuli.
INFLAMMOPHARMACOLOGY
(2023)
Article
Physiology
Yingjun Liu, Junying Du, Junfan Fang, Xuaner Xiang, Yingling Xu, Sisi Wang, Haiju Sun, Jianqiao Fang
Summary: The study demonstrated that 100Hz and 2Hz electroacupuncture stimulation can effectively reduce hyperalgesia in rats with inflammatory and neuropathic pain. This effect is partly achieved by inhibiting the co-expression and indirect interaction between peripheral TRPV1 and P2X3.
PHYSIOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Erh-Chuang Tu, Wei-Li Hsu, Jason T. C. Tzen
Summary: Theacrine and strictinin from Yunnan Kucha tea were found to be the major ingredients responsible for the anti-influenza activity. Strictinin was able to completely eliminate mouse hepatitis virus (MHV) infection, while theacrine had no such effect. In addition, strictinin and remdesivir showed potential for inhibiting MHV infection through multiple mechanisms.
Article
Biochemistry & Molecular Biology
Cian-Fen Jhuo, Sheng-Kuo Hsieh, Wen-Ying Chen, Jason T. C. Tzen
Summary: This study evaluated the therapeutic effects of Teaghrelin, a natural compound from oolong tea, on muscle atrophy caused by dexamethasone. The results showed that Teaghrelin can reduce the reduction in muscle mass and alleviate muscle protein degradation. In addition, Teaghrelin inhibited the signaling pathway for protein degradation by activating Akt phosphorylation. Rating: 9/10
Article
Plant Sciences
Yu-Hung Lai, Wei-Lun Liu, Tsung-Ying Lee, Chung-Wen Kuo, Yu-Ru Liu, Chi-Yuan Huang, Yung-Hsiang Chen, I-Ling Chen, Szu-Hui Wu, Shu-Chi Wang, Po-Yen Lee, Ching-Chih Liu, Jung Lo, Yo-Chen Chang, Hsuan-Fu Kuo, Chong-Chao Hsieh, Chia-Yang Li, Po-Len Liu
Summary: This study aimed to investigate the treatment of retinoblastoma caused by early embryonic development. The results showed that Magnolol could inhibit the development of retinoblastoma by regulating EMT, suppressing tumor growth and metastasis.
Article
Biology
I. -Fan Liu, Tzu-Chieh Lin, Shu-Chi Wang, Chia-Hung Yen, Chia-Yang Li, Hsuan-Fu Kuo, Chong-Chao Hsieh, Chia-Yuan Chang, Chuang-Rung Chang, Yung-Hsiang Chen, Yu-Ru Liu, Tsung-Ying Lee, Chi-Yuan Huang, Chih-Hsin Hsu, Shing-Jong Lin, Po-Len Liu
Summary: Long-term consumption of excessive fat and sucrose diet can lead to metabolic syndrome and cardiovascular disease. The study found that CAV-1 and caveolae proteins are related to abnormal lipid accumulation in the endothelium and myocardium, as well as dysfunction in microvascular endothelial cells and mitochondrial remodeling.
Review
Biochemistry & Molecular Biology
Jason T. C. Tzen
Summary: Strictinin is a major constituent in the Pu'er tea plant and possesses various functional activities such as antiviral, antibacterial, anti-obesity, anticaries, and anticancer effects. It has been used as an active ingredient in food, cosmetics, and beverages, and has also been combined with other teas to develop new types of tea. Future research is anticipated to discover more functional activities and practical applications of strictinin.
Article
Oncology
Daniel Winardi, Chieh-Hsin Wu, Jen-Huai Chiang, Yung-Hsiang Chen, Ching-Liang Hsieh, Juan-Cheng Yang, Yang-Chang Wu
Summary: In this retrospective cohort study, the influence of San-Huang-Xie-Xin-Tang (SHXXT) and its constituents on the mortality rate of breast cancer patients was explored. The study confirmed that SHXXT and its constituents are a useful alternative therapy in decreasing breast cancer mortality rate. The anti-tumor effect is more pronounced with increasing cumulative days of use and annual average dose.
Article
Agronomy
Tzu-Chiao Liao, Chung-Tse Chen, Mao-Chang Wang, Shang-Ling Ou, Jason T. C. Tzen, Chin-Ying Yang
Summary: The expression levels of CsARAD1 and CsARAD2 are higher in nonlignified tissues and are influenced by environmental factors. CsARAD1 and CsARAD2 exhibit different regulation patterns under temperature stress, saline, and drought-like conditions. These findings provide a basis for further research and breeding applications.
Article
Medicine, General & Internal
Jia-Jyun Jhang, Szu-Ju Chen, Chi-Ping Huang, Huey-Yi Chen, Wei-Ching Lin, Yung-Hsiang Chen, Wen-Chi Chen
Summary: This case report presents a 28-year-old male patient with spontaneous intratesticular hematoma. Initial suspicion of testicular malignancy was ruled out and a hematoma was diagnosed, possibly related to long-term use of sulfasalazine.
Review
Biochemistry & Molecular Biology
Chien-Zhi Lai, Szu-Ju Chen, Chi-Ping Huang, Huey-Yi Chen, Ming-Yen Tsai, Po-Len Liu, Yung-Hsiang Chen, Wen-Chi Chen
Summary: Varicocele is a common urological disorder with a prevalence rate of 8% to 15% in healthy men. However, the incidence is higher in male patients with infertility, with up to 35% to 80% of cases occurring in this population. Clinical manifestations of varicocele include an asymptomatic mass, chronic scrotal pain, and infertility. Postoperative scrotal pain may persist due to varicocele recurrence, hydrocele, neuralgia, referred pain, ureteral lesions, or nutcracker syndrome. Clinicians should consider these conditions as potential causes and take measures to address them in order to optimize surgical outcomes.
Article
Health Care Sciences & Services
Yi-Huei Chang, Szu-Ying Pan, Chia-Yu Lin, Chi-Ping Huang, Chi-Jung Chung, Yung-Hsiang Chen, Wen-Chi Chen
Summary: Prostate abscess (PA) is a potentially life-threatening condition that requires prompt treatment. However, the declining incidence of PA in developing countries and high-risk patients can hinder early diagnosis. This study aimed to review the etiology, pathophysiology, diagnosis, and treatment options for PA, as well as analyze the characteristics and clinical course of patients. The findings can guide the development of a personalized treatment strategy for patients with PA.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Chemistry, Medicinal
Shen-Wei Hou, Szu-Ju Chen, Jing-Dung Shen, Huey-Yi Chen, Shih-Jing Wang, Chia-Han Wang, Kee-Ming Man, Po-Len Liu, Ming-Yen Tsai, Yung-Hsiang Chen, Wen-Chi Chen
Summary: This study aimed to explore the therapeutic effect of emodin, a Chinese herbal extract, in a rat model of hyperuricemia and gout. The results demonstrated that emodin reduced serum uric acid levels and achieved effective treatment of hyperuricemia and gout by increasing urinary excretion.
Article
Biology
Kuo-Ching Huang, Yu-Ting Chang, Rosita Pranata, Yung-Hsuan Cheng, Yu-Chi Chen, Ping-Chung Kuo, Yi-Hsuan Huang, Jason T. C. Tzen, Rong-Jane Chen
Summary: Strictinin, a natural polyphenol from Pu'er tea, has been found to alleviate the risk of gout caused by hyperuricemia. It reduces xanthine oxidase activity, uric acid production, and inflammation, and promotes healthy gut microbiota. Strictinin shows great potential as a functional ingredient for the prevention of hyperuricemia.
Article
Medicine, General & Internal
Szu-Ying Pan, Chien-Zhi Lai, Wen-Chi Chen, Yung-Hsiang Chen, Che-Hung Lin, Han Chang, Chi-Ping Huang, Ching-Chung Yeh
Summary: Chondrosarcoma of the upper urinary tract is a rare condition with clinical manifestations similar to other urinary tract diseases. Surgical removal of the tumor is the primary treatment, with radiation or chemotherapy used for advanced cases. However, due to limited patient numbers, there are no established guidelines for chemotherapy and the outcomes of treatment are unclear.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Szu-Ying Pan, Chi-Ping Huang, Wen-Chi Chen, Yung-Hsiang Chen, Eric Chieh-Lung Chou
Summary: Endoscopic combined intrarenal surgery (ECIRS) is a new operative technique that integrates the advantages of PCNL and RIRS for the treatment of staghorn stones. We performed RIRS followed by PCNL in a 72-year-old female patient, which provided a more convenient and effective approach with high stone reduction efficiency and no complications.
MEDICINA-LITHUANIA
(2023)
Meeting Abstract
Surgery
Yi-Wen Lin, Tien-Chou Soong, Zhi-Han Sun, Wei-Jei Lee, Chung-Yen Chen, Kong-Han Ser