Article
Medicine, General & Internal
Keiko Ogawa-Ochiai, Kazunori Ohama
Summary: The study retrospectively analyzed the efficacy of shokenchuto (SKT) in treating 110 patients with nocturnal enuresis (NE). It found that SKT was significantly effective in patients aged 10 years and older, suggesting it as a good alternative treatment when alarm or DDAVP therapies are ineffective. Prospectively evaluating SKT for NE treatment is recommended.
Article
Pharmacology & Pharmacy
Satoko Suzuki, Taku Obara, Tomofumi Ishikawa, Aoi Noda, Fumiko Matsuzaki, Ryutaro Arita, Minoru Ohsawa, Nariyasu Mano, Akiko Kikuchi, Shin Takayama, Tadashi Ishii
Summary: This study examined the association between the use of Kampo medicine containing rhubarb rhizome during the first trimester of pregnancy and the risk of congenital malformations in newborns. The results showed that there was no difference in the risk of congenital malformations between pregnant women prescribed KRR or MgO in the first trimester of pregnancy.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Chemistry, Medicinal
Alireza Heiran, Kamran Bagheri Lankarani, Ryan Bradley, Alireza Simab, Mehdi Pasalar
Summary: Herbal remedies showed better improvement in symptoms and quality of life for patients with functional dyspepsia (FD) compared to placebo, with no significant differences in adverse events. Further high-quality studies are needed to firmly establish the clinical efficacy of herbal remedies.
PHYTOTHERAPY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Hideaki Isago, Akihisa Mitani, Shiho Kohno, Saki Nagoshi, Taro Ishimori, Minako Saito, Hiroyuki Tamiya, Naoya Miyashita, Takashi Ishii, Hirotaka Matsuzaki, Yutaka Yatomi, Takahide Nagase, Taisuke Jo
Summary: The herbal medicine TJ-41 has been found to have anti-inflammatory effects in a mouse model of lung emphysema. It can mitigate acute inflammation and potentially serve as a new therapy for COPD patients.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Chisato Iba, Miyuki Unekawa, Yoshikane Izawa, Jin Nakahara, Tsubasa Takizawa
Summary: The study found that chronic treatment with Goreisan does not affect cortical spreading depolarization (CSD) susceptibility in migraines. This suggests that the drug treats headaches via mechanisms that do not involve CSD modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Daisuke Shigemi, Yohei Hashimoto, Nobuaki Michihata, Hideo Yasunaga
Summary: The study found that Japanese herbal Kampo medicines may improve the live birth rate in patients with recurrent pregnancy loss, with patients receiving Kampo medicines having a slightly higher live birth rate compared to those who did not.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Review
Integrative & Complementary Medicine
Ichiro Arai
Summary: Japanese Kampo medicine, rooted in ancient Chinese medicine, has undergone a shift towards evidence-based practice with the establishment of methodological foundations for clinical assessments and the increase in randomized controlled trials. Post-marketing clinical trials of Kampo products have also become necessary for ethical and scientific assurance in this field.
INTEGRATIVE MEDICINE RESEARCH
(2021)
Review
Neurosciences
Masataka Sunagawa, Yasunori Takayama, Mami Kato, Midori Tanaka, Seiya Fukuoka, Takayuki Okumo, Mana Tsukada, Kojiro Yamaguchi
Summary: Kampo medicine, a traditional medicine practiced in Japan, uses formulae composed of multiple crude drugs to treat various conditions. These formulae are often used in place of or in combination with Western medicines, with Yokukansan (YKS) emerging as a popular choice for pain treatment. The holistic healing properties of Kampo formulae are attributed to their combination of natural ingredients with pharmacological effects.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Blanca Ibanez, Ana Melero, Alegria Montoro, Juan F. Merino-Torres, Jose M. Soriano, Nadia San Onofre
Summary: In recent years, there has been increasing interest in finding natural radioprotectors to mitigate the harmful effects of radiation. This review examines herbal preparations from Ayurvedic, Traditional Chinese, and Kampo Medicines that have demonstrated potential radioprotective effects. Ten herbal preparations, including Abana, Amalakyadi Churna, Amritaprasham, Brahma, Bu-zhong-yi-qi-tang (BZYQT), Chyavanaprasha, Cystone, Geriforte, Mentat, and Triphala, are highlighted for their potential radioprotective properties. Exploring the ethnobotany of traditional Asian medicine may lead to the discovery of new active compounds with radioprotective properties.
Article
Plant Sciences
Kenny Kuchta, Silke Cameron, Minwon Lee, Shao-Qing Cai, Yukihiro Shoyama
Summary: While Western research focuses on COVID-19 vaccination, East Asia explores traditional herbal prescriptions for SARS-CoV2 therapy. Japan uses Maoto, Thailand approves Andrographis paniculata, and China incorporates TCM medications with antiviral, immunmodulatory, and anti-inflammatory effects in their official treatment guidelines. The efficacy and mechanisms of these East Asian herbal remedies for COVID-19 are discussed in relation to viral entry and replication.
PHYTOCHEMISTRY REVIEWS
(2022)
Article
Plant Sciences
Mana Tsukada, Hideshi Ikemoto, Xiao-Pen Lee, Takashi Takaki, Naoko Tsuchiya, Keita Mizuno, Tatsuki Inoue, Yoshiki Tsunokawa, Takayuki Okumo, Takaaki Matsuyama, Masataka Sunagawa
Summary: The study found that KKT can alleviate stress response in rats with acute stress model, and the increased secretion of oxytocin may be one of the mechanisms underlying this phenomenon.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shin Takayama, Takao Namiki, Ryutaro Arita, Rie Ono, Akiko Kikuchi, Minoru Ohsawa, Natsumi Saito, Satoko Suzuki, Hajime Nakae, Seiichi Kobayashi, Tetsuhiro Yoshino, Tomoaki Ishigami, Koichiro Tanaka, Kotaro Nochioka, Airi Takagi, Masaru Mimura, Takuhiro Yamaguchi, Tadashi Ishii, Akito Hisanaga, Kazuo Mitani, Takashi Ito
Summary: A randomized trial involving 161 patients with mild and moderate COVID-19 showed that the traditional Japanese medicine of kakkonto with shosaikotokakikyosekko can effectively relieve fever and suppress disease progression, with faster symptom relief and lower risk of disease progression compared to conventional treatment, while showing no significant drug-related side effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Hiroki Teragawa, Chikage Oshita, Yuko Uchimura
Summary: Patients with symptoms of ischemic heart disease but without obstructed coronary arteries (INOCA) are increasingly recognized. The gold standard for diagnosing INOCA is coronary angiography with spasm provocation test and pressure wires for evaluating microvascular function. However, there is currently no well-established treatment for INOCA, especially for microvascular spasm or dysfunction. Japanese herbal medicine (Kampo) has shown promise in treating INOCA and this review focuses on its effects and potential mechanisms for this condition.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Obstetrics & Gynecology
Nobuaki Michihata, Daisuke Shigemi, Hayato Yamana, Hiroki Matsui, Taisuke Jo, Hideo Yasunaga
Summary: The study found that using herbal Kampo medicines to treat depression during pregnancy did not increase the incidence of congenital anomalies, low birth weight, or preterm birth.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Multidisciplinary Sciences
Junko Kohno, Tsuyoshi Kawamura, Akiko Kikuchi, Tetsuya Akaishi, Shin Takayama, Tadashi Ishii
Summary: Traditional Japanese (Kampo) medicines, particularly hochuekkito, may facilitate VRE (vancomycin-resistant enterococci) conversion in patients, reducing mortality. Probiotics usage and higher serum albumin levels are also associated with VRE conversion.
SCIENTIFIC REPORTS
(2021)