Article
Plant Sciences
Hee Jin Kim, Min Yeong Lee, Gyu Ri Kim, Hyun Jun Lee, Leandro Val Sayson, Darlene Mae D. Ortiz, Jae Hoon Cheong, Mikyung Kim
Summary: This study investigated the effects and mechanisms of Korean Red Ginseng (KRG) in alcohol-induced responses. The results showed that KRG can alleviate alcohol-induced spatial working memory impairments and addictive responses through anti-neuroinflammatory activity rather than through the PKA-CREB signaling pathway.
JOURNAL OF GINSENG RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Kyoung Ah Kang, Mei Jing Piao, Pincha Devage Sameera Madushan Fernando, Herath Mudiyanselage Udari Lakmini Herath, Joo Mi Yi, Jin Won Hyun
Summary: This study investigates whether Korean red ginseng (KRG) can inhibit PM2.5-induced senescence in skin keratinocytes. The results show that KRG can suppress PM2.5-induced cellular senescence and protect skin keratinocytes by epigenetic regulation of the p16(INK4A) gene.
Article
Plant Sciences
Young Kyun Kim, Keun-Sang Yum
Summary: This study explores the effects of red ginseng extract on the gut microbiome. The results indicate that ingestion of red ginseng extract can increase gut microbiome richness and significantly impact the abundance of certain strains in the gut microbiome.
JOURNAL OF GINSENG RESEARCH
(2022)
Article
Plant Sciences
Siming Wang, Yuchu Zhao, Junjie Yang, Shichao Liu, Weifeng Ni, Xueyuan Bai, Ze Yang, Daqing Zhao, Meichen Liu
Summary: This study aimed to investigate the protective effect of GPS on oxidatively damaged RBCs and explore the molecular mechanisms from the perspective of glycolysis and gluconeogenesis pathways. The results showed that GPS effectively protected RBCs from oxidative stress damage, promoted glycolysis, and regulated antioxidant defense system and energy metabolism. GPS achieved these effects by activating the PGC-1 alpha pathway and inhibiting gluconeogenesis.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Ho Jun Kang, Nicholas Chargo, Soumya Chennupati, Kerri Neugebauer, Jae Youl Cho, Robert Quinn, Laura R. McCabe, Narayanan Parameswaran
Summary: This study aimed to test the effect of Korean Red Ginseng extract on bone and gut health using an antibiotics-induced dysbiosis-induced bone loss model in mice. The results showed that the extract can prevent antibiotics-induced bone loss and restore the diversity of gut microbiota and intestinal permeability.
JOURNAL OF GINSENG RESEARCH
(2023)
Article
Plant Sciences
H. M. Arif Ullah, Evelyn Saba, Yuan Yee Lee, Seung-Bok Hong, Sun-Hee Hyun, Yi-Seong Kwak, Chae-Kyu Park, Sung Dae Kim, Man Hee Rhee
Summary: This study investigated the effects of Rg3-RGE and PT on a mouse model of UC and found that the combination treatment significantly improved colon length, body weight, and disease activity index, reduced histological injury, decreased levels of nitric oxide, inflammatory mediators, and cytokines. Also, the combination treatment suppressed NLRP3 inflammasome and NF-κB activity, and increased the number of immune cell subtypes.
JOURNAL OF GINSENG RESEARCH
(2022)
Article
Plant Sciences
Huijeong Ahn, Byung-Cheol Han, Eui-Ju Hong, Beum-Soo An, Eunsong Lee, Seung-Ho Lee, Geun-Shik Lee
Summary: The study found that RGE and its saponins can inhibit the secretion of IL-1 beta in response to UV exposure in skin keratinocytes and macrophages, with RGE primarily interrupting the priming step in keratinocytes.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Plant Sciences
Muhammad Irfan, Yuan Yee Lee, Ki-Ja Lee, Sung Dae Kim, Man Hee Rhee
Summary: This study investigated the antiplatelet effects of red ginseng extract (RGE) and fermented red ginseng extract (FRG) and found that both extracts can inhibit platelet aggregation and calcium mobilization, indicating their potential for maintaining cardiovascular health and preventing platelet-related cardiovascular disorders.
JOURNAL OF GINSENG RESEARCH
(2022)
Article
Nutrition & Dietetics
Ji-Eun Shin, So-Hyun Jeon, Sang-Jun Lee, Se-Young Choung
Summary: Sarcopenic obesity, a combined state of sarcopenia and obesity, is a serious health problem related to metabolic diseases. A study found that Panax ginseng berry extract (GBE) can attenuate both obesity and sarcopenia by activating the PI3K/Akt pathway, which regulates muscle synthesis and degradation.
Article
Food Science & Technology
Iftikhar Younis Mallhi, Muhammad Sohaib, Azmat Ullah Khan, Imtiaz Rabbani
Summary: This study investigated the potential of strawberry extracts to lower blood sugar, improve antioxidant levels and reduce blood lipid levels in diabetic rats. The results showed that treatment with strawberry extract at doses of 250, 500, and 750 mg/kg body weight significantly reduced blood glucose levels, improved renal function and lipid profile, and increased body weight and insulin activity.
Article
Endocrinology & Metabolism
Jung Hoon Park, Yeonggwang Hwang, Yen Nhi Doan Nguyen, Hyoung-Chun Kim, Eun-Joo Shin
Summary: The neuroprotective effects of ramelteon, a selective agonist of melatonin receptors, were investigated in a mouse model of KA-induced neurotoxicity. Ramelteon attenuated oxidative stress, restored glutathione homeostasis, and inhibited neuroinflammatory changes in the hippocampus after KA treatment. The activation of melatonin receptors by ramelteon provided neuroprotection by activating Nrf2 signaling and inhibiting NF kappa B signaling.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Plant Sciences
Do-Yeon Cho, Daniel Skinner, Shaoyan Zhang, Ahmed Lazrak, Dong Jin Lim, Christopher G. Weeks, Catherine G. Banks, Chang Kyun Han, Si-Kwan Kim, Guillermo J. Tearney, Sadis Matalon, Steven M. Rowe, Bradford A. Woodworth
Summary: The study revealed that red ginseng aqueous extract can enhance airway surface liquid depth and ciliary beat frequency by promoting chloride secretion in nasal epithelium, indicating its therapeutic potential in both CF and non-CF chronic rhinosinusitis.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Plant Sciences
Seoung-Woo Lee, Su-Min Baek, Young-Jin Lee, Tae-Un Kim, Jae-Hyuk Yim, Jun-Hyeok Son, Hee-Yeon Kim, Kyung-Ku Kang, Jong Hun Kim, Man Hee Rhee, Sang-Joon Park, Seong-Kyoon Choi, Jin-Kyu Park
Summary: This study explored the therapeutic effects of Rg3-enriched red ginseng extract (Rg3-RGE) on the progression of NAFLD and found that Rg3-RGE treatment can ameliorate NAFLD progression by inhibiting chemotaxis activities in liver sinusoidal endothelial cells (LSECs).
JOURNAL OF GINSENG RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Mun-Ock Kim, Jae-Won Lee, Jae Kyoung Lee, Yu Na Song, Eun Sol Oh, Hyunju Ro, Dahye Yoon, Yun-Hwa Jeong, Ji-Yoon Park, Sung-Tae Hong, Hyung Won Ryu, Su Ui Lee, Dae Young Lee
Summary: Korean black ginseng extract inhibits airway inflammation and mucus secretion by decreasing the activation of TAK1, suggesting it could be a potential adjuvant in the treatment of airway inflammatory diseases caused by cigarette smoke.
Article
Chemistry, Medicinal
Xing Xing Zheng, Ying Chun Li, Kai Lin Yang, Zhou Xiao He, Zhao Liang Wang, Xing Wang, Hui Ling Jing, Yan Jun Cao
Summary: Icariin demonstrated protective effects against Glu-induced excitatory neurotoxicity, enhancing cell viability and reducing apoptosis, oxidative stress, and other negative impacts. These findings suggest that Icariin could be a potential therapeutic candidate for neurological disorders associated with glutamate toxicity.
PHYTOTHERAPY RESEARCH
(2021)