Review
Gastroenterology & Hepatology
Alessandra Mangia, Rosa Cotugno, Giovanna Cocomazzi, Maria Maddalena Squillante, Valeria Piazzolla
Summary: The World Health Organization's goal of eliminating Hepatitis C virus (HCV) by 2030 using direct-acting antiviral treatments has become less attainable post the 2020 pandemic of coronavirus disease 2019. Therefore, a more realistic approach of micro-elimination in population segments where targeted strategies of prevention and treatment are easily attained has been promoted in Europe. Active involvement of stakeholders and community participation are essential components for the success of a micro-elimination project tailored at the geographical level according to HCV epidemiology and individual country's income.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Penglei Jiang, Hongyu Jia, Xinyue Qian, Tian Tang, Yingli Han, Zhaoru Zhang, Lingli Jiang, Zebin Yu, Lin Zheng, Guodong Yu, Huan Cai, Shanyan Zhang, Xiaoli Zhang, Jueqing Gu, Chanyuan Ye, Lisha Yang, Yingfeng Lu, Heng Liu, Xiaoqing Lu, Ciliang Jin, Yue Ren, Miaomiao Lu, Lingling Xu, Jiong Yu, Xi Jin, Yida Yang, Pengxu Qian
Summary: This study used single-cell RNA sequencing to investigate the transcriptomic landscape of peripheral immune cells in CHB patients before and after PegIFN-alpha therapy. The study identified specific cell subsets associated with CHB and found that PegIFN-alpha treatment could decrease hyperactivated monocytes, increase long-lived naive/memory T cells, and enhance effector T cell cytotoxicity. Furthermore, the treatment altered the transcriptional profiles of immune cells and enhanced innate antiviral response.
Article
Virology
Maria C. Lopez-Osorio, Jose Aldemar Usme-Ciro, Jose William Martinez, Dioselina Pelaez-Carvajal, Javier Hernandez, Sergio Hoyos, Juan Carlos Restrepo, Maria-Cristina Navas
Summary: This study investigated the HCV genotypes and resistance-associated substitutions in individuals with a history of transfusion events before 1996 in Colombia. Different genotypes and subgenotypes were identified, along with several resistance-associated substitutions. This research provides valuable information on the diversity of HCV in Colombia and highlights the importance of monitoring resistance mutations.
Article
Gastroenterology & Hepatology
Sarah Blach, Marianne Blome, Ann-Sofi Duberg, Anna Jerkeman, Martin Kaberg, Per-Erik Klasa, Martin Lagging, Devin Razavi-Shearer, Homie Razavi, Soo Aleman
Summary: This analysis evaluates Sweden's progress towards the World Health Organization (WHO) elimination targets for hepatitis C virus (HCV), highlighting the need for expanding harm reduction programs to achieve greater success in reaching the targets.
LIVER INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Heiner Wedemeyer, Soo Aleman, Maurizia Rossana Brunetto, Antje Blank, Pietro Andreone, Pavel Bogomolov, Vladimir Chulanov, Nina Mamonova, Natalia Geyvandova, Viacheslav Morozov, Olga Sagalova, Tatyana Stepanova, Annemarie Berger, Dmitry Manuilov, Vithika Suri, Qi An, Ben Da, John Flaherty, Anu Osinusi, Yang Liu, Uta Merle, Julian Schulze zur Wiesch, Stefan Zeuzem, Sandra Ciesek, Markus Cornberg, Pietro Lampertico
Summary: Bulevirtide treatment reduces HDV RNA and ALT levels in patients with chronic hepatitis D, with a dose-dependent effect.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Heiner Wedemeyer, Soo Aleman, Maurizia Rossana Brunetto, Antje Blank, Pietro Andreone, Pavel Bogomolov, Vladimir Chulanov, Nina Mamonova, Natalia Geyvandova, Viacheslav Morozov, Olga Sagalova, Tatyana Stepanova, Annemarie Berger, Dmitry Manuilov, Vithika Suri, Qi An, Ben Da, John Flaherty, Anu Osinusi, Yang Liu, Uta Merle, Julian Schulzezur Wiesch, Stefan Zeuzem, Sandra Ciesek, Markus Cornberg, Pietro Lampertico
Summary: In this study, it was found that bulevirtide is effective in inhibiting the entry of hepatitis D virus and reducing the progression of liver disease in patients with chronic hepatitis B. The recommended dosage of bulevirtide is 2 mg or 10 mg per day.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Bacary Djilocalisse Sadio, Martin Faye, Marco Kaiser, Maryam Diarra, Fanny Balique, Cheikh Tidiane Diagne, Oumar Faye, Moussa Moise Diagne, Gamou Fall, Oumar Ndiaye, Cheikh Loucoubar, Abdourahmane Sow, Ousmane Faye, Adama Faye, Cheikh Saad Bouh Boye, Amadou Alpha Sall
Summary: The rapid proliferation of traditional gold mining sites in the Kedougou region has led to a Hepatitis E virus outbreak. The study found a high rate of HEV infection among suspected cases, with a case fatality rate in pregnant women. Further research is needed to identify the virus reservoir and environmental risk factors.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Joelma Goetz de Gois, Sthefanny Josephine Klein Ottoni Guedes, Ana Paula Vieira, Franciele Ani Caovilla Follador, Luis Fernando Dip, Leia Carolina Lucio, Kerley Braga Pereira Bento Casaril, Paulo Cezar Nunes Fortes, Valdir Spada Junior, Guilherme Welter Wendt, Lirane Elize Defante Ferreto
Summary: HBV infection among inmates in prisons is a serious public health challenge. This study found a high prevalence of HBV exposure among inmates in high security prisons in Brazil. Risk factors included prison location, age, tattoo procedures in prison, sexual activities with drug users, and previous history of hepatitis B or C infection. Public policies targeting both incarcerated individuals and the general population are necessary to reduce the prevalence of HBV and its associated consequences.
Article
Oncology
Shih-Han Hung, Tzong-Hann Yang, Yen-Fu Cheng, Chin-Shyan Chen, Herng-Ching Lin
Summary: This case-control study investigates the associations between head and neck cancer (HNC), hepatitis B virus (HBV), and hepatitis C virus (HCV) infection, and suggests a potential association between HBV and HCV infections and the risk of HNC.
Review
Gastroenterology & Hepatology
Chun-Jen Liu, Pei-Jer Chen
Summary: Transmission of HBV and HCV is similar, leading to dual HBV/HCV infection in populations at risk. With universal childhood HBV vaccination and public education programs, the epidemiology of HBV and HCV infections is changing. Introduction of anti-HBV agents and direct acting antivirals for HCV will further impact the prevalence of dual HBV/HCV infection worldwide.
LIVER INTERNATIONAL
(2022)
Article
Virology
Aron Balazs Ulbert, Matyas Bhurka, Anett Magyari, Zita Turi, Edit Hajdu, Katalin Burian, Gabriella Terhes
Summary: In this study, the epidemiological features of HEV infections among patients in various departments of a university hospital in Hungary were determined. The study found a high seroprevalence of HEV IgG antibodies in adult and elderly patients.
JOURNAL OF CLINICAL VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Alexander Nersesov, Arnur Gusmanov, Byron Crape, Gulnara Junusbekova, Salim Berkinbayev, Almagul Jumabayeva, Jamilya Kaibullayeva, Saltanat Madenova, Mariya Novitskaya, Margarita Nazarova, Abduzhappar Gaipov, Aiymkul Ashimkhanova, Kainar Kadyrzhanuly, Kuralay Atageldiyeva, Sandro Vento, Alpamys Issanov
Summary: High-intermediate endemicity for HBsAg and high endemicity for anti-HCV antibodies were found in three large regions of Kazakhstan. Blood transfusion was associated with anti-HCV seropositivity, but further epidemiological studies are needed to assess the effectiveness of preventive measures in healthcare settings.
Article
Multidisciplinary Sciences
Heba Issa Odeh, Sara Rashid Al-badi, Basma Karima, Takrim Abdulwali Saeed, Nazeerullah Rahamathullah, Eman Hassan Ibrahim, May Khalil Ismail, Zahra Arshad Khan
Summary: This study explored the prevalence of low and high-risk HPV genotypes in PAP smear samples of women in the northern region of the UAE. The most common genotypes were 6, 45, 16, 11, 67, and 62/81, while HPV18 had a lower prevalence. This finding highlights the importance of molecular genotyping in cervical screening.
Article
Multidisciplinary Sciences
Bayan Othman, Muna Barakat, Amin Omar, Amani Al-Rawashdeh, Yazan Qashou, Rafat Zrieq, Mohammad A. A. Al-Najjar
Summary: This study assessed the knowledge, practices, and beliefs regarding hepatitis B virus infection among the Jordanian population. The findings revealed a lack of knowledge and low vaccination rates among the participants.
Article
Medicine, General & Internal
Ilona Argirion, Parag Mahale, Ruth M. Pfeiffer, Ping Liu, Adaora A. Adimora, Matthew J. Akiyama, Hector H. Bolivar, Audrey French, Michael Plankey, Jennifer C. Price, Aadia Rana, Anandi Sheth, Jill Koshiol, Eric C. Seaberg, Mark H. Kuniholm, Jeffrey Glenn, Thomas R. O'Brien
Summary: HBV infection is more common among HIV-infected women, while HDV infection primarily occurs with participants enrolled during 2013-2015 and HBV carriers. Among HBsAg-positive women, HDV infection is associated with the presence of advanced fibrosis/cirrhosis. These results highlight the importance of HDV testing in HBV-infected US women.
FRONTIERS IN MEDICINE
(2023)
