Article
Oncology
Thomas van Doeveren, Jose A. Nakauma-Gonzalez, Andrew S. Mason, Geert J. L. H. van Leenders, Tahlita C. M. Zuiverloon, Ellen C. Zwarthoff, Isabelle C. Meijssen, Angelique C. van der Made, Antoine G. van Der Heijden, Kees Hendricksen, Bas W. G. van Rhijn, Charlotte S. Voskuilen, Job van Riet, Winand N. M. Dinjens, Hendrikus J. Dubbink, Harmen J. G. van de Werken, Joost L. Boormans
Summary: By sequencing genes in 15 UTUC patients treated by RNU, it was found that the majority of patients had a clonal relationship between UTUC and subsequent UCB, supporting the idea that UCBs following UTUC surgery are primarily clonally derived recurrences.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Jang Hee Han, Seung-hwan Jeong, Si Hyun Kim, Hyeong Dong Yuk, Chang Wook Jeong, Cheol Kwak, Ja Hyeon Ku
Summary: This study aimed to investigate the use of tubular damage biomarker as prognostic markers for upper tract urothelial cancer (UTUC). The results showed that increased levels of urine B2-MG were associated with disease recurrence and metastasis in UTUC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Guoyao Zhang, Wanping Shi, Enzhao Jia, Lei Zhang, Yongsheng Han, Ronald Rodriguez, Tianjiang Ma
Summary: The study validated a correlation between low FOXO3A expression and advanced stage, lymph node metastasis, lymphovascular invasion, and shorter survival time in UTUC patients. Multivariate analysis indicated that FOXO3A was a significant predictor for overall survival and recurrence-free survival in UTUC patients. The results suggest that FOXO3A may be involved in UTUC recurrence and have clinical value in therapeutic targeting and prognostic evaluation.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Zheng Wang, Haoqing Shi, Yifan Xu, Yu Fang, Jiaao Song, Wentao Jiang, Demeng Xia, Zhenjie Wu, Linhui Wang
Summary: This comprehensive review focuses on the current status and future prospects of intravesical therapy for upper urinary tract urothelial carcinoma (UTUC). It emphasizes the importance of personalized strategies in optimizing treatment outcomes and reducing intravesical recurrence risk. By summarizing historical development, clinical trials, and clinical applications, this review provides valuable insights and aims to guide future research in UTUC.
Article
Oncology
Haidar Abdul-Muhsin, Noel De Lucia, Vijay Singh, Kassem Faraj, Kyle Rose, Stephen Cha, Nan Zhang, Nathanael Judge, Anojan Navaratnam, Mark Tyson, Thai Ho, Kenneth Jacobsohn, Erik Castle
Summary: This study aimed to predict survival outcomes for upper tract urothelial carcinoma patients following radical nephroureterectomy using simple patient data. The model showed high accuracy in predicting overall survival, cancer specific survival, and metastasis specific survival, with validation accuracy ranging from 71.4% to 78.4%.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Oncology
Kosuke Miyai, Kazuki Kawamura, Keiichi Ito, Susumu Matsukuma, Hitoshi Tsuda
Summary: The study revealed that high stromal periostin expression in invasive UTUCs is associated with adverse clinicopathological factors and may be a useful predictor for patient outcomes.
Article
Biochemistry & Molecular Biology
Alessandra Cinque, Anna Capasso, Riccardo Vago, Matteo Floris, Michael W. Lee, Roberto Minnei, Francesco Trevisani
Summary: Upper urinary tract urothelial carcinoma (UTUC) is a rare but aggressive malignancy occurring in the renal pelvis or ureter. UTUC is often diagnosed at an advanced stage due to non-specific symptoms and the lack of early biomarkers. However, microRNAs (miRNAs) show promise as novel biomarkers for optimizing the diagnosis and prognosis of UTUC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
David D'Andrea, Surena Matin, Peter C. Black, Firas G. Petros, Homayoun Zargar, Colin P. Dinney, Michael S. Cookson, Wassim Kassouf, Marc A. Dall'Era, John S. McGrath, Jonathan L. Wright, Andrew C. Thorpe, Todd M. Morgan, Jeffrey M. Holzbeierlein, Trinity J. Bivalacqua, Srikala S. Sridhar, Scott North, Daniel A. Barocas, Yair Lotan, Andrew J. Stephenson, Bas W. van Rhijn, Philippe E. Spiess, Siamak Daneshmand, Shahrokh F. Shariat
Summary: The study found that patients with UTUC had a lower rate of pathological complete response but a higher rate of pathological objective response after NAC treatment. Cox regression analysis revealed that UTUC patients had better overall survival and cancer-specific survival outcomes.
Review
Oncology
Lukasz Bialek, Konrad Bilski, Jakub Dobruch, Wojciech Krajewski, Tomasz Szydelko, Piotr Kryst, Slawomir Poletajew
Summary: This study aimed to evaluate the effectiveness of non-invasive tests in the diagnosis of upper urinary tract urothelial carcinoma (UTUC). Among the 10,084 screened publications, 25 were included in the analysis. Most of the studies had small sample sizes and heterogeneous control groups. Voided urinary cytology was the most commonly used test, with low sensitivity and good specificity. Fluorescence in situ hybridization in diagnostic cytology showed higher sensitivity and similarly good specificity. Other urine or blood tests had limited research and varied results. Currently, there is a lack of high-quality data confirming the effectiveness of non-invasive tests in the diagnosis of UTUC.
Article
Oncology
Hui-Ying Liu, Yen Ta Chen, Shun-Chen Huang, Hung-Jen Wang, Yuan-Tso Cheng, Chih Hsiung Kang, Wei Ching Lee, Yu-Li Su, Chun-Chieh Huang, Yin-Lun Chang, Yao-Chi Chuang, Hao Lun Luo, Po Hui Chiang
Summary: This study assessed the association of tumor architecture with cancer recurrence, metastasis, and cancer-specific survival in UTUC patients treated with RNU. Results showed a significant association between tumor architecture and various disease features and prognosis factors. Papillary and sessile tumor architecture were independent predictors of metastatic disease and CSS.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Fangzheng Zhao, Nienie Qi, Chu Zhang, Ning Xue, Shuaishuai Li, Raorao Zhou, Zeyu Chen, Ruiqin Yao, Haitao Zhu
Summary: For patients with UTUC, the surgical wait time should be limited to less than 3 months. For UTUC patients with hydronephrosis, the OS and CSS of patients with surgical wait time of more than 60 days were relatively shorter than those of patients with surgical wait time of less than 60 days.
FRONTIERS IN ONCOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Jing-Rong Jhuang, Po-Chun Chiu, Tung-Che Hsieh, Chung-Hsin Chen, Yeong-Shiau Pu, Wen-Chung Lee
Summary: This study investigated the latency period between AA exposure and UTUC development and found that the risk of UTUC decreased after the ban on AA in Taiwan. The latency periods of UTUC varied with age, the dose of AA exposure, and sex, with 9 years for middle-aged women and 8 years for middle-aged men with moderate AA exposure.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Wojciech Polom, Wojciech Cytawa, Anna Polom, Mikolaj Frankiewicz, Edyta Szurowska, Piotr Lass, Marcin Matuszewski
Summary: The study evaluated the possibility of detecting sentinel lymph nodes in patients with suspicion of upper tract urothelial carcinoma using a radioisotope-based technique. Results showed that detecting SLNs in the upper urinary tract is possible yet challenging, with only 2 out of 19 cases detecting SLNs. Most cases did not show lymphatic outflow.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Jang Hee Han, Seung-hwan Jeong, Hyeong Dong Yuk, Chang Wook Jeong, Cheol Kwak, Ja Hyeon Ku
Summary: Acidic urine is independently associated with reduced disease-free survival and overall survival in upper tract urothelial cancer. It may promote the acquisition of aggressive behavior in advanced tumors within an acidic environment.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Xiao Zhou, Guangcheng Luo
Summary: This study conducted a meta-analysis and found that adjuvant radiotherapy had no significant effect on the prognosis of patients with upper tract urothelial carcinoma (UTUC), while radiotherapy alone had adverse effects on UTUC patients.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Urology & Nephrology
Ryutaro Ishitsuka, Jun Miyazaki, Daishi Ichioka, Takamitsu Inoue, Susumu Kageyama, Mikio Sugimoto, Koji Mitsuzuka, Yoshiyuki Matsui, Yusuke Shiraishi, Hidefumi Kinoshita, Hironobu Wakeda, Takeshi Nomoto, Eiji Kikuchi, Koji Kawai, Hiroyuki Nishiyama
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2017)
Article
Urology & Nephrology
Hiroshi Hongo, Eiji Kikuchi, Kazuhiro Matsumoto, Satoshi Yazawa, Kent Kanao, Takeo Kosaka, Ryuichi Mizuno, Akira Miyajima, Shiro Saito, Mototsugu Oya
INTERNATIONAL JOURNAL OF UROLOGY
(2017)
Article
Urology & Nephrology
Keisuke Shigeta, Eiji Kikuchi, Masayuki Hagiwara, Toshiyuki Ando, Ryuichi Mizuno, Takayuki Abe, Shuji Mikami, Akira Miyajima, Ken Nakagawa, Mototsugu Oya
JOURNAL OF UROLOGY
(2017)
Article
Urology & Nephrology
Kazuhiro Matsumoto, Akari Komatsuda, Yoshinori Yanai, Naoya Niwa, Takeo Kosaka, Ryuichi Mizuno, Eiji Kikuchi, Akira Miyajima, Mototsugu Oya
JOURNAL OF UROLOGY
(2017)
Article
Urology & Nephrology
Laura-Maria Krabbe, Okyaz Eminaga, Shahrokh F. Shariat, Ryan C. Hutchinson, Yair Lotan, Arthur I. Sagalowsky, Jay D. Raman, Christopher G. Wood, Alon Z. Weizer, Marco Roscigno, Francesco Montorsi, Christian Bolenz, Giacomo Novara, Eiji Kikuchi, Harun Fajkovic, Leonid M. Rapoport, Peter V. Glybochko, Richard Zigeuner, Mesut Remzi, Karim Bensalah, Wassim Kassouf, Vitaly Margulis
JOURNAL OF UROLOGY
(2017)
Article
Oncology
Ryuichi Mizuno, Akira Miyajima, Taizo Hibi, Aya Masuda, Toshiaki Shinojima, Eiji Kikuchi, Masahiro Jinzaki, Mototsugu Oya
Article
Oncology
Keisuke Shigeta, Eiji Kikuchi, Masayuki Hagiwara, Toshiyuki Ando, Ryuichi Mizuno, Akira Miyajima, Ken Nakagawa, Mototsugu Oya
SURGICAL ONCOLOGY-OXFORD
(2017)
Article
Oncology
Kazuhiro Matsumoto, Eiji Kikuchi, Yoshinori Yanai, Nozomi Hayakawa, Yujiro Ito, Takahiro Maeda, Hirohiko Nagata, Akira Miyajima, Mototsugu Oya
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2017)
Article
Oncology
Tatsuaki Daimon, Takeo Kosaka, Eiji Kikuchi, Shuji Mikami, Yasumasa Miyazaki, Ari Hashimoto, Shigeru Hashimoto, Ryuichi Mizuno, Akira Miyajima, Yasunori Okada, Hisataka Sabe, Mototsugu Oya
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2017)
Article
Urology & Nephrology
Naoya Niwa, Kazuhiro Matsumoto, Makoto Miyahara, Minami Omura, Hiroaki Kobayashi, Eiji Kikuchi, Akira Miyajima, Kazutoyo Miyata, Mototsugu Oya
WORLD JOURNAL OF UROLOGY
(2017)
Article
Oncology
Koichiro Ogihara, Eiji Kikuchi, Keitaro Watanabe, Ryohei Kufukihara, Yoshinori Yanai, Kimiharu Takamatsu, Kazuhiro Matsumoto, Satoshi Hara, Masafumi Oyama, Tetsuo Monma, Takeshi Masuda, Shintaro Hasegawa, Mototsugu Oya
Article
Oncology
N. Hayakawa, E. Kikuchi, S. Mikami, K. Fukumoto, M. Oya
Article
Oncology
Naoya Niwa, Eiji Kikuchi, Kazuhiro Matsumoto, Takeo Kosaka, Ryuichi Mizuno, Mototsugu Oya
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2018)
Article
Oncology
Frederik Konig, Nico C. Grossmann, Francesco Soria, David D'Andrea, Tristan Juvet, Aaron Potretzke, Hooman Djaladat, Alireza Ghoreifi, Eiji Kikuchi, Nozomi Hayakawa, Andrea Mari, Zine-Eddine Khene, Kazutoshi Fujita, Jay D. Raman, Alberto Breda, Matteo Fontana, John P. Sfakianos, John L. Pfail, Ekaterina Laukhtina, Pawel Rajwa, Maximilian Pallauf, Giovanni E. Cacciamani, Thomas van Doeveren, Joost L. Boormans, Alessandro Antonelli, Marcus Jamil, Firas Abdollah, Jeffrey Budzyn, Guillaume Ploussard, Axel Heidenreich, Siamak Daneshmand, Stephen A. Boorjian, Morgan Roupret, Michael Rink, Shahrokh F. Shariat, Benjamin Pradere
Summary: Measuring the quality of care is important in improving patient outcomes. In this study, five indicators were identified to assess the quality of care for patients with upper urinary tract cancer who undergo surgical removal of the affected kidney and ureter. Patients who achieved all five indicators had higher chances of survival and lower rates of recurrence. There were no patient-related factors that predicted a failure to achieve these indicators.
Article
Urology & Nephrology
Naoya Niwa, Tadashi Yoshida, Ryuichi Mizuno, Eiji Kikuchi, Akira Miyajima, Matsuhiko Hayashi, Mototsugu Oya
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2018)