Article
Urology & Nephrology
Matthew Zibelman, Aeen M. Asghar, Daniel C. Parker, John O'Neill, Shuanzeng Wei, Richard E. Greenberg, Marc C. Smaldone, David Y. T. Chen, Rosalia Viterbo, Robert G. Uzzo, Evan Bloom, Rutika Kokate, Daniel M. Geynisman, Pooja Ghatalia, Mengying Deng, Eric A. Ross, Elizabeth Plimack, Philip H. Abbosh, Alexander Kutikov
Summary: This study aimed to evaluate the reliability and limitations of cystoscopic evaluation in candidates for radical cystectomy, showing that systematic endoscopic evaluation was unable to accurately predict post-operative pathology results. Further research is needed to explore novel imaging and biomarker strategies to optimize decision making regarding bladder preservation.
JOURNAL OF UROLOGY
(2021)
Article
Oncology
Heikki Joensuu, Pirkko-Liisa Kellokumpu-Lehtinen, Riikka Huovinen, Arja Jukkola, Minna Tanner, Johan Ahlgren, Paivi Auvinen, Outi Lahdenpera, Kenneth Villman, Paul Nyandoto, Greger Nilsson, Paula Poikonen-Saksela, Vesa Kataja, Petri Bono, Jouni Junnila, Henrik Lindman
Summary: The study suggests that adding capecitabine to a chemotherapy regimen containing docetaxel, epirubicin, and cyclophosphamide can prolong the survival of patients with early breast cancer. Data shows that patients in the TX-CEX group had longer survival compared to those in the T-CEF group, especially for patients with estrogen receptor-negative and triple-negative cancer.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Urology & Nephrology
Matthieu Simonet, Ana Dominguez Gutierrez, Angelo Territo, Thomas Prudhomme, Ricardo Campi, Iulia Andras, Michael Baboudjian, Vital Hevia, Romain Boissier
Summary: In solid organ transplanted patients under immunosuppressive treatment, both endovesical chemotherapy and BCG are safe, but the level of evidence concerning efficacy in comparison with the general population is low.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Oncology
Roy S. Herbst, Yi-Long Wu, Thomas John, Christian Grohe, Margarita Majem, Jie Wang, Terufumi Kato, Jonathan W. Goldman, Konstantin Laktionov, Sang-We Kim, Chong-Jen Yu, Huu Vinh Vu, Shun Lu, Kye Young Lee, Guzel Mukhametshina, Charuwan Akewanlop, Filippo de Marinis, Laura Bonanno, Manuel Domine, Frances A. Shepherd, Damien Urban, Xiangning Huang, Ana Bolanos, Marta Stachowiak, Masahiro Tsuboi
Summary: The study demonstrates that adjuvant osimertinib provides a prolonged disease-free survival (DFS) benefit, reduces the risk of recurrence, improves central nervous system (CNS) DFS, and has a consistent safety profile in resected EGFR-mutated NSCLC.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Mina S. Sedrak, Can-Lan Sun, Jingran Ji, Harvey J. Cohen, Cary P. Gross, William P. Tew, Heidi D. Klepin, Tanya M. Wildes, Efrat Dotan, Rachel A. Freedman, Tracey O'Connor, Selina Chow, Mary Ann Fenton, Beverly Moy, Andrew E. Chapman, William Dale, Vani Katheria, Nicole M. Kuderer, Gary H. Lyman, Allison Magnuson, Hyman B. Muss
Summary: Older women with high-risk early breast cancer often suffer from toxic side effects during adjuvant chemotherapy, leading to dose reductions and delays. Identifying women at risk of receiving suboptimal dose intensity may improve treatment discussions and guide early supportive care interventions.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
J. L. van Dam, E. M. M. Verkolf, E. N. Dekker, B. A. Bonsing, S. O. Bratlie, L. A. A. Brosens, O. R. Busch, L. M. J. W. van Driel, C. H. J. van Eijck, S. Feshtali, P. Ghorbani, D. J. A. de Groot, J. W. B. de Groot, B. C. M. Haberkorn, I. H. de Hingh, B. van der Holt, T. M. Karsten, M. B. van der Kolk, K. J. Labori, M. S. L. Liem, O. J. L. Loosveld, I. Q. Molenaar, M. B. Polee, H. C. van Santvoort, J. de Vos Geelen, M. L. Wumkes, G. van Tienhoven, M. Y. V. Homs, M. G. Besselink, J. W. Wilmink, B. Groot Koerkamp, Dutch Pancreatic Cancer Grp
Summary: This study aims to compare the effectiveness of adjuvant chemotherapy after surgery and neoadjuvant chemotherapy followed by surgery. The objective is to find the optimal approach for the treatment of resectable pancreatic cancer.
Article
Oncology
Tao Ma, Xueli Bai, Qichun Wei, Yongjie Shui, Mengyi Lao, Wen Chen, Bingfeng Huang, Risheng Que, Shunliang Gao, Yun Zhang, Wei Chen, Ji Wang, Tingbo Liang
Summary: This study suggests that adjuvant stereotactic body radiation therapy (SBRT) does not provide a survival benefit or improve local disease control in resected stage II pancreatic adenocarcinoma (PDAC).
Editorial Material
Oncology
Niamh C. Cunningham, Nicholas C. Turner
Summary: CDK4/6 inhibitors have shown consistent efficacy in the treatment of metastatic breast cancer, but recent adjuvant trials for early stage breast cancer have produced conflicting results, highlighting the need for further research on their clinical utility and future trial design.
Article
Oncology
Se Young Choi, Moon Soo Ha, Byung Hoon Chi, Jin Wook Kim, In Ho Chang, Tae-Hyoung Kim, Soon Chul Myung, Myoungsuk Kim, Kyung-Eun Lee, Yuwon Kim, Hyun-Ki Woo, Dae-Sung Kyoung, Hasung Kim
Summary: This study compared the perioperative outcomes, overall survival, and treatment trends in patients with bladder cancer who underwent radical cystectomy and received either neoadjuvant or adjuvant chemotherapy. The findings suggest that neoadjuvant chemotherapy is associated with better overall survival and lower administration of granulocyte colony-stimulating factor when compared to adjuvant chemotherapy. Therefore, neoadjuvant chemotherapy should be considered as a treatment option for bladder cancer patients undergoing radical cystectomy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Hyeon-Min Cho, Hyungjin Kim, RiNa Yoo, Gun Kim, Bong-Hyeon Kye
Summary: The study aimed to evaluate the impact of biofeedback therapy (BFT) during temporary stoma period after sphincter-preserving surgery (SPS) on preventing defecation dysfunction. Results showed that BFT during temporary stoma may be associated with reduced liquid stool incontinence at 12 months post-SPS, as well as more stable mean resting pressure (MRP) and better maximal sensory threshold (Max RST).
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Fabiola Giudici, Barbara Pistilli, Ines Vaz-Luis, Maryam Karimi, Suzette Delaloge, Thomas Bachelot, Stefan Michiels, Aurelie Bardet
Summary: This study demonstrates the survival benefit of extended adjuvant tamoxifen in women with estrogen receptor-positive early breast cancer. Non-adherence may underestimate treatment effects, highlighting the importance of adherence and the usefulness of complex statistical analysis.
BRITISH JOURNAL OF CANCER
(2023)
Article
Geriatrics & Gerontology
Kouji Izumi, Hiroaki Iwamoto, Hiroshi Yaegashi, Takahiro Nohara, Kazuyoshi Shigehara, Yoshifumi Kadono, Shigeki Nanjo, Tadaaki Yamada, Koshiro Ohtsubo, Seiji Yano, Atsushi Mizokami
Summary: This study suggests that testosterone replacement therapy may have beneficial effects on improving cancer-related symptoms in male advanced cancer patients, especially in terms of psychological aspects such as 'unhappiness'.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Oncology
Takuji Iwase, Shigehira Saji, Kotaro Iijima, Kenji Higaki, Shoichiro Ohtani, Yasuyuki Sato, Yasuo Hozumi, Yoshie Hasegawa, Yasuhiro Yanagita, Hiroyuki Takei, Maki Tanaka, Hideji Masuoka, Masahiko Tanabe, Chiyomi Egawa, Yoshifumi Komoike, Toshitaka Nakamura, Hiroshi Ohtsu, Hirofumi Mukai
Summary: This study investigated the effects of extending the treatment with an aromatase inhibitor for 10 years on disease-free survival in postmenopausal hormone receptor-positive breast cancer patients. The results showed that extending the treatment with an aromatase inhibitor for an additional 5 years improved disease-free survival.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Julia Heinzelbecker, Natalie Spieler, Michael Kuehn, Claus Fischer, Bjoern Volkmer, Friedrich von Rundstedt, Peter Albers, Eduard Becht, Andreas Bannowsky, H. Matthias Weber, Rainer Hofmann, Markus Mueller, Sigrun Langbein, Gabriel Steiner, Margitta Retz, Joern Karmradt, Gudrun Wagenpfeil, Stefan Wellek, Jan Lehmann, Michael Stoeckle
Summary: This study compared the effects of immediate adjuvant treatment with gemcitabine versus treating at progression in platinum-ineligible high-risk urinary bladder cancer patients. The results showed that adjuvant treatment did not significantly prolong overall survival and progression-free survival, and patients in the adjuvant treatment group had worse quality of life. These findings underline the importance of implementing and developing new perioperative treatments for platinum-ineligible urinary bladder cancer patients.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Obstetrics & Gynecology
Olivia O. Cardenas-Trowers, Alyce G. Abraham, Thomas K. Dotson, Brooke A. Houlette, Jeremy T. Gaskins, Sean L. Francis
Summary: The study evaluated the addition of triamcinolone acetonide to a standard bladder instillation solution for the treatment of interstitial cystitis-bladder pain syndrome, and found that it did not improve symptoms in patients.
OBSTETRICS AND GYNECOLOGY
(2021)