Review
Biochemistry & Molecular Biology
Avan Kader, Julia Brangsch, Jan O. Kaufmann, Jing Zhao, Dilyana B. Mangarova, Jana Moeckel, Lisa C. Adams, Ingolf Sack, Matthias Taupitz, Bernd Hamm, Marcus R. Makowski
Summary: This review summarizes recent developments in molecular imaging markers for magnetic resonance imaging of prostate cancer, aiming to improve the molecular characterization of the tumor and enable targeted therapies to suppress tumor growth or reduce tumor size in a non-invasive manner.
Review
Chemistry, Multidisciplinary
Thecla Trinity Wheeler, Pei Cao, Muhammad Daniyal Ghouri, Tianjiao Ji, Guangjun Nie, Yuliang Zhao
Summary: This review highlights the need for precise diagnostic and therapeutic strategies for prostate cancer (PCa) due to its high incidence rates and complicated subtypes. It discusses the limitations of current clinical imaging techniques and presents the potential of nanotechnology in improving diagnostic accuracy. It also addresses the challenges and provides suggestions and perspectives for nanotechnology-based PCa diagnosis.
SCIENCE CHINA-CHEMISTRY
(2022)
Article
Cell Biology
Neda Gholizadeh, Peter B. Greer, John Simpson, Jonathan Goodwin, Caixia Fu, Peter Lau, Saabir Siddique, Arend Heerschap, Saadallah Ramadan
Summary: The addition of novel H-1 magnetic resonance spectroscopic imaging (MRSI) to routine multiparametric MRI (mp-MRI) significantly improves the diagnostic accuracy of detection and aggressiveness assessment of transition zone prostate cancer, especially when combined with T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and quantitative dynamic contrast enhancement (DCE).
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Chemistry, Analytical
Xinyu Zhan, Yu Liu, Zhiguo Chen, Jie Luo, Sha Yang, Xiang Yang
Summary: Most tumors lack specific clinical signs and symptoms in the early stage, leading to easy missed and misdiagnosis. Terahertz (THz) spectroscopy and imaging have made significant progress in the past two decades, providing an alternative for early tumor diagnosis.
Review
Radiology, Nuclear Medicine & Medical Imaging
Angeliki Stamatelatou, Tom W. J. Scheenen, Arend Heerschap
Summary: This paper reviews the developments of H-1-MR spectroscopic imaging methods in investigating prostate cancer, highlighting recent advancements and future developments to overcome challenges in clinical applications.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Analytical
Ze Wang, Annan Liu, Xingchen Li, Lin Guan, Huiyuan Xing, Liang He, Linan Fang, Andrei V. Zvyagin, Xiaoyu Yang, Bai Yang, Quan Lin
Summary: The high incidence and complex subtypes of prostate cancer require accurate diagnosis. A multifunctional nanoprobe Au/Gd nanodots were designed and fabricated for multi-mode imaging and accurate diagnosis of bone metastatic prostate cancer. The results showed that combining multiple imaging modes achieved high-precision detection and accurate treatment guidance. Additionally, the Au/Gd nanodots demonstrated good biocompatibility and biosafety in in vitro/vivo experiments, making them a potential strategy for precise diagnosis in metastatic prostate cancer.
Article
Biology
Yvonne Wimper, Jurgen J. Futterer, Joyce G. R. Bomers
Summary: MRI-guided therapy plays an important role in the treatment of prostate cancer, providing accurate lesion targeting and real-time treatment monitoring. Cryoablation, focal laser ablation, high intensity focused ultrasound, and transurethral ultrasound ablation are widely used in personalized treatment. However, these new technologies still face challenges and require further development.
Article
Urology & Nephrology
David Eldred-Evans, Martin J. Connor, Mariana Bertoncelli Tanaka, Edward Bass, Deepika Reddy, Uma Walters, Luke Stroman, Easter Espinosa, Raj Das, Nalin Khosla, Henry Tam, Elizabeth Pegers, Hasan Qazi, Stephen Gordon, Mathias Winkler, Hashim U. Ahmed
Summary: The RAPID prostate cancer diagnostic pathway allows 43% of men to avoid biopsy while accurately detecting clinically significant cancers and having a low detection rate for insignificant cancers. There are some variations among different centers.
Article
Multidisciplinary Sciences
Hiroaki Koyama, Ryo Kurokawa, Shimpei Kato, Masanori Ishida, Ryohei Kuroda, Tetsuo Ushiku, Haruki Kume, Osamu Abe
Summary: In this study, we investigated the differences in prostate MRI and clinical findings between patients with osteoblastic and non-osteoblastic bone metastases of prostate cancer.
SCIENTIFIC REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Matthew Gibbons, Olga Starobinets, Jeffry P. Simko, John Kurhanewicz, Peter R. Carroll, Susan M. Noworolski
Summary: This study aimed to characterize the MR signatures of various benign prostate tissues and differentiate them from cancer using mpMRI. The study demonstrated the capability of mpMRI to discriminate between benign and cancerous tissues effectively.
MAGNETIC RESONANCE IMAGING
(2022)
Article
Chemistry, Analytical
Jihun Jang, Jinwoo Kim, Hak Jong Lee, Jin Ho Chang
Summary: The TRUS-PA probe, combining transrectal ultrasound and photoacoustic imaging, is able to visualize morphological changes and microvasculature distribution in the prostate, improving the quality of photoacoustic images.
Article
Chemistry, Analytical
Brian T. Scarpitti, Chureeporn Chitchumroonchokchai, Steven K. Clinton, Zachary D. Schultz
Summary: The ability to monitor the uptake and distribution of food nutrients in in vitro cell culture models is vital for understanding the effectiveness of nutraceuticals in treating and preventing diseases. In this study, live-cell Raman microscopy was used to visualize the delivery of lycopene to prostate cancer cells and assess its cellular uptake. The results showed that lycopene likely accumulates in lipid membranes of cytoplasmic organelles. This label-free technique provides a convenient and sensitive method for detecting and quantifying lycopene uptake in living cells.
ANALYTICAL CHEMISTRY
(2022)
Article
Clinical Neurology
M. Natsumeda, H. Matsuzawa, M. Watanabe, K. Motohashi, R. Gabdulkhaev, Y. Tsukamoto, Y. Kanemaru, J. Watanabe, R. Ogura, M. Okada, S. Kurabe, K. Okamoto, A. Kakita, H. Igarashi, Y. Fujii
Summary: This study found that 7T SWI was useful in distinguishing astrocytomas and oligodendrogliomas in the corticomedullary junction. Observation of tapering of the cortex was most sensitive and specific for diagnosing astrocytomas. Reliably predicting malignant grade was also possible by 7T SWI.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hao Li, Dong Luo, Chaonan Yuan, Xinning Wang, Jing Wang, James P. Basilion, Thomas J. Meade
Summary: PSMA is a transmembrane protein highly expressed in aggressive prostate cancer, utilized in various imaging modalities as a biomarker. MR imaging provides detailed information but requires development of molecular contrast agents for improved sensitivity. In this study, targeted and activatable MR contrast agents were successfully used to differentiate between PSMA+ and PSMA- prostate cancer cells.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Asha Daryanani, Baris Turkbey
Summary: This article provides an overview of the current status and recent advancements of CT and MRI in prostate cancer imaging, including promising results in tissue characterization, quantification, and nodal staging achieved through new techniques.
SEMINARS IN NUCLEAR MEDICINE
(2022)
Article
Ophthalmology
Livia Faes, Kathrin Golla, Meriam Islam, Kenny R. Lienhard, Martin K. Schmid, Dawn A. Sim, Lucas M. Bachmann
Summary: This study evaluates the usability and long-term adherence to the mobile hyperacuity app Alleye in patients with retinal pathology. The majority of patients showed satisfaction with the usability and had a positive attitude towards its trustworthiness and usefulness.
Article
Ophthalmology
Frantisek Sanak, Philipp Baenninger, Katja Iselin, Claude Kaufmann, Lucas Bachmann, Daniela Buhl, Michael Thiel
Summary: This study measured the concentration of VEGF-A in SED and PRGF eye drops, and found that the VEGF concentration was significantly higher in SED compared to PRGF. This is an important finding for the potential treatment of dry eye disease in patients with neuropathic eye disease.
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2022)
Article
Psychology, Clinical
Eileen Krinke, Ulrike Held, Klaus Steigmiller, Kim Felmingham, Birgit Kleim
Summary: This study examined the associations between sex hormones and cortisol during memory consolidation and the development of intrusive memories. The results showed that higher progesterone levels and lower estradiol levels predicted more intrusive memories. Further research is needed to better understand the roles of gonadal and adrenal hormones in trauma memory formation and their influence on the development of PTSD.
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
(2022)
Article
Clinical Neurology
Kevin Akeret, Raphael M. Buzzi, Moritz Saxenhofer, Kathrin Bieri, Deborah Chiavi, Bart R. Thomson, Manuela Gruttner-Durmaz, Nina Schwendinger, Rok Humar, Luca Regli, Tristan P. C. van Doormaal, Ulrike Held, Emanuela Keller, Michael Hugelshofer, Dominik J. Schaer
Summary: This study aims to validate the association between EVD and LD based CSF-Hb and SAH-SBI, and assess the discrimination ability of CSF-Hb. The strength of association will be quantified using a generalized additive model, and receiver operating characteristic analysis will be used for discrimination ability assessment.
Article
Clinical Neurology
Martin Hansel, Klaus Steigmiller, Andreas R. Luft, Catherine Gebhard, Ulrike Held, Susanne Wegener
Summary: Increasing women's economic participation in Switzerland is associated with higher prevalence of non-traditional vascular risk factors in both women and men. This highlights the need for improved vascular risk stratification and implementation of effective preventive measures for neurovascular and cardiovascular diseases.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Rheumatology
Alexandru Garaiman, Klaus Steigmiller, Catherine Gebhard, Carina Mihai, Rucsandra Dobrota, Cosimo Bruni, Marco Matucci-Cerinic, Joerg Henes, Jeska De Vries-Bouwstra, Vanessa Smith, Andrea Doria, Yannick Allanore, Lorenzo Dagna, Branimir Anic, Carlomaurizio Montecucco, Otylia Kowal-Bielecka, Mickael Martin, Yoshiya Tanaka, Anna-Maria Hoffmann-Vold, Ulrike Held, Oliver Distler, Mike Oliver Becker
Summary: The DU-VASC model was developed and validated to assist in decision-making for the management of digital ulcers in patients with systemic sclerosis. The model showed that PI treatment was the most important predictor associated with reduced occurrence of digital ulcers.
Article
Hematology
Stefano Barco, Davide Voci, Ulrike Held, Tim Sebastian, Roland Bingisser, Giuseppe Colucci, Daniel Duerschmied, Andre Frenk, Bernhard Gerber, Andrea Goetschi, Stavros Konstantinides, Francois Mach, Helia Robert-Ebadi, Thomas Rosemann, Noemi R. Simon, Herve Spechbach, David Spirk, Stefan Stortecky, Lukas Vaisnora, Marc Righini, Nils Kucher
Summary: This study aimed to investigate whether thromboprophylaxis with enoxaparin would prevent hospitalization and death in symptomatic COVID-19 outpatients. The results showed that enoxaparin did not reduce the risk of hospitalization and death among these patients.
LANCET HAEMATOLOGY
(2022)
Article
Pediatrics
Celine Steger, Maria Feldmann, Julia Borns, Cornelia Hagmann, Beatrice Latal, Ulrike Held, Andras Jakab, Ruth O'Gorman Tuura, Walter Knirsch
Summary: Reduced white matter NAA/Cho ratios in neonates undergoing cardiac surgery for congenital heart defects may indicate delayed brain maturation. Further research is needed to understand the clinical impact of altered metabolites on brain development and outcome.
PEDIATRIC RESEARCH
(2023)
Article
Surgery
Gabriela Schmid-Mohler, Sonja Beckmann, Patrizia Zala, Laura Huber, Ulrike Held, Thomas Fehr, Rudolf Peter Wuthrich, Heidi Petry, Thomas F. Mueller
Summary: This study aimed to test two models for identifying patients at risk for weight gain and increase in adipose tissue mass in the first year after kidney transplantation. The models included various predictors such as physical activity, smoking cessation, self-reported health status, and baseline body mass index. The results showed that the models have the potential to assess patients' risk, but further testing is needed before implementation in clinical practice.
PROGRESS IN TRANSPLANTATION
(2022)
Article
Medicine, Research & Experimental
Christian D. Fankhauser, Andres Affentranger, Beatrice Cortonesi, Urs Jeker, Markus Gass, Fabrizio Minervini, Georg Jung, Corina Christmann, Christine Brambs, Milo A. Puhan, Ulrike Held
Summary: This study aims to analyze the impact of a preoperative high-intensity smoking cessation intervention on surgical complications and various outcomes in smokers undergoing surgery.
Review
Ophthalmology
Livia Faes, Peter M. Maloca, Katja Hatz, Thomas J. Wolfensberger, Marion R. Munk, Dawn A. Sim, Lucas M. Bachmann, Martin K. Schmid
Summary: Ophthalmology faces challenges in providing eye care to an increasing group of people. Health systems will be pushed to their limits due to the quantitative patient increase and new treatment availability. Better networking and patient involvement can lead to efficiency gains, and digitalization has shown potential during the pandemic.
Article
Hematology
Davide Voci, Andrea Gotschi, Ulrike Held, Roland Bingisser, Giuseppe Colucci, Daniel Duerschmied, Riccardo M. Fumagalli, Bernhard Gerber, Barbara Hasse, Dagmar I. Keller, Stavros V. Konstantinides, Francois Mach, Silvana K. Rampini, Marc Righini, Helia Robert-Ebadi, Thomas Rosemann, Stephanie Roth-Zetzsche, Tim Sebastian, Noemi R. Simon, David Spirk, Stefan Stortecky, Lukas Vaisnora, Nils Kucher, Stefano Barco
Summary: The benefits of early thromboprophylaxis in symptomatic COVID-19 outpatients remain unclear. This study presents the 90-day results from the OVID phase III trial, which showed that early thromboprophylaxis with enoxaparin did not improve the course of COVID-19 in terms of hospitalization, death, or resolution of symptoms.
THROMBOSIS RESEARCH
(2023)
Article
Urology & Nephrology
Stephanie A. Stalder, Oliver Gross, Collene E. Anderson, Lucas M. Bachmann, Sarah Baumann, Veronika Birkhauser, Mirjam Bywater, Giulio del Popolo, Daniel S. Engeler, Enrico Finazzi Agro, Susanne Friedl, Nuno Grilo, Stephan Kiss, Miriam Koschorke, Lorenz Leitner, Martina D. Liechti, Ulrich Mehnert, Stefania Musco, Helen Sadri, Lara Stachele, Jure Tornic, Stephanie van Der Lely, Stephen Wyler, Thomas M. Kessler
Summary: This study protocol describes a randomized controlled trial investigating the efficacy and safety of transcutaneous tibial nerve stimulation (TTNS) for refractory neurogenic lower urinary tract dysfunction (NLUTD). The primary outcome is improvement in bladder diary variables at study end compared to baseline values. Secondary outcomes include urodynamic, neurophysiological, and bowel function measures, as well as safety assessments.
Article
Cardiac & Cardiovascular Systems
Bettina Reich, Sabrina Schwan, Kristina Heye, Thushiha Logeswaran, Andreas Hahn, Andrea Goetschi, Ulrike Held, Kristina Wetterling, Celine Steger, Raimund Kottke, Beatrice Latal, Walter Knirsch
Summary: This study evaluated the long-term effects on brain growth in children with univentricular congenital heart disease. The results showed that these children had impaired neurodevelopmental outcomes and structural brain lesions during school age.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Review
Clinical Neurology
Ilona Stefanos-Yakoub, Kevin Wingeier, Ulrike Held, Beatrice Latal, Elaine Wirrell, Mary Lou Smith, Georgia Ramantani
Summary: In addition to seizure freedom, pediatric epilepsy surgery aims to stabilize and potentially optimize cognitive development. The study conducted a systematic review and meta-analysis to evaluate the changes in intelligence or developmental quotients (IQ/DQ) before and after surgery in children with focal lesional epilepsy. The findings suggest stabilization of intellectual and developmental functioning at long-term follow-up. Cessation of antiseizure medication after achieving seizure freedom may further optimize intellectual and developmental trajectories in affected children.
