Article
Oncology
Irene Barjolle, Loic Ah-Thiane, Eric Frampas, Georges Karam, Jerome Rigaud, Arthur David
Summary: This retrospective descriptive study evaluated the efficacy and safety of cryoablation for T1b renal tumors. The results showed good oncologic outcomes and low rates of complications, supporting cryoablation as a potential alternative to surgery for tumors up to 7 cm in diameter.
FRONTIERS IN ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiao Wu, Johannes Uhlig, Brian M. Shuch, Annemarie Uhlig, Hyun S. Kim
Summary: In this study, a cost-effectiveness analysis was performed to assess the benefits of partial nephrectomy (PN) and percutaneous cryoablation (PCA) for patients with cT1a renal cell carcinoma (RCC). The results suggest that PCA is more cost-effective than PN in the majority of scenarios, although the currently available evidence is of limited quality.
EUROPEAN RADIOLOGY
(2023)
Article
Urology & Nephrology
Luyao Chen, Wen Deng, Yixing Luo, Weipeng Liu, Yu Li, Xiaoqiang Liu, Gongxian Wang, Bin Fu
Summary: This study compared the perioperative, functional, and oncologic outcomes of robot-assisted partial nephrectomy (RAPN) and laparoscopic partial nephrectomy (LPN) for renal hilar tumors. The results showed that RAPN had better perioperative outcomes, with less blood loss and shorter warm ischemia time, and also resulted in better preservation of postoperative renal function. RAPN may be the preferred surgical treatment for renal hilar tumors.
JOURNAL OF ENDOUROLOGY
(2022)
Article
Urology & Nephrology
Satoshi Kobayashi, Jun Mutaguchi, Eiji Kashiwagi, Ario Takeuchi, Masaki Shiota, Junichi Inokuchi, Masatoshi Eto
Summary: This study found that robot-assisted partial nephrectomy allows better preservation of split renal function than laparoscopic partial nephrectomy by increasing the parenchymal preservation ratio. This translates into better postoperative global renal function.
INTERNATIONAL JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Longbin Xiong, Jane K. Nguyen, Yulu Peng, Zhaohui Zhou, Kang Ning, Nan Jia, Jing Nie, Dongxiang Wen, Zeshen Wu, Gustavo Roversi, Diego Aguilar Palacios, Emily Abramczyk, Carlos Munoz-Lopez, Jack A. Campbell, Yun Cao, Wencai Li, Xuepei Zhang, Zhisong He, Xiang Li, Jiwei Huang, Jianzhong Shou, Jitao Wu, Minfeng Chen, Xiaofeng Chen, Jiaxuan Zheng, Congjie Xu, Wen Zhong, Zaishang Li, Wen Dong, Juping Zhao, Hailang Zhang, Junhang Luo, Jianye Liu, Fanghu Sun, Hui Han, Shengjie Guo, Pei Dong, Fangjian Zhou, Chunping Yu, Steven C. Campbell, Zhiling Zhang
Summary: After partial nephrectomy, histologic deterioration of the preserved renal parenchyma may occur, primarily correlated with comorbidities such as hypertension, diabetes mellitus, or chronic kidney disease, rather than ischemia insult. The subsequent decline in renal function is mild and independent of histologic changes. This suggests that conventional, limited durations of ischemia have only limited impact on parenchyma deterioration after partial nephrectomy.
Article
Oncology
Shohei Kawaguchi, Kouji Izumi, Renato Naito, Suguru Kadomoto, Hiroaki Iwamoto, Hiroshi Yaegashi, Takahiro Nohara, Kazuyoshi Shigehara, Kotaro Yoshida, Yoshifumi Kadono, Atsushi Mizokami
Summary: Advances in diagnostic imaging have led to increased opportunities for treating small-diameter renal cell carcinomas in the elderly. This study compared the efficacy of RAPN and PCA in elderly patients with small-diameter renal cell carcinomas, finding that RAPN is a safe and effective treatment, while PCA is a safe alternative for high-risk patients.
Review
Urology & Nephrology
Antonio Celia, Claudio Pusceddu, Tommaso Silvestri, Giovanni B. Gidaro, Fabrizio Iannello, Elena P. Lanati, Anna D'Ausilio
Summary: The study found that in Italy, PCA is not only more cost-effective than OPN in treating small renal masses, but also more resource-efficient from both the National Healthcare System and hospital perspectives.
MINERVA UROLOGY AND NEPHROLOGY
(2021)
Review
Oncology
Li Wang, Jing-ya Deng, Cai Liang, Ping-yu Zhu
Summary: This study compared the outcomes of robotic partial nephrectomy (RPN) and laparoscopic partial nephrectomy (LPN) for treating complex renal tumors. The results showed that RPN was associated with shorter operative time, warm ischemia time, length of stay, lower transfusion rate, and incidence of intraoperative complications compared to LPN, while maintaining oncological control and avoiding renal function decline.
FRONTIERS IN ONCOLOGY
(2023)
Article
Surgery
Yonghui Chen, Xiaorong Wu, Jiale Zhou, Jin Zhang, Jiwei Huang, Yiran Huang, Wei Xue
Summary: This study reports the preliminary results of thermal ablation assisted laparoscopic partial nephrectomy for cT1b renal tumors. The study shows that thermal ablation assisted laparoscopic partial nephrectomy is a safe and effective nephron-sparing treatment for selective cT1b renal tumors.
MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES
(2022)
Article
Medicine, General & Internal
Ulysse Frantz, Antoine Bouvier, Thibaut Culty, Merzouka Zidane, Souhil Lebdai, Pierre Bigot
Summary: This study evaluated the long-term oncological and functional outcomes of laparoscopic partial nephrectomy (LPN) after hyperselective embolization of tumor vessels (HETV) in a hybrid operating room (HOR). The results showed that this surgical approach is safe and efficient for treating localized kidney tumors, with high rates of tumor control and survival.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Xiang-Min Zhang, Ji-Dong Xu, Jian-Min Lv, Xiu-Wu Pan, Jian-Wei Cao, Jian Chu, Xin-Gang Cui
Summary: This study retrospectively analyzed 15 patients who underwent high-power GreenLight laser non-ischemic laparoscopic partial nephrectomy (LPN) for T1a exogenous renal tumors. The surgery was successfully completed without the need for open or radical nephrectomy. The renal artery was not clamped, resulting in zero ischemic time. No blood transfusions were required and no postoperative complications occurred. The mean operation time was 104.3 +/- 8.2 min. Postoperative pathological results showed various types of renal tumors. The renal function and creatinine levels remained stable after surgery. GreenLight laser has advantages in cutting and sealing small renal tumors during LPN, but the generation of excessive smoke should be noted.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Oncology
Koichi Aikawa, Takafumi Yanagisawa, Wataru Fukuokaya, Kanichiro Shimizu, Keiichiro Miyajima, Minoru Nakazono, Kosuke Iwatani, Akihiro Matsukawa, Koki Obayashi, Shoji Kimura, Shunsuke Tsuzuki, Hiroshi Sasaki, Hirokazu Abe, Shunichi Sadaoka, Jun Miki, Takahiro Kimura
Summary: This study compared the clinical outcomes of patients with cT1b renal tumors treated with partial nephrectomy (PN) versus percutaneous cryoablation (PCA). A retrospective analysis of 119 patients was conducted, and it was found that PCA was more likely to be chosen for octogenarians. The IPW-adjusted analysis showed that PCA had a significantly worse local recurrence-free survival compared to PN, but provided comparable distant oncologic outcomes.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Julien Rossi, Roberto Luigi Cazzato, Pierre de Marini, Pierre Auloge, Pierre-Alexis Autrusseau, Danoob Dalili, Thibault Tricard, Baptiste Poussot, Julien Garnon, Herve Lang, Afshin Gangi
Summary: The study retrospectively investigated the safety and oncological outcomes of cryoablation for residual/recurring renal cell carcinoma in the ipsilateral kidney following partial nephrectomy. The results showed that cryoablation is safe and results in high estimates of local tumor progression-free survival.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Article
Urology & Nephrology
Rodney H. Breau, Dean A. Fergusson, Greg Knoll, Kristen McAlpine, Christopher Morash, Sonya Cnossen, Luke T. Lavallee, Ranjeeta Mallick, Antonio Finelli, Michael A. S. Jewett, Bradley C. Leibovich, Jonathan A. Cook, Anil Kapoor, Frederic Pouliot, Jonathan Izawa, Ricardo Rendon, Ilias Cagiannos
Summary: The study found that inducing renal hypothermia during partial nephrectomy did not effectively preserve kidney function in patients with normal or mildly impaired renal function, and had no significant impact on surgical outcomes or patient-reported quality of life.
JOURNAL OF UROLOGY
(2021)
Review
Urology & Nephrology
Pengxiu Lin, Minhong Wu, Hongyong Gu, Lanzhen Tu, Shilan Liu, Zhiling Yu, Qingsheng Chen, Cailing Liu
Summary: For complex renal tumors, RAPN is more favorable than LPN in terms of lower rate of conversion to radical surgery, shorter ischemia time, shorter length of stay, less eGFR decline, and lower rate of CKD upstaging.
MINERVA UROLOGY AND NEPHROLOGY
(2021)
Letter
Biochemistry & Molecular Biology
Giovanni E. Cacciamani, Timothy N. Chu, Daniel I. Sanford, Andre Abreu, Vinay Duddalwar, Assad Oberai, C. -C. Jay Kuo, Xiaoxuan Liu, Alastair K. Denniston, Baptiste Vasey, Peter McCulloch, Robert F. Wolff, Sue Mallett, John Mongan, Charles E. Kahn, Viknesh Sounderajah, Ara Darzi, Philipp Dahm, Karel G. M. Moons, Eric Topol, Gary S. Collins, David Moher, Inderbir S. Gill, Andrew J. Hung
Article
Oncology
Richard Mateo Mora, Alireza Ghoreifi, Seyedeh-Sanam Ladi-Seyedian, Farshad Sheybaee Moghaddam, Jie Cai, Gus Miranda, Monish Aron, Anne Schuckman, Mihir Desai, Inderbir Gill, Siamak Daneshmand, Hooman Djaladat
Summary: This study evaluated the perioperative and functional outcomes of radical cystectomy and urinary diversion in patients with a single kidney compared to those with double kidneys. The results showed that patients with a single kidney had a longer length of hospital stay and greater decline in glomerular filtration rate, but similar rates of complications, readmission, and mortality compared to patients with double kidneys. Continent urinary diversion in single kidney patients was as safe as in double kidney patients.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Oncology
Alireza Ghoreifi, Anirban P. Mitra, George McClintock, Fady Baky, Zachary McDowell, Etienne Lavalle, Ragheed Saoud, Jie Cai, Inderbir S. Gill, John Sfakianos, James Porter, Aditya Bagrodia, Nariman Ahmadi, Scott Eggener, John F. Ward, Hooman Djaladat
Summary: This retrospective study evaluated the perioperative and oncological/functional outcomes of robotic post-chemotherapy retroperitoneal lymph node dissection for testicular cancer. The results showed that robotic post-chemotherapy retroperitoneal lymph node dissection appears to be safe and effective with appropriate patient selection at centers with expertise in testicular cancer and minimally invasive surgery.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Review
Surgery
Giovanni E. Cacciamani, Luis G. Medina, Aref S. Sayegh, Anibal La Riva, Laura C. Perez, Michael B. Eppler, Inderbir Gill, Rene Sotelo
Summary: This study systematically evaluated perioperative adverse events in patients undergoing inguinal lymph node dissection and found that the incidence of intraoperative and postoperative AEs is significant. Lymphatic AEs were the most commonly reported. High BMI, comorbidities, and diabetes were independent predictors of AEs. The quality of AEs reporting was suboptimal, indicating the need for a standardized reporting system.
WORLD JOURNAL OF SURGERY
(2023)
Article
Cell Biology
Hong-Tao Li, H. Josh Jang, Krizia Rohena-Rivera, Minmin Liu, Hemant Gujar, Justin Kulchycki, Shuqing Zhao, Sandrin Billet, Xinyi Zhou, Daniel J. Weisenberger, Inderbir Gill, Peter A. Jones, Neil A. Bhowmick, Gangning Liang
Summary: Tumors with mutations in chromatin regulators, such as SETD2, are sensitive to DNA hypomethylating agent DAC therapy, which activates viral mimicry responses through mis-splicing events. Comprehensive epigenomic analysis reveals that H3K9me3 deposition across intronic TEs contributes to increased mis-splicing rates. SETD2-deficient kidney cancers are prone to mis-splicing, and DAC treatment can exacerbate this effect to enhance viral mimicry activation and synergize with immuno-therapy approaches.
Review
Surgery
Tamir N. Sholklapper, Jorge Ballon, Aref S. Sayegh, Anibal La Riva, Laura C. Perez, Sherry Huang, Michael Eppler, Gregg Nelson, Giovanni Marchegiani, Robert Hinchliffe, Luca Gordini, Marc Furrer, Michael J. Brenner, Salome Dell-Kuster, Chandra Shekhar Biyani, Nader Francis, Haytham M. A. Kaafarani, Matthias Siepe, Des Winter, Julie A. Sosa, Francesco Bandello, Robert Siemens, Jochen Walz, Alberto Briganti, Christian Gratzke, Andre L. Abreu, Mihir M. Desai, Rene Sotelo, Riaz Agha, Keith D. Lillemoe, Steven Wexner, Gary S. Collins, Inderbir Gill, Giovanni E. Cacciamani
Summary: This study assesses the prevalence and typology of perioperative adverse event reporting guidelines among surgery and anesthesiology journals. Results show that 46.5% of the queried journals recommend surgical adverse event reporting. Journals in the surgery, urology, and anesthesia categories are most likely to recommend reporting; those in the top SJR quartiles and based in Western Europe, North America, and the Middle East are also more likely to recommend.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Oncology
Felix Preisser, Reha-Baris Incesu, Pawel Rajwa, Marcin Chlosta, Mohamed Ahmed, Andre Luis Abreu, Giovanni Cacciamani, Luis Ribeiro, Alexander Kretschmer, Thilo Westhofen, Joseph A. Smith, Markus Graefen, Giorgio Calleris, Yannic Raskin, Paolo Gontero, Steven Joniau, Rafael Sanchez-Salas, Shahrokh F. Shariat, Inderbir Gill, Robert Jeffrey Karnes, Paul Cathcart, Henk van der Poel, Giancarlo Marra, Derya Tilki
Summary: Lymph node invasion is a poor prognostic factor for salvage prostatectomy patients. This study found that lymph node invasion significantly affects the oncologic outcomes after salvage prostatectomy. On the other hand, there is no benefit for lymph node dissection during salvage prostatectomy. These findings highlight the importance of cautious selection of lymph node dissection and strict postoperative monitoring for salvage prostatectomy patients with lymph node invasion.
Proceedings Paper
Computer Science, Artificial Intelligence
Alexander Te-Wei Shieh, Steven Yong Cen, Bino Varghese, Darryl Hwa Hwang, Xiaomeng Lei, Kirthika Gurumurthy, Imran Siddiqi, Manju Aron, Inderbir Gill, William Dean Wallace, Vinay Anant Duddalwar
Summary: This study investigates the correlation between radiomic features extracted from CT imaging and tumor immune microenvironment (TIME) measurements from multiplex immunohistochemistry (mIHC) analysis. The findings show a significant correlation between these radiomic features and the levels of PD-L1 expression and CD8(+)PD-1(+) T cell to CD8(+) T cell ratio.
18TH INTERNATIONAL SYMPOSIUM ON MEDICAL INFORMATION PROCESSING AND ANALYSIS
(2023)
Article
Urology & Nephrology
Arnauld Villers, Denis Seguier, Philippe Puech, Georges-Pascal Haber, Mihir M. Desai, Sebastien Crouzet, Xavier Leroy, Julien Labreuche, Inderbir S. Gill, Jonathan Olivier
Summary: This report describes the long-term outcomes of robotic-assisted anterior partial prostatectomy (APP) for anteriorly located tumors. The results show that continence and erectile function were well preserved, and the cancer recurrence rate was 62.7%. Overall, this surgical procedure has good functional outcomes and acceptable oncological results, but there is a risk of recurrence.
EUROPEAN UROLOGY OPEN SCIENCE
(2023)
Letter
Multidisciplinary Sciences
Giovanni E. Cacciamani, Inderbir S. Gill, Gary S. Collins
Article
Urology & Nephrology
Alireza Ghoreifi, Masatomo Kaneko, Samuel Peretsman, Atsuko Iwata, Jessica Brooks, Aliasger Shakir, Dordaneh Sugano, Jie Cai, Giovanni Cacciamani, Daniel Park, Amir H. Lebastchi, Osamu Ukimura, Duke Bahn, Inderbir Gill, Andre Luis Abreu
Summary: This study aimed to evaluate the treatment decision satisfaction and regret among patients who underwent focal therapy (FT) for localized prostate cancer. The results showed that FT is well accepted by patients with a low regret rate. Factors that affect treatment regret include higher post-treatment prostate-specific antigen (PSA) levels, presence of cancer on follow-up biopsy, bothersome postoperative urinary symptoms, and impotence.
EUROPEAN UROLOGY OPEN SCIENCE
(2023)
Article
Oncology
Derek H. Liu, Komal A. Dani, Sharath S. Reddy, Xiaomeng Lei, Natalie L. Demirjian, Darryl H. Hwang, Bino A. Varghese, Suhn K. Rhie, Felix Y. Yap, David I. Quinn, Imran Siddiqi, Manju Aron, Ulka Vaishampayan, Haris Zahoor, Steven Y. Cen, Inderbir S. Gill, Vinay A. Duddalwar
Summary: This study investigated the use of quantitative texture analysis to identify radiogenomic correlations with ccRCC biomarkers. Radiomic features from CT images were extracted and machine learning algorithms evaluated the predictive ability of these features for clinical biomarkers. Texture analysis showed potential in predicting the presence of biomarkers and may have prognostic implications.
Article
Urology & Nephrology
Raj Kumar, Richard Matulewicz, Andrea Mari, Marco Moschini, Saum Ghodoussipour, Benjamin Pradere, Michael Rink, Riccardo Autorino, Mihir M. Desai, Inderbir Gill, Giovanni E. Cacciamani
Summary: The paper aims to provide evidence on the associations between smoking and urologic cancers including prostate, bladder, renal, and upper tract urothelial cancer (UTUC). Smoking is associated with higher tumor grade, stage, poorer outcomes, and increased risk of recurrence in these cancers. Smoking cessation may have a protective effect.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Giovanni E. Cacciamani, Daniel I. Sanford, Timothy N. Chu, Masatomo Kaneko, Andre L. De Castro Abreu, Vinay Duddalwar, Inderbir S. Gill
Summary: Artificial intelligence (AI) is expected to revolutionize healthcare by improving the quality of care for patients and overcoming human fatigue barriers. In the field of oncology, AI has the potential to standardize the interpretation of radiological imaging, especially for prostate imaging. Combining AI with radiologist assessment shows superior performance in detecting prostate cancer, offering a hybrid system that maximizes patient care quality while reducing physician workload and burnout.
EUROPEAN UROLOGY OPEN SCIENCE
(2023)
Article
Urology & Nephrology
Anibal La Riva, Aref S. Sayegh, Laura C. Perez, Jaime Poncel, Luis G. Medina, Brittany Adamic, Ryan Powers, Giovanni E. Cacciamani, Monish Aron, Inderbir Gill, Rene Sotelo
Summary: This study retrospectively analyzed video content provided by robotic surgeons from high-volume centers to describe the ways in which obturator nerve injury occurs during pelvic surgery and the corresponding management strategies. Proper identification of the anatomy and high-risk areas, prompt recognition, and repair of obturator nerve injury can prevent this complication and offer patients the best chance of recovery.
