Article
Biochemistry & Molecular Biology
Ali Alquraini
Summary: This study evaluated the efficacy of hexaconazole to bind with sex hormone-binding globulin (SHBG) and found that it has a stable molecular interaction with SHBG, leading to significant endocrine disruption during agricultural work.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Yutang Wang
Summary: This study established criteria for low SHBG among US adults and found the estimated national prevalence to be 3.3% in men and 2.7% in women. Risk factors for this condition include higher BMI, diabetes, ethnicity, COPD, coronary heart disease, and smoking.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Nutrition & Dietetics
Rebecca Ahlin, Natalja P. Norskov, Sanna Nybacka, Rikard Landberg, Viktor Skokic, Johan Stranne, Andreas Josefsson, Gunnar Steineck, Maria Hedelin
Summary: Phytoestrogens, through ER beta modulation, may have an anti-proliferative role in prostate cancer. However, a high intake of phytoestrogen-rich foods does not significantly affect hormone concentrations in patients, except for a potential decrease in estradiol concentration in a specific genetic subgroup of ER beta.
Article
Biochemistry & Molecular Biology
Sabrina Zidi, Mouna Stayoussef, Feryel K. Sontini, Amel Mezlini, Besma Yacoubi-Loueslati, Wassim Y. Almawi
Summary: This study evaluated the involvement of common SHBG gene variants in ovarian cancer susceptibility and evolution. The results showed that SHBG rs9898876 was associated with a decreased risk of ovarian cancer, and could potentially serve as a diagnostic biomarker for ovarian cancer.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Nuozhou Liu, Ying Feng, Xinyao Luo, Xue Ma, Fang Ma
Summary: This study reveals an association between a proinflammatory diet and decreased levels of SHBG in women, particularly in premenopausal women.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Andrology
Bangbei Wan, Likui Lu, Cai Lv
Summary: The study aims to provide causal estimates of the connection between sex hormone-binding globulin and prostate cancer and investigate the mediating function of other modifiable risk indicators. The results support the potentially protective causal effect of sex hormone-binding globulin on prostate cancer with mediation by bioavailable testosterone. More research is needed to understand the mechanism of this link.
Article
Oncology
Justin C. Brown, Kathleen Sturgeon, David B. Sarwer, Andrea B. Troxel, Angela M. DeMichele, Crystal S. Denlinger, Kathryn H. Schmitz
Summary: Insufficient physical activity and obesity in breast cancer survivors are linked to an increased risk of cancer recurrence and death. However, this study found that exercise alone, diet alone, or exercise plus diet did not significantly change sex steroid hormone concentrations in postmenopausal breast cancer survivors who were insufficiently physically active and had overweight or obesity at week 52.
ENDOCRINE-RELATED CANCER
(2022)
Article
Clinical Neurology
Rob Molenberg, Chris H. L. Thio, Marlien W. Aalbers, Maarten Uyttenboogaart, Susanna C. Larsson, Mark K. Bakker, Ynte M. Ruigrok, Harold Snieder, J. Marc C. van Dijk
Summary: Using a 2-sample MR study, we found that genetic predisposition to elevated SHBG levels, with secondary lower BioT levels, is associated with an increased risk of aSAH in women.
Article
Endocrinology & Metabolism
Bingyan Xu, Wei Mo, Xiangliang Tan, Peizhen Zhang, Junlin Huang, Chensihan Huang, Dan Guo, Xueyun Wei, Yating Liu, Xuzhen Lei, Weijuan Dou, Jiayang Lin, Deying Liu, Linjie Yang, Yan Huang, Huijie Zhang, Yunfei Liao
Summary: This study found that lower levels of testosterone and free testosterone were associated with an increased risk of atrial fibrillation and bradyarrhythmia in men. Higher levels of free testosterone were associated with an increased risk of atrial fibrillation and ventricular arrhythmia. Higher SHBG concentrations were associated with an increased risk of atrial fibrillation, ventricular arrhythmia, and bradyarrhythmia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Bu B. Yeap, Ross J. Marriott, Leen Antonio, Yi X. Chan, Suchitra Raj, Girish Dwivedi, Christopher M. Reid, Bradley D. Anawalt, Shalender Bhasin, Adrian S. Dobs, Graeme J. Hankey, Alvin M. Matsumoto, Paul E. Norman, Terence W. O'Neill, Claes Ohlsson, Eric S. Orwoll, Dirk Vanderschueren, Gary A. Wittert, Frederick C. W. Wu, Kevin Murray
Summary: The study showed that lower serum testosterone levels were independently associated with higher all-cause and cancer-related mortality in middle-aged to older men, while lower SHBG levels were independently associated with lower all-cause, CVD-related, and cancer-related mortality. Confirmation of these associations and causality would require mechanistic studies and prospective trials.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Ke Xu, Yicheng Fu, Buzi Cao, Mingyi Zhao
Summary: This study aims to evaluate the association between sex hormones and sex hormone-binding globulin (SHBG) with bone mineral density (BMD) in adolescents. The results show differences in the association of sex hormones with BMD in boys and girls, where an appropriate increase in serum testosterone levels may be beneficial for skeletal development in girls and keeping estradiol levels below a certain level in boys may be considered.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Food Science & Technology
Laura Brianso-Llort, Olga Simo-Servat, Lorena Ramos-Perez, Javier Torres-Torronteras, Cristina Hernandez, Rafael Simo, David M. Selva
Summary: The study found that red wine rich in resveratrol can reduce total cholesterol in both men and women, and only increase SHBG levels in women, which may be beneficial for cardiovascular protection. Further research is needed to explore the potential enhancement of SHBG by resveratrol in cardiovascular protection between women and men.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Medicine, General & Internal
Haojie Zhang, Chi Chen, Xuan Zhang, Yuying Wang, Heng Wan, Yi Chen, Wen Zhang, Fangzhen Xia, Yingli Lu, Ningjian Wang
Summary: This study aimed to investigate the association between sex hormone-binding globulin (SHBG) and renal function in a community-based Chinese population. Lower levels of SHBG were significantly associated with lower estimated glomerular filtration rate (eGFR) and a higher prevalence of low eGFR in Chinese men, independent of demographics, lifestyle, metabolic-related risk factors, and testosterone.
CHINESE MEDICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Justin Harbs, Sabina Rinaldi, Pekka Keski-Rahkonen, Xijia Liu, Richard Palmqvist, Bethany Van Guelpen, Sophia Harlid
Summary: Endogenous sex hormones and DNA methylation have important roles in various diseases, but their interaction is largely unknown. This study investigated the associations between circulating sex hormones, sex hormone binding globulin (SHBG), and DNA methylation in blood samples from 77 men. The findings suggest a relationship between circulating sex hormones and DNA methylation, and several differentially methylated regions were associated with hormone-related genes and diseases.
Review
Andrology
Qiyou Wan, Yan Xie, Yuanzhong Zhou, Xubo Shen
Summary: Sex hormone-binding globulin, synthesised by hepatocytes, specifically binds and transports sex hormones to regulate their bioavailability, potentially leading to male reproductive system diseases and affecting men's quality of life.
Article
Biotechnology & Applied Microbiology
Jung Kwon Kim, Hak Jong Lee, Sung Il Hwang, Gheeyoung Choe, Sung Kyu Hong
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Urology & Nephrology
Myong Kim, Hoyoung Ryu, Hak Jong Lee, Sung Il Hwang, Gheeyoung Choe, Sung Kyu Hong
Summary: This study identified age, PSA density, prior biopsy history, and PI-RADS score as significant predictors for the absence of clinically significant prostate cancer in MRI fusion-targeted biopsies. Patients with low PSA density may safely evade MRIFTB, while those with high PSA density need to be more cautious.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Hwanik Kim, Jung Kwon Kim, Sung Kyu Hong, Chang Wook Jeong, Ja Hyeon Ku, Cheol Kwak
Summary: This study aimed to evaluate the role of multiparametric magnetic resonance imaging in Gleason score 3 + 4 prostate cancer and found that age, initial prebiopsy PSA level, and the presence of PI-RADS lesion >= 4 were independent predictors of Gleason score upgrading.
WORLD JOURNAL OF UROLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sung Kyu Hong, Hakmin Lee
Summary: Focused ultrasound (FUS) has evolved from whole-gland treatment to focal treatment for localized prostate cancer, aiming to ablate tumors while preserving normal prostate tissue. This new treatment technique ensures better preservation of urinary and erectile function for patients.
Article
Urology & Nephrology
Hwanik Kim, Sangchul Lee, Seok-Soo Byun, Sung Kyu Hong
Summary: Metastatic prostate cancer (mPCa) rarely occurs in individuals under 60 years old. This study found that younger mPCa patients have earlier biochemical recurrence and significantly reduced overall survival compared to older patients. Special caution is necessary when treating these younger mPCa patients.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Sang Hun Song, Eunae Kim, Eunjin Woo, Eunkyung Kwon, Sungroh Yoon, Jung Kwon Kim, Hakmin Lee, Jong Jin Oh, Sangchul Lee, Sung Kyu Hong, Seok-Soo Byun
Summary: An ethnic-specific polygenic risk score (PRS) was developed and validated in Korean males to predict susceptibility to clinically significant prostate cancer (csPCa). The selection of candidate SNPs and construction of PRS can serve as potential biomarkers to predict individual risk.
INVESTIGATIVE AND CLINICAL UROLOGY
(2022)
Article
Oncology
Hyungwoo Ahn, Sung Il Hwang, Taek Min Kim, Hak Jong Lee, Gheeyoung Choe, Sung Kyu Hong, Seok-Soo Byun, Hakmin Lee
Summary: This study evaluated the diagnostic performance of follow-up multiparametric MRI after high-intensity focused ultrasound (HIFU) for predicting recurrent prostate cancer and identified other clinical or radiological predictors. The post-HIFU MRIs of 110 patients who underwent follow-up biopsies were analyzed, and the likelihood of recurrence was assessed using a Likert scale. Results showed that high suspicion on post-HIFU MRI and a higher number of cancer-positive cores on initial biopsy were independent predictors of recurrence. Although the sensitivity of post-HIFU MRI was low, its high specificity suggests clinical significance, especially considering the possibility of sampling error in biopsies.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Urology & Nephrology
Sang Hun Song, Jin Hyuck Kim, Jung Kwon Kim, Jong Jin Oh, Sangchul Lee, Seong Jin Jeong, Seok-Soo Byun, Sung Kyu Hong, Hakmin Lee
Summary: This study evaluated the use of retrograde bladder filling method after transurethral prostatectomy and found it to be a safe and effective method that can shorten time to void and time to discharge.
INVESTIGATIVE AND CLINICAL UROLOGY
(2022)
Article
Urology & Nephrology
Changhee Ye, Jin-Nyoung Ho, Dan Hyo Kim, Sang Hun Song, Hwanik Kim, Hakmin Lee, Seong Jin Jeong, Sung Kyu Hong, Seok-Soo Byun, Hyungwoo Ahn, Sung Hwang, Hak Jong Lee, Sangchul Lee
Summary: This study evaluated the effectiveness of PHI and mpMRI in predicting prostate cancer and clinically significant prostate cancer. The results showed that combining PHI and mpMRI provides the most accurate prediction of both types of prostate cancer. In the absence of mpMRI, PHI is superior to PSA alone as a predictor of prostate cancer, and adding PHI to PSA can increase the detection rate of both prostate cancer and clinically significant prostate cancer.
INVESTIGATIVE AND CLINICAL UROLOGY
(2022)
Article
Urology & Nephrology
Gyoohwan Jung, Jung Kwon Kim, Hasung Kim, Jungkuk Lee, Sung Kyu Hong
Summary: By retrospectively investigating the database of the National Health Insurance Service, this study found that prostatitis is associated with an increased incidence of prostate cancer, and acute prostatitis carries a higher risk compared to chronic prostatitis.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Andrology
Myong Kim, Seok-Soo Byun, Sung Kyu Hong
Summary: The systematic review suggests that compared to TRT-untreated patients, TRT-treated patients may not have increased risks for disease progression in prostate cancer. However, the quality of current evidence is extremely poor. TRT may be harmful in men with advanced disease burden, in those with untreated prostate cancer undergoing AS, and in those with successfully treated prostate cancer but having high-risk disease.
WORLD JOURNAL OF MENS HEALTH
(2021)
Review
Urology & Nephrology
Jeong Hyun Kim, Sung Kyu Hong
Summary: Although PSA testing for prostate cancer screening has limitations, it still plays an important role in reducing disease-specific mortality. Novel biomarkers have shown potential in aiding patient selection for biopsy and identifying men at risk for clinically significant prostate cancer. Further validation and research are needed to determine the clinical utility and commercial availability of these biomarkers.
INVESTIGATIVE AND CLINICAL UROLOGY
(2021)
Article
Urology & Nephrology
Sang Hun Song, Jung Kwon Kim, Hakmin Lee, Sangchul Lee, Sung Kyu Hong, Seok Soo Byun
Summary: Active surveillance (AS) is a feasible option for low-risk prostate cancer patients, with a small portion ultimately discontinuing surveillance for various reasons. In carefully selected patients, AS is still able to significantly reduce biochemical recurrence rates. Further larger prospective studies are necessary to determine optimal criteria for AS, especially in Korean prostate cancer patients.
INVESTIGATIVE AND CLINICAL UROLOGY
(2021)
Article
Urology & Nephrology
Duc Minh Pham, Jung Kwon Kim, Sangchul Lee, Sung Kyu Hong, Seok-Soo Byun, Sang Eun Lee
INVESTIGATIVE AND CLINICAL UROLOGY
(2020)
Article
Urology & Nephrology
Jae Young Park, Bum Sik Tae, Chorok Wook Jeong, Cheryn Song, Seong Il Seo, Sung Kyu Hong, Jinsoo Chung, Sang-Hoo Hong, Eu Chang Hwang, Cheol Kwak, Ill Young Seo, Suyeon Park, Chanwang Park
INVESTIGATIVE AND CLINICAL UROLOGY
(2020)