An understanding of intervertebral disc development, maturation and cell phenotype provides clues to direct cell-based tissue regeneration therapies for disc degeneration

Identification of novel nucleus pulposus markers

(2013) R. Rodrigues-Pinto et al.   Bone & Joint Research

A systematic review of the global prevalence of low back pain

(2012) Damian Hoy et al.   ARTHRITIS AND RHEUMATISM

Bi-Directional Exchange of Membrane Components Occurs during Co-Culture of Mesenchymal Stem Cells and Nucleus Pulposus Cells

(2012) Sandra Strassburg et al.   PLoS One

Changes in the Molecular Phenotype of Nucleus Pulposus Cells with Intervertebral Disc Aging

(2012) Xinyan Tang et al.   PLoS One

Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc

(2012) Daisuke Sakai et al.   Nature Communications

Gastrulation: Making and Shaping Germ Layers

(2011) Lila Solnica-Krezel et al.   Annual Review of Cell and Developmental Biology

Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development

(2011) M. R. McCann et al.   Disease Models & Mechanisms

Calcification in human intervertebral disc degeneration and scoliosis

(2011) Gergana I. Hristova et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Non-specific low back pain

(2011) Federico Balagué et al.   LANCET

Adjacent Level Disk Disease—Is it Really a Fusion Disease?

(2011) Teija Lund et al.   ORTHOPEDIC CLINICS OF NORTH AMERICA

Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration

(2011) W Erwin et al.   ARTHRITIS RESEARCH & THERAPY

Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation

(2010) Ben M. Minogue et al.   ARTHRITIS AND RHEUMATISM

Epithelial to mesenchymal transition during gastrulation: An embryological view

(2010) Yukiko Nakaya et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Toward an understanding of the role of notochordal cells in the adult intervertebral disc: From discord to accord

(2010) Makarand V. Risbud et al.   DEVELOPMENTAL DYNAMICS

Immunohistochemical identification of notochordal markers in cells in the aging human lumbar intervertebral disc

(2010) Christoph Weiler et al.   EUROPEAN SPINE JOURNAL

Interleukin-17 synergizes with IFNγ or TNFα to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells

(2010) Mostafa A. Gabr et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Isolation and Characterization of Mesenchymal Stromal Cells From Human Degenerated Nucleus Pulposus

(2010) Juan F. Blanco et al.   SPINE

ISSLS Prize Winner: A Study of Effects of In Vivo Mechanical Forces on Human Lumbar Discs With Scoliotic Disc as a Biological Model

(2010) S. Rajasekaran et al.   SPINE

Differential expression level of cytokeratin 8 in cells of the bovine nucleus pulposus complicates the search for specific intervertebral disc cell markers

(2010) Audrey Gilson et al.   ARTHRITIS RESEARCH & THERAPY

Expression of semaphorin 3A and its receptors in the human intervertebral disc: potential role in regulating neural ingrowth in the degenerate intervertebral disc

(2010) Sotonye K Tolofari et al.   ARTHRITIS RESEARCH & THERAPY

Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes

(2010) Ben M Minogue et al.   ARTHRITIS RESEARCH & THERAPY

Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration

(2009) Aneta J. Pockert et al.   ARTHRITIS AND RHEUMATISM

Notochordal intervertebral disc cells: Sensitivity to nutrient deprivation

(2009) Thorsten Guehring et al.   ARTHRITIS AND RHEUMATISM

Expression of Laminin Isoforms, Receptors, and Binding Proteins Unique to Nucleus Pulposus Cells of Immature Intervertebral Disc

(2009) Jun Chen et al.   CONNECTIVE TISSUE RESEARCH

Sensitivity of notochordal disc cells to mechanical loading: an experimental animal study

(2009) Thorsten Guehring et al.   EUROPEAN SPINE JOURNAL

Injury-induced sequential transformation of notochordal nucleus pulposus to chondrogenic and fibrocartilaginous phenotype in the mouse

(2009) Fan Yang et al.   JOURNAL OF PATHOLOGY

Variations in gene and protein expression in human nucleus pulposus in comparison with annulus fibrosus and cartilage cells: potential associations with aging and degeneration

(2009) J. Rutges et al.   OSTEOARTHRITIS AND CARTILAGE

Development of the vertebrate central nervous system: formation of the neural tube

(2009) Nicholas D. E. Greene et al.   PRENATAL DIAGNOSIS

Association of a Single Nucleotide Polymorphism in the Insulin-Like Growth Factor-1 Receptor Gene With Spinal Disc Degeneration in Postmenopausal Japanese Women

(2009) Tomohiko Urano et al.   SPINE

Transplantation of Human Mesenchymal Stems Cells Into Intervertebral Discs in a Xenogeneic Porcine Model

(2009) Helena B. Henriksson et al.   SPINE

Differential Phenotype of Intervertebral Disc Cells

(2009) Daisuke Sakai et al.   SPINE

2009 ISSLS Prize Winner: Does Discography Cause Accelerated Progression of Degeneration Changes in the Lumbar Disc

(2009) Eugene J. Carragee et al.   SPINE

Identification of Cell Proliferation Zones, Progenitor Cells and a Potential Stem Cell Niche in the Intervertebral Disc Region

(2009) Helena B. Henriksson et al.   SPINE

Prevalence and Pattern of Lumbar Magnetic Resonance Imaging Changes in a Population Study of One Thousand Forty-Three Individuals

(2009) Kenneth M. C. Cheung et al.   SPINE

A Phenotypic Comparison of Proteoglycan Production of Intervertebral Disc Cells Isolated from Rats, Rabbits, and Bovine Tails; Which Animal Model is Most Suitable to Study Tissue Engineering and Biological Repair of Human Disc Disorders?

(2009) Tsuyoshi Miyazaki et al.   TISSUE ENGINEERING PART A

Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc

(2009) Stephen M Richardson et al.   ARTHRITIS RESEARCH & THERAPY

Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: Implications for disk degeneration and chordoma formation

(2008) Kyung-Suk Choi et al.   DEVELOPMENTAL DYNAMICS

Cell transplantation in lumbar spine disc degeneration disease

(2008) C. Hohaus et al.   EUROPEAN SPINE JOURNAL

Expenditures and Health Status Among Adults With Back and Neck Problems

(2008) Brook I. Martin   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

TNF-Alpha in Nucleus Pulposus Induces Sensory Nerve Growth

(2008) Shinu Hayashi et al.   SPINE

Notochordal cells stimulate migration of cartilage end plate chondrocytes of the intervertebral disc in in vitro cell migration assays

(2008) Ki-Won Kim et al.   Spine Journal

The Notochord, Notochordal cell and CTGF/CCN-2: ongoing activity from development through maturation

(2008) W. Mark Erwin   Journal of Cell Communication and Signaling

Human mesenchymal stem cell differentiation to NP-like cells in chitosan–glycerophosphate hydrogels

(2007) Stephen M. Richardson et al.   BIOMATERIALS