Journal
EUROPEAN SPINE JOURNAL
Volume 24, Issue 2, Pages 227-233Publisher
SPRINGER
DOI: 10.1007/s00586-014-3701-4
Keywords
Scoliosis; Vestibular System; Adolescent idiopathic scoliosis; Labyrinth; Vestibular
Categories
Funding
- department of Neurosurgery at Washington University
- department of Otolaryngology at Washington University
- NIH [T32NS007205]
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Despite its high prevalence, the etiology underlying idiopathic scoliosis remains unclear. Although initial scrutiny has focused on genetic, biochemical, biomechanical, nutritional and congenital causes, there is growing evidence that aberrations in the vestibular system may play a role in the etiology of scoliosis. In this article, we discuss putative mechanisms for adolescent idiopathic scoliosis and review the current evidence supporting a role for the vestibular system in adolescent idiopathic scoliosis. A comprehensive search of the English literature was performed using PubMed Research articles studying interactions between adolescent idiopathic scoliosis and the vestibular system were selected and evaluated for inclusion in a literature review. Eighteen manuscripts of level 3-4 clinical evidence to support an association between adolescent idiopathic scoliosis (AIS) and dysfunction of the vestibular system were identified. These studies include data from physiologic and morphologic studies in humans. Clinical data are supported by animal model studies to suggest a causative link between the vestibular system and AIS. Clinical data and a limited number of animal model studies suggest a causative role of the vestibular system in AIS, although this association has not been reproduced in all studies.
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