Article
Health Care Sciences & Services
Suncica Kapor, Milica Vukotic, Tijana Suboticki, Dragoslava Dikic, Olivera Mitrovic Ajtic, Milica Radojkovic, Vladan P. Cokic, Juan F. Santibanez
Summary: The study found that HU inhibits the growth of BMMSC, causing senescence-like changes and affecting cellular differentiation and immunoregulatory functions.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cell & Tissue Engineering
Jeroen van de Peppel, Gerben J. Schaaf, Adriana Arruda Matos, Yuan Guo, Tanja Strini, Wenda Verschoor, Amel Dudakovic, Andre J. van Wijnen, Johannes P. T. M. van Leeuwen
Summary: This research suggests that the cell surface glycoprotein CD24 could serve as a selective biomarker for identifying subpopulations of BMSCs with varying osteogenic potential. CD24(pos) cells have increased expression of genes related to cell adhesion, motility, and extracellular matrix, while also showing reduced proliferation compared to CD24(neg) cells.
STEM CELLS AND DEVELOPMENT
(2021)
Article
Cell Biology
Domenico Aprile, Nicola Alessio, Ibrahim H. Demirsoy, Tiziana Squillaro, Gianfranco Peluso, Giovanni Di Bernardo, Umberto Galderisi
Summary: The study demonstrated that multi-lineage stem cells can be isolated from a mouse model, offering a valid alternative for disease research and cell therapy, and showing potential applications for these cells.
Article
Biochemistry & Molecular Biology
Hyun Hee Jang, Youngsook Son, Gabee Park, Ki-Sook Park
Summary: This study demonstrates that bone marrow-derived mesenchymal stem cells (MSCs) have vasculogenic properties. Different populations of MSCs vary in angiogenic factor expression and vasculogenic properties. The vasculogenic MSCs (vMSCs), distinct from endothelial progenitor cells (EPCs), may contribute to neovascularization and could be a promising cellular therapy for cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Orthopedics
Christina Holmes, Wataru Ishida, Alexander Perdomo-Pantoja, Benjamin D. Elder, Ethan Cottrill, John Locke, Timothy F. Witham
Summary: The study compared the efficacy of ASCs and BMCs for successful fusion in a rat lumbar fusion model. Results showed that rASCs yielded the largest fusion masses, although statistically comparable to rBMCs. The in vitro osteogenic differentiation capacities of P2 rASCs and rBMCs were similar.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Cell Biology
Juan C. Henao, Adriana Grismaldo, Alfonso Barreto, Viviana M. Rodriguez-Pardo, Claudia Camila Mejia-Cruz, Efrain Leal-Garcia, Rafael Perez-Nunez, Patricio Rojas, Ramon Latorre, Ingrid Carvacho, Yolima P. Torres
Summary: The study demonstrates that TRPM8 channels are expressed in human bone marrow MSCs and are involved in osteogenic differentiation, with agonists promoting osteogenic differentiation and antagonists leading to a decrease in osteogenic differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Fei Xiao, Jianping Peng, Yang Li, Xing Zhou, Ding Ma, Liming Dai, Jie Yuan, Xiaodong Chen, Chuandong Wang
Summary: This study investigated the cellular senescence mechanism of BMSCs and identified the expression changes of small noncoding RNAs during the senescence process, providing potential clues for developing new targeting senescence strategies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yongbo Li, Zhe Tan, Jixiang Zhang, Junhan Mu, Han Wu
Summary: In this study, nano-deer bone meal was successfully prepared and found to have a higher Ca/P ratio and enriched beneficial trace elements compared to cow bone. The nano-deer bone meal showed good biocompatibility and met the standards of medical biomaterials. Cell function studies demonstrated its excellent performance in the proliferation and differentiation of bone marrow mesenchymal stem cells. These findings suggest the potential use of nano-deer bone meal as an active nanomaterial in bone tissue engineering.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Andrea Sorrentino, Emil Malucelli, Francesca Rossi, Concettina Cappadone, Giovanna Farruggia, Claudia Moscheni, Ana J. Perez-Berna, Jose Javier Conesa, Chiara Colletti, Norberto Roveri, Eva Pereiro, Stefano Iotti
Summary: Biomineralization is the process by which living organisms generate organized mineral crystals, especially in human cells the mechanism and propagation of the mineral remain largely unexplained and controversial. This study provides insight into the calcium depositions in human bone mesenchymal stem cells, suggesting a potentially redefined model for biomineralization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Min Wang, Tianming Dai, Qingqi Meng, Wen Wang, Siming Li
Summary: This study aimed to investigate the regulatory effects of miR-28 on osteogenic differentiation of hBMMSCs. It was found that miR-28 could inhibit STAT1 expression, upregulate AKP and RUNX2 expression, and promote osteogenic differentiation.
Article
Biochemistry & Molecular Biology
Szu-Hsien Wu, Yu-Ting Liao, Chi-Han Huang, Yi-Chou Chen, En-Rung Chiang, Jung-Pan Wang
Summary: ADSCs tend to spontaneously differentiate into neuron-like cells during high confluence culture, with enhanced expression of neuronal markers and neurotrophins, while BMSCs do not show this tendency. Additionally, ADSCs do not exhibit spontaneous adipogenic and osteogenic differentiation during this process.
Article
Biochemistry & Molecular Biology
Zahra Eydian, Alaleh Mohammad Ghasemi, Samira Ansari, Ali Naghi Kamali, Maryam Khosravi, Sima Momtaz, Sanaz Riki, Laleh Rafighdoost, Reza Entezari Heravi
Summary: This study demonstrates the differentiation of mesenchymal stem cells (MSCs) from human adipose tissue and bone marrow into functional beta-islet cells. It suggests that adipose stem cells may be a better choice for the treatment of diabetes mellitus due to their higher potency.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Multidisciplinary Sciences
Thomas H. Ambrosi, Owen Marecic, Adrian McArdle, Rahul Sinha, Gunsagar S. Gulati, Xinming Tong, Yuting Wang, Holly M. Steininger, Malachia Y. Hoover, Lauren S. Koepke, Matthew P. Murphy, Jan Sokol, Eun Young Seo, Ruth Tevlin, Michael Lopez, Rachel E. Brewer, Shamik Mascharak, Laura Lu, Oyinkansola Ajanaku, Stephanie D. Conley, Jun Seita, Maurizio Morri, Norma F. Neff, Debashis Sahoo, Fan Yang, Irving L. Weissman, Michael T. Longaker, Charles K. F. Chan
Summary: Aging of skeletal stem cells in mice alters bone marrow signaling and differentiation of bone and blood lineages, resulting in fragile bones with poor regeneration. Aged SSCs have decreased bone-forming potential but produce more stromal lineages expressing pro-inflammatory cytokines, contributing to bone marrow niche transformation.
Article
Agriculture, Dairy & Animal Science
Young-Bum Son, Yeon Ik Jeong, Yeon Woo Jeong, Mohammad Shamim Hossein, Per Olof Olsson, Alex Tinson, Kuhad Kuldip Singh, Sang-Yun Lee, Woo Suk Hwang
Summary: This study demonstrates the differentiation potential into chondrocytes of mesenchymal stem cells (MSCs) from bone marrow (BM) and synovial fluid (SF) of the same donor Camelus dromedarius. SF-MSCs showed higher chondrogenic capacity and may serve as a potential source for treating camel chondrocyte-related issues. This is the first study to establish and compare BM-MSCs and SF-MSCs from the same camel donor, providing insight into their differentiation potential in camel regenerative medicine.
Article
Biochemistry & Molecular Biology
Araceli Aparecida Hastreiter, Guilherme G. dos Santos, Edson Naoto Makiyama, Ed Wilson Cavalcante Santos, Primavera Borelli, Ricardo Ambrosio Fock
Summary: Protein malnutrition alters the synthesis of specific growth factors and cytokines by mesenchymal stem cells, leading to the impairment of hematopoietic stem cells and hematopoietic progenitors. This study demonstrates for the first time the role of mesenchymal stem cells in regulating hematopoietic cells under protein malnutrition conditions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Pathology
Giovanni Barbanti Brodano, Cristiana Griffoni, Giancarlo Facchini, Elisa Carretta, Francesca Salamanna, Rohan Gala, Giuseppe Tedesco, Gisberto Evangelisti, Silvia Terzi, Riccardo Ghermandi, Stefano Bandiera, Marco Girolami, Valerio Pipola, Milena Fini, Alessandro Gasbarrini
Summary: The retrospective analysis of 14 patients treated with bone marrow concentrated (BMC) injection for aneurysmal bone cyst (ABC) of the spine showed that BMC injection can promote ossification of the cyst and improve clinical outcomes. The study emphasized the importance of BMC as a valid alternative for spinal ABC management.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Obstetrics & Gynecology
Luca Gianaroli, Anna Pia Ferraretti, Davide Perruzza, Gaia Terzuoli, Silvia Azzena, Andor Crippa, Aneta Dworakowska, Carla Tabanelli, M. Cristina Magli
Summary: This study found that the efficacy of imported vitrified oocytes is influenced by the cryobank of origin. Medical centers should evaluate results and take necessary measures to maximize treatment efficacy when collaborating with oocyte cryobanks.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Luca Gianaroli, Amerigo Vitagliano, Anna P. Ferraretti, Silvia Azzena, Gaia Terzuoli, Davide Perruzza, Guido Ambrosini, Carla Tabanelli, M. Cristina Magli
Summary: This study investigated the effectiveness and safety of a mild ovarian stimulation program called IVF Lite in good prognosis patients. The results showed that the program was effective and safe for patients with a good response to clomiphene citrate stimulation, and two-thirds of the patients achieved a live birth at the completion of the program.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Clinical Neurology
Giovanni Barbanti Brodano, Eleonora Pesce, Cristiana Griffoni, Elisa Carretta, Luigi Emanuele Noli, Costantino Errani, Federica Trentin, Martina Piccinni Leopardi, Loredana Mavilla, Alessandro Gasbarrini
Summary: This study aimed to translate and validate the Italian version of the Spine Oncology Study Group Outcome Questionnaire (SOSGOQ), a specific tool for measuring health-related quality of life in Italian-speaking patients with spinal metastases. The results of the study showed that the Italian version of the SOSGOQ had high reliability and validity among Italian-speaking patients affected by spinal metastases.
GLOBAL SPINE JOURNAL
(2023)
Article
Obstetrics & Gynecology
M. Cristina Magli, Andor Crippa, Davide Perruzza, Silvia Azzena, Serena Graziosi, Francesco Coppola, Carla Tabanelli, Anna P. Ferraretti, Luca Gianaroli
Summary: Selecting sperm cells with birefringence properties under polarized light is a successful strategy to identify viable spermatozoa. This approach improves fertilization, embryo development, and implantation rates compared to non-birefringent cells, leading to higher cumulative live birth rates.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Obstetrics & Gynecology
L. Gianaroli, D. Perruzza, C. Albanese, S. Azzena, C. Tabanelli, Anna P. Ferraretti, M. Cristina Magli
Summary: This study found that the presence of DNA in the blastocoel fluid (BF) of expanded blastocysts, assessed by whole genome amplification (WGA), is associated with the clinical outcome at the first transfer. Blastocysts with negative BF-WGA have a higher chance of implanting and developing to term compared to those with positive BF-WGA, in both preimplantation genetic testing for aneuploidies (PGT-A) cycles and in IVF/ICSI conventional cycles.
HUMAN REPRODUCTION
(2023)
Article
Medicine, General & Internal
Silvia Terzi, Federica Trentin, Cristiana Griffoni, Elisa Carretta, Stefano Bandiera, Cristina Ferrari, Fabio Vita, Alberto Righi, Margherita Maioli, Dario De Biase, Annalisa Monetta, Giovanni Barbanti Brodano, Gisberto Evangelisti, Marco Girolami, Valerio Pipola, Marco Gambarotti, Alessandro Gasbarrini
Summary: This retrospective study aimed to evaluate the overall survival of surgically treated patients with lung cancer spinal metastases and identify factors associated with better survival. The results showed that surgical treatment can improve the quality of life and control pain, thereby enhancing autonomy.
Article
Obstetrics & Gynecology
P. Verdyck, G. Altarescu, S. Santos-Ribeiro, C. Vrettou, U. Koehler, G. Griesinger, V Goossens, C. Magli, C. Albanese, M. Parriego, L. Coll, R. Ron-El, K. Sermon, J. Traeger-Synodinos
Summary: The study found that known chromosome segregation errors accounted for 90.4% of abnormal chromosome copy numbers in polar bodies of oocytes from women of advanced maternal age. These errors were associated with impaired embryo development.
HUMAN REPRODUCTION
(2023)
Letter
Obstetrics & Gynecology
L. Gianaroli, D. Perruzza, C. Albanese, S. Azzena, C. Tabanelli, A. P. Ferraretti, M. C. Magli
HUMAN REPRODUCTION
(2023)
Article
Biochemistry & Molecular Biology
Francesca Salamanna, Deyanira Contartese, Veronica Borsari, Stefania Pagani, Maria Sartori, Matilde Tschon, Cristiana Griffoni, Gianluca Giavaresi, Giuseppe Tedesco, Giovanni Barbanti Brodano, Alessandro Gasbarrini, Milena Fini
Summary: Recently, our group studied the use of vertebral bone marrow (vBMA) clot as a cell therapy for spinal fusion. We compared the properties of vBMA clots and derived vertebral mesenchymal stem cells (MSCs) from female and male patients who underwent spinal fusion procedures and received vBMA clot treatment. The results showed that vBMA clots and MSCs from males had higher expression of growth factors (GFs) and greater osteogenic and chondrogenic potential compared to females. The findings also revealed differences in the gene expression profiles of MSCs derived from vBMA clots between female and male donors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Riccardo Ghermandi, Giovanni Tosini, Alberto Lorenzi, Cristiana Griffoni, Luigi La Barbera, Marco Girolami, Valerio Pipola, Giovanni Barbanti Brodano, Stefano Bandiera, Silvia Terzi, Giuseppe Tedesco, Gisberto Evangelisti, Annalisa Monetta, Luigi Emanuele Noli, Luigi Falzetti, Alessandro Gasbarrini
Summary: CFR-PEEK is increasingly popular in spinal oncological applications due to its advantages over titanium. In this study, CFR-PEEK instrumentation was used to treat lumbar degenerative diseases (DDs). The results showed high fusion rates and significant improvement in clinical outcomes. Carbon fiber implants were well-tolerated and had no mechanical complications. This pilot study supports the efficacy and safety of CFR-PEEK implants in spinal degenerative diseases.
BIOENGINEERING-BASEL
(2023)
Article
Obstetrics & Gynecology
Christian De Geyter, Carlos Calhaz-Jorge, Veerle Goossens, Cristina M. Magli, Jesper Smeenk, Kristina Vesela, Nathalie Vermeulen, Christine Wyns
Summary: More than 20 years ago, the European IVF Monitoring initiative began surveying activities in medically assisted reproduction (MAR) and issuing annual reports. These reports have contributed to the transparency and surveillance of reproductive care. Changes in treatment modalities and the introduction of new technologies necessitate a shift towards cumulative outcome results and a data registry for MAR activities. The EuMAR project aims to establish a transnational registry for prospective cycle-by-cycle MAR and fertility preservation data, funded by the European Union.
HUMAN REPRODUCTION OPEN
(2023)
Article
Oncology
Stefano Bandiera, Luigi Emanuele Noli, Cristiana Griffoni, Giovanni Tosini, Elisa Carretta, Stefano Pasini, Eleonora Pesce, Alfio Damiano Ruinato, Giovanni Barbanti Brodano, Giuseppe Tedesco, Marco Girolami, Silvia Terzi, Riccardo Ghermandi, Gisberto Evangelisti, Valerio Pipola, Alessandro Gasbarrini
Summary: En bloc resection is a surgical technique that improves survival and reduces recurrence rate, but carries a high risk of complications. This study found that although complications were common, they did not affect overall survival.
Meeting Abstract
Obstetrics & Gynecology
C. Albanese, M. C. Magli, D. Perruzza, G. Terzuoli, S. Azzena, A. Crippa, C. Tabanelli, L. Gianaroli
HUMAN REPRODUCTION
(2022)
