Article
Medicine, General & Internal
Masaaki Machino, Hiroaki Nakashima, Keigo Ito, Kei Ando, Sadayuki Ito, Fumihiko Kato, Shiro Imagama
Summary: This study found that occupation and type of labor may have no effect on intervertebral disc degeneration (IDD) in the cervical spine, based on the results of cervical spine MRI scans in a cohort of healthy individuals.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Eduard Bezuglov, Artemii Lazarev, Arseniy Petrov, Alesia Brodskaia, Anastasiya Lyubushkina, Kamila Kubacheva, Evgeny Achkasov, Vladimir Nikolenko
Summary: Elite professional soccer players have a high prevalence of asymptomatic degenerative lumbar spinal changes, which are significantly associated with age. The most common pathologic condition was disc desiccation. Age was found to be associated with degenerative changes, while weight and body mass index did not show any association.
Article
Clinical Neurology
Xinhua Liu, Lixia Jin, Chang Jiang, Xiaoxing Jiang, Zixian Chen, Yuanwu Cao
Summary: This study observed cervical intervertebral discs in asymptomatic subjects and found that disc degeneration is correlated with age, gender, BMI, and cervical alignment. Early intervention of related factors may help delay disc degeneration and prevent future neck and shoulder pain.
EUROPEAN SPINE JOURNAL
(2023)
Article
Clinical Neurology
Mohamed Kamal Mesregah, Michael Repajic, Paul Mgbam, Zoe Fresquez, Jeffrey C. Wang, Zorica Buser
Summary: This study evaluated the trends and patterns of cervical degenerative disc disease in different age groups of symptomatic patients. The results showed that the number and severity of degenerated intervertebral discs increased significantly with age.
EUROPEAN SPINE JOURNAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marcus Raudner, Markus M. Schreiner, Tom Hilbert, Tobias Kober, Michael Weber, Anna Szelenyi, Reinhard Windhager, Vladimir Juras, Siegfried Trattnig
Summary: The study evaluated GRAPPATINI, an accelerated T-2 mapping sequence that combines undersampling and model-based reconstruction to facilitate clinical implementation of T-2 mapping of the lumbar intervertebral disc. Results showed that T2 values obtained using GRAPPATINI were significantly different for normal discs compared to bulging or herniated discs, as well as discs with and without annular tears. The study concluded that GRAPPATINI can be used as a quantitative imaging biomarker to detect disc pathologies while significantly reducing acquisition time.
EUROPEAN RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Luis Becker, Lukas Schoennagel, Tim Victor Mihalache, Henryk Haffer, Friederike Schoemig, Hendrik Schmidt, Matthias Pumberger
Summary: Patients with LSTV exhibit reduced range of motion in the transitional segment and significantly increased motion distribution to the cranial adjacent segment in flexion-extension radiographs. These findings may explain the higher rates of degeneration within the segment.
Article
Multidisciplinary Sciences
Yasmina Al Khalil, Edoardo A. Becherucci, Jan S. Kirschke, Dimitrios C. Karampinos, Marcel Breeuwer, Thomas Baum, Nico Sollmann
Summary: MRI is widely used for diagnosing and monitoring spinal disorders. Manual segmentation of examined structures is time-consuming and prone to errors. This study presents a manually segmented lumbar spine MRI database for developing and testing automated lumbar spine segmentation algorithms in multi-domain scenarios.
Article
Clinical Neurology
Yu Wang, Guoliang Chen, Jiajin Lin, Weicheng Huang, Jing Wang, Honglin Teng
Summary: This study showed a significant correlation between FT and subaxial cervical disc herniation, with greater facet angle differences and FT incidence in the herniation group compared to control groups. However, the severity of cervical disc degeneration was not associated with FT.
Article
Clinical Neurology
Anni Aavikko, Martina Lohman, Leena Ristolainen, Hannu Kautiainen, Kalevi Osterman, Dietrich Schlenzka, Teija Lund
Summary: This study investigated the development of lumbar intervertebral discs from childhood to adulthood and explored the association between disc degeneration and low back pain. The results showed that subjects with low back pain at age 34 had more extensive or severe disc degeneration at age 18 compared to those without low back pain.
EUROPEAN SPINE JOURNAL
(2022)
Article
Orthopedics
Garrett K. Harada, Youping Tao, Philip K. Louie, Bryce A. Basques, Fabio Galbusera, Frank Niemeyer, Hans-Joachim Wilke, Edward Goldberg, Howard S. An, Dino Samartzis
Summary: Degenerative spine imaging findings in the cervical region were analyzed in patients undergoing anterior cervical discectomy and fusion. Various imaging phenotypes were associated with patient-reported outcomes and adjacent segment degeneration/disease. The Cervical Phenotype Index was found to be a significant predictor of postoperative symptoms and degeneration, indicating its potential clinical relevance in prognosticating outcomes after surgery.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Clinical Neurology
Noah B. Bonnheim, Ann A. Lazar, Anika Kumar, Zehra Akkaya, Jiamin Zhou, Xiaojie Guo, Conor O'Neill, Thomas M. Link, Jeffrey C. Lotz, Roland Krug, Aaron J. Fields
Summary: The study aimed to distinguish degenerative changes associated with chronic low back pain (cLBP) from normal aging using imaging biomarkers of disc biochemical composition. The results showed that cLBP patients had lower T1 rho values in the nucleus pulposus, especially at the L5-S1 level, which decreased with age. Therefore, the NP-T1 rho values at L5-S1 are highly relevant to clinical phenotyping, especially in younger individuals.
EUROPEAN SPINE JOURNAL
(2023)
Review
Biotechnology & Applied Microbiology
Ian J. Wellington, Cameron Kia, Ergin Coskun, Barrett B. Torre, Christopher L. Antonacci, Michael R. Mancini, John P. Connors, Sean M. Esmende, Heeren S. Makanji
Summary: While traditional fusion-based procedures have been commonly used to treat spinal disc pathology, there is growing interest in motion-preserving disc arthroplasties. These arthroplasties aim to avoid drawbacks associated with fusion, such as loss of motion and increased risks of adjacent segment disease. Recent advances in implant design and technology have shown promising outcomes, leading to increased utilization of disc arthroplasty. However, this procedure is not without risks, and efforts are being made to develop improved implant designs to minimize adverse outcomes.
BIOENGINEERING-BASEL
(2022)
Article
Orthopedics
A. P. Goode, R. J. Cleveland, V. B. Kraus, K. A. Taylor, S. Z. George, T. A. Schwartz, J. Renner, J. L. Huebner, J. M. Jordan, Y. M. Golightly
Summary: This study investigates the association between baseline biomarkers and longitudinal changes in disc space narrowing, vertebral osteophytes, and low back pain. The findings suggest that markers of inflammation and perceived pressure pain sensitivity are associated with the longitudinal worsening of low back pain.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Orthopedics
Xiaolong Chen, Dong Xue, Peng Cui, Ying Zhao, Shibao Lu
Summary: This study provides the first evidence that severe periodontitis is associated with a higher occurrence rate of disc structural failures and poor clinical outcomes in patients with cervical degenerative disorders.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Clinical Neurology
Masaaki Machino, Hiroaki Nakashima, Keigo Ito, Kei Ando, Sadayuki Ito, Fumihiko Kato, Shiro Imagama
Summary: The aim of this study was to investigate the age-related changes and gender-specific differences in cervical disc degeneration and to examine the correlation between the severity of cervical disc degeneration and mobility. The study found that cervical disc degeneration progresses with age and is greater in males compared to females. Furthermore, the severity of disc degeneration is negatively correlated with cervical range of motion.
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
