Review
Medicine, General & Internal
Wenqiao Wang, Weimin Huang, Xiuchun Yu, Lei Wang, Xiaoduo Xu
Summary: This study aims to systematically review, analyze, and discuss the probability of disc rehydration by Dynamic Stabilization Systems (DSS) designed for the treatment of lumbar degenerative disease (LDD). The results show that DSS may promote disc rehydration and delay the development of LDD to some extent. This provides important evidence for the clinical application of DSS.
Article
Engineering, Biomedical
Wei Fan, Chi Zhang, Dong-Xiang Zhang, Li-Xin Guo, Ming Zhang
Summary: This study aimed to compare the effects of two commonly used nonfusion posterior dynamic stabilization (NPDS) devices, PSDS and IPS, on the biomechanics of the implanted lumbar spine under static and vibration loadings. The results showed that the nonfusion models had higher range of motion (ROM) at L4-L5 level compared to the rigid fusion model, but lower ROM at adjacent levels. Additionally, there were biomechanical differences between the Bioflex and DIAM systems.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Li He, Zhai Liu, Chunying Liu, Zhimei Gao, Qingyun Ren, Licun Lei, Jialiang Ren
Summary: This study aimed to explore a lumbar spine MRI-based radiomics model for detecting osteoporosis, successfully establishing classification models for normal, osteopenia, and osteoporosis. The results showed potential value for the radiomic models based on lumbar spine MRI in osteoporosis detection.
ACADEMIC RADIOLOGY
(2021)
Article
Clinical Neurology
Anna-Katharina Calek, Jonas Widmer, Marie-Rosa Fasser, Mazda Farshad
Summary: The study tested two different synthetic lumbar vertebral stabilization techniques for use after unilateral total facetectomy. The results showed that both techniques reduced the range of motion after surgery.
Article
Multidisciplinary Sciences
Yasmina Al Khalil, Edoardo A. Becherucci, Jan S. Kirschke, Dimitrios C. Karampinos, Marcel Breeuwer, Thomas Baum, Nico Sollmann
Summary: MRI is widely used for diagnosing and monitoring spinal disorders. Manual segmentation of examined structures is time-consuming and prone to errors. This study presents a manually segmented lumbar spine MRI database for developing and testing automated lumbar spine segmentation algorithms in multi-domain scenarios.
Article
Clinical Neurology
Chen Zhao, Liehua Liu, Lei Luo, Pei Li, Yiyang Wang, Lichuan Liang, Xueping Wen, Dianming Jiang, Qiang Zhou
Summary: The study compared the clinical efficacy of decompression of the spinal canal with or without discectomy on the treatment of lumbar degenerative diseases using Dynesys dynamic fixation. Results showed that decompression without discectomy may lead to better preservation of intervertebral height and range of motion, and reduce disc degeneration.
PAIN RESEARCH & MANAGEMENT
(2021)
Article
Orthopedics
Malin Kristin Meier, Samira Scheuber, Markus Simon Hanke, Pascal Cyrill Haefeli, Adrian Cyrill Ruckli, Emanuel Francis Liechti, Nicolas Gerber, Till Dominic Lerch, Moritz Tannast, Klaus Arno Siebenrock, Simon Damian Steppacher, Florian Schmaranzer
Summary: This study longitudinally evaluated dGEMRIC indices in patients who underwent FAI correction and in a control group. The results showed that after 3 years, the dGEMRIC indices improved compared with the short-term 1-year follow-up. This improvement may be attributed to normalized joint biomechanics or regressive postoperative activation of the inflammatory cascade.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Review
Agriculture, Dairy & Animal Science
Chiara Caterino, Federica Aragosa, Giovanni Della Valle, Gerardo Fatone
Summary: The aim of this paper is to review the available literature on canine seventh vertebra lumbar fracture. The lack of prospective studies with a large study population and univocal data collection about complications, outcome, and post-surgical treatment is a major problem addressed. The results showed that non-ambulatory paraparesis/plegia, sciatic nerve involvement, faecal/urinary incontinence, and severe back lumbar pain were the most reported signs. Surgical treatment had a good long-term prognosis for outcome and neurological recovery.
Article
Multidisciplinary Sciences
Julien Ognard, Nicolas Demany, Jawad Mesrar, Ludwig Serge Aho-Glele, Alain Saraux, Douraied Ben Salem
Summary: This study investigated the lumbar spine of 46 subjects and found a craniocaudal gradient of vertebral medullar adiposity that increases with age. The gradient is independent of sex or BMI. The IDEAL sequence enables quick and reproducible measurement of spine vertebral medullar adiposity.
Article
Biotechnology & Applied Microbiology
Paul Mcmullin, Darian Emmett, Andrew Gibbons, Kelly Clingo, Preston Higbee, Andrew Sykes, David T. Fullwood, Ulrike H. Mitchell, Anton E. Bowden
Summary: This study utilized an optical motion capture system and a new marker set to non-invasively measure the dynamic, 3D in vivo segmental kinematics of the lower spine in a laboratory setting. The results were consistent with previous studies and identified motion coupling paradigms in the lumbar spinal segments.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Clinical Neurology
Mazda Farshad, Christos Tsagkaris, Jonas Widmer, Marie-Rosa Fasser, Frederic Cornaz, Anna-Katharina Calek
Summary: The purpose of this study was to develop ligamentous vertebral stabilization techniques that can be used after microsurgical decompression and midline decompression, and to elaborate their biomechanical characteristics. The results showed that vertebral stabilization significantly reduced the range of motion, especially in flexion-extension.
EUROPEAN SPINE JOURNAL
(2023)
Article
Endocrinology & Metabolism
Amir Masoud Afsahi, Alecio F. Lombardi, Zhao Wei, Michael Carl, Jiyo Athertya, Koichi Masuda, Mark Wallace, Roland R. Lee, Ya-Jun Ma
Summary: Ultra-short echo time (UTE) MRI with post-processing is proposed as a technique for imaging bone structures in the lumbar spine. The technique produces a similar contrast to computed tomography (CT) and shows high intermodality agreement with CT images.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Anna-Katharina Calek, Franziska Altorfer, Marie-Rosa Fasser, Jonas Widmer, Mazda Farshad
Summary: The purpose of this study is to develop and test a technique called synthetic vertebropexy that can be used after decompression surgery and compare it with the standard dorsal fusion procedure. The research found that both techniques have similar effects in reducing lumbar segmental motion, but differ in shear forces.
EUROPEAN SPINE JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lieve Morbee, Min Chen, Nele Herregods, Pim Pullens, Lennart B. O. Jans
Summary: This study demonstrated the equivalency of MRI-based synthetic CT to conventional CT in geometric measurements of the lumbar spine, showing good reliability. This opens up new possibilities for diagnosis and surgical planning without ionizing radiation, while combining soft tissue information from conventional MRI.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Medicine, General & Internal
Gustavo Plaza-Manzano, Marcos J. Navarro-Santana, Juan Antonio Valera-Calero, Raul Fabero-Garrido, Cesar Fernandez-de-las-Penas, Ibai Lopez-de-Uralde-Villanueva
Summary: The study found that ultrasound imaging is a reliable method for assessing lumbar multifidus thickness at rest and during contraction in patients with low back pain. Results indicated that measuring LM thickness at 3 seconds after maintaining ASLR, as well as using the mean of three measurements, is the most reliable method for assessing LM muscle thickness during ASLR.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biotechnology & Applied Microbiology
Marco Giacometti, Marco Monticelli, Marco Piola, Francesca Milesi, Lorenzo P. Coppadoro, Enrico Giuliani, Emanuela Jacchetti, Manuela T. Raimondi, Giorgio Ferrari, Spinello Antinori, Gianfranco B. Fiore, Riccardo Bertacco
Summary: This study systematically characterizes an easy-to-operate lab-on-chip for the magnetophoretic capture of malaria-infected red blood cells. The method achieves high capture efficiency in a short amount of time and requires simple sample preparation.
BIOTECHNOLOGY AND BIOENGINEERING
(2022)
Article
Materials Science, Multidisciplinary
Claudio Conci, Emanuela Jacchetti, Laura Sironi, Lorenzo Gentili, Giulio Cerullo, Roberto Osellame, Giuseppe Chirico, Manuela Teresa Raimondi
Summary: The current methods for assessing biomaterial biocompatibility are outdated and unethical, and there is a need for a real-time research method. This study develops and validates the Microatlas window, providing a chicken embryo experimental model for biomaterial biocompatibility assessment and microscope field repositioning.
ADVANCED OPTICAL MATERIALS
(2022)
Article
Clinical Neurology
Carla Daniela Anania, Beatrice Claudia Bono, Mariapia Tropeano, Maurizio Fornari, Franco Servadei, Francesco Costa
Summary: This study evaluated the feasibility of using spinal navigation for the treatment of thoracolumbar burst fractures with a single-stage posterior corpectomy and fixation. The results showed that this approach provided satisfactory outcomes in terms of correction of vertebral height ratio, reduction of kyphosis, and biomechanical stability.
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2023)
Review
Surgery
Delia Cannizzaro, Davide Milani, Ismail Zaed, Maria Pia Tropeano, Federico Nicolosi, Francesco Costa, Franco Servadei, Maurizio Fornari, Vincenzo D'Angelo, Andrea Cardia
Summary: The study proposes an updated approach to the preoperative management of tentorial incisura meningiomas in order to reduce postoperative deficits. A multidisciplinary approach is crucial for planning the treatment of these tumors, and preoperative simulation imaging can aid in the safe treatment of residual tumors with radiosurgery.
FRONTIERS IN SURGERY
(2022)
Article
Clinical Neurology
Delia Cannizzaro, Cristina Mancarella, Davide Nasi, Maria P. Tropeano, Carla D. Anania, Giovanni Cataletti, Daniela Milani, Enrica M. Fava, Reza Ghadirpour, Francesco Costa, Franco Servadei, Maurizio Fornari
Summary: This retrospective study from two Italian centers highlights the usefulness of intraoperative electrophysiological monitoring (IONM) in the surgical management of intramedullary tumors. The use of IONM significantly reduces postoperative neurological deficits, and D-Wave shows higher accuracy in predicting postoperative deficits compared with SSEP and MEP.
JOURNAL OF NEUROSURGICAL SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Gianfranco Parati, Alexandra Goncalves, David Soergel, Rosa Maria Bruno, Enrico Gianluca Caiani, Eva Gerdts, Felix Mahfoud, Lorenzo Mantovani, Richard J. McManus, Paola Santalucia, Thomas Kahan
Summary: Hypertension is a common and preventable risk factor for cardiovascular disease, but a large number of patients are undiagnosed or inadequately treated. A comprehensive approach is needed to improve hypertension management.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Biology
Marco Penso, Sara Moccia, Enrico G. Caiani, Gloria Caredda, Maria Luisa Lampus, Maria Ludovica Carerj, Mario Babbaro, Mauro Pepi, Mattia Chiesa, Gianluca Pontone
Summary: In this study, an automatic deep learning-based algorithm was proposed to classify coronary artery stenosis lesions according to the CCTA images. The experimental results showed that the algorithm achieved high accuracy and sensitivity in classifying significant coronary artery stenosis and in CAD-RADS classification.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Sara Caramaschi, Gabriele B. Papini, Enrico G. Caiani
Summary: Tracking a person's activities is relevant in various contexts, and this study investigates the impact of device orientation changes on human activity recognition (HAR). A model based on a three-axis accelerometer is proposed, capable of recognizing activities from multiple movement patterns.
APPLIED SCIENCES-BASEL
(2023)
Review
Medicine, General & Internal
Malte Ottenhausen, Elena Greco, Giacomo Bertolini, Andrea Gerosa, Salvatore Ippolito, Erik H. Middlebrooks, Graziano Serrao, Maria Grazia Bruzzone, Francesco Costa, Paolo Ferroli, Emanuele La Corte
Summary: The craniovertebral junction is a complex area between the skull and cervical spine. Pathologies in this area can lead to joint instability. There is no consensus on fixation techniques after craniovertebral oncological surgery. This review summarizes the anatomy, pathology, and available surgical approaches for joint instability in this area.
Article
Emergency Medicine
Stefano Spina, Lorenzo Gianquintieri, Francesco Marrazzo, Maurizio Migliari, Giuseppe Maria Sechi, Maurizio Migliori, Andrea Pagliosa, Rodolfo Bonora, Thomas Langer, Enrico Gianluca Caiani, Roberto Fumagalli
Summary: ML-based models can enhance EMS's ability to identify patients with SARS-CoV-2 infection and guide the allocation of hospital resources.
EMERGENCY MEDICINE JOURNAL
(2023)
Review
Clinical Neurology
Francesco Costa, Carla Daniela Anania, Umberto Agrillo, Assietti Roberto, Bernucci Claudio, Bistazzoni Simona, Bongetta Daniele, Brembilla Carlo, Cappelletto Barbara, Cocciaro Ardico, Costella Giovanni Battista, De Falco Raffaele, De Rosa Andrea, Del Vecchio Carlo, Dobran Mauro, Fiorenza Vito, Garbossa Diego, Guizzardi Giancarlo, Iaccarino Corrado, Irace Claudio, Incerti Michele, Gualtiero Innocenzi, Landi Alessandro, Lastrucci Giancarlo, Maida Giuseppe, Mastrantuoni Ciro, Maugeri Rosario, Meglio Vincenzo, Montemurro Nicola, Nina Pierpaolo, Parlangeli Andrea, Pinna Giovanni, Pretti Pier Federico, Rapana Armando, Ricci Alessandro, Rispoli Rossella, Romoli Stefano, Per Filippo Sbaffi, Somma Teresa, Tessitore Enrico, Vitali Matteo, Alberto Zerbi, Zona Gianluigi, Andrea Barbanera, SINch Spine Section Grp
Summary: Cervical spondylotic myelopathy (CSM) is becoming more common due to the aging population, and finding the best diagnosis and treatment solutions is challenging. Many neurosurgical societies are working on guidelines to help spinal surgeons in their daily practice. The Italian Neurosurgical Society's Spinal Section adopted the recommendations of the World Federation of Neurosurgical Societies (WFNS) with some revisions based on the Italian context. They reviewed the literature and analyzed the WFNS recommendations to create a list of contemporary treatment concepts for CSM.
Article
Engineering, Biomedical
Francesca Donnaloja, Manuela Teresa Raimondi, Letizia Messa, Bianca Barzaghini, Federica Carnevali, Emanuele Colombo, Davide Mazza, Chiara Martinelli, Lucia Boeri, Federica Rey, Cristina Cereda, Roberto Osellame, Giulio Cerullo, Stephana Carelli, Monica Soncini, Emanuela Jacchetti
Summary: Mechanical stimuli from the extracellular environment affect cell morphology and functionality. The use of a custom-made 3D microscaffold, called the Nichoid, for cultivating mesenchymal stem cells (MSCs) has been shown to enhance the expression of stemness markers. This device appears to regulate gene activity by altering intracellular force transmission. The findings suggest that the Nichoid can influence MSC behavior and gene regulation through mechanical manipulation.
APL BIOENGINEERING
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Yijun Ren, Enrico Gianluca Caiani
Summary: Under the European Union Medical Device Regulation, expert panel's scientific opinions on high-risk medical devices are required. To assist in this process, a framework was proposed to collect and display publicly available safety notices, using named entity recognition and natural language processing techniques.
2023 IEEE EMBS INTERNATIONAL CONFERENCE ON BIOMEDICAL AND HEALTH INFORMATICS, BHI
(2023)
Review
Public, Environmental & Occupational Health
Julia Nawaro, Lorenzo Gianquintieri, Andrea Pagliosa, Giuseppe M. Sechi, Enrico Gianluca Caiani
Summary: This study analyzed the effects of heat on cardiovascular morbidity and mortality, focusing on the adopted heat definitions and their impact on the analysis results. Multiple combinations of criteria for defining heat were found, with larger deviations from the mean annual temperature and higher temperature thresholds in the same study location leading to stronger negative effects. An international harmonization effort to define a common standard is recommended for better analyzing trends in heatwaves characteristics and their impact on cardiovascular health.
PUBLIC HEALTH REVIEWS
(2023)