Journal
EUROPEAN RESPIRATORY JOURNAL
Volume 45, Issue 2, Pages 328-337Publisher
EUROPEAN RESPIRATORY SOC JOURNALS LTD
DOI: 10.1183/09031936.00060214
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Funding
- European Commission as part of HITEA [211488]
- Federal Ministry for Education, Science, Research and Technology, Helmholtz Zentrum Munich
- Helmholtz Centre for Environmental Research - UFZ
- Research Institute at Marien-Hospital Wesel
- Paediatric Practice (Bad Honnef, Germany)
- Federal Ministry for Environment (IUF Dusseldorf) [FKZ 20462296]
- Netherlands Organization for Health Research and Development (The Hague, The Netherlands)
- Netherlands Organization for Scientific Research (The Hague)
- Netherlands Asthma Fund (Amersfoort)
- Netherlands Ministry of Spatial Planning
- Housing, and the Environment (The Hague)
- Netherlands Ministry of Health, Welfare, and Sport (The Hague)
- Fondo de Investigacion Sanitaria, ISCIII, Ministerio de Sanidad y Servicios Sociales (Madrid, Spain) [97/0588, 00/0021-2, G03/176, PI061756, PS0901958]
- EC [QLK4-CT-2000-00263]
- Fundacio Roger Tome (Barcelona, Spain)
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Inverse associations have been found between exposure to bio-contaminants and asthma and allergies. The aim of this study was to prospectively assess whether early exposure to bio-contaminants in dust is associated with asthma and allergy later in childhood among children from (sub)-urban areas. In subsets of three European birth cohorts (PIAMA: n=553; INMA: n=481; and LISAplus: n=395), endotoxin, (1,3,)-beta-D-glucan and extracellular polysaccharide were measured in dust from living rooms shortly after birth. Current asthma at 6 years and 10 years of age and ever asthma up to 10 years of age were assessed by parental questionnaires. Specific IgE levels at 8 years (PIAMA) and 10 years (LISAplus) were available. Adjusted, cohort-specific logistic regression analyses were performed. Higher endotoxin concentrations were positively associated with current asthma at 6 years of age in PIAMA (adjusted OR 1.96, 95% CI 1.07-3.58), but were inversely related with ever asthma up to 10 years of age in INMA (adjusted OR 0.39, 95% CI 0.16-0.94). No associations with asthma were found for LISAplus. No associations were observed with atopic sensitisation in all cohorts. All associations with (1,3,)-beta-D-glucan and extracellular polysaccharide were statistically nonsignificant. The suggested immunological mechanisms of early exposure to bio-contaminants with regards to asthma and allergy might be different for children growing up in (sub)-urban environments.
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