Article
Cardiac & Cardiovascular Systems
Angel M. Alonso Gomez, Lucas Tojal Sierra, Noris Mora Mora, Estefania Toledo, Alvaro Alonso, Maria Garrido Uriarte, Carolina Sorto Sanchez, Maria P. Portillo, Luis Lopez Rodriguez, Elena Escribano Arellano, Helmut Schroder, Jordi Salas-Salvado
Summary: This study confirms the low prevalence of diastolic dysfunction in overweight/obese patients with metabolic syndrome. Adding the left atrial strain criterion to the current recommendations significantly reduces the number of indeterminate patients by reclassifying them as normal.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Gary C. H. Gan, Aditya Bhat, Henry H. L. Chen, Kennith H. Gu, Fernando Fernandez, Krishna K. Kadappu, Karen Byth, Suzanne Eshoo, Liza Thomas
Summary: This study investigated the relationship between left atrial function and exercise capacity in patients with chronic kidney disease, finding that LASr is the parameter most strongly correlated with exercise capacity and has similar diagnostic value to exercise E/e'. LASr could serve as a resting biomarker of functional capacity in this population.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Julian C. Dunkley, Camila I. Irion, Keyvan Yousefi, Serene A. Shehadeh, Guerline Lambert, Krista John-Williams, Keith A. Webster, Jeffrey J. Goldberger, Lina A. Shehadeh
Summary: In a mouse model of heart failure with preserved ejection fraction (HFpEF), exercise and carvedilol synergistically improved systolic function without affecting diastole. Carvedilol alone or in combination with exercise also improved kidney function. The observed improvements in cardiorenal functions were mediated at least in part by effects on serum osteopontin and related inflammatory cytokine cascades, presenting new potential therapeutic targets and approaches for HFpEF.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Rehabilitation
Ali Ashraf, Siamak Rimaz, Abbas Seddighinejad, Amin Karimi, Afagh Hassanzadeh-Rad, Mahboobeh Gholipour, Mahsa Motiei, Mohammad Ali Yazdanipour, Sheida Rimaz
Summary: This study investigated the effect of physical activity level on diastolic function of the left ventricle. The results showed an inverse relationship between physical activity level and diastolic dysfunction, suggesting that maintaining an appropriate level of physical activity can reduce the risk of cardiovascular events in patients undergoing non-cardiac surgeries.
BMC SPORTS SCIENCE MEDICINE AND REHABILITATION
(2023)
Article
Cardiac & Cardiovascular Systems
Allard T. van den Hoven, Sultan Yilmazer, Lidia R. Bons, Roderick W. J. van Grootel, L. W. Geenen, An M. van Berendoncks, Anthonie L. Duijnhouwer, Hans-Marc J. Siebelink, Jolien W. Roos-Hesselink, Annemien E. van den Bosch
Summary: Women with Turner syndrome (TS) exhibit significantly reduced systolic and diastolic strain, as well as exercise capacity compared to healthy women. Impaired left ventricular global longitudinal strain (LvGLS) and left ventricular peak early diastolic strain rate (Sre) were observed in TS women, along with lower maximal workload, oxygen uptake, and maximal heart rate during exercise. Multivariable linear regression analysis showed associations between Sre and Age, karyotype, and QT-duration in the TS population.
CONGENITAL HEART DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Thijs P. Kerstens, Jerremy Weerts, Arie P. J. van Dijk, Gert Weijers, C. Knackstedt, Thijs M. H. Eijsvogels, David Oxborough, Vanessa P. M. van Empel, Dick H. J. Thijssen
Summary: This study investigated the association between left ventricular diastolic dysfunction and heart failure. The findings suggest that non-invasive assessment using strain-volume loop characteristics may help detect diastolic dysfunction. These results provide new insights and opportunities for non-invasive evaluation in cardiovascular medicine.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Henning O. Ness, Kristine Ljones, Randi H. Gjelsvik, Arnt Erik Tjonna, Vegard Malmo, Hans Olav Nilsen, Siri Marte Hollekim-Strand, Havard Dalen, Morten Andre Hoydal
Summary: This study evaluated the acute cardiac stress response after high-intensity interval training in patients with type 2 diabetes compared to healthy controls. The findings showed changes in certain cardiac parameters after exercise in both groups, while the T2D group had a higher rate of pre-existing cardiac arrhythmias that remained unchanged after exercise.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Marijana Tadic, Jelena Suzic-Lazic, Vladan Vukomanovic, Cesare Cuspidi, Sanja Ilic, Vera Celic
Summary: This study evaluated cardiorespiratory fitness in type 2 diabetic patients with different levels of left ventricular diastolic dysfunction (LVDD). The findings showed that LVDD significantly impacted functional capacity in diabetic patients, with parameters such as left ventricular hypertrophy and diastolic function being affected.
ACTA DIABETOLOGICA
(2021)
Article
Biology
Or Shimoni, Roman Korenfeld, Sorel Goland, Valery Meledin, Dan Haberman, Jacob George, Sara Shimoni
Summary: In patients who had recovered from COVID-19 infection, both LV and RV strain are significantly lower compared to control patients. The exercise capacity of these patients correlates with LV strain values.
Article
Cardiac & Cardiovascular Systems
Aviram Hochstadt, Joshua Arnold, Roni Rosen, Chen Sherez, Jack Sherez, Liat Mor, Yonatan Moshkovits, Ilan Merdler, Yishay Szekely, Yaron Arbel, Zach Rozenbaum, Livia Kapusta, Yan Topilsky, Michal Laufer-Perl
Summary: This study evaluated the correlation of diastolic strain slope (Dss) with routine echocardiography diastolic parameters and found a significant association between Dss changes and the development of systolic dysfunction. Particularly, changes in mid segment Dss were identified to have independent early predictive value for systolic dysfunction development.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Anna Brand, Elena Romero Dorta, Adrian Wolf, Daniela Blaschke-Waluga, Ute Seeland, Claudia Crayen, Sven Bischoff, Isabel Mattig, Henryk Dreger, Karl Stangl, Vera Regitz-Zagrosek, Ulf Landmesser, Fabian Knebel, Verena Stangl
Summary: This study aimed to evaluate the predictive value of maximum left atrial volume index (LAVI), phasic left atrial strain (LAS), and other standard echocardiographic parameters in discriminating future worsening of diastolic function (DD) in high-risk patients, and to compare their clinical impact. The results showed that LASr and LAScd had higher discriminative value in predicting the deterioration of diastolic function, while the predictive value of LAVI was limited.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Physiology
Meng Ding, Lan Zheng, Qiu Fang Li, Wan Li Wang, Wan Da Peng, Meng Zhou
Summary: Exercise-training can regulate the expression of apoLpp, improve heart function, and enhance exercise capacity, resisting obesity-induced heart insufficiency. However, reducing apoLpp may not fully alleviate heart damage and low exercise capacity caused by a high-fat diet in Drosophila model.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Zheina Cherneva, Dinko Valev, Vania Youroukova, Radostina Cherneva
Summary: This study aimed to evaluate the predictive value of inflammatory, oxidative stress, cardio-pulmonary, and echocardiographic parameters at rest for the diagnosis of stress LVDD in non-severe COPD patients. Results showed a high prevalence of masked HFpEF in COPD patients, with parameters like RV E/A >0.75 being the best independent predictors for stress LVDD.
Article
Anesthesiology
Farzad Ebrahimi, Mohammad Hadi Gharedaghi, Hamed Shafaroodi, Mehdi Ghasemi, Katayoun Aghajani, Kenneth Candido
Summary: Late diastolic peak longitudinal strain rate is correlated with the severity of diastolic dysfunction in patients undergoing cardiac surgery, potentially aiding in intraoperative assessment of diastolic function.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Article
Cardiac & Cardiovascular Systems
Man Liu, Hong Liu, Feng Feng, An Xie, Gyeoung-Jin Kang, Yang Zhao, Cody R. Hou, Xiaoxu Zhou, Samuel C. Dudley
Summary: Magnesium deficiency can cause reversible diastolic cardiomyopathy associated with mitochondrial dysfunction and oxidative modificaton of cMyBPC. Magnesium supplementation may represent a novel treatment for diastolic heart failure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Medicine, General & Internal
Satish Ramkumar, Hiroshi Kawakami, Edmond Wong, Mark Nolan, Thomas H. Marwick
Summary: This study compared the cost-effectiveness of two screening strategies for atrial fibrillation and found that imaging-guided screening was more cost-effective with lower costs and better outcomes. The study suggests that targeted screening for specific populations based on clinical and imaging risk parameters is more meaningful for detecting atrial fibrillation.
INTERNAL MEDICINE JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Edgar M. Hidalgo, Leah Wright, Mats Isaksson, Gavin Lambert, Thomas H. Marwick
Summary: With advances in robotics and telecommunications, robot-assisted teleoperated ultrasound examination can help with medical diagnosis in remote areas, reducing health inequalities. Studies have shown that robots can safely perform ultrasound examinations by following the hand movements of sonographers and researchers. However, real-time transmission of video and ultrasound images requires high bandwidth, and improvements are needed in robot control and interface design.
JACC-CARDIOVASCULAR IMAGING
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Thomas H. Marwick, Y. Chandrashekhar
JACC-CARDIOVASCULAR IMAGING
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Neville Tan, Thomas H. Marwick, Nitesh Nerlekar
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Review
Cardiac & Cardiovascular Systems
Neville Tan, Damini Dey, Thomas H. Marwick, Nitesh Nerlekar
Summary: Coronary computed tomography can quantify coronary inflammation by mapping changes in pericoronary adipose tissue, but there are significant knowledge gaps in its interpretation.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Health Care Sciences & Services
James A. Black, Conor Lees, Niamh Chapman, Liam Kelleher, Julie A. Campbell, Petr Otahal, Kevin Cheng, Thomas H. Marwick, James E. Sharman
Summary: This study evaluated the effectiveness of a telehealth chest pain clinic established during the COVID-19 pandemic. The results showed that telehealth patients had a reduced need for additional testing compared to face-to-face consultations, and achieved similar clinical outcomes with high patient satisfaction.
TELEMEDICINE AND E-HEALTH
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Y. Chandrashekhar, Thomas H. Marwick, Leslee J. Shaw
JACC-CARDIOVASCULAR IMAGING
(2023)
Review
Cardiac & Cardiovascular Systems
Joshua Wong, Stacey Peters, Thomas H. Marwick
Summary: Heart failure is a heterogeneous disease, and genetic testing provides additional information to imaging in distinguishing phenotypes. Advances in genetic testing have identified harmful variants in specific heart failure phenotypes (dilated cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, and hypertrophic cardiomyopathy), with implications for specific treatments. However, the diagnostic yield of genetic testing is modest, and many rare variants have incomplete penetrance and variable expressivity. The heterogeneity of the heart failure phenotype is also influenced by environmental factors and co-morbidities. Future research should focus on the cumulative impact of genetic polymorphisms on the development of heart failure.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Mohammad Shah, Marie-Jeanne Buscot, Jing Tian, Hoang T. Phan, Brooklyn J. Fraser, Thomas H. Marwick, Terence Dwyer, Alison Venn, Seana Gall
Summary: This study analyzed long-term follow-up data from the Australian Schools Health and Fitness Survey and found that childhood risk factors contribute to sex differences in adult carotid artery plaques and intima-media thickness. After adjusting for relevant adult risk factors, the sex differences decreased. The conclusion is that prevention strategies throughout the life course are important for reducing sex differences in cardiovascular diseases.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Paaladinesh Thavendiranathan, Christian Houbois, Thomas H. Marwick, Tiffanie Kei, Sudipta Saha, Kyle Runeckles, Flora Huang, Tamar Shalmon, Kevin E. Thorpe, Rossanna C. Pezo, Anca Prica, Dawn Maze, Husam Abdel-Qadir, Kim A. Connelly, Joyce Chan, Filio Billia, Coleen Power, Kate Hanneman, Bernd J. Wintersperger, Christine Brezden-Masley, Eitan Amir
Summary: This study aimed to assess whether statins can prevent decline in left ventricular ejection fraction in patients treated with anthracyclines. The results showed that primary prevention with atorvastatin did not ameliorate early decline in LVEF, left ventricular remodeling, therapy-related cardiac dysfunction, changes in serum cardiac biomarkers, or myocardial tissue changes in patients at increased risk of CTRCD.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Roberto Enrique Azcui Aparicio, Melinda J. Carrington, Quan Huynh, Jocasta Ball, Thomas H. Marwick
Summary: The study investigated the association between Fuster-BEWAT Score (FBS), Framingham Risk Score (FRS), and Pooled Cohort Equation (PCE) with carotid plaque presence, aiming to develop a stepped screening process for the primary prevention of cardiovascular disease (CVD). The results showed that FBS was able to identify carotid plaque in asymptomatic individuals, suggesting its potential use in initial risk delineation could improve patient selection for further assessment and reduce cost and time.
CARDIOVASCULAR DIGITAL HEALTH JOURNAL
(2023)
Review
Oncology
Yueyang Bao, John Lee, Udit Thakur, Satish Ramkumar, Thomas H. Marwick
Summary: This study compared the atrial fibrillation (AF) detection rate between cancer survivors and the general population and found that the AF risk in cancer survivors was not significantly increased.
Article
Medicine, General & Internal
Quan Huynh, Noah Wexler, Joel Smith, Leah Wright, Felicia Ho, Richard Allwood, Yusuke Sata, Stefano Manca, Erin Howden, Thomas H. Marwick
Summary: This study compared the symptoms and functional impairment of patients with previous COVID-19 infection to uninfected community controls. It found that patients with COVID-19 had lower functional capacity and more depression compared to controls. A pilot group also showed an increase in peak workload after exercise training. The study suggests that an exercise training program might be beneficial for selected patients.
INTERNAL MEDICINE JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Thomas H. Marwick, Wojciech Kosmala
JACC-CARDIOVASCULAR IMAGING
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Neville Tan, Nitesh Nerlekar, Thomas H. Marwick
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)