Article
Medicine, General & Internal
Melanie Chin, Tetyana Kendzerska, Jiro Inoue, Michael Aw, Linda Mardiros, Christopher Pease, Melissa K. Andrew, Smita Pakhale, Alan J. Forster, Sunita Mulpuru
Summary: Frailty is a significant issue among individuals with COPD, and interventions like pulmonary rehabilitation can help reverse frailty. However, frailty is not routinely measured in pulmonary clinical practice. A study compared the Hospital Frailty Risk Score (HFRS) with the Clinical Frailty Scale (CFS) and found that the HFRS had low sensitivity but high specificity in identifying frail individuals compared to the CFS.
Article
Respiratory System
Alexandre J. Pratt, Andrew Purssell, Tinghua Zhang, Vanessa P. J. Luks, Xavier Bauza, Sunita Mulpuru, Miranda Kirby, Shawn D. Aaron, Juthaporn Cowan
Summary: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a complex clinical syndrome, and patients may have concurrent diseases such as pneumonia or congestive heart failure causing dyspnea. This study aimed to identify clinical, radiographic, and laboratory characteristics that could help distinguish AECOPD from other dominant diseases. The findings suggest the need for a more specific clinical tool to diagnose AECOPD.
BMC PULMONARY MEDICINE
(2023)
Article
Physiology
Xiaoyan Gai, Chenglin Guo, Linlin Zhang, Lijiao Zhang, Mairipaiti Abulikemu, Juan Wang, Qingtao Zhou, Yahong Chen, Yongchang Sun, Chun Chang
Summary: The study found that during acute exacerbation of chronic obstructive pulmonary disease (AECOPD), specific glycerophospholipids were significantly reduced in expression. These glycerophospholipids were able to predict the acute exacerbation and recovery stages, particularly in the non-eosinophilic subtype. Abnormalities in glycerophospholipid metabolism may be associated with the onset of AECOPD.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Ali Hussain, Hee-Eun Choi, Hyo-Jung Kim, Satyabrata Aich, Muhammad Saqlain, Hee-Cheol Kim
Summary: A voting ensemble classifier using 24 features was proposed to identify the severity of COPD patients using machine-learning techniques. The classifier outperformed regular machine-learning methods, helping respiratory physicians estimate disease severity early and guide treatment strategies for COPD patients.
Article
Multidisciplinary Sciences
Kentaro Hyodo, Hironori Masuko, Hisayuki Oshima, Rie Shigemasa, Haruna Kitazawa, Jun Kanazawa, Hiroaki Iijima, Hiroichi Ishikawa, Takahide Kodama, Akihiro Nomura, Katsunori Kagohashi, Hiroaki Satoh, Takefumi Saito, Tohru Sakamoto, Nobuyuki Hizawa
Summary: This study aimed to investigate the exacerbation-prone phenotypes beyond disease labels in asthma and COPD using shared risk factors and to examine the role of the IL4RA gene polymorphism related to type 2 inflammation. The results showed common exacerbation-prone endotypes in chronic inflammatory airway diseases, supporting the use of a treatable traits approach for prevention.
Article
Environmental Sciences
Zihui Wang, Yumin Zhou, Yongbo Zhang, Xiaoliang Huang, Xianzhong Duan, Duohong Chen, Yubo Ou, Longhui Tang, Shiliang Liu, Wei Hu, Chenghao Liao, Yijia Zheng, Long Wang, Min Xie, Jinzhen Zheng, Sha Liu, Ming Luo, Fan Wu, Zhishan Deng, Heshen Tian, Jieqi Peng, Huajing Yang, Shan Xiao, Xinwang Wang, Nanshan Zhong, Pixin Ran
Summary: In Guangdong, the reduction in PM2.5, PM10, and SO2 concentrations may lead to a decrease in attributable hospital admissions for AECOPD, while ozone (O-3) has emerged as an important risk factor.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Geriatrics & Gerontology
Kenta Ushida, Akio Shimizu, Shinsuke Hori, Yoshinori Yamamoto, Ryo Momosaki
Summary: This study aimed to investigate the association between frailty risk and functional outcomes in patients with acute exacerbations of chronic obstructive pulmonary disease (COPD). The study found that patients with a higher frailty risk had worse outcomes in terms of prolonged hospitalization, in-hospital mortality, poor activities of daily living, and difficulty in returning home.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2022)
Review
Respiratory System
Mairi MacLeod, Alberto Papi, Marco Contoli, Bianca Beghe, Bartolome R. Celli, Jadwiga A. Wedzicha, Leonardo M. Fabbri
Summary: Exacerbations in COPD significantly impact disease progression, comorbidities, wellbeing, and mortality. They represent a major socioeconomic burden. Current definitions of exacerbations focus on worsening respiratory symptoms, but other factors can also contribute. Objective measurements like blood counts and C-reactive protein should be used to improve accuracy in diagnosis. Acute management includes interventions like corticosteroids, antibiotics, and non-invasive ventilation. Long-term prevention strategies, such as inhaled therapy and tailored approaches based on clinical phenotypes, are needed to better manage exacerbations.
Article
Cardiac & Cardiovascular Systems
Tanveer Mir, Mohammed Uddin, Amir Khalil, Prateek Lohia, Lekiesha Porter, Neelambuj Regmi, Jarrett Weinberger, Parvaiz A. Koul, Ayman O. Soubani
Summary: This study revealed a strong association between aspergillosis infection and high mortality among patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Malignancy and organ transplant status were identified as predominant predictors of aspergillosis development in AECOPD patients. The study also found a decrease in the yearly rate of aspergillosis, while the mortality trend remained steady.
RESPIRATORY MEDICINE
(2022)
Article
Biology
Yong Jun Choi, Taehee Kim, Hye Jung Park, Jae Hwa Cho, Min Kwang Byun
Summary: Sarcopenia in patients with chronic obstructive pulmonary disease (COPD) is associated with a higher rate of acute exacerbation events, all-cause mortality, and pneumonia occurrence. Sarcopenia is an independent risk factor for COPD exacerbation. Hand grip strength and skeletal muscle mass index are associated with various clinical assessments and outcomes in COPD patients.
Article
Geriatrics & Gerontology
Xuanna Zhao, Ruoxin Su, Rongwei Hu, Yujuan Chen, Xiaoyong Xu, Yalian Yuan, Jinhong Zhang, Wenchao Zhang, Yu Yang, Min Chen, Dongming Li, Bin Wu, Dan Huang, Dong Wu
Summary: This study aimed to assess the value of the sarcopenia index (SI) in predicting clinically important outcomes in elderly patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The results showed that SI was negatively associated with the risk of respiratory failure and had predictive ability in both frequent and non-frequent exacerbation subgroups.
Article
Respiratory System
Yifei Duan, Siyi Zhou, Jianmiao Wang
Summary: Our previous studies have shown that BRD4 is increased in the lungs of stable COPD patients and is involved in inflammatory responses. In this study, we investigated the role of BRD4 in viral exacerbations of COPD.
RESPIRATORY RESEARCH
(2023)
Article
Critical Care Medicine
Siddharth S. Madapoosi, Charmion Cruickshank-Quinn, Kristopher Opron, John R. Erb-Downward, Lesa A. Begley, Gen Li, Igor Barjaktarevic, R. Graham Barr, Alejandro P. Comellas, David J. Couper, Christopher B. Cooper, Christine M. Freeman, MeiLan K. Han, Robert J. Kaner, Wassim Labaki, Fernando J. Martinez, Victor E. Ortega, Stephen P. Peters, Robert Paine, Prescott Woodruff, Jeffrey L. Curtis, Gary B. Huffnagle, Kathleen A. Stringer, Russell P. Bowler, Charles R. Esther, Nichole Reisdorph, Yvonne J. Huang
Summary: The study found that lung microbiota and metabolites are associated with clinical markers in patients with milder COPD, suggesting their potential collaborative roles in disease pathogenesis.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Respiratory System
M. Vitacca, A. Malovini, A. Spanevello, P. Ceriana, M. Paneroni, M. Maniscalco, B. Balbi, L. Rizzello, R. Murgia, R. Bellazzi, N. Ambrosino
Summary: Due to the low availability of pulmonary rehabilitation (PR) for individuals recovering from a COPD exacerbation (ECOPD), this study aimed to identify subpopulations with different responses to PR based on clustering analysis of baseline characteristics. The results can be used to define priority criteria for PR.
Article
Public, Environmental & Occupational Health
Amanda Y. Kong, Christopher D. Baggett, Nisha C. Gottfredson, Kurt M. Ribisl, Paul L. Delamater, Shelley D. Golden
Summary: Research shows a significant positive association between tobacco retailer density and COPD-related hospitalization rate as well as total COPD-related hospital costs per population. Therefore, reducing the number of tobacco retailers may help in lowering smoking-related health burdens and costs.
Article
Allergy
Sara Vazquez-Mera, Laura Martelo-Vidal, Pablo Miguens-Suarez, Paula Saavedra-Nieves, Pilar Arias, Coral Gonzalez-Fernandez, Mar Mosteiro-Anon, Maria Dolores Corbacho-Abelaira, Marina Blanco-Aparicio, Paula Mendez-Brea, Francisco Javier Salgado, Juan Jose Nieto-Fontarigo, Francisco Javier Gonzalez-Barcala
Summary: The study evaluated specific T-cell miRNA signatures in serum exosomes from different subgroups of asthmatic patients, and identified miRNAs related to asthma phenotype and severity.
Article
Statistics & Probability
Joaquin Martinez-Minaya, Finn Lindgren, Antonio Lopez-Quilez, Daniel Simpson, David Conesa
Summary: This article introduces a Laplace approximation method for Bayesian inference in Dirichlet regression models, which allows analyzing skewed and heteroscedastic variables on a simplex without data transformation. The article provides theoretical foundations, implementation details, and introduces the dirinla package in R-language for Dirichlet regression. Simulation studies validate the proposed method, and a real data case-study demonstrates its application.
JOURNAL OF COMPUTATIONAL AND GRAPHICAL STATISTICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stijn E. Verleden, Arno Vanstapel, Joseph Jacob, Tinne Goos, Jeroen Hendriks, Laurens J. Ceulemans, Dirk E. Van Raemdonck, Laurens De Sadeleer, Robin Vos, Johanna M. Kwakkel-van Erp, Arne P. Neyrinck, Geert M. Verleden, Matthieu N. Boone, Wim Janssens, Els Wauters, Birgit Weynand, Danny D. Jonigk, Johny Verschakelen, Wim A. Wuyts
Summary: This study determined the correlation between radiologic findings and histopathologic results in CT-defined interstitial lung abnormalities (ILAs) in human lung explants.
Article
Allergy
Abel Pallares-Sanmartin, Maria del Mar Mosteiro-Anon, Maria Macia, Nagore Blanco, David Barros-Casas, Maria Dolores Corbacho Abelaira, Toni Fernandez-Sanchez, Federico Fiorentino
Summary: This study aimed to determine predictors of asthma control improvement or worsening in asthmatic smokers. The results showed that adhering to treatment is the main intervention for achieving asthma control. An eosinophil count greater than 300 was the main predictor for achieving control. Fluticasone propionate/formoterol FP/FORM was associated with a greater likelihood of improving ACQ score.
Article
Respiratory System
Kenneth Verstraete, Iwein Gyselinck, Helene Huts, Nilakash Das, Marko Topalovic, Maarten De Vos, Wim Janssens
Summary: This study developed machine learning models to estimate and predict individual treatment effects of interventions in patients with chronic obstructive pulmonary disease (COPD). The results showed that poor lung function and blood eosinophils were the strongest predictors of individual treatment effects. The findings suggest that machine learning models can be used to guide personalized treatment decisions in COPD.
Editorial Material
Respiratory System
Wim Janssens, Geert M. Verleden
EUROPEAN RESPIRATORY REVIEW
(2023)
Article
Nutrition & Dietetics
Matthias Loeckx, Fernanda M. Rodrigues, Astrid Blondeel, Stephanie Everaerts, Wim Janssens, Heleen Demeyer, Thierry Troosters
Summary: The study found that implementing a 9-month PA telecoaching program significantly improves the physical activity level of COPD patients, especially after PR and during follow-up. However, this improvement in PA was not accompanied by the maintenance of other PR-acquired benefits.
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2023)
Article
Cardiac & Cardiovascular Systems
Astrid Blondeel, Fien Hermans, Sofie Breuls, Marieke Wuyts, Stephanie Everaerts, Iwein Gyselinck, Nikolaas De Maeyer, Thessa Verniest, Eric Derom, Wim Janssens, Thierry Troosters, Heleen Demeyer
Summary: This study identified correlates of physical activity in patients with Chronic Obstructive Pulmonary Disease (COPD) based on a comprehensive ecological model. The results showed that physiological, psychological, socio-demographic, and environmental factors were associated with physical activity. However, these factors only partly explained the variance in physical activity, suggesting that it is a complex behavior that is difficult to predict.
RESPIRATORY MEDICINE
(2023)
Article
Respiratory System
Maria Torres-Duran, Jose Luis Lopez-Campos, Myriam Calle Rubio, Carmen Montero-Martinez, Ana Priegue Carrera, Rosanel Amaro Rodriguez, Miriam Barrecheguren, Maria Angeles Barrio Guirado, Francisco Javier Callejas-Gonzalez, Francisco Casas-Maldonado, Layla Diab-Caceres, Pilar Garcia-Meseguer, Jose Maria Hernandez-Perez, Lourdes Lazaro-Asegurado, Cristina Martinez-Gonzalez, Carlos Martinez Rivera, Francisco Javier Michel, Jose-Bruno Montoro-Ronsano, Raquel Sanchez, Marta Ortiz-Pica, Isabel Parra, Jose Pablo Quintero Garcia, Maria del Rosario Ruiz-Serrano-de la Espada, Begona Tortajada-Goitia, Marc Miravitlles
Summary: This study provides recommendations for the implementation of a self-administration program for patients with AAT deficiency, including patient selection criteria, roles of healthcare professionals, training, and logistic issues. The proposal aims to increase awareness and facilitate the implementation of self-administration programs for AAT therapy, with the potential for improving patient experience and outcomes.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)
Article
Respiratory System
Vincent Geudens, Jan Van Slambrouck, Gitte Aerts, Lynn Willems, Tinne Goos, Janne Kaes, Andrea Zajacova, Iwein Gyselinck, Celine Aelbrecht, Astrid Vermaut, Hanne Beeckmans, Marie Vermant, Charlotte De Fays, Annelore Sacreas, Lucia Aversa, Michaela Orlitova, Arno Vanstapel, Ivan Josipovic, Matthieu N. Boone, John E. McDonough, Birgit Weynand, Charles Pilette, Wim Janssens, Lieven Dupont, Wim A. Wuyts, Geert M. Verleden, Dirk E. van Raemdonck, Robin Vos, Ghislaine Gayan-Ramirez, Laurens J. Ceulemans, Bart M. Vanaudenaerde
Summary: This study assessed disease progression in COVID-19 patients using in vivo CT and ex vivo microCT, and described the changes in lung volume and density as well as airway morphology. Results showed that COVID-19 lung volumes decreased and densities increased over time, mainly in the lower lobes. Ex vivo microCT revealed a 60% reduction in lung volume compared to controls, and increased visibility of airways in COVID-19 lungs, possibly due to fibrosis and increased airway diameter. Small-partition microCT further showed deformations in airway morphology and heterogeneous fibrotic organization in severely affected regions, which was confirmed by histology.
JOURNAL OF THORACIC DISEASE
(2023)
Review
Medicine, General & Internal
Esperanza Dona, Rocio Reinoso-Arija, Laura Carrasco-Hernandez, Adolfo Domenech, Antonio Dorado, Jose Luis Lopez-Campos
Summary: In order to improve health outcomes and disease prognosis, clinicians and researchers are proposing new ways to identify early-stage COPD. However, there is currently no unanimously accepted definition for patients in the initial stages of the disease, despite the concepts proposed by GOLD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Juan Luis Rodriguez Hermosa, Marc Miravitlles, Jose Luis Lopez-Campos, Myriam Calle Rubio
Summary: This study evaluates tobacco use and COPD knowledge among Spanish adults and compares the results with a survey conducted in 2011. The findings show a decrease in smoking prevalence and an increase in COPD awareness, but significant geographic variability exists among different regions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Jose Luis Lopez-Campos, Rocio Reinoso-Arija, Marta Ferrer Galvan, Auxiliadora Romero Falcon, Francisco J. Alvarez-Gutierrez, Francisco Ortega-Ruiz, Esther Quintana-Gallego
Summary: There is confusion over the dosage of inhaled medications, with each drug potentially having up to four different doses. Clinicians need to be aware of this when prescribing.
Meeting Abstract
Critical Care Medicine
M. Topalovic, P. Desbordes, J. Maes, F. de Jong, K. Sylvester, C. Vogelmeier, A. Dinh-Xuan, J. Mortensen, W. Janssens
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Meeting Abstract
Critical Care Medicine
K. Verstraete, I. Gyselinck, H. Huts, M. Staes, M. De Vos, W. Janssens
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)