Editorial Material
Cardiac & Cardiovascular Systems
David J. Hall, Jefree J. Schulte, Erik E. Lewis, Swaroop R. Bommareddi, Charles T. Rohrer, Samir Sultan, James D. Maloney, Malcolm M. DeCamp, Daniel P. McCarthy
Summary: This article reports a case of lung transplantation for post-COVID-19 pulmonary fibrosis. The patient recovered rapidly after the surgery and has done well in follow-up.
ANNALS OF THORACIC SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Amalia Ruiz-Serrano, Josep M. Monne Rodriguez, Julia Gunter, Samantha P. M. Sherman, Agnieszka E. Jucht, Pascal Fluechter, Yulia L. Volkova, Svende Pfundstein, Giovanni Pellegrini, Carsten A. Wagner, Christoph Schneider, Roland H. Wenger, Carsten C. Scholz
Summary: OTUB1 is a highly expressed deubiquitinase that plays a role in lung development and pathogenesis, but its physiological function remains unknown. Deletion of Otub1 in mice leads to perinatal lethality due to respiratory failure, indicating its essential role in lung development and homeostasis. Additionally, Otub1 deletion enhances cell proliferation and mTOR signaling in lung tissues, suggesting OTUB1 is a negative regulator of mTOR signaling with crucial functions in lung biology and respiratory regulation.
Article
Medicine, Research & Experimental
Qiaoyi Xu, Shuya Mei, Fang Nie, Zhiyun Zhang, Junqi Feng, Jinyuan Zhang, Xiaoqing Qian, Yuan Gao, Zhengyu He, Shunpeng Xing
Summary: The study demonstrates that lipopolysaccharide induces activation of the JNK signaling pathway and TNF-alpha secretion in pulmonary macrophages, leading to interaction between inflammation and metabolism that promotes lung fibroblast glycolysis. This interaction plays a crucial role in lipopolysaccharide-induced pulmonary fibrosis.
LABORATORY INVESTIGATION
(2022)
Review
Biochemistry & Molecular Biology
Francesco Amati, Anna Stainer, Marco Mantero, Andrea Gramegna, Edoardo Simonetta, Giulia Suigo, Antonio Voza, Anoop M. Nambiar, Umberto Cariboni, Justin Oldham, Philip L. Molyneaux, Paolo Spagnolo, Francesco Blasi, Stefano Aliberti
Summary: Interstitial lung diseases are a complex group of diseases with unclear causes and mechanisms of progression. Recent research suggests that the lung microbiome may play a role in the development and progression of these diseases. However, the specific mechanisms are not yet understood. This review aims to discuss the role of altered lung microbiome in various interstitial lung diseases. Understanding the interaction between the host and microbiome in the lungs is a priority for research on these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Xiaoting Yang, Jing Wang, Wei Liu
Summary: In this study, molecular markers associated with type II alveolar epithelial cell injury in acute lung injury (ALI) were identified using bioinformatics methods. The results provide new insights for the diagnosis and treatment of ALI/ARDS.
SCIENTIFIC REPORTS
(2023)
Review
Critical Care Medicine
Steven D. Nathan
Summary: Pulmonary hypertension, a common complication of fibrotic interstitial lung disease, is associated with increased morbidity and mortality. The effectiveness of treatment for pulmonary hypertension in the context of interstitial lung disease has been uncertain, with some studies suggesting benefit and others demonstrating harm. However, recent research has shown the potential benefits of treatment, leading to the approval of the first therapy for patients with interstitial lung disease complicated by pulmonary hypertension in the United States. This review also provides a management algorithm and considerations for future clinical trials.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Plant Sciences
JunMei Wang, Chunxiu Ren, WenHui Bi, Wuliji Batu
Summary: Glycyrrhiza glabra L. is a widely used traditional Chinese medicine with various therapeutic effects. This study found that its active ingredient, glycyrrhizin, has anti-inflammatory effects and can alleviate acute lung injury (ALI) by interfering with the NF-κB/NLRP3 signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaoyu Han, Lu Chen, Yanqing Fan, Osamah Alwalid, Xi Jia, Yuting Zheng, Jie Liu, Yumin Li, Yukun Cao, Jin Gu, Jia Liu, Chuansheng Zheng, Qing Ye, Heshui Shi
Summary: This prospective study longitudinally assessed changes in chest CT abnormalities and pulmonary function in individuals after recovery from SARS-CoV-2 infection. The study found that more than one-third of the participants had persistent interstitial lung abnormalities 2 years after infection, which were associated with respiratory symptoms and decreased diffusion pulmonary function.
Review
Biochemistry & Molecular Biology
Fotios Drakopanagiotakis, Elisavet Stavropoulou, Christina Tsigalou, Evangelia Nena, Paschalis Steiropoulos
Summary: The microbiome plays a crucial role in triggering and maintaining immune-mediated diseases in connective tissue diseases and pulmonary vasculitis. However, current research data are limited, and further studies are needed.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Mark C. Murphy, Brent P. Little
Summary: This case report describes a patient with severe COVID-19 pneumonia who required ICU admission and had a prolonged hospital stay. The infection led to long-term morbidity, functional decline, and abnormal chest CT findings. The article discusses the mechanisms of long-term lung injury, imaging appearances, and the role of imaging in follow-up after COVID-19 infection.
Article
Medicine, General & Internal
Diana C. Sanchez-Ramirez
Summary: This study retrospectively analyzed the impact of a publicly funded pulmonary rehabilitation program on patients with various lung diseases. The results showed that the program significantly improved patients' exercise capacity, self-efficacy, and health-related quality of life. The effects varied across different lung diseases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cell Biology
Zachary A. Haynes, Abhimanyu Chandel, Christopher S. King
Summary: The article provides a comprehensive review of pulmonary hypertension in interstitial lung disease, including its pathophysiology, updated diagnostic approaches, and recent clinical trials, offering an effective approach for medical management.
Article
Multidisciplinary Sciences
Corina N. D'Alessandro-Gabazza, Taro Yasuma, Tetsu Kobayashi, Masaaki Toda, Ahmed M. Abdel-Hamid, Hajime Fujimoto, Osamu Hataji, Hiroki Nakahara, Atsuro Takeshita, Kota Nishihama, Tomohito Okano, Haruko Saiki, Yuko Okano, Atsushi Tomaru, Valeria Fridman D'Alessandro, Miyako Shiraishi, Akira Mizoguchi, Ryoichi Ono, Junpei Ohtsuka, Masayuki Fukumura, Tetsuya Nosaka, Xuenan Mi, Diwakar Shukla, Kensuke Kataoka, Yasuhiro Kondoh, Masaki Hirose, Toru Arai, Yoshikazu Inoue, Yutaka Yano, Roderick Mackie, Isaac Cann, Esteban C. Gabazza
Summary: The authors demonstrate that a monoclonal neutralizing antibody against the proapoptotic peptide corisin, derived from the lung microbiota, can improve acute exacerbation of pulmonary fibrosis and the severity of endotoxin-induced acute lung injury in mice. The study provides insights into the processing and release of corisin and shows that an anticorisin monoclonal antibody can ameliorate lung fibrosis and acute lung injury. These findings highlight the role of corisin in the pathogenesis of the diseases and offer a novel approach to treating the incurable disease.
NATURE COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Dong Liu, Mengmeng Long, Leilei Gao, Yanjun Chen, Fang Li, Yang Shi, Ning Gu
Summary: The respiratory system is crucial in vertebrate biology, but viral infections can cause severe damage. Currently, there are no effective treatments, but nanomedicine shows potential. This review provides a summary of the pathology and clinical treatments of respiratory injuries, focusing on nanomedicine formulations tested in preclinical models.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Medicine, General & Internal
Amalia Baroutidou, Alexandra Arvanitaki, Adam Hatzidakis, Georgia Pitsiou, Antonios Ziakas, Haralambos Karvounis, George Giannakoulas
Summary: Haemoptysis is a severe bleeding manifestation in the clinical course of pulmonary arterial hypertension associated with congenital heart disease. Dysfunction of the pulmonary vascular bed increases the risk of haemoptysis episodes, and despite treatment strategies like BAE, bleeding recurrences are prevalent. There is currently no clear guideline regarding the use of oral anticoagulation in patients with haemoptysis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Letter
Dermatology
O. Gaudin, B. Milpied, B. Papouin, S. Hue, N. Ortonne, E. Regnier, P. Wolkenstein, O. Chosidow, N. de Prost, S. Ingen-Housz-Oro
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Letter
Dermatology
Thomas Bettuzzi, Camille Hua, Emmanuelle Diaz, Audrey Colin, Pierre Wolkenstein, Nicolas de Prost, Saskia Ingen-Housz-Oro
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Critical Care Medicine
Damien Contou, Tomas Urbina, Nicolas de Prost
INTENSIVE CARE MEDICINE
(2022)
Letter
Critical Care Medicine
Segolene Gendreau, Brice Benelli, Maxime Deliere, Samuel Tuffet, Nicolas de Prost, Keyvan Razazi, Guillaume Carteaux, Armand Mekontso Dessap
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Medicine, General & Internal
Romain Arrestier, Segolene Gendreau, David Mokrani, Jean-Philippe Bastard, Soraya Fellahi, Francois Bagate, Paul Masi, Thomas D'Humieres, Keyvan Razazi, Guillaume Carteaux, Nicolas De Prost, Vincent Audard, Armand Mekontso-Dessap
Summary: AKI is common in COVID-19 patients hospitalized in ICU, and it appears to be related to tubular lesions rather than glomerular injury. Urinary proteinuria profile could be a non-invasive tool to investigate the pathophysiological process underlying AKI in COVID-19 patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Virology
Slim Fourati, Etienne Audureau, Romain Arrestier, Stephane Marot, Claire Dubois, Guillaume Voiriot, Charles-Edouard Luyt, Tomas Urbina, Julien Mayaux, Anne-Marie Roque-Afonso, Tai Pham, Luce Landraud, Benoit Visseaux, Damien Roux, Raphael Bellaiche, Anne-Sophie L'honneur, Zakaria Ait Hamou, Segolene Brichler, Stephane Gaudry, Maud Salmona, Raphael Clere-Jehl, Elie Azoulay, Laurence Morand-Joubert, Anne-Genevieve Marcelin, Marie-Laure Chaix, Diane Descamps, Armand Mekontso Dessap, Christophe Rodriguez, Jean-Michel Pawlotsky, Nicolas de Prost
Summary: This study aimed to investigate the relationship between SARS-CoV-2 variants and clinical outcomes. The findings showed that the alpha variant did not increase the risk of mortality compared to other variants. Additionally, there was no association between specific variants or mutations and day-28 mortality.
Article
Medicine, General & Internal
Keyvan Razazi, Flora Delamaire, Vincent Fihman, Mohamed Ahmed Boujelben, Nicolas Mongardon, Segolene Gendreau, Quentin de Roux, Nicolas de Prost, Guillaume Carteaux, Paul-Louis Woerther, Armand Mekontso Dessap
Summary: This study evaluated the application of a new rapid PCR method in mechanically ventilated patients. The results showed that this method had high sensitivity and specificity in diagnosing lung infections, and it could effectively guide antibiotic therapy. However, further research is needed to assess the potential of this method in antibiotic stewardship.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Nicolas de Prost, Etienne Audureau, Nicholas Heming, Elyanne Gault, Tai Pham, Amal Chaghouri, Nina de Montmollin, Guillaume Voiriot, Laurence Morand-Joubert, Adrien Joseph, Marie-Laure Chaix, Sebastien Preau, Raphael Favory, Aurelie Guigon, Charles-Edouard Luyt, Sonia Burrel, Julien Mayaux, Stephane Marot, Damien Roux, Diane Descamps, Sylvie Meireles, Frederic Pene, Flore Rozenberg, Damien Contou, Amandine Henry, Stephane Gaudry, Segolene Brichler, Jean-Francois Timsit, Antoine Kimmoun, Cedric Hartard, Louise-Marie Jandeaux, Samira Fafi-Kremer, Paul Gabarre, Malo Emery, Claudio Garcia-Sanchez, Sebastien Jochmans, Aurelia Pitsch, Djillali Annane, Elie Azoulay, Armand Mekontso Dessap, Christophe Rodriguez, Jean-Michel Pawlotsky, Slim Fourati
Summary: In this prospective study, it was found that the clinical phenotype of patients infected with the Omicron variant differs from those infected with the Delta variant. Immunocompromised patients infected with the Omicron variant have a significantly higher mortality rate compared to non-immunocompromised patients. However, no association was observed between specific sublineages or viral genome polymorphisms/mutational profiles of the Omicron variant and mortality.
NATURE COMMUNICATIONS
(2022)
Correction
Multidisciplinary Sciences
Nicolas de Prost, Etienne Audureau, Nicholas Heming, Elyanne Gault, Tai Pham, Amal Chaghouri, Nina de Montmollin, Guillaume Voiriot, Laurence Morand-Joubert, Adrien Joseph, Marie-Laure Chaix, Sebastien Preau, Raphael Favory, Aurelie Guigon, Charles-Edouard Luyt, Sonia Burrel, Julien Mayaux, Stephane Marot, Damien Roux, Diane Descamps, Sylvie Meireles, Frederic Pene, Flore Rozenberg, Damien Contou, Amandine Henry, Stephane Gaudry, Segolene Brichler, Jean-Francois Timsit, Antoine Kimmoun, Cedric Hartard, Louise-Marie Jandeaux, Samira Fafi-Kremer, Paul Gabarre, Malo Emery, Claudio Garcia-Sanchez, Sebastien Jochmans, Aurelia Pitsch, Djillali Annane, Elie Azoulay, Armand Mekontso Dessap, Christophe Rodriguez, Jean-Michel Pawlotsky, Slim Fourati
NATURE COMMUNICATIONS
(2022)
Letter
Hematology
Segolene Gendreau, Jerome Cecchini, Francois Perier, Keyvan Razazi, Guillaume Carteaux, Nicolas De Prost, Pablo Bartolucci, Anoosha Habibi, Armand Mekontso Dessap
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Letter
Critical Care Medicine
Nicolas de Prost, Marie Laurent
ANNALS OF INTENSIVE CARE
(2023)
Article
Immunology
Pierre Bay, Cloe Loegel, Arnaud Ly, Alexandre Soulier, Melissa N'Debi, Sarah Seng, Christian Kassasseya, Christophe Rodriguez, Jean-Michel Pawlotsky, Nicolas de Prost, Slim Fourati
Summary: A study investigating the clinical phenotypes and genetic diversity of respiratory syncytial virus (RSV) found no clustering by severity. Patients infected with RSV-B at risk for severe pneumonia had higher fusion protein diversity. No substitutions conferring resistance to nirsevimab were detected.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Critical Care Medicine
Victor Penaud, Thibault Duburcq, Come Bureau, Charlotte Salmon Gandonniere, Romain Arrestier, Samuel Henri, Martin Dres, Sophie Jacquier, Nicolas De Prost, Raphael Giraud, Jean-Damien Ricard, Damien Roux, Fabrice Uhel, David Legouis, Charles Verney
Summary: This study suggests that in patients with severe ARDS requiring VV ECMO, initiation of VV ECMO leads to an increase in daily urine output and natriuresis, without changes in glomerular filtration rate.
JOURNAL OF INTENSIVE CARE MEDICINE
(2023)
Article
Immunology
Thomas Frapard, Giuliana Amaddeo, Maxens Decavele, Paer-Selim Abback, Antoine Gaillet, Charlotte Bouzbib, Claire Vanlemmens, Romy Younan, Emmanuel Canet, Anne Sophie Moreau, Mathilde Neuville, Elie Azoulay, Alexandre Sitbon, Djamel Mokart, Sylvie Radenne, Armand Abergel, Celine Guichon, Olivier Roux, Agnes Bonadona, Armand Mekontso Dessap, Audrey De Jong, Jerome Dumortier, Nicolas de Prost
Summary: The clinical features and short-term prognosis of patients admitted to the intensive care unit for herpes hepatitis are lacking. Among the 33 patients admitted between 2006 and 2022, 22 were immunocompromised, 4 were pregnant women, and 23 died. Sixteen patients developed a hemophagocytic syndrome.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Critical Care Medicine
Nicolas de Prost, Etienne Audureau, Sebastien Preau, Raphael Favory, Aurelie Guigon, Pierre Bay, Nicholas Heming, Elyanne Gault, Tai Pham, Amal Chaghouri, Guillaume Voiriot, Laurence Morand-Joubert, Sebastien Jochmans, Aurelia Pitsch, Sylvie Meireles, Damien Contou, Amandine Henry, Adrien Joseph, Marie-Laure Chaix, Fabrice Uhel, Diane Descamps, Malo Emery, Claudio Garcia-Sanchez, Charles-Edouard Luyt, Stephane Marot, Frederic Pene, Anne-Sophie Lhonneur, Stephane Gaudry, Segolene Brichler, Lucile Picard, Armand Mekontso Dessap, Christophe Rodriguez, Jean-Michel Pawlotsky, Slim Fourati, SEVARVIR Investigators
Summary: A study found that critically ill patients with Omicron BQ.1.1 infection showed a different clinical phenotype than those infected with earlier Omicron sublineage, but there was no difference in day-28 mortality.
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2023)