Journal
EUROPEAN RESPIRATORY JOURNAL
Volume 33, Issue 1, Pages 11-20Publisher
EUROPEAN RESPIRATORY SOC JOURNALS LTD
DOI: 10.1183/09031936.00068508
Keywords
Airway smooth muscle; asthma; ion channels; myosin light chain; receptors
Categories
Funding
- Canadian Institutes of Health Research (Ottawa, ON, Canada)
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Reversible airflow obstruction and nonspecific airway hyperresponsiveness are: 1) the two key features of asthma; 2) the primary concern for asthma patients; and 3) both directly caused by the airway smooth muscle (ASM). As such, controlling bronchoconstriction should be of primary importance. Unfortunately, all existing pharmacological asthma therapies that specifically target the ASM are based on decades old strategies. In the present study, the evolution of pharmacological asthma therapy will be briefly discussed, some explanations will be suggested as to why substantial new advances in this area have not occurred in several years and, finally, several new directions for novel asthma therapies will be proposed.
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