Article
Medicine, General & Internal
Christine Elizabeth Loftis, Emilia Dulgheru, Adolfo Kaplan
Summary: This case report describes a female patient with rheumatoid arthritis who was successfully treated with rituximab for organising pneumonia (OP) after failing multiple treatment regimens. It highlights the importance of identifying new therapeutic agents to minimize the use of glucocorticoids.
Review
Respiratory System
Ganesh Raghu, Keith C. Meyer
Summary: Organising pneumonia (OP) is a nonspecific lung injury response associated with various imaging patterns seen on high-resolution computed tomography (HRCT) of the chest, characterized histopathologically by the presence of inflammatory cells and connective tissue matrix in distal airspaces of the lungs. OP is linked to different conditions like connective tissue disorders, infections, drug reactions, hypersensitivity pneumonitis, and aspiration. When OP cannot be attributed to any specific condition, it is termed cryptogenic organising pneumonia.
EUROPEAN RESPIRATORY REVIEW
(2021)
Review
Immunology
Mohammad Afzal Khan, Christine L. Lau, Alexander Sasha Krupnick
Summary: By studying the levels of Tregs/FOXP3 gene expression, it can serve as a crucial prognostic biomarker for the progression of chronic lung allograft dysfunction (CLAD) in lung transplant recipients, and provide potential therapeutic options to improve lung transplant survival rates.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Respiratory System
Tang-Hsiu Huang, Sheng-Huan Wei, Li-Ting Huang, Hong-Ping Er, Yu-Ting Yu, Chung-Ta Lee, Yau-Lin Tseng, Chao-Liang Wu
Summary: This study investigated the impact of CT patterns and extent of OP on the diagnostic and therapeutic management of patients. It found that patients with multilobe involvement or mixed patterns were more likely to have secondary OP and receive immunosuppressants. These patients also had a higher risk of recurrence and severe disease, and decreased survival probabilities.
Article
Immunology
Isabella Hanka, Thomas Stamminger, Martina Ramsperger-Gleixner, Annika V. Kuckhahn, Regina Mueller, Michael Weyand, Christian Heim
Summary: The study found that CMV infection accelerates chronic airway rejection, while deletion of the chemokine receptor M33 attenuates rejection.
TRANSPLANT IMMUNOLOGY
(2021)
Article
Geriatrics & Gerontology
Cecilia Soderberg-Naucler
Summary: The majority of people infected with SARS-CoV-2 show no symptoms or have mild symptoms, but a small percentage may develop severe illness, especially among the elderly. It remains unclear why some individuals progress to severe COVID-19, and there may be a potential link to the reactivation of latent viruses.
Article
Cell Biology
Laura Bergantini, Miriana d'Alessandro, Elda De Vita, Felice Perillo, Antonella Fossi, Luca Luzzi, Piero Paladini, Anna Perrone, Paola Rottoli, Piersante Sestini, Elena Bargagli, David Bennett
Summary: In acute rejection (AR) and chronic lung allograft dysfunction, the balance between immune cells is different, with a predominance of Th17 cells subtypes and depletion of Tregs observed in AR patients. Understanding the balance between regulatory and effector cells can effectively discriminate patients' immunological status.
Article
Hematology
Marc-Henri Stern
Summary: T-cell prolymphocytic leukemia is a rare and aggressive form of leukemia with limited treatment options, mainly affecting the elderly. It can also manifest in children with ataxia telangiectasia, originating from mature T lymphocytes at the end of thymic differentiation. The genomic profile is complex, with chromosomal translocation activating TCL1 oncogene family members being a key feature of T-PLL.
Article
Multidisciplinary Sciences
Yoshiko Yamasuji-Maeda, Hisakazu Nishimori, Keisuke Seike, Akira Yamamoto, Hideaki Fujiwara, Taiga Kuroi, Kyosuke Saeki, Haruko Fujinaga, Sachiyo Okamoto, Ken-Ichi Matsuoka, Nobuharu Fujii, Takehiro Tanaka, Masahiro Fujii, Katsumi Mominoki, Takuro Kanekura, Yoshinobu Maeda
Summary: Intrabone marrow stem cell transplantation (IBM-SCT) shows superiority in reducing non-infectious pulmonary complications, improving clinical and pathological outcomes of lung chronic GVHD.
Article
Environmental Sciences
Emma L. House, So-Young Kim, Carl J. Johnston, Angela M. Groves, Eric Hernady, Ravi S. Misra, Matthew D. McGraw
Summary: Repeated exposure to diacetyl vapor induced mixed, granulocytic lung inflammation in rats, with increased CD4(+)CD25(+) T cells in the lungs, directly correlated with IL-17a levels in BALF.
Review
Virology
Lloyd Einsiedel, Fabian Chiong, Hubertus Jersmann, Graham P. Taylor
Summary: HTLV-1 infection can lead to various pulmonary diseases, such as interstitial pneumonia and bronchiolitis, possibly through the recruitment of other inflammatory cells in the pathogenesis. Additionally, HTLV-1 associated pulmonary disease may result in significant parenchymal damage, progressing to bronchiectasis.
Article
Immunology
Simona Nemska, Francois Daubeuf, Adeline Obrecht, Dominique Israel-Biet, Marc Stern, Romain Kessler, Antoine Roux, Reza Tavakoli, Pascal Villa, Adrien Tissot, Richard Danger, Laurent Reber, Eugenie Durand, Aurore Foureau, Sophie Brouard, Antoine Magnan, Nelly Frossard
Summary: The study demonstrates that inhibition of the proinflammatory mitogen- and stress-activated kinase 1 (MSK1) kinase can effectively alleviate damage caused by lung transplantation, suggesting its potential as a therapeutic target for chronic lung allograft dysfunction (CLAD).
Article
Immunology
Simona Nemska, Francois Daubeuf, Adeline Obrecht, Dominique Israel-Biet, Marc Stern, Romain Kessler, Antoine Roux, Reza Tavakoli, Pascal Villa, Adrien Tissot, Richard Danger, Laurent Reber, Eugenie Durand, Aurore Foureau, Sophie Brouard, Antoine Magnan, Nelly Frossard, COLT consortium
Summary: Inhibition of the proinflammatory MSK1 kinase shows promise as a marker or potential therapeutic target for lung dysfunction posttransplantation, with effects on mitigating damage and reducing inflammation demonstrated through experiments and case studies.
Review
Immunology
Rokhaya Ba, Estelle Geffard, Venceslas Douillard, Francoise Simon, Laurent Mesnard, Nicolas Vince, Pierre-Antoine Gourraud, Sophie Limou
Summary: In the era of big data, the quantity of available data in both research and care is increasing, which presents challenges for patients, caregivers, and researchers. In the field of transplantation, omics studies have greatly impacted research and the understanding of transplant outcomes. Integrating omics data is challenging due to biases and errors, and normalization and imputation methods have been developed to address these issues. The transplantation field brings additional complexity to omics analysis, and new strategies such as combined risk scores are emerging to better understand graft mechanisms.
Article
Immunology
Tathagat Narula, Samir Khouzam, Francisco Alvarez, David Erasmus, Zhuo Li, Yousif Abdelmoneim, Mohamed Elrefaei
Summary: The study found that induction immunosuppression with a single dose of rATG is associated with a significant reduction in de novo DSA production in lung transplant recipients.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Letter
Hematology
William G. Dunn, Muxin S. Gu, Margarete A. Fabre, Jonathan Cooper, Josep F. Nomdedeu, Laura Koumas, Katerina Nicolaou, Jiangxiang Chi, Paul Costeas, George S. Vassiliou
ANNALS OF HEMATOLOGY
(2022)
Article
Hematology
Guadalupe Onate, Alex Bataller, Ana Garrido, Montserrat Hoyos, Montserrat Arnan, Susana Vives, Rosa Coll, Mar Tormo, Antonia Sampol, Lourdes Escoda, Olga Salamero, Antoni Garcia, Joan Bargay, Alba Aljarilla, Josep F. Nomdedeu, Jordi Esteve, Jorge Sierra, Marta Pratcorona
Summary: This study analyzed the impact of DNMT3A(mut) in FLT3-ITD subsets and found that DNMT3A(mut) did not modify the overall prognosis exerted by FLT3-ITD in AML-NPM1, despite delayed MRD clearance, possibly because of MRD-driven preemptive intervention.
Article
Clinical Neurology
Ana Zabalza, Georgina Arrambide, Susana Otero-Romero, Agustin Pappolla, Paula Tagliani, Samuel Lopez-Maza, Simon Cardenas-Robledo, Juliana Esperalba, Candela Fernandez-Naval, Monica Martinez-Gallo, Mireia Castillo, Merce Bonastre, Mireia Resina-Salles, Jordina Bertran, Marta Rodriguez-Barranco, Pere Carbonell-Mirabent, Marina Gonzalez, Miguel Merchan, Ana Quiroga-Varela, Albert Miguela, Imma Gomez, Gary Alvarez, Rene Robles, Dunia Perez Del Campo, Xavier Queralt, Maria Jose Soler, Irene Agraz, Fernando Martinez-Valle, Breogan Rodriguez-Acevedo, Luciana Midaglia, Angela Vidal-Jordana, Alvaro Cobo-Calvo, Carmen Tur, Ingrid Galan, Joaquin Castillo, Jordi Rio, Carmen Espejo, Manuel Comabella, Carlos Nos, Jaume Sastre-Garriga, Lluis Ramio-Torrenta, Mar Tintore, Xavier Montalban
Summary: Anti-CD20 and S1PRM modify the immunological responses to SARS-CoV-2 vaccines, with humoral response decreasing under these treatments and with longer duration, while patients on anti-CD20 can still present cellular responses even in the absence of antibodies.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Medicine, General & Internal
Monica Martinez-Gallo, Juliana Esperalba, Ricardo Pujol-Borrell, Victor Sanda, Iria Arrese-Munoz, Candela Fernandez-Naval, Andres Anton, Victoria Cardona, Moises Labrador-Horrillo, Tomas Pumarola, Manuel Hernandez-Gonzalez
Summary: This study aimed to assess the feasibility of a validated assay of T-cell responses as a complement to antibody tests for evaluating the levels of protection generated by natural infection or SARS-CoV-2 vaccines. The results showed that the IGRA test detected T-cell responses in naturally exposed and vaccinated individuals, and there was a high correlation with specific antibody levels. These findings suggest that the IGRA test could be a promising tool for measuring the state of the immune response to SARS-CoV-2.
Article
Immunology
Adrian Sanchez-Montalva, Daniel Alvarez-Sierra, Monica Martinez-Gallo, Janire Perurena-Prieto, Iria Arrese-Munoz, Juan Carlos Ruiz-Rodriguez, Juan Espinosa-Pereiro, Pau Bosch-Nicolau, Xavier Martinez-Gomez, Andres Anton, Ferran Martinez-Valle, Mar Riveiro-Barciela, Albert Blanco-Grau, Francisco Rodriguez-Frias, Pol Castellano-Escuder, Elisabet Poyatos-Canton, Jordi Bas-Minguet, Eva Martinez-Caceres, Alex Sanchez-Pla, Coral Zurera-Egea, Aina Teniente-Serra, Manuel Hernandez-Gonzalez, Ricardo Pujol-Borrell
Summary: Currently used laboratory tests for clinical management of COVID-19 patients have limited predictive power due to redundancy. This limitation could be overcome by adding immunological tests with independent predictive power.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Juan Carlos Ruiz-Rodriguez, Luis Chiscano-Camon, Adolf Ruiz-Sanmartin, Clara Palmada, Ivan Bajana, Gloria Iacoboni, Camilo Bonilla, Alejandra Garcia-Roche, Erika Paola Plata-Menchaca, Carolina Maldonado, Marcos Perez-Carrasco, Monica Martinez-Gallo, Clara Franco-Jarava, Manuel Hernandez-Gonzalez, Ricard Ferrer
Summary: This case report discusses the treatment process of a HLH patient, including diagnosis, treatment options, and the effectiveness of using Cytosorb(R) for cytokine hemoadsorption. Through cytokine hemoadsorption therapy, the patient's cytokine levels were successfully reduced, leading to significant hemodynamic improvement.
FRONTIERS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Gara Arteaga-Henriquez, Jorge Lugo-Marin, Laura Gisbert, Imanol Setien-Ramos, Monica Martinez-Gallo, Ricardo Pujol-Borrell, Josep Antoni Ramos-Quiroga
Summary: Individuals with Autism spectrum disorder (ASD) exhibit differences in immune cell levels and inflammation markers compared to typically developing (TD) controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Gerard Godoy-Tena, Anis Barmada, Octavio Morante-Palacios, Carlos de la Calle-fabregat, Ricardo Martins-Ferreira, Anna G. Ferrete-Bonastre, Laura Ciudad, Adolfo Ruiz-Sanmartin, Monica Martinez-Gallo, Ricard Ferrer, Juan Carlos Ruiz-Rodriguez, Javier Rodriguez-Ubreva, Roser Vento-Tormo, Esteban Ballestar
Summary: Peripheral blood monocytes in severe COVID-19 patients undergo epigenetic and transcriptional reprogramming during hyperinflammatory responses, which may be associated with the release of aberrant immune cells, increased systemic levels of pro-inflammatory cytokines, and changes in immune cell crosstalk.
Article
Hematology
Moraima Jimenez, Candela Fernandez-Naval, Victor Navarro, Sandra Novoa, Monica Martinez-Gallo, Daniel Medina, Cristina Andres, Andres Anton, Soraya Peralta, Gemma Pujadas, Cristina Hernandez, Carlota Pages, Elisa Roldan, Tomas Pumarola, Mercedes Gironella, Isabel Ruiz-Camps, Xavier Martinez-Gomez, David Valcarcel, Manuel Hernandez, Francesc Bosch, Marta Crespo, Juliana Esperalba, Pau Abrisqueta
Summary: The study evaluated the long-term cellular and humoral immunogenicity induced by two and three doses of the mRNA-1273 SARS-CoV-2 vaccine in patients with hematologic malignancies and its relationship with the severity of breakthrough SARS-CoV-2 infection. The results showed a decline in seroconversion rate and anti-S titers after the second dose, especially in older patients or those with chronic lymphocytic leukemia. Cellular immunogenicity remained positive in most cases. A third vaccine dose improved the immune response in previously negative patients. COVID-19 severity was associated with impaired vaccine-induced immunogenicity.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Letter
Hematology
Oskar Marin-Bejar, Damia Romero-Moya, Javier Rodriguez-Ubreva, Maximiliano Distefano, Francesca Lessi, Paolo Aretini, Alessandro Liquori, Julio Castano, Emilia Kozyra, Lili Kotmayer, Clara Bueno, Jose Cervera, Jose Carlos Rodriguez-Gallego, Josep F. Nomdedeu, Laura Murillo-Sanjuan, Cristina Diaz de Heredia, Antonio Perez-Martinez, Felix Lopez-Cadenas, Carolina Martinez-Laperche, Nieves Dorado-Herrero, Francisco M. Marco, Felipe Prosper, Pablo Menendez, David Valcarcel, Esteban Ballestar, Csaba Bodor, Anna Bigas, Albert Catala, Marcin W. Wlodarski, Alessandra Giorgetti
Article
Allergy
Blanca Garcia-Solis, Ana Den Van Den Rym, Laura Martinez-Martinez, Teresa Franco, Jareb J. Perez-Caraballo, Janet Markle, Carolina Cubillos-Zapata, Ana Marin, Maria J. Recio, Jose R. Regueiro, Alfonso Navarro-Zapata, Carmen Mestre-Duran, Cristina Ferreras, Carla Martin Cotazar, Rocio Mena, Carlos de la Calle-Fabregat, Alberto Lopez-Lera, Miguel Fernandez Arquero, Antonio Perez-Martinez, Eduardo Lopez-Collazo, Silvia Sanchez-Ramon, Jean-Laurent Casanova, Ruben Martinez-Barricarte, Oscar de la Calle-Martin, Rebeca Perez de Diego
Summary: This study investigated a patient with an unknown genetic cause of inborn errors of immunity (IEI) and identified a homozygous missense mutation in the ezrin gene. The mutation resulted in a loss of function of ezrin, which affected the assembly and signaling of cellular and humoral immunity.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Daniel Alvarez-Sierra, Nerea Sanchez-Gaona, Maria Cruz Cobo, Alba Escriche, Maria Abad, Aroa Gomez-Brey, Irene Bello, Enric Caubet, Oscar Gonzalez, Carles Zafon, Carmela Iglesias, Pablo Moreno, Anna Petitj, Marco Antonio Fernandez-Sanmartin, Monica Martinez-Gallo, Ricardo Pujol-Borrell
Summary: Immune Checkpoint Receptors play a role in regulating immune responses and preventing tissue damage. Inhibiting the PD-1/PD-L1 receptor axis has shown promising results in cancer immunotherapy but can also lead to autoimmune adverse effects. This study investigates the role of PD-1/PD-L1 in the interaction between T cells and thyroid cells, and suggests that TFCs suppress T cell proliferation through the expansion of DN T cells, rather than PD-1/PD-L1. These findings contribute to our understanding of immune regulation and suggest alternative pathways for tumor evasion.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Immunology
Laura Batlle-Maso, Jacques G. Riviere, Clara Franco-Jarava, Andrea Martin-Nalda, Marina Garcia-Prat, Alba Parra-Martinez, Aina Aguilo-Cucurull, Neus Castells, Monica Martinez-Gallo, Pere Soler-Palacin, Roger Colobran
Summary: Chronic granulomatous disease (CGD) is an inborn error of immunity characterized by phagocytes' inability to produce reactive oxygen species, leading to dysregulated inflammatory responses and susceptibility to severe infections. The most common and severe form of CGD is X-linked CGD (XL-CGD), caused by mutations in the CYBB gene. This study illustrates the molecular challenges in the genetic diagnosis of XL-CGD through the analysis of three affected families, including heterozygous deletions of CYBB exon 13, hemizygous deletion of CYBB exon 7, and a novel intronic variant affecting splicing process.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Meeting Abstract
Hematology
Albert Esquirol, Yolanda Guillen, Elena Bussaglia, Vanesa Criado, Maite Carricondo, Pamela Acha, Manel Esteller, Jorge Sierra, Francesc Sole, Anna Bigas, Josep F. Nomdedeu
Meeting Abstract
Hematology
Alicia Artigas-Baleri, Helena Castellet, Marta Pratcorona, Lurdes Zamora, Monica Lopez-Guerra, Barbara Tazon, Susana Vives, Mar Tormo, Montserrat Arnan, Antoni Garcia-Guinon, Rosa Coll, Antonia Sampol, Joan Bargay, Ferran Vall-Llovera, Olga Salamero, Felix Lopez-Cadenas, Ana Garrido Diaz, Jordi Esteve, Jorge Sierra, Josep F. Nomdedeu