Article
Biochemistry & Molecular Biology
Sandra L. Grimm, Rachel E. Stading, Matthew J. Robertson, Tanmay Gandhi, Chenlian Fu, Weiwu Jiang, Guobin Xia, Krithika Lingappan, Cristian Coarfa, Bhagavatula Moorthy
Summary: Oxygen supplementation is crucial for premature infants and COVID-19 patients, but it can also cause long-term pulmonary injury due to inflammation, with xenobiotic-metabolizing CYP enzymes playing a crucial role.
Review
Medicine, General & Internal
Kun Yang, Wenbin Dong
Summary: BPD is a chronic and debilitating disease that affects premature infants, mainly due to oxidative stress. High levels of oxygen lead to harmful events like mitochondrial dysfunction, inflammation, reduced autophagy, increased apoptosis, and fibrosis. Understanding the signaling pathways related to SIRT1 could potentially lead to new therapeutic targets for BPD.
FRONTIERS IN MEDICINE
(2021)
Review
Nutrition & Dietetics
Xianpeng Yang, Shanyu Jiang, Xianhui Deng, Zichen Luo, Ailing Chen, Renqiang Yu
Summary: In this review, the role of oxidative stress (OS) in the pathophysiology of bronchopulmonary dysplasia (BPD) and the potential of antioxidants in human milk to prevent and treat BPD were explored. The findings suggest that human milk may have a beneficial effect in preventing and improving the prognosis of BPD.
FRONTIERS IN NUTRITION
(2022)
Article
Cell & Tissue Engineering
Paola Bisaccia, Fabio Magarotto, Stefania D'Agostino, Arben Dedja, Silvia Barbon, Diego Guidolin, Cristina Liboni, Roberta Angioni, Giada De Lazzari, Federico Caicci, Antonella Viola, Marcin Jurga, Gabrielis Kundrotas, Dimitri Stevens, Domenico Mancuso, Elisabetta Gramegna, Bruno Seitaj, Rudra Kashyap, Beatrice De Vos, Veronica Macchi, Eugenio Baraldi, Andrea Porzionato, Raffaele De Caro, Maurizio Muraca, Michela Pozzobon
Summary: This study investigated the effects of clinical-grade mesenchymal stromal cells-derived extracellular vesicles (MSC-EVs) on lung and brain in a rat model of bronchopulmonary dysplasia (BPD). The results showed that MSC-EVs treatment protected against oxidative stress, improved lung epithelial function, and inhibited fibrosis development. This study suggests that MSC-EVs could be a potential new therapy for preventing the progression of BPD.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Cai Qing, Zhao Xinyi, Yu Xuefei, Xue Xindong, Fu Jianhua
Summary: Bronchopulmonary dysplasia (BPD) is a common devastating pulmonary complication in preterm infants, characterized by alveolar maldevelopment associated with oxidative stress and excessive apoptosis. Gap26, a connexin 43-inhibiting peptide, has been shown to improve alveolar development by inhibiting intercellular communication in BPD.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ashley Kimble, Mary E. Robbins, Marta Perez
Summary: This article explores the interaction between oxidative stress (OS) and genetic regulation and reviews 'omics' data related to OS in bronchopulmonary dysplasia (BPD). It presents data from animal models and human studies, showing differential expression of OS-related genes in murine models mimicking BPD, premature infants at risk of BPD, and infants with established lung disease. The data from metabolomics and proteomics also suggest the potential involvement of OS-related pathways in BPD. However, the difficulty of obtaining timely and appropriate human samples remains a limitation in many studies.
Article
Obstetrics & Gynecology
Nadja Bednarczuk, Emma E. Williams, Anne Greenough, Theodore Dassios
Summary: Higher COHb levels in prematurely born infants were associated with the development of BPD and IVH, but not with the duration of ventilation, BPD severity, or survival to discharge.
EARLY HUMAN DEVELOPMENT
(2022)
Article
Endocrinology & Metabolism
Sandra L. L. Grimm, Samuel Reddick, Xiaoyu Dong, Connor Leek, Amy Xiao Wang, Manuel Cantu Gutierrez, Sean M. M. Hartig, Bhagavatula Moorthy, Cristian Coarfa, Krithika Lingappan
Summary: This study demonstrates the essential role of miR-30a in regulating lung development and angiogenesis. Wild-type female mice show greater protection against hyperoxic lung injury than males, and this sex-dependent difference is eliminated when miR-30a is deleted. Transcriptomic analysis reveals that miR-30a deletion affects pathways related to cell cycle and neuroactive ligand-receptor interaction in female lungs. The findings suggest that miR-30a is a key factor in mediating the resilience of the female preterm lung to neonatal hyperoxic lung injury.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Respiratory System
Min Yang, Yanping Chen, Xueshan Huang, Fang Shen, Yanni Meng
Summary: This study investigated the role of E26 oncogene homolog 1 (ETS1) in oxidative stress-induced ferroptosis. The results showed that ETS1 overexpression reduced cell death and inflammation, and improved redox capacity. The protective effect of ETS1 was also observed in animal experiments, where it alleviated oxidative stress-induced lung injury.
Review
Biochemistry & Molecular Biology
Laura Cannavo, Serafina Perrone, Valeria Viola, Lucia Marseglia, Gabriella Di Rosa, Eloisa Gitto
Summary: Premature infants are at higher risk of oxidative stress-related lung injury, which can lead to respiratory distress syndrome and pulmonary hypertension. Oxidative stress is a key factor in the pathogenesis of these lung diseases in preterm newborns.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pediatrics
Chien-Chou Hsiao, Cheng-Han Lee, Rei-Cheng Yang, Jia-Yuh Chen, Tzu-Cheng Su, Yu-Jun Chang, Ching-Yuang Lin, Yi-Giien Tsai
Summary: This study revealed that Hsp-70 levels are associated with oxidative injury in the development of BPD. The development of BPD was significantly correlated with gestational age, respiratory distress syndrome, and TA Hsp-70 and 8-OHdG levels on post-natal Day 28. Further, the TA Hsp-70 level positively correlated with TA 8-OHdG level on both Day 1 and Day 28 of life.
FRONTIERS IN PEDIATRICS
(2021)
Review
Pediatrics
Vivek V. Shukla, Namasivayam Ambalavanan
Summary: Bronchopulmonary dysplasia (BPD) is a chronic lung disease that commonly occurs in preterm infants who require significant respiratory support. Despite improvements in neonatal care leading to increased survival rates, the incidence of BPD remains stable or even increasing. The pathogenesis of BPD is multifactorial, with high mortality rates, and prevention and management continue to be challenging.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Pharmacology & Pharmacy
X-G Li, X. Song, J-Y Wang, C-H Sun, Z-Q Li, L-L Meng, S-H Chi
Summary: The study showed that hyperoxia-induced lung injury in mice resulted in decreased expression of FGF18 and exogenous FGF18 was found to reduce oxidative stress and inflammation levels in lung epithelial cells, thus reducing cell injury caused by hyperoxia.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Ann Hellstrom, Aldina Pivodic, Lotta Granse, Pia Lundgren, Ulrika Sjobom, Anders K. Nilsson, Helena Soderling, Anna-Lena Hard, Lois E. H. Smith, Chatarina Alice Lofqvist
Summary: This study found that higher mean daily serum levels of DHA during the first 28 postnatal days were associated with less severe ROP, even after adjustment for known risk factors, but only in infants with sufficiently high AA levels. Further research is needed to identify LC-PUFA supplementation strategies that may prevent ROP and other morbidities.
Article
Pharmacology & Pharmacy
Xiaocheng Hu, Jian Xu, Ning Liu
Summary: This study found that rhubarb was able to alleviate inflammation, oxidative stress, and lung injury induced by hyperoxia in a neonatal rat model of BPD by inhibiting oxidative stress and reducing the levels of inflammatory factors.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Pediatrics
Eveline P. de Jong, Herma C. Holscher, Sylke J. Steggerda, Jeanine M. M. Van Klink, Erika P. M. van Elzakker, Enrico Lopriore, Frans J. Walther, Frank Brus
EUROPEAN JOURNAL OF PEDIATRICS
(2017)
Article
Physiology
Xueyu Chen, Mar Orriols, Frans J. Walther, El Houari Laghmani, Annemarie M. Hoogeboom, Anne C. B. Hogen-Esch, Pieter S. Hiemstra, Gert Folkerts, Marie-Jose T. H. Goumans, Peter Ten Dijke, Nicholas W. Morrell, Gerry T. M. Wagenaar
FRONTIERS IN PHYSIOLOGY
(2017)
Article
Physiology
Xueyu Chen, Frans J. Walther, El H. Laghmani, Annemarie M. Hoogeboom, Anne C. B. Hogen-Esch, Ingrid van Ark, Gert Folkerts, Gerry T. M. Wagenaar
FRONTIERS IN PHYSIOLOGY
(2017)
Article
Pharmacology & Pharmacy
Meng Li, Betty C. A. M. van Esch, Gerry T. M. Wagenaar, Johan Garssen, Gert Folkerts, Paul A. J. Henricks
EUROPEAN JOURNAL OF PHARMACOLOGY
(2018)
Article
Pediatrics
Reiko Sakurai, Cindy Lee, Humphrey Shen, Alan J. Waring, Frans J. Walther, Virender K. Rehan
Article
Immunology
Eveline P. de Jong, Monique G. A. van den Beuken, Erika P. M. van Elzakker, Katja C. Wolthers, Arwen J. Sprij, Enrico Lopriore, Frans J. Walther, Frank Brus
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2018)
Article
Hematology
Marco Heestermans, Salam Salloum-Asfar, Tom Streef, El Houari Laghmani, Daniela Salvatori, Brenda M. Luken, Sacha S. Zeerleder, Henri M. H. Spronk, Suzanne J. Korporaal, Daniel Kirchhofer, Gerry T. M. Wagenaar, Henri H. Versteeg, Pieter H. Reitsma, Thomas Renne, Bart J. M. van Vlijmen
Editorial Material
Respiratory System
Frans J. Walther, Larry M. Gordon, Alan J. Waring
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2019)
Article
Pediatrics
Xueyu Chen, Junyan Zhong, Dongshan Han, Fang Yao, Jie Zhao, Gerry. T. M. Wagenaar, Chuanzhong Yang, Frans J. Walther
Summary: Bronchopulmonary dysplasia (BPD) is a neonatal chronic lung disease with characteristics of arrested alveolar and vascular development, caused by lung immaturity, ventilator-induced lung injury, and hyperoxia exposure. Studies have shown a close association between platelet biogenesis and alveolarization in the developing lung. This association may explain the reduced platelet count in extremely premature infants with BPD.
FRONTIERS IN PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
Alan J. Waring, Julian P. Whitelegge, Shantanu K. Sharma, Larry M. Gordon, Frans J. Walther
Summary: The three-dimensional structure of the synthetic lung Surfactant Protein B Peptide Super Mini-B was determined using mass spectrometry and isotope enhanced Fourier-transform infrared (FTIR) spectroscopy. Analysis confirmed the correct folding and disulfide pairing using oxidative structure-promoting solvent systems. The residue-specific analysis indicated well-defined alpha-helical sequences in the N-terminal and C-terminal domains. Molecular dynamics simulation further refined the structure and revealed a helical hairpin structure resembling critical elements of the predicted full-length Surfactant Protein B structure.
Article
Biochemistry & Molecular Biology
Alan J. Waring, Grace C. -L. Jung, Shantanu K. Sharma, Frans J. Walther
Summary: Lung surfactant prevents lung collapse and is involved in innate immunity. Synthetic lung surfactant has shown clinical efficacy in surfactant-deficient premature infants and critically ill patients with acute respiratory distress syndrome (ARDS). COVID-19 pneumonia can cause loss and dysfunction of lung surfactant, which can be relieved by treatment with an exogenous lung surfactant. Synthetic lung surfactant peptide mimics can act as competitive inhibitors of the binding of viral receptor-binding domain (RBD) to the cellular receptor angiotensin-converting enzyme 2 (ACE2).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Critical Care Medicine
Hendrik J. F. Helmerhorst, Laura R. A. Schouten, Gerry T. M. Wagenaar, Nicole P. Juffermans, Joris J. T. H. Roelofs, Marcus J. Schultz, Evert de Jonge, David J. van Westerloo
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2017)
Article
Pediatrics
Henriette Anje van Zanten, Steffen C. Pauws, Ben J. Stenson, Frans J. Walther, Enrico Lopriore, Arjan B. te Pas
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2018)