Article
Nursing
Chestharid Borriboon, Jindarat Chaiard, Chiraporn Tachaudomdach, Sue Turale
Summary: This study aimed to investigate the relationship between health belief model factors and CPAP adherence in Thai individuals with obstructive sleep apnoea. Results showed a low rate of CPAP adherence, with perceived seriousness of the conditions being the only significant factor associated with adherence. Healthcare professionals, especially nurses, should provide support and education to encourage regular CPAP use and be aware of psychological factors affecting patients' perception of sleep apnoea and CPAP treatment. Intervention strategies targeting these factors should be developed and implemented in clinical practice.
JOURNAL OF CLINICAL NURSING
(2022)
Article
Medicine, General & Internal
Subash S. Heraganahally, Kyi K. Zaw, Sai Tip, Xinlin Jing, Joy J. Mingi, Timothy Howarth, Anil Roy, Henrik Falhammar, Dimitar Sajkov
Summary: This retrospective study explored the clinical characteristics, polysomnographic features, and adherence to continuous positive airway pressure (CPAP) therapy among Australian women with obstructive sleep apnoea (OSA). The results showed that age, BMI, and hypertension were predictors of OSA presence and severity. Adherence to CPAP therapy was associated with symptomatic OSA and severe oxygen desaturation.
INTERNAL MEDICINE JOURNAL
(2022)
Article
Ophthalmology
Meltem Guzin Altinel, Hasim Uslu, Ayse Yagmur Kanra, Orhan Dalkilic
Summary: The study evaluated the effect of OSAS and CPAP therapy on choroidal structural changes and CVI in patients with OSAS. OSAS was associated with stromal edema in the choroid, which improved after 12 months of CPAP therapy. CVI can be an important parameter for monitoring patients with OSAS.
Article
Clinical Neurology
Mariana Fernandes, Luisa Mari, Agostino Chiaravalloti, Barbara Paoli, Marzia Nuccetelli, Francesca Izzi, Maria Pia Giambrone, Riccardo Camedda, Sergio Bernardini, Orazio Schillaci, Nicola Biagio Mercuri, Fabio Placidi, Claudio Liguori
Summary: The study found cognitive impairment, reduced cerebral glucose consumption, and alterations in CSF biomarkers in OSA patients, which may reinforce the hypothesis of AD neurodegenerative processes triggered by OSA. Notably, cognition and brain glucose consumption improved after beneficial CPAP treatment. Further studies are needed to evaluate the long-term effects of CPAP treatment on these AD biomarkers.
JOURNAL OF NEUROLOGY
(2022)
Article
Health Care Sciences & Services
Manuel Fernandes, Catarina Antunes, Cristina Martinho, Joao Carvalho, Tiago Abreu, Ana Oliveira, Paula Pinto, Cristina Barbara
Summary: This study found that, with a comprehensive educational programme during positive airway pressure adaptation, telemonitoring did not show significant benefits in terms of compliance and efficacy compared to usual care or phone-call care. Further long-term follow-up is needed to evaluate the outcomes of telemonitoring programmes.
JOURNAL OF TELEMEDICINE AND TELECARE
(2021)
Review
Clinical Neurology
Marcello Bosi, Serena Incerti Parenti, Antonio Sanna, Giuseppe Plazzi, Andrea De Vito, Giulio Alessandri-Bonetti
Summary: The phenotyping of obstructive sleep apnoea (OSA) is crucial for tailored treatments and poses a major challenge in clinical practice. Advanced techniques have provided insights into the variability of endotypic traits in OSA patients, impacting the success of treatment options.
SLEEP MEDICINE REVIEWS
(2021)
Article
Respiratory System
Macy Mei-Sze Lui, Hung-Fat Tse, David Chi-Leung Lam, Kui-Kai Lau, Carmen Wing-Sze Chan, Mary Sau-Man Ip
Summary: In subjects with OSA and difficult-to-control hypertension, short-term CPAP treatment improved ambulatory blood pressure, alleviated subclinical myocardial injury and strain. This study suggests potential benefits of CPAP therapy in reducing cardiovascular risk in this high-risk population.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Respiratory System
Jean-Benoit Martinot, Nhat-Nam Le-Dong, Atul Malhotra, Jean-Louis Pepin
Summary: Respiratory effort is a main feature of obstructive sleep apnoea (OSA), and is associated with sympathetic overactivity. This study found that the percentage of total sleep time spent with increased respiratory effort (REMOV,%TST), measured by mandibular jaw movements, can predict the prevalence of hypertension in adults with OSA.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Multidisciplinary Sciences
Narongkorn Saiphoklang, Kanyada Leelasittikul, Apiwat Pugongchai
Summary: Continuous positive airway pressure (CPAP) is an effective treatment for obstructive sleep apnea patients, and a predictive equation for CPAP in Thai patients was developed in this study, with neck circumference, body mass index, respiratory disturbance index, and lowest pulse oxygen saturation being significant factors in predicting the optimal pressure. The equation accounted for 50% of the variance in optimal pressure, providing insight into tailored CPAP therapy for Thai patients with OSA.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Konstantinos Chaidas, Kallirroi Lamprou, Amberley Munnings, John R. Stradling, Annabel H. Nickol
Summary: This study aimed to investigate the association between CPAP usage and nasal symptoms in patients with obstructive sleep apnoea. The findings suggested that runny nose was a predictive factor for poorer CPAP adherence and worsened after three months of high-CPAP usage.
Article
Medicine, General & Internal
Laetitia S. Gaspar, Janina Hesse, Muge Yalcin, Barbara Santos, Catarina Carvalhas-Almeida, Mafalda Ferreira, Joaquim Moita, Angela Relogio, Claudia Cavadas, Ana Rita Alvaro
Summary: The study revealed that obstructive sleep apnea (OSA) affects the biological clock, and long-term continuous positive airway pressure (CPAP) treatment can partially restore normal clock function. However, the treatment does not fully reverse the impact on clock gene expression levels.
Article
Medicine, General & Internal
Jae Hyuk Choi, Eunkyu Lee, Sang Duk Hong, Seung Kyu Chung, Yong Gi Jung, Hyo Yeol Kim
Summary: A retrospective analysis of OSA patients undergoing CPAP therapy showed significant improvements in laryngopharyngeal reflux symptoms and examination findings, independent of body mass index or OSA severity.CPAP treatment has the potential to reduce laryngeal reflux symptoms and improve laryngeal examination results in OSA patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Yoko Fujino, Yasunori Oka, Tomoko Wakamura
Summary: This study found that seasonal differences can impact the CPAP adherence of patients with obstructive sleep apnea. Patients in the adherent group had lower CPAP use rate and shorter duration in summer, while the non-adherent group showed significant differences between winter and summer.
Article
Respiratory System
Zhihao Yang, Guodong Du, Lei Ma, Yunhui Lv, Yang Zhao, Tung On Yau
Summary: The study included 206 ED patients with OSA from seven publications, and the results showed that ED patients receiving CPAP treatment significantly improved their IIEF-5 scores. However, high heterogeneity was mainly due to Zhang's data, who had a higher AHI compared to other studies. A moderate heterogeneity was found after excluding Zhang's data.
CLINICAL RESPIRATORY JOURNAL
(2021)
Article
Medicine, General & Internal
Baixin Chen, Miaolan Guo, Yueksel Peker, Neus Salord, Luciano F. Drager, Geraldo Lorenzi-Filho, Xiangdong Tang, Yun Li
Summary: CPAP treatment leads to a significant decrease in total cholesterol but has no effect on other lipid profiles in patients with obstructive sleep apnea. Factors such as age, gender, body mass index, daytime sleepiness, OSA severity, follow-up duration, CPAP compliance, and presence of cardiometabolic disease do not moderate the effects of CPAP treatment on lipid profiles.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pediatrics
Caterina Ribot, Daniel Morell-Garcia, Javier Pierola, Jose A. Pena-Zarza, Pilar Sanchis, Jesus Muniz, Monica de la Pena, Alberto Alonso-Fernandez, Antonia Barcelo
Summary: This study aimed to evaluate the concentration of SP-D in children with suspected obstructive sleep apnea (OSA). While no statistical correlation was found between SP-D concentration and apnea-hypopnea index (AHI), changes in SP-D levels could be related to arousals associated with hypopneas.
PEDIATRIC PULMONOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Enrique Alfaro, Elena Diaz-Garcia, Sara Garcia-Tovar, Ester Zamarron, Alberto Mangas, Raul Galera, Eduardo Lopez-Collazo, Francisco Garcia-Rio, Carolina Cubillos-Zapata
Summary: This study suggests that hypoxia may induce the overexpression of proteasome genes in COVID-19 patients, which is associated with lymphocyte count reduction, increased inflammatory markers, and clinical complications.
Article
Infectious Diseases
Matilde Sanchez-Conde, Pilar Vizcarra, Jose Manuel Perez-Garcia, Maria Gion, Maria Pilar Martialay, Javier Taboada, Alberto Alonso-Fernandez, Miguel Sampayo-Cordero, Andrea Malfettone, Isabel Tena, Sergio De la Torre, Antonio Llombart-Cussac, Javier Cortes
Summary: The study evaluated the efficacy and safety of Pembrolizumab and tocilizumab in hospitalized COVID-19 pneumonia patients at high risk without mechanical ventilation. The results showed that adding Pembrolizumab and tocilizumab to the treatment regimen reduced the hospitalization period, resulted in faster discharges, and had no adverse effects.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Letter
Critical Care Medicine
Ester Zamarron, Francisco Garcia-Rio
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Respiratory System
Elena Diaz-Garcia, David Sanz-Rubio, Sara Garcia-Tovar, Enrique Alfaro, Pablo Cubero, Ana Gil, Jose M. Marin, Carolin Cubillos-Zapta, Francisco Garcia-Rio
Summary: This study found that OSA patients, especially those with eSA, have high levels of oxLDL, as well as an overexpression of NLRP3 cascade components and TF. In addition, oxLDL and plasma from OSA patients synergistically activate NLRP3 and enhance the inflammatory response, pyroptosis, and TF release. Therefore, there is a pathway mediated by oxLDL that contributes to the interaction between OSA and the development of atherosclerosis.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Francisco Garcia-Rio, Marc Miravitlles, Joan B. Soriano, Borja G. Cosio, Juan Jose Soler-Cataluna, Ciro Casanova, Pilar de Lucas, Inmaculada Alfageme, Jose Miguel Rodriguez Gonzalez-Moro, Maria Guadalupe Sanchez Herrero, Julio Ancochea
Summary: A study on COPD patients and subjects without airflow limitation found that almost half of them maintain a sedentary lifestyle, with different risk factors for sedentarism between the two groups.
RESPIRATORY MEDICINE
(2023)
Article
Respiratory System
Juan Jose Soler-Cataluna, Luis Puente Maestu, Miguel Roman Rodriguez, Cristobal Esteban, Joaquin Gea, Roberto Bernabeu Mora, Eulogio Pleguezuelos Cobo, Julio Ancochea, Francisco Garcia-Rio
Summary: This study analyzed the validity and sensitivity to change of the Spanish Activity Questionnaire in COPD (SAQ-COPD), a short and simple physical activity measurement instrument for patients with COPD. The SAQ-COPD questionnaire was found to be a valid instrument for classifying physical activity in patients with COPD and demonstrated good sensitivity to change.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Article
Respiratory System
Francisco Garcia-Rio, Marc Miravitlles, Joan B. Soriano, Borja G. Cosio, Juan Jose Soler-Cataluna, Ciro Casanova, Pilar de Lucas, Inmaculada Alfageme, Jose Miguel Rodriguez Gonzalez-Moro, Maria Guadalupe Sanchez Herrero, Julio Ancochea
Summary: This study aimed to describe the prevalence of reduced diffusing capacity of the lungs for carbon monoxide (DLCO) in a population-based sample of smokers without airflow limitation, as well as its morphological, functional, and clinical implications. The study found that smokers had a higher prevalence of reduced DLCO, which was associated with decreased exercise capacity and early vascular damage.
BMJ OPEN RESPIRATORY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Elena Diaz-Garcia, Aldara Garcia-Sanchez, David Sanz-Rubio, Enrique Alfaro, Cristina Lopez-Fernandez, Raquel Casitas, Eva Manas Baena, Irene Cano-Pumarega, Pablo Cubero, Marta Marin-Oto, Eduardo Lopez-Collazo, Jose Maria Marin, Francisco Garcia-Rio, Carolina Cubillos-Zapata
Summary: Patients with obstructive sleep apnea (OSA) are more likely to develop atherosclerosis, leading to cardiovascular diseases. The transforming growth factor (TGF-beta) is crucial in atherosclerosis development, and SMAD4 is the central regulator of TGF-beta pathway. This study analyzed SMAD4 levels in OSA patients and found elevated levels in both plasma and monocytes, especially in patients with early subclinical atherosclerosis (eSA). The study also revealed that intermittent hypoxia and NLRP3 play a role in SMAD4 upregulation and release. This research underscores the potential of sSMAD4 as a biomarker for atherosclerosis risk in OSA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Manuel Sanchez-de-la-Torre, Carolina Cubillos, Olivia J. Veatch, Francisco Garcia-Rio, David Gozal, Miguel Angel Martinez-Garcia
Summary: Previous clinical studies have shown that obstructive sleep apnea (OSA) is related to certain types of cancer, but the relationship is complex and diverse due to various underlying pathophysiological mechanisms. The hypoxia inducible transcription factor (HIF-1 alpha), expressed in situations of hypoxemia like OSA, seems to be a key factor. However, recent research has discovered additional pathophysiological pathways involving biomarkers, immune cell dysfunction, exosomes, genetics, and microbiome alterations. Moreover, different tumor cell lines respond differently to intermittent hypoxia. This indicates that the relationship between OSA and cancer is multifaceted and involves multiple factors.
Article
Biochemistry & Molecular Biology
Nerea Corbacho-Alonso, Elena Rodriguez-Sanchez, Tamara Sastre-Oliva, Elisa Mercado-Garcia, Ines Perales-Sanchez, Cristina Juarez-Alia, Luis F. Lopez-Almodovar, Luis R. Padial, Teresa Tejerina, Laura Mourino-Alvarez, Gema Ruiz-Hurtado, Maria G. Barderas
Summary: Calcific aortic stenosis (CAS) and type 2 diabetes mellitus (T2DM) often coexist and are related, accompanied by common comorbidities. Oxidative stress plays a role in CAS and vascular complications in T2DM. Metformin, a medication for T2DM, may reduce oxidative stress. This study evaluated the oxidative status in plasma from CAS patients, with or without T2DM and metformin treatment, suggesting that reducing oxidative stress or enhancing antioxidant capacity could be a strategy for managing CAS.
Review
Biochemistry & Molecular Biology
Esther Solano-Perez, Carlota Coso, Maria Castillo-Garcia, Sofia Romero-Peralta, Sonia Lopez-Monzoni, Eduardo Lavina, Irene Cano-Pumarega, Manuel Sanchez-de-la-Torre, Francisco Garcia-Rio, Olga Mediano
Summary: Obstructive sleep apnea (OSA) is a common but underdiagnosed illness in children, causing repetitive upper airway obstruction during sleep and impacting sleep quality. It has significant consequences in metabolic, cardiovascular, and neurological aspects. However, there have been limited advances in diagnostic and therapeutic management for pediatric OSA, leading to the need for updated management strategies, new biomarkers for risk stratification, and simplified diagnostic algorithms.
Article
Biochemistry & Molecular Biology
Pilar Resano-Barrio, Enrique Alfaro, Esther Solano-Perez, Carlota Coso, Carolina Cubillos-Zapata, Elena Diaz-Garcia, Sofia Romero-Peralta, Jose Luis Izquierdo-Alonso, Ferran Barbe, Francisco Garcia-Rio, Manuel Sanchez-de-la-Torre, Olga Mediano
Summary: This study aimed to evaluate the role of ischemia-modified albumin (IMA) as a biomarker for determining the impact of obstructive sleep apnea (OSA) in acute coronary syndrome (ACS) patients. The results showed that IMA levels were significantly higher in severe and moderate OSA patients compared to mild/no OSA patients. However, IMA levels were only weakly related to apnea-hypopnea index (AHI) and had a significant relationship with days of hospital stay after adjusting for sex, age, and BMI. This suggests a potentially weaker role of OSA in the synthesis of the cardiovascular risk biomarker IMA in patients with ACS compared to primary prevention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Respiratory System
Borja G. Cosio, Ciro Casanova, Juan Jose Soler-Cataluna, Joan B. Soriano, Francisco Garcia-Rio, Pilar de Lucas, Inmaculada Alfageme, Jose Miguel Rodriguez Gonzalez-Moro, Guadalupe Sanchez, Julio Ancochea, Marc Miravitlles
Summary: This study aimed to identify individuals at risk of developing COPD and compare their clinical characteristics with those who develop the disease at a young age and the overall population. The results showed that 22.3% of the population had a risk of developing COPD, with similar symptomatic and structural changes to those with well-established disease without airflow obstruction.
Article
Respiratory System
Marc Miravitlles, Juan Jose Soler-Cataluna, Joan B. Soriano, Francisco Garcia-Rio, Pilar De Lucas, Inmaculada Alfageme, Ciro Casanova, Jose Miguel Rodriguez Gonzalez-Moro, Guadalupe Sanchez, Julio Ancochea, Borja G. Cosio
Summary: This study investigated the prevalence and determinants of respiratory symptoms in the general adult population in Spain. The results showed that approximately half of the adult Spanish population have respiratory symptoms and this prevalence has remained quite stable over the last 20 years. Smoking remains the main factor associated with respiratory symptoms, but female sex, comorbidities, high BMI and low FEV1 and low physical activity are also significantly associated with respiratory symptoms.