Review
Biochemistry & Molecular Biology
Andras Bikov, Martina Meszaros, Esther Irene Schwarz
Summary: Obstructive sleep apnoea (OSA) is a common disease characterized by upper airway collapse during sleep, leading to chronic intermittent hypoxaemia and systemic inflammation. OSA is associated with increased risk for cardiovascular morbidity and mortality, affecting coagulation and fibrinolysis processes. Further research is needed to understand the mechanisms and clinical implications of OSA-related changes in these processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Susan Redline, Ali Azarbarzin, Yuksel Peker
Summary: In this Review, the authors summarize the shared risk factors and causal links between obstructive sleep apnoea (OSA) and cardiovascular disease (CVD), as well as the emerging knowledge on the heterogeneity of OSA. They also explore the potential role of new biomarkers for cardiovascular risk stratification in patients with OSA.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Andras Bikov, Martina Meszaros, Laszlo Kunos, Alina Gabriela Negru, Stefan Marian Frent, Stefan Mihaicuta
Summary: Patients with OSA had higher AIP and triglyceride, and lower HDL-C levels. AIP was significantly correlated with the Epworth Sleepiness Scale score, the apnoea-hypopnoea index, and oxygen desaturation index, but not with markers of sleep quality.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Peter G. Middleton
Summary: This review provides a summary of the interactions between pregnancy and breathing during sleep, and highlights the changes in respiratory function that can increase the incidence and severity of sleep-disordered breathing. The increased risk of snoring and obstructive sleep apnea hypopnea syndrome during pregnancy is discussed, and the potential impact of increasing obesity rates on sleep-disordered breathing in pregnant women is considered.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2022)
Review
Cell Biology
James Saleeb-Mousa, Demitris Nathanael, Andrew M. Coney, Manish Kalla, Keith L. Brain, Andrew P. Holmes
Summary: Obstructive sleep apnoea (OSA) is associated with a higher risk of atrial fibrillation (AF), affecting its induction, maintenance, severity, and treatment. The current prevention method, continuous positive airway pressure (CPAP), has limited effectiveness due to poor compliance. Understanding the underlying mechanisms of arrhythmia in OSA can lead to the development of better therapies and treatment selection to complement CPAP. Chronic intermittent hypoxia (CIH) in OSA leads to long-term changes in ion channel currents, inflammation, and fibrosis, contributing to atrial remodeling and dysregulation of electrical function. Atrial stretch during apneas further promotes structural remodeling and affects calcium handling. This review provides a comprehensive overview of the mechanistic insights and their roles in arrhythmia.
Article
Clinical Neurology
Renata L. Riha, Serafeim-Chrysovalantis Kotoulas, Athanasia Pataka, John Arthur Kvamme, Pavol Joppa, Jan Hedner
Summary: The study compared the severity of OSA and the prevalence of cardiovascular, metabolic and respiratory co-morbidities between OSA patients who had undergone tonsillectomy and those who had not. Patients who had undergone tonsillectomy presented with less severe OSA at the time of diagnosis, and had a lower prevalence of Type II diabetes mellitus and cardiovascular co-morbidities.
Article
Medicine, General & Internal
Domenico Scrutinio, Pietro Guida, Maria Aliani, Giorgio Castellana, Patrizia Guido, Mauro Carone
Summary: This study found that comorbidities in patients with severe OSAS are closely related to all-cause mortality, with age and comorbidities being key predictors of death. Recursive-partitioning analysis showed that patients with a combination of CKD and CVD or COPD have the highest mortality risk.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Respiratory System
Jean-Benoit Martinot, Nhat-Nam Le-Dong, Atul Malhotra, Jean-Louis Pepin
Summary: Respiratory effort is a main feature of obstructive sleep apnoea (OSA), and is associated with sympathetic overactivity. This study found that the percentage of total sleep time spent with increased respiratory effort (REMOV,%TST), measured by mandibular jaw movements, can predict the prevalence of hypertension in adults with OSA.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Andras Bikov, Helga Szabo, Marton Piroska, Laszlo Kunos, Marcell Szily, Balazs Ligeti, Nora Makra, Dora Szabo, David Laszlo Tarnoki, Adam Domonkos Tarnoki
Summary: Obstructive sleep apnoea (OSA) is associated with subtle changes in the gut microbiome, and further studies should investigate the role of gut dysbiosis in OSA.
APPLIED SCIENCES-BASEL
(2022)
Article
Multidisciplinary Sciences
Adam Domonkos Tarnoki, David Laszlo Tarnoki, Csaba Olah, Marcell Szily, Daniel T. Kovacs, Andras Dienes, Marton Piroska, Bianka Forgo, Marina Pinheiro, Paulo Ferreira, Laszlo Kostyal, Martina Meszaros, Judit Pako, Laszlo Kunos, Andras Bikov
Summary: This study found that patients with OSA had more lumbar abnormalities compared to non-OSA controls, and markers of OSA severity were correlated with the development of lumbar spondylosis in these patients.
SCIENTIFIC REPORTS
(2021)
Article
Respiratory System
Chamara V. Senaratna, Adrian Lowe, E. Haydn Walters, Michael J. Abramson, Dinh Bui, Caroline Lodge, Bircan Erbas, John Burgess, Jennifer L. Perret, Garun S. Hamilton, Shyamali C. Dharmage
Summary: This study provides the first known evidence for individual and profiled early-life and childhood risk factors for OSA in adults.
Article
Multidisciplinary Sciences
Mia Tranfic Duplancic, Renata Pecotic, Linda Lusic Kalcina, Ivana Pavlinac Dodig, Maja Valic, Marija Roguljic, Dunja Rogic, Ivana Lapic, Katarina Grdisa, Kristina Peros, Zoran Dogas
Summary: The aim of this cross-sectional study was to objectively assess the salivary flow rate and composition and periodontal inflammation in obstructive sleep apnoea (OSA) patients. The study found that subjects without OSA had higher salivary cortisol concentrations than OSA groups, and higher plaque scores were associated with a higher AHI. Subjects with hyposalivation had higher concentrations of salivary electrolytes and lower salivary pH levels.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Vusal Nacafaliyev, Pinar Ortan, Sevgi Sidika Sayin
Summary: This study found a significant relationship between obstructive sleep apnea syndrome (OSAS) and the incidence of silent brain infarcts (SBI). Patients with moderate and severe OSAS had a higher risk of developing SBI, possibly due to desaturations during sleep.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Clinical Neurology
Timothy P. Howarth, Natalie Gentin, Nayellin Reyes-Chicuellar, Catherine Jonas, Bruce Williamson, Greg Blecher, John Widger, Subash S. Heraganahally
Summary: This study found that Indigenous Australian children have issues with sleep quality, including a higher prevalence and severity of obstructive sleep apnoea, higher daytime sleepiness scores, later bedtimes, and reduced total sleep time compared to their non-Indigenous peers.
Review
Respiratory System
Margaret Gleeson, Walter T. McNicholas
Summary: Obstructive sleep apnoea (OSA) is often associated with various comorbidities, including metabolic, cardiovascular, renal, pulmonary, and neuropsychiatric conditions. There is evidence to suggest a bidirectional relationship between OSA and comorbidity, with some comorbidities possibly predisposing to the development of OSA. The impact of therapy in bidirectional relationships is also reviewed, emphasizing the importance of accurate diagnosis.
EUROPEAN RESPIRATORY REVIEW
(2022)
Article
Public, Environmental & Occupational Health
Rinat Avraham, Dina Van Dijk, Tzahit Simon-Tuval
PSYCHOLOGY HEALTH & MEDICINE
(2016)
Article
Environmental Sciences
Maya Profis, Tzahit Simon-Tuval
Article
Economics
Tzahit Simon-Tuval, Amir Shmueli, Ilana Harman-Boehm
Review
Health Care Sciences & Services
Tzahit Simon-Tuval, Peter J. Neumann, Dan Greenberg
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
(2016)
Article
Multidisciplinary Sciences
Oded Vered, Tzahit Simon-Tuval, Pablo Yagupsky, Miki Malul, Assi Cicurel, Nadav Davidovitch
Review
Infectious Diseases
V. Mintzer, J. Moran-Gilad, T. Simon-Tuval
CLINICAL MICROBIOLOGY AND INFECTION
(2019)
Article
Multidisciplinary Sciences
Gila Adler, Galit Kaufman, Tzahit Simon-Tuval
Article
Nursing
Rinat Avraham, Tzahit Simon-Tuval, Dina Van Dijk
JOURNAL OF ADVANCED NURSING
(2020)
Article
Nutrition & Dietetics
Ofira Katz-Shufan, Tzahit Simon-Tuval, Liron Sabag, Danit R. Shahar
Article
Nutrition & Dietetics
Ofira Katz-Shufan, Danit R. Shahar, Liron Sabag, Tzahit Simon-Tuval
Summary: Eating in catering systems has been identified as a driver of poor diet quality. Interventions within catering systems can improve the nutrient content of dishes without increasing costs, which encourages caterers to implement policies to improve the nutritional quality of food served and potentially improve public health.
Article
Environmental Sciences
Ofira Katz-Shufan, Tzahit Simon-Tuval, Danit R. Shahar, Paula Feder-Bubis
Summary: Studying the food choices of diners in catering systems of kibbutzim revealed that diners value their freedom of food choice, which may impact the debate over whether catering systems should only offer healthy foods.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Ronit Hadad, Diana Likhtenshtein, Nimrod Maimon, Tzahit Simon-Tuval
SCIENTIFIC REPORTS
(2020)
Article
Medicine, General & Internal
Tzahit Simon-Tuval, Amir Shmueli, Ilana Harman-Boehm
CURRENT MEDICAL RESEARCH AND OPINION
(2018)
Article
Economics
Tzahit Simon-Tuval, Noa Triki, Gabriel Chodick, Dan Greenberg
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2016)
Article
Health Policy & Services
Tzahit Simon-Tuval, Tuvia Horev, Giora Kaplan
ISRAEL JOURNAL OF HEALTH POLICY RESEARCH
(2015)
