Journal
ANNALS OF MEDICINE
Volume 47, Issue 6, Pages 519-526Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/07853890.2015.1077989
Keywords
Echography; elevated liver enzymes; fatty liver; Fatty Liver Index; liver; NAFLD; non-alcoholic fatty liver disease; sedentary lifestyle; television; ultrasound
Categories
Funding
- Academy of Finland [126925, 121584, 124282, 129378, 117797, 41071]
- Social Insurance Institution of Finland
- Kuopio Fund
- Tampere Fund
- Turku University Hospital Medical Fund
- Juho Vainio Foundation
- Paavo Nurmi Foundation
- Yrjo Jahnsson Foundation
- Finnish Foundation of Cardiovascular Research
- Finnish Cultural Foundation
- Sigrid Juselius Foundation
- Tampere Tuberculosis Foundation
- Emil Aaltonen Foundation
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Introduction. Both sedentary behaviour and fatty liver are associated with increased risk of obesity and non-communicable diseases, but their relationship remains unknown. We investigated the relationship of television (TV) viewing time with serum gamma-glutamyltransferase (GGT) and Fatty Liver Index (FLI), and ultrasonographically assessed liver fat. Methods. A total of 1,367 adults of the population-based Cardiovascular Risk in Young Finns study (748 women, 619 men, aged 34-49 years) had fasting serum GGT, triglycerides, weight, height, and waist circumference, and self-reported TV time data from 2001, 2007, and 2011. Changes in GGT and FLI, and liver ultrasound images in 2011 were studied in groups with constantly low (<= 1 h/d), moderate (1-3 h/d), or high (>= 3 h/d) daily TV time, and in groups with >= 1 hour increase/decrease in daily TV time between 2001 and 2011. Results. Constantly high TV time was associated with higher GGT and FLI (P < 0.02 in both), and 2.3-fold (95% CI 1.2-4.5) increased risk of fatty liver regardless of age, sex, leisure-time and occupational physical activity, energy intake, diet composition, alcohol use, sleep duration, socioeconomic status, and smoking. Adjustment for BMI partly attenuated the associations. Conclusions. High TV viewing increases fatty liver risk. It may be one mechanism linking sedentary behaviour with increased cardiometabolic disease risks.
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