Article
Clinical Neurology
Kristine Dilba, Dianne H. K. Van Dam-Nolen, Genevieve A. J. C. Crombag, Anja G. van der Kolk, Peter J. Koudstaal, Paul J. Nederkoorn, Jeroen Hendrikse, Marianne Eline Kooi, Antonius F. W. van der Steen, Jolanda J. Wentzel, Aad van der Lugt, Daniel Bos
Summary: This study investigated the prevalence and risk factors of dolichoarteriopathies in patients with cerebrovascular symptoms, finding that age, obesity, and hypercholesterolemia may play important roles in the pathophysiology of these abnormalities. Dolichoarteriopathies of the extracranial part of the internal carotid artery were common among these patients, with tortuosity being the most common type.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Krista Nuotio, Suvi M. Koskinen, Laura Makitie, Jarno Tuimala, Petra Ijas, Hanna M. Heikkila, Jani Saksi, Pirkka Vikatmaa, Pia Sorto, Sonja Kasari, Ilari Paakkari, Heli Silvennoinen, Leena Valanne, Mikko I. Mayranpaa, Lauri Soinne, Petri T. Kovanen, Perttu J. Lindsberg
Summary: The study found that long-term use of the anticoagulant warfarin may lead to calcification of carotid atherosclerotic plaques, particularly in locations known to cause stroke. This highlights the importance of further research into the potential adverse effects of anticoagulant drugs.
FRONTIERS IN NEUROLOGY
(2021)
Article
Surgery
Lijuan Zhang, Xiaoshuang Liu, Beibei Gong, Qi Li, Tianyou Luo, FaJin Lv, Yineng Zheng, Wanlin Zheng, Haoming Guo
Summary: This study found that arterial tortuosity is associated with sCCD, with greater tortuosity of the cervical artery indicating an increased risk of arterial dissection.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Sang Woo Ha, Chan-Hyuk Lee, Hak Sung Kim, Eung Koo Yeon, Seung Jae Lee, Byoung-Soo Shin, Hyun Goo Kang
Summary: Accurate determination of occlusion sites in acute internal carotid artery occlusions is crucial for rapid revascularization interventions and improved prognosis. This study identified the shape, length, and atrial fibrillation as significant factors associated with the correspondence between actual occlusion sites and those detected by CT angiography.
Article
Clinical Neurology
Kevin Cheng, Andrew Lin, Ximena Stecher, Tomas Bernstein, Paulo Zuniga, Enrico Mazzon, Alejandro Brunser, Violeta Diaz, Gonzalo Martinez, William Cameron, Stephen J. Nicholls, Sanjay Patel, Damini Dey, Dennis T. L. Wong, Paula Munoz Venturelli
Summary: This study evaluated the computed tomography (CT) attenuation of perivascular adipose tissue (PVAT) in spontaneous cervical artery dissection (sCAD). The results showed higher PVAT attenuation in the presence of dissection compared to the contralateral artery and non-dissection patients, and a decrease in PVAT attenuation following the acute event. Therefore, PVAT may serve as an inflammatory biomarker in sCAD.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yao Lu, Ruoyao Cao, Sheng Jiao, Ling Li, Chao Liu, Hailong Hu, Zhuangfei Ma, Yun Jiang, Juan Chen
Summary: This study evaluated the application of black-blood CT in carotid artery wall imaging and confirmed its accuracy in diagnosing stenosis rate and plaque burden of carotid artery. Black-blood CT showed good consistency with CTA and VW-MR in identifying stenosis rate and plaque burden, providing clear visualization of the artery wall, especially for patients with contraindication to MRI.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Junfeng Liu, Jincheng Wan, William Robert Kwapong, Wendan Tao, Chen Ye, Ming Liu, Bo Wu
Summary: This study investigated the relationship between retinal microvasculature and cerebral hemodynamics in patients with internal carotid artery (ICA) stenosis. The results showed a strong correlation between retinal microvascular perfusion and cerebral perfusion in the superficial vascular layer, especially in patients with stenosis. Larger studies are needed to confirm these findings.
Article
Dentistry, Oral Surgery & Medicine
Bruna Neves de Freitas, Raphael Jurca Goncalves da Motta, Ruben Pauwels, Christiano Oliveira-Santos, Camila Tirapelli
Summary: This study evaluated the influence of metal artefact reduction (MAR) on the diagnosis of dental implant contact with the mandibular canal (MC) using cone beam computed tomography (CBCT). The results showed that MAR had limited efficacy in the diagnosis of implant-MC contact, thus it is not recommended to use MAR in CBCT scans for this purpose.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Clinical Neurology
Tim C. van den Beukel, Janine E. van der Toorn, Meike W. Vernooij, Maryam Kavousi, Ali C. Akyildiz, Pim A. de Jong, Aad van der Lugt, M. Kamran Ikram, Daniel Bos
Summary: This study investigated the prevalence and stroke risk associated with different morphological subtypes of intracranial carotid arteriosclerosis in the general population. Among the participants, 39% had the intimal subtype, 48% had the IEL subtype, and 13% had the mixed subtype. All three subtypes were associated with an increased risk of stroke, with noticeable age and sex-specific differences.
Article
Medicine, Research & Experimental
Uriel Katz, Gabriel Nakache, Eran E. Alon, Arkadi Yakirevitch
Summary: This study aimed to investigate the feasibility of transnasal echography for internal carotid artery (ICA) imaging during endoscopic procedures. The results indicated a good agreement between transnasal echography and CT measurements, providing a safer approach for transnasal surgeries near the ICA.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiao Chen, Zhongfeng Niu, Kun Zhan, Xinwei Tao, Fengjuan Tian, Jing Ding, Zhexia Jin, Xiuhua Hu
Summary: This study evaluated the performance of a dual-energy calcium removal software in assessing ICA stenosis compared to DSA images. The results showed that the VNCa images had no significant difference with DSA images in all segments, while there were differences between mixed and DSA images in certain segments. The ICC values between VNCa and DSA images were higher than those between mixed and DSA images, indicating promising performance of the DECT algorithm for calcium removal in ICA stenosis evaluation.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Victor Aquino Wanderley, Karla de Faria Vasconcelos, Andre Ferreira Leite, Ruben Pauwels, Sohaib Shujaat, Reinhilde Jacobs, Matheus L. Oliveira
Summary: This study objectively assessed dimensional alteration on dental implants using 13 CBCT devices with device-specific scanning protocols. The results showed significant dimensional alterations in implant size with different scanning protocols, and B&C adjustments were effective in reducing implant blooming visualization.
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Miriam Fernandez-Gomez, Laila Zitan-Saidi, Felix Gallo-Pineda, Carlos Hidalgo-Barranco, Gracia Castro-Luna
Summary: This research compares the accuracy of multiphase CTA and single-phase CTA in differentiating the intracranial and extracranial location of acute ICA occlusion. The results show that multiphase CTA has higher sensitivity (79.31%) and specificity (100%) in diagnosing isolated intracranial ICA occlusion compared to single-phase CTA.
Article
Clinical Neurology
Xiaohong Hu, Jianhui Chen, Huajun Fu, Yinjuan Chen, Daofeng Fan, Yangui Chen, Chaoxiong Shen
Summary: This study retrospectively evaluated the association between pericarotid inflammation and the presence of embolic stroke of undetermined source (ESUS). The results showed increased fat density around the carotid artery in ESUS patients, suggesting the presence of an inflammatory reaction that extends beyond the vessel lumen.
FRONTIERS IN NEUROLOGY
(2022)
Article
Physiology
Ying Zhu, Liwei Chen, Wenjie Lu, Yongjun Gong, Ximing Wang
Summary: This study utilized the nnU-Net-based model to assist in the evaluation of CAS and carotid atherosclerotic plaques using CTA imaging. The nnU-Net model showed good performance and consistency in CAS diagnosis and plaque segmentation, with a shorter evaluation time compared to physicians.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas Sartoretti, Victor Mergen, Lisa Jungblut, Hatem Alkadhi, Andre Euler
Summary: The study aimed to compare the accuracy of iodine quantification in liver parenchyma and lesions between PCD-CT and EID-CT, and to demonstrate the feasibility of iodine quantification with PCD-CT in patients. Results showed that PCD-CT was accurate for iodine quantification in simulated liver parenchyma and lesions, regardless of radiation dose, iodine concentration, and base attenuation. In patients, iodine quantification was feasible in common liver lesions.
ACADEMIC RADIOLOGY
(2023)
Article
Clinical Neurology
Risto Grkovski, Leyla Acu, Uzeyir Ahmadli, Robert Terziev, Tilman Schubert, Susanne Wegener, Zsolt Kulcsar, Shakir Husain, Hatem Alkadhi, Sebastian Winklhofer
Summary: This study evaluated the feasibility and accuracy of TwinSpiral DECT in distinguishing between intracranial hemorrhage (ICH) and extravasation of iodinated contrast media (contrast staining [CS]) in patients with acute ischemic stroke after endovascular thrombectomy. The results showed that TwinSpiral DECT has high accuracy and specificity in detecting ICH and CS, and improves inter-reader agreement for detecting ICH compared to standard mixed images.
CLINICAL NEURORADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Damien Racine, Victor Mergen, Anais Viry, Matthias Eberhard, Fabio Becce, David C. Rotzinger, Hatem Alkadhi, Andre Euler
Summary: This study assessed the image noise, diagnostic performance, and potential for radiation dose reduction of photon-counting detector (PCD) computed tomography (CT) with quantum iterative reconstruction (QIR) in the detection of hypoattenuating and hyperattenuating focal liver lesions. The results showed that compared with energy-integrating detector (EID) CT, PCD-CT with QIR substantially improved focal liver lesion detection, especially at low radiation dose. This enables substantial radiation dose reduction while maintaining diagnostic accuracy.
INVESTIGATIVE RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Barbara D. Wichtmann, Felix N. Harder, Kilian Weiss, Stefan O. Schoenberg, Ulrike I. Attenberger, Hatem Alkadhi, Daniel Pinto dos Santos, Bettina Baessler
Summary: Before implementing radiomics in routine clinical practice, it is important to understand the repeatability and reproducibility of radiomic features. This study systematically investigates the influence of image processing parameters on radiomic features from MRI, including feature values and test-retest repeatability.
INVESTIGATIVE RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas Sartoretti, Michael Mcdermott, Victor Mergen, Andre Euler, Bernhard Schmidt, Gregor Jost, Joachim Wildberger, Hatem Alkadhi
Summary: This study assessed the impact of low kilo-electronvolt (keV) virtual monoenergetic image (VMI) energies and iterative reconstruction on image quality of coronary CT angiography (CCTA). The results showed that 40 keV VMI with QIR-4 significantly improved image quality of CCTA.
BRITISH JOURNAL OF RADIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Joachim E. E. Wildberger, Hatem Alkadhi
Summary: Noninvasive vascular imaging with CT has become essential in clinical practice, and the introduction of PCD-CT has further expanded its applications. Technical improvements of PCD-CT, including reduced noise levels, improved contrast-to-noise ratio, and full spectral multienergy data, have the potential to impact clinical decision making and patient outcomes. Early experience with PCD-CT technology has shown these improvements in various aspects. This review summarizes the advantages of PCD-CT for vascular imaging and discusses the PureLumen and PureCalcium algorithms.
INVESTIGATIVE RADIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Thomas Sartoretti, Joachim E. Wildberger, Thomas Flohr, Hatem Alkadhi
Summary: Since the 1970s, X-ray CT has become a significant diagnostic imaging technology in modern medicine, thanks to technological advances improving image quality and diagnostic value. Photon-counting detector (PCD)-CT, a novel technology, has emerged with the potential to overcome limitations of current CT systems and offer improved capabilities. This review summarizes the first clinical experience of PCD-CT, focusing on recent prototypes and clinically approved systems, presenting initial publications and corresponding clinical cases.
BRITISH JOURNAL OF RADIOLOGY
(2023)
Article
Clinical Neurology
Risto Grkovski, Leyla Acu, Uzeyir Ahmadli, Dominik Nakhostin, Patrick Thurner, Lorenz Wacht, Zsolt Kulcsar, Hatem Alkadhi, Sebastian Winklhofer
Summary: This study aimed to assess a new dual-energy computed tomography (DECT) technique for better visualization of ischemic brain tissue after mechanical thrombectomy. DECT head scans using a new sequential technique (TwinSpiral DECT) were performed on 41 ischemic stroke patients and retrospectively analyzed. The results showed that virtual non-contrast (VNC) images had significantly better visibility of the infarcted tissue compared to mixed images, but with higher image noise.
CLINICAL NEURORADIOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Ladina Geering, Thomas Sartoretti, Victor Mergen, Giulia Cundari, Stephane Rusek, Filippo Civaia, Philippe Rossi, Joachim E. Wildberger, Christian Templin, Robert Manka, Matthias Eberhard, Hatem Alkadhi
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2023)
Article
Medicine, General & Internal
Florian A. A. Huber, Cynthia S. S. Schmidt, Hatem Alkadhi
Summary: This study aimed to evaluate the diagnostic performance and inter-reader agreement of a novel "Darth Vader sign" for detecting spondylolysis in non-musculoskeletal abdominal CT imaging. The results showed that the Darth Vader sign demonstrated good inter-reader agreement and excellent diagnostic capabilities with high sensitivity and specificity for detecting spondylolysis.
Article
Cardiac & Cardiovascular Systems
Mihaly Karolyi, Marton Kolossvary, Lucas Weber, Ioannis Matziris, Malgorzata Polacin, Justyna M. Sokolska, Alexander Gotschy, Hatem Alkadhi, Robert Manka
Summary: This study investigated the association between electrocardiogram (ECG) parameters and late gadolinium enhancement (LGE) in cardiac magnetic resonance imaging (CMR) in patients with acute myocarditis. The results showed that only ST-segment elevation (STE) was significantly associated with LGE, and it was most frequent in lateral and inferior ECG leads. However, the usability of ECG to estimate the territorial involvement and dynamical changes of LGE in myocarditis is generally limited, and CMR should be considered for this purpose.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kai Higashigaito, Victor Mergen, Matthias Eberhard, Lisa Jungblut, Monika Hebeisen, Susan Ratzer, Bettina Zanini, Adrian Kobe, Katharina Martini, Andre Euler, Hatem Alkadhi
Summary: This study aimed to develop and evaluate a low-volume contrast media protocol for thoracoabdominal CT angiography using a photon-counting detector (PCD) CT. The objective and subjective image quality of PCD CT was compared with energy-integrating detector (EID) CT at equal radiation doses. The study showed that PCD CT provided noninferior image quality at a lower dose compared to EID CT.
RADIOLOGY-CARDIOTHORACIC IMAGING
(2023)
Article
Medicine, Research & Experimental
Henrik Teuber, Sascha Halvachizadeh, Melvin Muthirakalayil, Luxu Yin, Harry Eisenkrein, Frank Hildebrand, Philipp Kobbe, Kai Sprengel, Ladislav Mica, Hatem Alkadhi, Hans-Christoph Pape, Roman Pfeifer
Summary: This study investigated the influence of ankylosing spondylitis (AS) on radiologic parameters used to detect traumatic and degenerative instability of the cervical spine. A retrospective analysis of AS patients and controls was performed, and no significant clinical or morphologic differences were found in the evaluated cervical radiologic parameters between the two groups. CT imaging may be diagnostically appropriate for assessing cervical pathologies in patients with AS.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martin J. Willemink, Domenico Mastrodicasa, Mohammad H. Madani, Marina Codari, Leonid L. Chepelev, Gabriel Mistelbauer, Kate Hanneman, Maral Ouzounian, Daniel Ocazionez, Rana O. Afifi, Joan M. Lacomis, Luigi Lovato, Davide Pacini, Gianluca Folesani, Ricarda Hinzpeter, Hatem Alkadhi, Arthur E. Stillman, Anna M. Sailer, Valery L. Turner, Virginia Hinostroza, Kathrin Baumler, Anne S. Chin, Nicholas S. Burris, D. Craig Miller, Michael P. Fischbein, Dominik Fleischmann
Summary: This study aimed to evaluate the reproducibility of expert-derived CTA measurements. The results showed that by optimizing the manual measurement method, inter-observer consistency can be improved, which is crucial for the ground-truth determination of machine learning models.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mihaly Karolyi, Alexander Gotschy, Malgorzata Polacin, Sven Plein, Ingo Paetsch, Cosima Jahnke, Michael Frick, Rolf Gebker, Hatem Alkadhi, Sebastian Kozerke, Robert Manka
Summary: This study aimed to test the accuracy of 3D cardiac magnetic resonance stress perfusion in the elderly population compared to reference standard fractional flow reserve (FFR). The results showed that 3D CMR perfusion has excellent diagnostic accuracy for the detection of hemodynamically relevant coronary stenosis, independent of patient age.
EUROPEAN RADIOLOGY
(2023)