Article
Medicine, General & Internal
Arghavan Jahandideh, Mia Stahle, Jenni Virta, Xiang-Guo Li, Heidi Liljenbaeck, Olli Moisio, Juhani Knuuti, Anne Roivainen, Antti Saraste
Summary: The study demonstrated the potential of using alpha(v)beta(3)-targeting PET imaging with [Ga-68]Ga-NODAGA-RGD to specifically detect myocardial inflammation in a rat model of autoimmune myocarditis. The results showed higher accumulation of the tracer in inflamed myocardium compared to non-inflamed tissue, indicating its efficacy in identifying active inflammatory lesions.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Maria Gronman, Olli Moisio, Xiang-Guo Li, Tarja Toimela, Outi Huttala, Tuula Heinonen, Juhani Knuuti, Anne Roivainen, Antti Saraste
Summary: In this study, the binding of [Ga-68]NODAGA-RGDyK to α(v)β(3) integrin in a human cell-based 3D in vitro model of angiogenesis was measured, showing a gradual increase in tracer binding with neovasculature density. The uptake of [Ga-68]NODAGA-RGDyK closely reflected the amount of angiogenesis, supporting further evaluation of RGD-based approaches for targeted imaging of angiogenesis.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ivan Ho Shon, Thomas Hennessy, Jennifer Guille, Michael P. Gotsbacher, Angelina J. Lay, Bruce McBride, Rachel Codd, Philip J. Hogg
Summary: This study evaluates the biodistribution, radiation dosimetry, safety, and tumor uptake of the novel radiopharmaceutical GA-68 ([GA-68] GA-CDI) for imaging multiple forms of cell death. The results demonstrate that GA-68 ([GA-68] GA-CDI) is safe, has low radiation dosimetry, and excellent biodistribution and imaging characteristics. It shows potential advantages over previous radiopharmaceuticals for imaging cell death and has progressed to a proof-of-concept trial.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Chemistry, Multidisciplinary
Catherine G. Fitzgerald Dickmann, Alexander F. F. McDonald, Nhi Huynh, Angela Rigopoulos, Zhanqi Liu, Nancy Guo, Laura D. D. Osellame, Michael A. A. Gorman, Michael W. W. Parker, Hui K. K. Gan, Andrew M. M. Scott, Uwe Ackermann, Ingrid J. G. Burvenich, Jonathan M. M. White
Summary: A novel molecule, [F-18]BiPET-2, radiolabelled with positron emitting fluorine-18, has been developed and evaluated in vitro and preclinically in glioblastoma models.
CHEMICAL COMMUNICATIONS
(2023)
Letter
Peripheral Vascular Disease
Yara Onetti, Roland E. Kaelin, Bettina Pitter, Mengzhuo Hou, Victor Arribas, Rainer Glass, Eloi Montanez
Summary: Endothelial alpha-pv is necessary for tumor angiogenesis and progression. Using an inducible knockout approach, researchers found that loss of endothelial alpha-pv reduces vessel density and vascular complexity in the pathological neo-vasculature of brain tumor-bearing mice. This reduction in tumor vascularization is associated with increased tumor cell apoptosis and decreased tumor volume.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sangwon Han, Yong-il Kim, Jungsu S. Oh, Seung Yeon Seo, Min-Jae Park, Geun Dong Lee, Sehoon Choi, Hyeong Ryul Kim, Yong-Hee Kim, Dong Kwan Kim, Seung-Il Park, Jin-Sook Ryu
Summary: The study evaluated the diagnostic and prognostic value of pretreatment 2-[F-18]FDG PET/CT in TETs patients. The results showed that SUVmax was excellent in distinguishing thymic carcinoma from other subtypes (low-risk thymoma, high-risk thymoma) and had significant prognostic value for predicting TC.
EUROPEAN RADIOLOGY
(2022)
Review
Medicine, General & Internal
Matthieu Dietz, Christel H. Kamani, Vincent Dunet, Stephane Fournier, Vladimir Rubimbura, Nathalie Testart Dardel, Ana Schaefer, Mario Jreige, Sarah Boughdad, Marie Nicod Lalonde, Niklaus Schaefer, Nathan Mewton, John O. Prior, Giorgio Treglia
Summary: Studies using arginine-glycine-aspartate (RGD)-PET agents in cardiovascular diseases have shown increasing importance, specifically in the detection of infarcted myocardium and evaluation of atherosclerosis. RGD PET/CT scans demonstrate clear expression of alpha(v)beta(3) integrin in the infarcted myocardium. RGD-based PET agents accumulate at the site of infarction and show correlation with CT plaque burden in large vessels. Additionally, increased PET signal is observed in stenotic areas of atherosclerotic carotid plaques.
FRONTIERS IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiang Wu, Jihong Tian, Yiyan Zhang, Hengshan Ji, Jingjing Sun, Xingang Wang, Chuanjin Sun, Li Wang, Zhaogang Teng, Guangming Lu, Hong Zhu, Xiaoyuan Chen
Summary: This study investigated the use of F-18-Alfatide II for evaluating axillary lymph nodes (ALN) in breast cancer patients and compared its performance with F-18-FDG. The results showed that both F-18-Alfatide II and F-18-FDG can improve the diagnostic sensitivity and negative predictive value of ALN, and the T/NT parameter of F-18-Alfatide II may be the most important for evaluating ALN.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Hematology
Enora Le Goff, Paul Blanc-Durand, Louise Roulin, Charlotte Lafont, Romain Loyaux, Diana-Laure MBoumbae, Ichrafe Benmaad, Alexis Claudel, Elsa Poullot, Cyrielle Robe, Guillaume Gricourt, Abdelrazak Aissat, Christiane Copie-Bergman, Francois Lemonnier, Philippe Gaulard, Emmanuel Itti, Corinne Haioun, Marie-Helene Delfau-Larue
Summary: This study aimed to evaluate the prognostic value of circulating tumour DNA (ctDNA) and total metabolic tumour volume (TMTV) in large B-cell lymphoma (LBCL). High ctDNA load or high TMTV were associated with shorter 1-year progression-free survival (PFS). Combining ctDNA load with TMTV improved risk stratification in aggressive LBCL patients. Therefore, high-risk patients may benefit from CAR T-cell therapy or bispecific antibodies as first-line treatments in the future.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Liping Chen, Haitian Fu, Huihui He, Kequan Lou, Qingbo Li, Jiacong Ye, Guokai Feng, Chunjing Yu
Summary: In this study, a novel high-affinity integrin alpha 6-targeted peptide RD2 was developed, and a [F-18]-AlF-NOTA-RD2 PET tracer was synthesized and evaluated for its potential application in pancreatic cancer imaging. The tracer showed good in vitro stability and demonstrated high tumor uptake and low liver uptake in a pancreatic cancer mouse model. Overall, this study demonstrates the promising application of this tracer as a noninvasive PET radiotracer for evaluating integrin alpha 6 expression in pancreatic cancer.
MOLECULAR PHARMACEUTICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Niels W. Schurink, Simon R. van Kranen, Maaike Berbee, Wouter van Elmpt, Frans C. H. Bakers, Sander Roberti, Joost J. M. van Griethuysen, Lisa A. Min, Max J. Lahaye, Monique Maas, Geerard L. Beets, Regina G. H. Beets-Tan, Doenja M. J. Lambregts
Summary: In imaging-based prediction models, local texture analysis has potential added value compared to global tumor features to predict response. However, when combined with clinical baseline parameters such as cTN-stage, the added value of local texture analysis appears to be limited. The overall performance to predict response when combining baseline variables with quantitative imaging parameters is promising and warrants further research.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gaetan Van Simaeys, Gilles Doumont, Coraline De Maeseneire, Nicolas Passon, Simon Lacroix, Cedric Lentz, Arnaud Horion, Corentin Warnier, David Torres, Corentin Martens, Irina Vierasu, Dominique Egrise, Serge Goldman
Summary: This preclinical study evaluated the changes in PSMA expression in CRPC tumors following standard treatment using [F-18]JK-PSMA-7 PET/CT. The results showed that PSMA expression decreased in tumor cells after successive ADT and chemotherapy, leading to a reduction in [F-18]JK-PSMA-7 PET uptake. Caution should be exercised when using PSMA-based imaging for therapy monitoring in CRPC patients.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Oncology
Alexander Heinzel, Daniela Dedic, Norbert Galldiks, Philipp Lohmann, Gabriele Stoffels, Christian P. Filss, Martin Kocher, Filippo Migliorini, Kim N. H. Dillen, Stefanie Geisler, Carina Stegmayr, Antje Willuweit, Michael Sabel, Marion Rapp, Michael J. Eble, Marc Piroth, Hans Clusmann, Daniel Delev, Elena K. Bauer, Garry Ceccon, Veronika Dunkl, Jurij Rosen, Caroline Tscherpel, Jan-Michael Werner, Maximilian I. Ruge, Roland Goldbrunner, Jurgen Hampl, Carolin Weiss Lucas, Ulrich Herrlinger, Gabriele D. Maurer, Joachim P. Steinbach, Joerg Mauler, Wieland A. Worthoff, Bernd N. Neumaier, Christoph Lerche, Gereon R. Fink, Nadim Jon Shah, Felix M. Mottaghy, Karl-Josef Langen
Summary: PET imaging using O-(2-[F-18]fluoroethyl)-L-tyrosine (FET) as a tracer has become essential for diagnosing brain tumors, with increasing demand seen for differentiating tumor progress and treatment-related changes. Referring physicians rate FET PET highly for diagnosing recurrent gliomas and brain metastases.
Article
Health Care Sciences & Services
Zaneta Warenczak-Florczak, Ewa Burchardt, Agnieszka Wilk, Andrzej Roszak
Summary: The study assessed the relationship between prognostic factors and treatment outcomes in patients with advanced cervical cancer, independent of changes in diagnostic and radiotherapy techniques. The results showed that regardless of these changes, the local stage of the tumor remained the most important prognostic factor for patients with cervical cancer.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jonathan Moore, Manil Subesinghe, Aida Santaolalla, Michael Green, Harriet Deere, Mieke Van Hemelrijck, Jesper Lagergren, Sugama Chicklore, Nick Maisey, James Gossage, Mark Kelly, Cara Baker, Andrew Davies
Summary: This study evaluated the role of FDG PET-CT in predicting pathological tumor response, nodal response, and survival in neoadjuvant therapy for esophageal cancer. The study found that metabolic tumor and nodal response can predict pathological tumor response and nodal response, and these responses are independent predictors of patient survival.
EUROPEAN RADIOLOGY
(2023)
Article
Critical Care Medicine
Jonathan R. Weir-McCall, Elise Debruyn, Scott Harris, Nagmi R. Qureshi, Robert C. Rintoul, Fergus Gleeson, Fiona J. Gilbert
Summary: A lung cancer prediction convolutional neural network (LCP-CNN) demonstrates diagnostic performance comparable to PET with CT imaging in the diagnosis of solitary pulmonary nodules. The LCP-CNN outperforms dynamic contrast-enhanced (DCE) CT imaging in accuracy, while being equal to PET with CT imaging.
Biographical-Item
Radiology, Nuclear Medicine & Medical Imaging
Gordon D. Waiter, Fiona J. Gilbert, Alison Murray, Beverly MacLennan
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Andrej Corovic, Christopher Wall, Meritxell Nus, Deepa Gopalan, Yuan Huang, Maria Imaz, Michal Zulcinski, Marta Peverelli, Anna Uryga, Jordi Lambert, Dario Bressan, Robert T. Maughan, Charis Pericleous, Suraiya Dubash, Natasha Jordan, David R. Jayne, Stephen P. Hoole, Patrick A. Calvert, Andrew F. Dean, Doris Rassl, Tara Barwick, Mark Iles, Mattia Frontini, Greg Hannon, Roido Manavaki, Tim D. Fryer, Luigi Aloj, Martin J. Graves, Fiona J. Gilbert, Marc R. Dweck, David E. Newby, Zahi A. Fayad, Gary Reynolds, Ann W. Morgan, Eric O. Aboagye, Anthony P. Davenport, Helle F. Jorgensen, Ziad Mallat, Martin R. Bennett, James E. Peters, James H. F. Rudd, Justin C. Mason, Jason M. Tarkin
Summary: This study investigates the feasibility of using somatostatin receptor 2 (SST2) as a molecular imaging target for inflammation in large vessel vasculitis (LVV), and provides evidence for its potential in the diagnosis and therapeutic monitoring of LVV.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Tanuj Puri, Michelle L. Frost, Amelia E. B. Moore, Gary J. R. Cook, Glen M. Blake
Summary: This article introduces the method of measuring bone metabolic flux (K-i) using [F-18] sodium fluoride ([F-18]NaF) positron emission tomography (PET) scans, and proposes a simplified method that estimates K-i values from static scans and venous blood samples. By reviewing different methods of measuring arterial input functions (AIF), a non-invasive method for studying bone metabolism without arterial blood sampling is provided, which shortens scan times, simplifies procedures, and reduces costs.
Review
Biotechnology & Applied Microbiology
Thomas Talbot, Haonan Lu, Eric O. Aboagye
Summary: High-grade serous ovarian carcinoma is characterized by universal TP53 mutations and widespread copy number alterations, including deletion of tumor suppressors and amplification of driver oncogenes. Amplified driver genes have been proposed as therapeutic targets. However, lack of validation and variable experimental procedures hinder clinical translation. This review collates candidate amplified therapeutic targets in high-grade serous ovarian carcinoma and quantitatively appraises the evidence for each gene.
CANCER GENE THERAPY
(2023)
Article
Oncology
Samuel J. Withey, Kasia Owczarczyk, Mariusz T. Grzeda, Connie Yip, Harriet Deere, Mike Green, Nick Maisey, Andrew R. Davies, Gary J. Cook, Vicky Goh
Summary: This study found that pre-treatment vascular and metabolic parameters of esophagogastric tumors may be associated with response to neoadjuvant therapy. However, these parameters showed no significant relationship with survival.
Article
Oncology
Mitchell Chen, Haonan Lu, Susan J. Copley, Yidong Han, Andrew Logan, Patrizia Viola, Alessio Cortellini, David J. Pinato, Danielle Power, Eric O. Aboagye
Summary: This study developed a radiomic-based signature for predicting disease response in patients with NSCLC undergoing PD-1 or PD-L1 immunotherapy. The radiomic signature was validated in two independent testing cohorts and demonstrated good prediction of treatment response and prognosis.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Jung Hyun Yoon, Fredrik Strand, Pascal A. T. Baltzer, Emily F. Conant, Fiona J. Gilbert, Constance D. Lehman, Elizabeth A. Morris, Lisa A. Mullen, Robert M. Nishikawa, Nisha Sharma, Ilse Vejborg, Linda Moy, Ritse M. Mann
Summary: This study evaluated the performance of artificial intelligence (AI) in the interpretation of digital mammography and digital breast tomosynthesis (DBT). The results showed that standalone AI performed as well as or better than radiologists in digital mammography, but there were insufficient studies to assess its performance in DBT interpretation.
Article
Radiology, Nuclear Medicine & Medical Imaging
Muhummad Sohaib Nazir, Daniel Johnathan Hughes, Gitasha Chand, Kathryn Adamson, Jessica Johnson, Damion Bailey, Victoria Gibson, Hong Hoi Ting, Alexander Lyon, Gary J. R. Cook
Summary: This study determines a non-invasive method for assessing myocardial PD-L1 expression using [Tc-99m]-labelled anti-PD-L1 single-domain antibody (NM-01) SPECT/CT. The study finds that myocardial PD-L1 expression is higher than skeletal muscle in lung cancer patients, and this technique has high reliability and specificity. It can be applied to investigate ICI-associated myocarditis and cardiomyopathies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniel Johnathan Hughes, Gitasha Chand, Jessica Johnson, Damion Bailey, Kathryn Adamson, Vicky Goh, Gary J. R. Cook
Summary: This study aims to determine the inter- and intra-rater agreement of the quantitative measurement of [Tc-99m]NM-01 SPECT/CT in NSCLC. The results show that using SUVmax and malignant lesion-to-blood pool ratios can provide accurate assessment of NSCLC. This study validates the effectiveness of [Tc-99m]NM-01 SPECT/CT in NSCLC.
Article
Oncology
Sophie Papa, Antonella Adami, Michael Metoudi, Richard Beatson, Molly Sarah George, Daniela Achkova, Evangelia Williams, Sefina Arif, Fiona Reid, Maria Elstad, Nicholas Beckley-Hoelscher, Abdel Douri, Marc Delord, Mike Lyne, Dharshene Shivapatham, Christopher Fisher, Andrew Hope, Sakina Gooljar, Arindam Mitra, Linda Gomm, Cienne Morton, Rhonda Henley-Smith, Selvam Thavaraj, Alice Santambrogio, Cynthia Andoniadou, Sarah Allen, Victoria Gibson, Gary J. R. Cook, Ana C. Parente-Pereira, David M. Davies, Farzin Farzaneh, Anna Schurich, Teresa Guerrero-Urbano, Jean-Pierre Jeannon, James Spicer, John Maher
Summary: This study developed an autologous CD28-based chimeric antigen receptor T-cell (CAR-T) therapy named T4 immunotherapy for locally advanced/recurrent head and neck squamous cell carcinoma (HNSCC). Patient-derived T-cells were engineered to express a panErbB-specific CAR and an IL-4-responsive chimeric cytokine receptor. Intratumoral delivery was used to mitigate off-tumor toxicity. The study demonstrated the safe and effective intratumoral administration of T4 immunotherapy in advanced HNSCC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Benjamin Hunter, Christos Argyros, Marianna Inglese, Kristofer Linton-Reid, Ilaria Pulzato, Andrew G. Nicholson, Samuel V. Kemp, Pallav L. Shah, Philip L. Molyneaux, Cillian Mcnamara, Toby Burn, Emily Guilhem, Marcos Mestas Nunez, Julia Hine, Anika Choraria, Prashanthi Ratnakumar, Susannah Bloch, Simon Jordan, Simon Padley, Carole A. Ridge, Graham Robinson, Hasti Robbie, Joseph Barnett, Mario Silva, Sujal Desai, Richard W. Lee, Eric O. Aboagye, Anand Devaraj
Summary: This study developed a radiomics model to assist in the diagnosis of lung cancer. By extracting radiomics features and using clustering methods, patients were stratified into different risk groups. The model showed high accuracy in predicting malignancy and has potential clinical applications.
BRITISH JOURNAL OF CANCER
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shahriar Islam, Marianna Inglese, Matthew Grech-Sollars, Preetha Aravind, Suraiya Dubash, Tara D. Barwick, Kevin O'Neill, James Wang, Azeem Saleem, James O'Callaghan, Giulio Anchini, Matthew Williams, Adam Waldman, Eric O. Aboagye
Summary: MRI and PET are used in neuro-oncology to detect and characterize malignant lesions. In this study, the uptake of FPIA in brain tumors was investigated using PET/MRI.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea G. Rockall, Xingfeng Li, Nicholas Johnson, Ioannis Lavdas, Shalini Santhakumaran, A. Toby Prevost, Shonit Punwani, Vicky Goh, Tara D. Barwick, Nishat Bharwani, Amandeep Sandhu, Harbir Sidhu, Andrew Plumb, James Burn, Aisling Fagan, Georg J. Wengert, Dow-Mu Koh, Krystyna Reczko, Qi Dou, Jane Warwick, Xinxue Liu, Christina Messiou, Nina Tunariu, Peter Boavida, Neil Soneji, Edward W. Johnston, Christian Kelly-Morland, Katja N. De Paepe, Heminder Sokhi, Kathryn Wallitt, Amish Lakhani, James Russell, Miriam Salib, Sarah Vinnicombe, Adam Haq, Eric O. Aboagye, Stuart Taylor, Ben Glocker
Summary: The study aimed to develop a machine learning algorithm to improve radiologists' sensitivity and specificity for metastasis detection in whole-body magnetic resonance imaging (WB-MRI). The results showed that using the algorithm can enhance the detection accuracy and reduce reading times for radiologists.
INVESTIGATIVE RADIOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Fiona Gilbert
Summary: Combining artificial intelligence with human expertise can be the best approach to enhance diagnostic accuracy in clinical imaging while ensuring safety.
