Article
Clinical Neurology
Filiz Osmanodja, Jan F. Scheitz, Jochen B. Fiebach, Ramanan Ganeshan, Kersten Villringer
Summary: The study found that intracranial time-of-flight (TOF) MRA can be a valuable diagnostic tool for predicting extracranial stenosis of the internal carotid artery (ICA).
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Hediyeh Baradaran, Tyrel Foster, Paul Harrie, J. Scott McNally, Matthew Alexander, Ankur Pandya, Yoshimi Anzai, Ajay Gupta
Summary: This study evaluated the reporting of carotid plaque features on neck CTAs at an academic institution, finding that while nearly all reports mentioned the degree of luminal stenosis, only a minority mentioned specific plaque features. There is a lack of comprehensive reporting on plaque features despite their importance in stroke risk assessment.
Article
Neurosciences
Chun Li, Jihong Meng, Baoxin Xu, Xiaodong Li, Miaomiao Li, Xue Du, Shaoyi Li, Weining Ma
Summary: This study aimed to investigate the relationship between CT angiography (CTA) manifestations in the anterior cerebral artery a1 segment (A1) and hemodynamics in patients with internal carotid artery stenosis (ICAS). A total of 97 cases were analyzed, and the degree of ICAS and symmetry of A1 were evaluated using CTA examination, while hemodynamic indexes were measured using transcranial Doppler (TCD). The study found that the presentation of A1 on the side of ICAS reflects the overall changes in intracranial hemodynamics, and a combination of TCD and CTA examination of A1 can help determine the location and degree of ICAS.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Benjamin Csippa, Zsuzsanna Mihaly, Zsofia Czinege, Marton Bence Nemeth, Gabor Halasz, Gyorgy Paal, Peter Sotonyi
Summary: The image reconstruction of stenotic carotid bifurcation can be managed by both medical practitioners and non-medical investigators; the differences between manual and semi-automatic segmentation may lead to conflicting results in blood flow simulations; the segmentations by medical practitioners and non-medical investigators play a crucial role in comparing with plaque image analysis.
APPLIED SCIENCES-BASEL
(2021)
Article
Medicine, General & Internal
Alison Halliday, Richard Bulbulia, Leo H. Bonati, Johanna Chester, Andrea Cradduck-Bamford, Richard Peto, Hongchao Pan
Summary: The international multicentre randomised trial ACST-2 compared the effects of CAS and CEA for asymptomatic patients with severe stenosis, showing that the long-term effects of these two procedures on fatal or disabling stroke are comparable.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yao Lu, Ruoyao Cao, Sheng Jiao, Ling Li, Chao Liu, Hailong Hu, Zhuangfei Ma, Yun Jiang, Juan Chen
Summary: This study evaluated the application of black-blood CT in carotid artery wall imaging and confirmed its accuracy in diagnosing stenosis rate and plaque burden of carotid artery. Black-blood CT showed good consistency with CTA and VW-MR in identifying stenosis rate and plaque burden, providing clear visualization of the artery wall, especially for patients with contraindication to MRI.
EUROPEAN RADIOLOGY
(2023)
Article
Multidisciplinary Sciences
Entesar Zawam Dalah, Abdulmunhem Obaideen, Sabaa Anam, Khalid Alzimami, Layal Khalid Jambi, David A. Bradley
Summary: This study estimated the lifetime risk of lung cancer in CAD patients receiving enhanced CCTA and unenhanced CTCS. The results showed significant differences in patient effective dose and organ doses between CTCS and CCTA. Female patients, younger patients, and those undergoing both CCTA and CTCS scans had higher risk. The mAs parameter had the greatest impact on patient dose.
Article
Biology
Antonio Pierro, Pietro Modugno, Roberto Iezzi, Savino Cilla
Summary: The study aimed to anatomically evaluate the carotid bulb using CT-angiography, propose a new index (RegX) for carotid stenosis quantification, and assess the accuracy of the relationship between NASCET and ECST methods in a large adult population. The results demonstrated that the RegX index provided a consistent and accurate measure of carotid stenosis through the application of the ECST method, departing from the previously established relationships between NASCET and ECST values.
Article
Clinical Neurology
K. Jain, B. Arun Prasad, S. E. Sreedharan, S. Kannath, R. P. Varma, P. N. Sylaja
Summary: Soft plaque thickness over 2.75 mm is an independent predictor of symptomatic carotid disease, and an increase in thickness of 4.0 mm significantly predicts the transition from asymptomatic to symptomatic carotid. These new measures help assess the risk of ischemic events in carotid atherosclerotic disease.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chankue Park, Ki Seok Choo, Yunsub Jung, Hee Seok Jeong, Jae-Yeon Hwang, Mi Sook Yun
Summary: Comparing ASIR-V and TFI in lower extremity CT angiography, higher blending factor or strength led to decreased noise, increased SNR and CNR values, and improved image sharpness. TF-H images exhibited superior qualitative image quality and increased sharpness compared to ASIR-V images, indicating a balanced image in terms of noise and sharpness.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
L. Saba, C. Loewe, T. Weikert, M. C. Williams, N. Galea, R. P. J. Budde, R. Vliegenthart, B. K. Velthuis, M. Francone, J. Bremerich, L. Natale, K. Nikolaou, J. N. Dacher, C. Peebles, F. Caobelli, A. Redheuil, M. Dewey, K. F. Kreitner, R. Salgado
Summary: The European Society of Cardiovascular Radiology focuses on cardiac and vascular imaging, aiming to continuously improve, develop, and standardize education, training, and best medical practice based on experience and evidence. This document discusses suggestions for standardized reporting based on scientific evidence and the experience of society members.
EUROPEAN RADIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yoichi Miura, Hidenori Suzuki
Summary: Both fasting and non-fasting hypertriglyceridemia are risk factors for atherosclerotic disease, but it is uncertain whether they increase the risks of carotid artery stenosis progression. Statins can prevent carotid plaque progression and improve plaque stability. However, there is currently no evidence that combining non-statin lipid-lowering drugs with statins provides additional benefits in preventing cerebrovascular events and stenosis progression in patients with carotid artery stenosis. This article explores the relationship between hypertriglyceridemia and carotid artery stenosis, as well as the potential role of lipid-lowering drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yue Wang, Yang Wang, Peng Hu, Zhongfeng Niu, Hongjie Hu
Summary: This study compared the image quality of low keV virtual monochromatic images (VMIs) from twin-beam dual energy (TBDE) mode to that from single energy (SE) mode in carotid computed tomography angiography (CTA). The results suggest that TBDE technique with low keV VMI reconstruction provides better image quality than low tube voltage scan in the SE mode.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Physiology
Ying Zhu, Liwei Chen, Wenjie Lu, Yongjun Gong, Ximing Wang
Summary: This study utilized the nnU-Net-based model to assist in the evaluation of CAS and carotid atherosclerotic plaques using CTA imaging. The nnU-Net model showed good performance and consistency in CAS diagnosis and plaque segmentation, with a shorter evaluation time compared to physicians.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Ruijun Liu, Jing Shao
Summary: The article reviews the reasons for the increasing number of cardiovascular and cerebrovascular disease patients in recent years, as well as the related risk factors, providing a theoretical basis for early detection and treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Samuel Heuts, Simon Schalla, Mitch J. F. G. Ramaekers, Elham Bidar, Casper Mihl, Joachim E. Wildberger, Bouke P. Adriaans
Summary: Acute type A aortic dissection (ATAAD) is a life-threatening condition that requires emergency surgery. Patients should undergo regular imaging examinations to evaluate the occurrence of complications.
Article
Cardiac & Cardiovascular Systems
Hedwig M. J. M. Nies, Suzanne Gommers, Geertruida P. Bijvoet, Luuk I. B. Heckman, Frits W. Prinzen, Gaston Vogel, Caroline M. Van de Heyning, Amedeo Chiribiri, Joachim E. Wildberger, Casper Mihl, Robert J. Holtackers
Summary: This study evaluated the performance of various semi-automated techniques for quantifying myocardial infarct size using histopathology as the reference standard. The results showed that the signal threshold vs. reference mean method with a threshold of 5 standard deviations demonstrated the most accurate quantification in both conventional bright-blood and novel dark-blood late gadolinium enhancement (LGE) images.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Endocrinology & Metabolism
Sibel Altintas, Samanta van Workum, Madeleine Kok, Ivo A. P. G. Joosen, Mathijs O. Versteylen, Patricia J. Nelemans, Joachim E. Wildberger, Harry J. G. M. Crijns, Marco Das, Bas L. J. H. Kietselaer
Summary: This study investigated the association between body mass index (BMI) and coronary artery calcification (CAC), and found no significant association after adjusting for other risk factors.
OBESITY SCIENCE & PRACTICE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas Sartoretti, Michael Mcdermott, Victor Mergen, Andre Euler, Bernhard Schmidt, Gregor Jost, Joachim Wildberger, Hatem Alkadhi
Summary: This study assessed the impact of low kilo-electronvolt (keV) virtual monoenergetic image (VMI) energies and iterative reconstruction on image quality of coronary CT angiography (CCTA). The results showed that 40 keV VMI with QIR-4 significantly improved image quality of CCTA.
BRITISH JOURNAL OF RADIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Joachim E. E. Wildberger, Hatem Alkadhi
Summary: Noninvasive vascular imaging with CT has become essential in clinical practice, and the introduction of PCD-CT has further expanded its applications. Technical improvements of PCD-CT, including reduced noise levels, improved contrast-to-noise ratio, and full spectral multienergy data, have the potential to impact clinical decision making and patient outcomes. Early experience with PCD-CT technology has shown these improvements in various aspects. This review summarizes the advantages of PCD-CT for vascular imaging and discusses the PureLumen and PureCalcium algorithms.
INVESTIGATIVE RADIOLOGY
(2023)
Article
Oncology
Cornelis M. de Mooij, Thiemo J. A. van Nijnatten, Briete Goorts, Loes F. S. Kooreman, Isabel W. M. Raymakers, Silke P. L. van Meijl, Maaike de Boer, Kristien B. M. I. Keymeulen, Joachim E. Wildberger, Felix M. Mottaghy, Marc B. I. Lobbes, Marjolein L. Smidt
Summary: This study investigated the feasibility of sequential hybrid [18F]FDG PET/MRI in predicting the treatment response in breast cancer patients undergoing neoadjuvant chemo(targeted) therapy. The qualitative or quantitative evaluation of PET/MRI after therapy was found to be unreliable in predicting the response of the primary tumor and axillary lymph nodes. However, combining the relative decrease in PET and MR imaging variables halfway through therapy improved the diagnostic accuracy, especially for predicting the response of axillary lymph nodes. These findings suggest that sequential hybrid [18F]FDG PET/MRI may have complementary value in the early prediction of treatment response in breast cancer.
Review
Radiology, Nuclear Medicine & Medical Imaging
Thomas Sartoretti, Joachim E. Wildberger, Thomas Flohr, Hatem Alkadhi
Summary: Since the 1970s, X-ray CT has become a significant diagnostic imaging technology in modern medicine, thanks to technological advances improving image quality and diagnostic value. Photon-counting detector (PCD)-CT, a novel technology, has emerged with the potential to overcome limitations of current CT systems and offer improved capabilities. This review summarizes the first clinical experience of PCD-CT, focusing on recent prototypes and clinically approved systems, presenting initial publications and corresponding clinical cases.
BRITISH JOURNAL OF RADIOLOGY
(2023)
Article
Geriatrics & Gerontology
Cas J. Fuchs, Remco Kuipers, Jan A. Rombouts, Kim Brouwers, Vera B. Schrauwen-Hinderling, Joachim E. Wildberger, Lex B. Verdijk, Luc J. C. van Loon
Summary: This study assessed the differences in muscle group volumes between young and older males and found that the most significant differences were observed in the thigh muscle group, with the quadriceps femoris showing the largest difference in muscle volume between young and older men. Overall, young men have larger muscle volumes compared to older men.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Michael C. Mcdermott, Babs M. F. Hendriks, Joachim E. Wildberger, Sanne W. de Boer
Summary: Manual dilution of contrast media in endovascular procedures can result in inaccurate and uneven concentration, leading to incorrect reporting of administered doses to patients.
INVESTIGATIVE RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mitch J. F. G. Ramaekers, Jos J. M. Westenberg, Max F. G. H. M. Venner, Joe F. Juffermans, Hans C. van Assen, Bastiaan J. C. te Kiefte, Bouke P. Adriaans, Hildo J. Lamb, Joachim E. Wildberger, Simon Schalla
Summary: This study compared the influence of static and multiphase segmentation methods on flow-related parameters in aortic 4D flow MRI and assessed the evolution of these parameters during systole. The results showed that static and multiphase segmentation yielded comparable results for flow-related parameters, eliminating the need for time-consuming multiple segmentations. However, multiphase quantification was necessary for assessing peak values of aortic flow-related parameters.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marc B. I. Lobbes, Lidewij M. F. H. Neeter, Frank Raat, Kim Turk, Joachim E. Wildberger, Thiemo J. A. van Nijnatten, Patricia J. Nelemans
Summary: Breast MRI is considered the best modality for preoperative staging of invasive lobular carcinoma (ILC). However, evidence of the accuracy of contrast-enhanced mammography (CEM) in women diagnosed with ILC is limited. This study aimed to retrospectively evaluate the accuracy of CEM and MRI in preoperative staging of ILC.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Endocrinology & Metabolism
Vera H. W. de Wit-Verheggen, Froukje Vanweert, Juho Raiko, Viktor Lienard, Gert Schaart, Anne Gemmink, Emmani B. M. Nascimento, Matthijs K. C. Hesselink, Joachim E. Wildberger, Roel Wierts, Peter J. Joris, Joel Haas, David Montaigne, Bart Staels, Esther Phielix, Patrick Schrauwen, Vera B. Schrauwen-Hinderling, Tineke van de Weijer
Summary: The objective of this study was to determine the direct effects of the PPARa agonist ciprofibrate on cardiac and hepatic metabolism, as well as its potential to improve insulin sensitivity and cardiac function in insulin-resistant individuals. The results showed that ciprofibrate treatment increased hepatic lipid accumulation but had no effect on whole-body insulin sensitivity and cardiac function.
Article
Cardiac & Cardiovascular Systems
Mohamed Kassem, Kelly P. H. Nies, Ellen Boswijk, Jochem van der Pol, Mueez Aizaz, Marion J. J. Gijbels, Debiao Li, Jan Bucerius, Werner H. Mess, Joachim E. Wildberger, Robert J. van Oostenbrugge, Rik P. M. Moonen, Zhaoyang Fan, M. Eline Kooi
Summary: This study compares the quantification of plaque composition with MATCH and multi-sequence MRI. The results show that MATCH can effectively quantify LRNC and IPH, but is not effective for calcifications. MATCH has the advantage of shorter scan time and inherent co-registration, despite lower image quality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Mitch J. F. G. Ramaekers, Jos J. M. Westenberg, Bouke P. Adriaans, Estelle C. Nijssen, Joachim E. Wildberger, Hildo J. Lamb, Simon Schalla
Summary: Four-dimensional flow magnetic resonance imaging is a promising technique for diagnosing and stratifying the risk of aortic disease. This review aims to provide clinicians with a guide to the basics of flow imaging, commonly used flow-related parameters, and their relevance in the context of aortic disease.
INSIGHTS INTO IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
E. C. Nijssen, P. J. Nelemans, R. J. Rennenberg, G. van Ommen, J. E. Wildberger
Summary: According to the latest ESUR contrast media guidelines, standard prophylaxis is no longer recommended for patients with moderate chronic kidney disease (CKD). The guideline updates are based on indirect evidence and expert opinion, as there is limited direct evidence supporting the withdrawal of standard prophylaxis in moderate CKD patients. The updated guideline recommendation has shown substantial benefits for patients and hospitals in terms of burden reduction.
EUROPEAN RADIOLOGY
(2023)
