Journal
EUROPEAN PSYCHIATRY
Volume 28, Issue 8, Pages 499-506Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.eurpsy.2012.07.001
Keywords
Corpus callosum; Region of interest; Voxel-based morphometry; Diffusion tensor imaging; Cortical gray matter; Neuropsychological tests
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Funding
- Italian Ministry of Health [RC07-08-09, RF 07-08]
- National Institutes of Health through the NIH Roadmap for Medical Research [U54 RR021813]
- National Center for Research Resources (NCRR) [P41 RR013642, M01 RR000865]
- National Institutes of Health (NIH)
- NIBIB [R01 EB007813, R01 EB008281, R01 EB008432]
- NICHHD [R01 HD050735]
- NIA [R01 AG020098]
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Abnormal brain connectivity has recently been reported in obsessive compulsive disorder (OCD). However, structural differences in the corpus callosum (CC), the primary structure connecting the two hemispheres, have not been extensively studied. In this case-control study, we recruited 30 patients with OCD and 30 healthy control subjects carefully matched for age, sex and handedness. Combining surface-based mesh-modeling and voxel-based morphometry (VBM), we compared callosal thickness and white matter (WM) density in patients and controls. We investigated associations between callosal structure and cortical gray matter (GM) density, and we related CC measures to neuropsychological performance in OCD. OCD patients showed small anterior and posterior callosal regions compared to healthy control subjects. In the OCD group, anterior callosal thickness was positively correlated with GM density of the right mid-dorso-lateral prefrontal (BA 9/46) area, while posterior callosal thickness was positively correlated with GM density in the left supramarginal gyrus (BA 40). Moreover, posterior callosal WM density was positively correlated with verbal memory, visuo-spatial memory, verbal fluency, and visuo-spatial reasoning performances. Callosal attributes were related to GM density in cortical areas innervated by the CC, and were also related to performance in cognitive domains impaired in the disorder. The CC may therefore be integrally involved in OCD. (C) 2012 Elsevier Masson SAS. All rights reserved.
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