Article
Polymer Science
Kokila Thirupathi, Thi Tuong Vy Phan, Madhappan Santhamoorthy, Vanaraj Ramkumar, Seong-Cheol Kim
Summary: The study developed a temperature and pH-responsive poly(N-isopropyl acrylamide)-co-poly(acrylamide) (PNIPAM-co-PAAm) using free radical polymerization. The resulting PNIPAm-co-PAAm-Mela HG system showed temperature-responsive phase transition characteristics and efficient drug release under pH and temperature stimuli. Additionally, the synthesized PNIPAm-co-PAAm-Mela HG exhibited biocompatibility on a human liver cancer cell line.
Article
Polymer Science
Emanuel A. Glitscher, Julian Bergueiro, Marcelo Calderon
Summary: The novel strategy of incorporating anisotropic gold nanoparticles into polymeric thermoresponsive nanogels has expanded their potential applications in the field of nanomedicine.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Polymer Science
Huiqi Wang, Aman Ullah
Summary: In this study, block copolymer micelles composed of renewable fatty-acid-based hydrophobic block and thermoresponsive hydrophilic block were synthesized and characterized for controlled drug delivery. The self-assembly of block copolymers with variable hydrophobic block length formed spherical nanoparticles with low critical micelle concentration in aqueous media. The in vitro drug release tests showed temperature-triggered response and accelerated drug release at 37 degrees C.
Article
Polymer Science
Madhappan Santhamoorthy, Seong-Cheol Kim
Summary: A dual pH- and temperature-sensitive copolymer nanogel was developed for efficient drug delivery, showing potential for application in cancer therapy.
Article
Pharmacology & Pharmacy
Cuixia Li, Sreekanth Reddy Obireddy, Wing-Fu Lai
Summary: Nanogels possess high tunability and stability, are widely used in drug delivery applications, and this article aims to introduce the latest knowledge on their preparation and application.
Review
Polymer Science
Sagar Pardeshi, Fouad Damiri, Mehrukh Zehravi, Rohit Joshi, Harshad Kapare, Mahendra Kumar Prajapati, Neha Munot, Mohammed Berrada, Prabhanjan S. Giram, Satish Rojekar, Faraat Ali, Md. Habibur Rahman, Hasi Rani Barai
Summary: Temperature-induced changes in the viscosity and formation of 3-D structure make thermosensitive hydrogels ideal for cell scaffolds or drug reservoirs. This review presents a comprehensive overview of the synthesis, mechanism, and biomedical applications of thermosensitive hydrogels, and discusses their commercial potential.
Article
Polymer Science
Tao Xu, Dimitrios Skoulas, Dawei Ding, Sally-Ann Cryan, Andreas Heise
Summary: In this study, responsive biocompatible nanogels were synthesized for controlled mucosal delivery and release of drugs. The nanogels exhibited suitable size and morphology, and showed responsiveness to reducing agents in the intracellular environment. This work provides a new approach for drug delivery in anti-cancer therapy by overcoming mucosal barriers.
Review
Biotechnology & Applied Microbiology
Xinjing Du, Yuting Gao, Qi Kang, Jinfeng Xing
Summary: In recent years, exploration of the tumor microenvironment has led to the development of tumor microenvironment-responsive nanogels as drug carriers, showing great potential in improving the efficacy of chemotherapy. Common preparation techniques include free radical polymerization, covalent cross-linking, and physical self-assembly, with drug loading methods such as physical encapsulation and chemical coupling also being utilized for controlled drug release behavior. Challenges and prospects of nanogels as drug carriers are briefly discussed in this review.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
A. A. Amirov, D. M. Yusupov, E. K. Murliev, C. A. Gritsenko, A. M. Aliev, A. M. Tishin
Summary: The state of a thermoresponsive polymer can be controlled through the magnetocaloric effect in a magnetic field, as demonstrated in in situ experiments. Composites made of PNIPAM polymer coated with magnetocaloric Gd showed a reversible phase transition induced by switching on/off a magnetic field at -32 degrees C. This smart effect may be useful for the development of new smart materials for biomedical applications.
Article
Biochemistry & Molecular Biology
Mohammad Shafee Alkanawati, Marina Machtakova, Katharina Landfester, Heloise Therien-Aubin
Summary: The development of responsive nanogel systems for drug delivery is challenging but promising due to their high stability in aqueous media and ability to respond to biochemical cues. In this study, multistimuli-responsive nanogels were synthesized using bio-orthogonal and reversible reactions, allowing for selective release of encapsulated cargos. These nanogels were pH-responsive and could be controlled for reversible release of payloads, and additionally responsive to enzymatic cleavage and oxidoreductive cues.
Article
Biophysics
Miao Lei, Wenqi Zhang, Chenxi Yi, Luke Yan, Yefei Tian
Summary: Zwitterionic nanogels with temperature sensitivity and redox responsiveness show ultra-high colloidal stability and non-specific protein adsorption resistance, exhibiting a prominent inhibitory impact on tumor cells and excellent drug release behavior.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Nanoscience & Nanotechnology
Nelli Morgulchik, Nazila Kamaly
Summary: Nanogels are a type of drug delivery system composed of cross-linked polymer networks with different characteristics and functionalities for the delivery of small molecule and macromolecular therapeutics. The stimuli-responsive cross-linkers in nanogels enable controlled release at target sites to improve therapeutic efficiency. Small molecule drugs conjugated to nanogels demonstrate diminished burst release, leading to more predictable release profiles.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Zhao Wang, Xinhua Li, Xiaojuan Zhang, Ruilong Sheng, Qing Lin, Wenli Song, Lingyun Hao
Summary: Therapeutic ophthalmic contact lenses with prolonged drug release and improved bioavailability were successfully developed using drug-loaded nanogels. These contact lenses can sustainably deliver drugs and exhibit good biocompatibility compared to traditional eye drops or ointment formulations, making them a promising alternative for long-term oculopathy treatment.
Review
Polymer Science
Mohsen Rahmanian, Fatemeh Oroojalian, Elham Pishavar, Prashant Kesharwani, Amirhossein Sahebkar
Summary: This article reviews the application of nanogels, nanodiscs, yeast cells, and metallo-complexes-based materials in curcumin delivery, and briefly evaluates their potential benefits for enhancing curcumin application in the pharmaceutical and clinical setting.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
David S. Spencer, Aaliyah B. Shodeinde, David W. Beckman, Bryan C. Luu, Hannah R. Hodges, Nicholas A. Peppas
Summary: By evaluating a series of nanoparticle formulations, this study identified candidates with low cytotoxicity, pH-dependent membrane disruption potential, highest siRNA loading, and transfection efficacy for in vitro applications.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Physical
Arundhati Sengupta, Satya Narayan Malik, D. Bahadur
APPLIED SURFACE SCIENCE
(2016)
Article
Engineering, Environmental
Dipa Dutta, Shankar Thiyagarajan, Dhirendra Bahadur
CHEMICAL ENGINEERING JOURNAL
(2016)
Article
Cell Biology
Manashjit Gogoi, Manish K. Jaiswal, Haladhar Dev Sarma, Dhirendra Bahadur, Rinti Banerjee
INTEGRATIVE BIOLOGY
(2017)
Article
Chemistry, Physical
Asifkhan Shanavas, Sisini Sasidharan, Dhirendra Bahadur, Rohit Srivastava
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2017)
Article
Materials Science, Multidisciplinary
Muhammad Shahbaz Beg, Jeotikanta Mohapatra, Lina Pradhan, D. Patkar, D. Bahadur
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2017)
Article
Chemistry, Physical
Prerna Bansal, Ajay Singh Panwar, Dhirendra Bahadur
JOURNAL OF PHYSICAL CHEMISTRY C
(2017)
Article
Chemistry, Multidisciplinary
Prasanta Kumar Sahoo, Bharati Panigrahy, Dinbandhu Thakur, Dhirendra Bahadur
NEW JOURNAL OF CHEMISTRY
(2017)
Article
Chemistry, Multidisciplinary
Arundhati Sengupta, Rohan Rao, D. Bahadur
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2017)
Article
Materials Science, Biomaterials
EswaraVara Prasadarao Komarala, Himanshu Tyagi, Shankar Thiyagarajan, Lina Pradhan, Mohammed Aslam, Dhirendra Bahadur
JOURNAL OF MATERIALS CHEMISTRY B
(2017)
Article
Materials Science, Multidisciplinary
Dushyant Kushavah, P. K. Mohapatra, Pintu Ghosh, Mamraj Singh, P. Vasa, D. Bahadur, B. P. Singh
MATERIALS RESEARCH EXPRESS
(2017)
Article
Materials Science, Multidisciplinary
Shravan Suresh, Anand Prakash, D. Bahadur
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2018)
Article
Materials Science, Multidisciplinary
Jagriti Gupta, Anand Prakash, Manish K. Jaiswal, Atanuu Agarrwal, D. Bahadur
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2018)
Article
Biophysics
Saumya Nigam, Dhirendra Bahadur
COLLOIDS AND SURFACES B-BIOINTERFACES
(2017)
Article
Biophysics
S. Indulekha, P. Arunkumar, D. Bahadur, R. Srivastava
COLLOIDS AND SURFACES B-BIOINTERFACES
(2017)
Article
Chemistry, Inorganic & Nuclear
Jagriti Gupta, Jeotikanta Mohapatra, D. Bahadur
DALTON TRANSACTIONS
(2017)
Article
Polymer Science
Mustafa Kalay, Abidin Esidir, Mahmut Ruzi, N. Burak Kiremitler, Mustafa Serdar Onses
Summary: This study proposes stable and addressable polymer PUFs, utilizing a cross-linkable polymer system, which demonstrates high stochastic characteristics and low-cost production. The performance of the polymer features is evaluated through various analyses, and direct image authentication is achieved using feature matching algorithms.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Jingyu Jin, Guoqiang Lu, Jun Nie, Xiaoqun Zhu
Summary: Photopolymerization technology is limited in the fields of food packaging and biomedicine due to the high migration of small molecules from photoinitiators. In this study, a polymerizable 2-vinyl thioxanthone (ETX) was synthesized to improve the migration stability of photoinitiators. Macromolecular photoinitiators (PPI1, PPI2) were also prepared to further reduce migration. The results showed that the ETX/TEOA system had higher initiation performance and PPI2 displayed favorable initiation ability. Additionally, the migration of ETX, PPI1, and PPI2 in photocured film was significantly reduced. These low-migration photoinitiators have potential applications in the fields of food packaging and biological materials.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Weijie Li, Jun Nie, Yingying Zhao, Xiaoqun Zhu
Summary: This study focuses on the development of high-performance, low-migration photoinitiators. A polymerizable photoinitiator (VBP) was synthesized by introducing an ethylene group into benzophenone, and three different molecular weight single-component photoinitiators (PVBN1-3) were synthesized based on VBP. The results show that these new photoinitiators have stronger absorption ability compared to benzophenone and significantly reduce the migration of initiators and co-initiators, addressing the safety concerns caused by migration.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Seira Morimune-Moriya, Yuki Iwahashi, Mitsuru Nakamura, Daisuke Ogawa, Keiji Nakamura
Summary: This study investigates the effect of plasma treatment on carbon nanotubes (CNTs) and the structure/properties of polyimide (PI) nanocomposites with ultra-low content of CNTs. The results show that plasma treatment introduces isocyanate groups on the surface of CNTs and enhances the interfacial interaction between PI and treated CNTs. This leads to a significant improvement in the mechanical properties of the nanocomposites, with even a small addition of treated CNTs showing a substantial increase in Young's modulus, tensile strength and toughness.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Yuanlong Li, Chaojie Chen, Guoqing Cui, Li Liu, Chao Zhou, Guangfeng Wu
Summary: In this study, a novel ion-conducting hydrogel was fabricated using a straightforward approach. The hydrogel showed excellent tensile properties and high toughness due to physical interactions and covalent binding. Additionally, the introduction of hydroxyethyl cellulose and lithium chloride improved the biocompatibility, mechanical properties, electrical conductivity, and frost resistance of the hydrogel, demonstrating its potential for cold climate applications.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Dengwei Yan, Jinxian Yang, Xuejun Pan, Xiaozheng Duan, Lianwei Li, Mo Zhu
Summary: The influence of backbone length on grafting efficiency during the graft-onto reaction process was investigated. It was found that the polydispersity effect of backbone length does not affect the final grafting efficiency, indicating that the local dynamics of chain segments dominate the graft-onto process.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Zhaoyi Luo, Xianjie Pan, Fanqi Liu, Quanxi Yi, Yanning Zeng, Yunhua Chen, Chaoyang Wang
Summary: This study provides a method to prepare high-performance epoxy materials with good malleability and thermal stability. The materials have self-healing and welding capabilities, thanks to the addition of specific chemical bonds and network structures. They exhibit mechanical properties comparable to commercial epoxy resins and show great potential for sustainable industrial development.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Chaoji Xiong, Hao Wang, Lihua Deng, Kun Liang, Chunhua Wu, Wei Wu, Qian Chen
Summary: In this study, four polyamides were synthesized and their adsorption performances for Hg2+ in aqueous systems were investigated. The polyamides exhibited high adsorption capacities and excellent reusability, with the involvement of sulfur, nitrogen, and oxygen in the chemical adsorption process of Hg2+.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Siim Laanesoo, Olivier Bonjour, Rauno Sedrik, Iris Tamsalu, Patric Jannasch, Lauri Vares
Summary: The insertion of rigid aliphatic or aromatic building blocks in polymer structures is an effective way to synthesize high -Tg polymer materials. In this study, a series of isosorbide-2-aryl carboxylate-5-methacrylate monomers (ArIMAs) were synthesized by functionalizing isosorbide 5-methacrylate with various aromatic lignin-inspired esters. These monomers were polymerized to obtain high molecular-weight poly(aryl carboxylate isosorbide methacrylates) (PArIMAs). The resulting polymers showed high glass transition temperatures and thermal stability, making them suitable for use as high-performance plastics and coatings.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Yuqian Wu, Weijie Xu, Jianliang Li, Zhangfeng Zhong, Liqing Huang, Shengke Li, Huaping Tan
Summary: This study investigates the improvement of degradation and drug release characteristics of dynamic Schiff base-mediated natural polysaccharide hydrogels using tannic acid (TA), leading to enhanced stability and functionality.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Xi Zhang, Xiangli Kong, Xin Zhou, Yiyan Gao, Yibo Sun, Guanghui Gao, Wei Liu, Kai Shi
Summary: Conductive hydrogels have great development prospects in flexible strain sensors, but long-term direct contact with human skin can cause bacterial infection. A hydrogel with antibacterial, biocompatibility, and toughness was designed and manufactured using a freeze-thaw method. The hydrogel maintains tensile properties and fatigue resistance at low temperatures and is resistant to bacteria. Therefore, hydrogel sensors can be used to monitor human movements.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Wei Zhang, Jiangang Yu, Mingyang Wu, Rui Li, Anqiang Zhang, Yaling Lin
Summary: In this study, polyacrylamide containing quaternary ammonium salts (PAM-X) were synthesized and found to effectively inhibit soil-borne pathogenic fungi while maintaining the balance of microbial population in soil. PAM-X also showed low toxicity to earthworms and fish, providing a new method for the prevention and control of soil-borne fungal diseases.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Jiawen He, Haojie Yu, Li Wang, Jian Yang, Yanhui Zhang, Wenbing Huang, Chenguang Ouyang
Summary: This review discusses the use of polymeric hydrogels for atmospheric water harvesting (AWH), including the mechanism of water sorption, fabrication methods, and strategies for optimizing the structure of hydrogels. The extended applications of hygroscopic photothermal hydrogels, such as agricultural irrigation and dehumidification, are also explored. The challenges and prospects of using polymeric hydrogels for AWH are summarized.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Ying Du, Shuaishuai Lu, Yuanna Sun, Qingshan Li, Xinhai He
Summary: This study introduces a method to improve the performance of hydrogels by incorporating proline, resulting in hydrogels with excellent stretchability, high conductivity, and long-term stability. The hydrogel remains flexible and conductive even at ultra-low temperatures.
EUROPEAN POLYMER JOURNAL
(2024)
