Article
Obstetrics & Gynecology
Lucia de Miguel-Gomez, Sara Lopez-Martinez, Hannes Campo, Emilio Frances-Herrero, Amparo Faus, Ana Diaz, Antonio Pellicer, Francisco Dominguez, Irene Cervello
Summary: The study aimed to investigate the effects of human plasma from different sources on endometrial regeneration, showing that umbilical cord blood plasma has a stronger regenerative effect and can be used for the treatment of endometrial pathologies.
FERTILITY AND STERILITY
(2021)
Article
Materials Science, Multidisciplinary
Zhitong Chen, Guojun Chen, Richard Obenchain, Rui Zhang, Fan Bai, Tianxu Fang, Hanwen Wang, Yingjie Lu, Richard E. Wirz, Zhen Gu
Summary: This article introduces the delivery methods of cold atmospheric plasma (CAP) in biomedical applications, such as sterilization, wound healing, and cancer therapy. It also presents the future research needs in this field, providing insights for researchers from various disciplines.
Article
Chemistry, Analytical
Izabella J. Jahn, Alexej Grjasnow, Henry John, Karina Weber, Juergen Popp, Walter Hauswald
Summary: The study compares and evaluates the performance of different confocal Raman spectrometers in biosensor applications, showing that the sample itself is the most crucial optical component in a Raman spectrometer and demonstrating the potential of mid-range equipment.
Article
Multidisciplinary Sciences
Emily R. Smith, Siran He, Kevin C. Klatt, Matthew D. Barberio, Ali Rahnavard, Negeena Azad, Carolyn Brandt, Bethany Harker, Emily Hogan, Padmini Kucherlapaty, Dina Moradian, Alison D. Gernand, Homa K. Ahmadzia
Summary: Research shows that women and pregnant individuals are often underrepresented in studies, with a significant proportion being excluded and having smaller sample sizes. Additionally, many studies do not report information on race and ethnicity.
Review
Food Science & Technology
Mina Allameh, V. Orsat
Summary: Anxiety is a disorder that can be managed with a combination of therapies or the use of complementary and alternative medicine. Scientists are searching for natural anxiolytics and have identified several medicinal plants with active components. However, further studies are needed to minimize side effects and enhance effectiveness. The use of natural anxiolytics can be improved by managing preparation protocols.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Physics, Fluids & Plasmas
Henrike Jakob, Minkwan Kim
Summary: Electrical models play a crucial role in characterizing nonthermal plasma sources, with new model focusing on complex electrode designs showing reasonable agreement with measurements.
IEEE TRANSACTIONS ON PLASMA SCIENCE
(2021)
Article
Engineering, Civil
Said M. Easa, Qing Chong You
Summary: This paper focuses on the design features of basic turbo roundabouts and develops analytical models for intersection sight distance (ISD) requirements. The models identify the required lateral clearance at the central island and clear sight triangles at the roundabout quadrants, which are crucial for establishing landscaping restrictions and determining the roadway right of way and property impacts.
JOURNAL OF TRANSPORTATION ENGINEERING PART A-SYSTEMS
(2023)
Article
Energy & Fuels
Nicolae Badea
Summary: This paper covers the role and possibilities of hydrogen as an energy carrier, detailing the efficiency of current hydrogen production technologies and the potential for hydrogen conversion. It also discusses the use of hydrogen fuel cells in electric vehicles and cogeneration systems for buildings, highlighting the need for traditional transport and distribution grids to adapt to the new energy market dynamics.
Review
Physics, Multidisciplinary
Juan I. Del Valle, Franklin R. Chang Diaz, Victor H. Granados
Summary: This article discusses the physics and practical applications of helicon plasma sources, emphasizing the importance of understanding ion density distribution, induced surface potentials, and low-energy sputtering reactions for proper modeling and predicting performance.
FRONTIERS IN PHYSICS
(2022)
Article
Oncology
Gilles Vassal, Peter J. Houghton, Stefan M. Pfister, Malcolm A. Smith, Huib N. Caron, Xiao-Nan Li, David J. Shields, Olaf Witt, Jan J. Molenaar, Sara Colombetti, Julia Schueler, Lou F. Stancato
Summary: Cancer remains the leading cause of disease-related death in children, with limited curative treatment options for those experiencing relapses of malignant solid tumors. Lack of molecular genetic data and appropriate patient-derived models are hindering preclinical drug testing efforts. Recommendations based on existing experiences are provided to guide preclinical pediatric cancer research and inform clinical development.
MOLECULAR CANCER THERAPEUTICS
(2021)
Review
Health Care Sciences & Services
Wanda Lattanzi, Cristian Ripoli, Viviana Greco, Marta Barba, Federica Iavarone, Angelo Minucci, Andrea Urbani, Claudio Grassi, Ornella Parolini
Summary: The rapid development in research areas has advanced personalized medicine by improving our understanding of genomic functions, patient phenotypes, and diseases, as well as enabling the design of innovative biological treatments tailored to individual patients. Meanwhile, diverse biotechnological advancements have uncovered disease mechanisms and prompted the development of personalized regenerative medicine strategies.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Rodolphe Poupardin, Martin Wolf, Dirk Strunk
Summary: Research shows a significant improvement in EV characterization in recent years, with papers using more methods and markers being more frequently cited. Papers citing MISEV criteria tend to use a higher number of characterization methods, indicating a positive impact of the guidelines on EV research quality.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Oncology
Neelima Vidula, Andrzej Niemierko, Giuliana Malvarosa, Megan Yuen, Jochen Lennerz, A. John Iafrate, Seth A. Wander, Laura Spring, Dejan Juric, Steven Isakoff, Jerry Younger, Beverly Moy, Leif W. Ellisen, Aditya Bardia
Summary: Plasma-based genotyping can identify high rates of actionable mutations, leading to significant application of matched therapy and improved overall survival in patients with metastatic breast cancer.
CLINICAL CANCER RESEARCH
(2021)
Article
Environmental Sciences
Balazs M. Fekete, Mihaly Bacsko, Jiaqi Zhang, Mengye Chen
Summary: Transitioning away from fossil fuels is crucial for a sustainable future, but intermittent energy supply is a major challenge. While decarbonization is a primary driver, the depletion of fossil energy sources also provides strong incentives. Many publications on achieving net-zero carbon emissions fall short of truly achieving a fossil fuel-free future without some dependence on fossil fuels with carbon capture and sequestration. The intermittency of renewable energy sources is the main obstacle to their wider adoption.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Kun Zhang, Lijie Wang, Jiayan Peng, Kangzhuo Sangji, Yuting Luo, Yujiao Zeng, Yongzhong Zeweng, Gang Fan
Summary: COVID-19 has caused significant harm worldwide, sparking interest in alternative treatments such as traditional medicine. Traditional Tibetan medicine (TTM) has a strong history in treating infectious diseases and this review explores its potential in addressing COVID-19. It provides insights into the theory, treatment strategies, and commonly used drugs in TTM, as well as discussing their efficacy and potential mechanisms based on experimental data. This review offers valuable information for the research, application, and development of traditional medicine in combating COVID-19 and future infectious diseases. Further pharmacological studies are necessary to uncover the therapeutic mechanisms and active ingredients of TTM drugs for COVID-19 treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Physics, Applied
Sander Bekeschus, Pietro Favia, Eric Robert, Thomas von Woedtke
PLASMA PROCESSES AND POLYMERS
(2019)
Review
Biochemistry & Molecular Biology
Kristian Wende, Thomas von Woedtke, Klaus-Dieter Weltmann, Sander Bekeschus
BIOLOGICAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Sybille Hasse, Marie-Christine Mueller, Karin Uta Schallreuter, Thomas von Woedtke
BIOLOGICAL CHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Sander Bekeschus, Juliane Moritz, Iris Helfrich, Lars Boeckmann, Klaus-Dieter Weltmann, Steffen Emmert, Hans-Robert Metelmann, Ingo Stoffels, Thomas von Woedtke
APPLIED SCIENCES-BASEL
(2020)
Article
Oncology
Christina M. Wolff, Juergen F. Kolb, Klaus-Dieter Weltmann, Thomas von Woedtke, Sander Bekeschus
Article
Oncology
Gabriella Pasqual-Melo, Thiago Nascimento, Larissa Juliani Sanches, Fernanda Paschoal Blegniski, Julya Karen Bianchi, Sanjeev Kumar Sagwal, Julia Berner, Anke Schmidt, Steffen Emmert, Klaus-Dieter Weltmann, Thomas von Woedtke, Rajesh Kumar Gandhirajan, Alessandra Lourenco Cecchini, Sander Bekeschus
Article
Oncology
Sybille Hasse, Tita Meder, Eric Freund, Thomas von Woedtke, Sander Bekeschus
Article
Biochemistry & Molecular Biology
Giuliana Bruno, Sebastian Wenske, Jan-Wilm Lackmann, Michael Lalk, Thomas von Woedtke, Kristian Wende
Article
Biochemistry & Molecular Biology
Sander Bekeschus, Dorothee Meyer, Kevin Arlt, Thomas von Woedtke, Lea Miebach, Eric Freund, Ramona Clemen
Summary: The study found that plasma treatment increased the expression levels of activation markers and cytokines in human dendritic cells, which may have beneficial effects on the tumor microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zahra Nasri, Mohsen Ahmadi, Johanna Striesow, Mehdi Ravandeh, Thomas von Woedtke, Kristian Wende
Summary: Cold physical plasma, as a new field of oxidative stress-based therapy, has the potential to generate a variety of reactive oxygen and nitrogen species (RONS), making it a promising tool for biomedical applications. However, the impact of plasma-derived RONS on cell membrane lipids and properties is not fully understood. This study investigated the changes in lipid bilayer functionality and revealed the strong impact of cholesterol on membrane permeabilization by plasma-derived species. Additionally, the chemical composition of the head group was found to influence the maintenance of barrier properties, with phosphatidylcholines being more susceptible than other lipid classes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Ramona Clemen, Kevin Arlt, Thomas von Woedtke, Sander Bekeschus
Summary: Protein vaccines can induce immune responses, but inflammation caused by reactive oxygen species (ROSs) can modify proteins and affect their functionality or immunogenicity. Gas plasma technology is used to study the immunogenicity of oxidized protein antigens. The findings suggest that gas plasma-modified proteins can induce dendritic cell maturation and activation.
Article
Cell Biology
Ramona Clemen, Kevin Arlt, Lea Miebach, Thomas von Woedtke, Sander Bekeschus
Summary: This study investigated the effects of oxidized and native proteins on cell surface marker expression and cytokine release in human monocyte-derived cells. The results showed that oxidized proteins led to elevated expression levels of cell surface markers and modified release of cytokines. These findings are important for further exploring the application of oxidized proteins in cancer therapy.
Article
Biochemistry & Molecular Biology
Mohsen Ahmadi, Debora Singer, Felix Potlitz, Zahra Nasri, Thomas von Woedtke, Andreas Link, Sander Bekeschus, Kristian Wende
Summary: Cold physical plasma is a partially ionized gas that operates at body temperature and has applications in heat-sensitive technical and medical fields. It can be used to introduce oxidative modifications to biomolecules, including the activation of anticancer prodrugs. In a proof-of-concept study, a boronic pinacol ester fenretinide prodrug was activated using an atmospheric pressure argon plasma jet. The study demonstrated that the activation of the prodrug led to enhanced cytotoxic effects in vitro, making cold physical plasma-mediated prodrug activation a promising approach for combination cancer treatment studies.
Meeting Abstract
Dermatology
S. Hasse, M. Mueller, T. von Woedtke
EXPERIMENTAL DERMATOLOGY
(2019)
Article
Medicine, Research & Experimental
Anke Schmidt, Thomas von Woedtke, Brigitte Vollmar, Sybille Hasse, Sander Bekeschus