Article
Dermatology
C. O'Connor, C. Gallagher, A. Hollywood, L. Paul, M. O'Connell
Summary: Anakinra may be an effective treatment option for patients with pyoderma gangrenosum, especially those with multiple comorbidities. Further research is needed to evaluate its safety and efficacy.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2021)
Article
Genetics & Heredity
Ran Fang, Jun Wang, Xiao-yun Jiang, Shi-hao Wang, Hao Cheng, Qing Zhou
Summary: Pyoderma gangrenosum (PG) is a rare, destructive inflammatory skin disease that is associated with trauma. A patient with PG had symptoms of high fever and excessive inflammation in the wound area due to dysregulation of the NF-kappa B signaling pathway caused by a genetic mutation.
FRONTIERS IN GENETICS
(2021)
Review
Dermatology
Hakim Ben Abdallah, Karsten Fogh, Christian Vestergaard, Rikke Bech
Summary: Interleukin inhibitors have shown promising effectiveness in treating Pyoderma gangrenosum in adults, with response rates of 70% and complete response rates of 57%. Further studies are required to investigate the efficacy and underlying disease importance of different interleukin inhibitors for the treatment of PG.
Article
Public, Environmental & Occupational Health
Ambra Di Altobrando, Cosimo Misciali, Beatrice Raone, Luciano Attard, Valeria Gaspari
Summary: Pyoderma gangrenosum is the most common type of reactive skin lesions in patients with inflammatory bowel disease, but infectious or malignant causes should be considered in cases of persistent cutaneous ulcerations despite treatment with biologic and immunosuppressive therapy.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Review
Dermatology
Aleksandra Opalinska, Dominika Kwiatkowska, Adrian Burdacki, Miroslaw Markiewicz, Dominik Samotij, Marek Dudzinski, Jadwiga Niemiec-Dudek, Elzbieta Ostanska, Adam Reich
Summary: Pyoderma gangrenosum (PG) is a serious skin disease with unknown etiology often associated with underlying conditions, making diagnosis and treatment challenging. Careful monitoring for comorbidities and early intervention are crucial for better prognosis.
DERMATOLOGY AND THERAPY
(2021)
Review
Immunology
Yumei Wang, Na Wu, Keyi Yu, Min Shen
Summary: This study described the characteristics of patients with PAPA syndrome in China and provided an up-to-date literature review. The clinical manifestations of PAPA syndrome are diverse, making diagnosis challenging, and gene testing is critically helpful for diagnosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Jundong Huang, Lemuel Shui-Lun Tsang, Wei Shi, Ji Li
Summary: Pyoderma gangrenosum, acne, and hidradenitis suppurativa syndrome is a rare inflammatory disease characterized by pyoderma gangrenosum, facial acne, and hidradenitis suppurativa. The exact etiology and pathogenesis of this syndrome remain unknown, but there are similar pathophysiological mechanisms, including neutrophil infiltration and overexpression of the interleukin-1 family. Existing research has provided guidance for the treatment of these refractory diseases.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
Khalaf Kridin, Giovanni Damiani, Arnon D. Cohen
Summary: The study found a significant association between rheumatoid arthritis (RA) and the subsequent development of pyoderma gangrenosum (PG), with RA increasing the odds of developing PG by more than threefold. Patients with RA-associated PG were older compared to other PG patients, suggesting the need for physicians to pay attention to this increased burden and advise RA patients to avoid precipitating factors for PG.
CLINICAL RHEUMATOLOGY
(2021)
Review
Rheumatology
Erika Sawka, Allison Zhou, Emile Latour, Marcia Friedman, Alex G. Ortega-Loayza
Summary: The study found a common association between inflammatory arthritis and PG, with rheumatoid arthritis being the most common type. Joint symptoms usually precede PG, and a variety of treatment options including corticosteroids and biologics can be effective in improving or resolving ulcers.
CLINICAL RHEUMATOLOGY
(2021)
Article
Dermatology
Fatma Tuncez Akyurek, Mehmet Akyurek, Emre Zekey, Ismail Can, Gulcan Saylam Kurtipek
Summary: Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis characterized by painful ulcers that can be triggered by various factors. Treatment should aim to control lesions and related diseases with minimal side effects, tailored to individual patient needs. Mycophenolate mofetil has been used successfully in treating both MG and PG in some cases.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Nursing
Martina Burlando, Andrea Paravisi, Giorgia Bodini, Emanuele Cozzani, Aurora Parodi
Summary: Peristomal pyoderma gangrenosum (PPG) is a variant of pyoderma gangrenosum (PG) that can be effectively treated with crushed corticosteroid tablets, especially in cases where conventional treatments have failed. This case study highlights the successful use of this novel treatment approach in a patient with Crohn's disease and refractory PPG.
JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
(2021)
Review
Medicine, General & Internal
Ling-Yun Lu, Xue-Yang Tang, Guo-Jing Luo, Meng-Jia Tang, Yi Liu, Xi-Jie Yu
Summary: PAPA syndrome, characterized by severe autoimmune inflammation, is caused by mutations in the PSTPIP1 gene. Whole-exome sequencing identified a missense mutation in a Chinese family, marking the first reported case of PAPA in China.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Editorial Material
Dermatology
Brett G. MacLeod, Carissa S. Klarich, Laurel L. Wessman, Kevin J. Gaddis, Nikifor K. Konstantinov, Angie Wubben, M. Mark Melin
Summary: A 64-year-old White woman developed a progressive hip ulceration after a hip replacement surgery, which was initially diagnosed as pyoderma gangrenosum. Through the use of the MolecuLight i:X device, infection was excluded and appropriate treatment was provided. The patient's condition improved with a combination of topical medication and immune suppressants.
ADVANCES IN SKIN & WOUND CARE
(2022)
Article
Rheumatology
Vanitha Agrahara Sathyanarayana, Debaditya Roy, Bhavya Nagaraju, Vijay K. R. Rao
Summary: Pyoderma gangrenosum (PG) is a rare autoinflammatory disorder characterized by distinctive non-infective, non-neoplastic skin ulceration. Effective treatment options for PG are lacking, but we have presented three cases successfully treated with Tofacitinib, a JAK/STAT pathway inhibitor, without relapse in follow up.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Letter
Dermatology
Akihiro Orita, Daichi Hoshina, Kuninori Hirosaki
Summary: This article presents a case of pyoderma gangrenosum (PG) caused by secukinumab and successfully treated with risankizumab. The literature review indicates that IL-23 may play a significant role in the pathogenesis of PG, suggesting IL-23-targeting therapies as a potential treatment option for PG.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
